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Öğe Asecretory POEMS syndrome with widespread osteosclerotic lesions(2000) Tombuloglu M.; Saydam, G..; Donmez A.; Cagirgan S.; Hekimgil M.; Soydan S.; Sencan M.; Buyukkececi F.POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes) is a rare disease and constitutes 1-2% of plasma cell dyscrasia. Most of the patients have few sclerotic bone lesions and more than 90% of patients have serum and/or urinary M-protein. In this report, we present a patient with POEMS syndrome who had severe polyneuropathy and unusual widespread osteosclerotic lesions without M-protein in serum and urine. According to our knowledge, this is the first case of asecretory POEMS syndrome with multiple sclerotic lesions and polyneuropathy. Our patient is still well and able to work actively 4 years after diagnosis with the treatment of 12 courses of VAD by reducing the vincristine dosage.