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Öğe 6 Expression and amplification of topoisomerase-2 alpha in type 1 and type 2 papillary renal cell carcinomas and its correlation with HER2/neu amplification(Springer, 2011) Duzcan, Fusun; Duzcan, S. Ender; Sen, Sait; Yorukoglu, Kutsal; Caner, Vildan; Sen Turk, Nilay; Cetin, G. Ozan; Kelten, Canan; Tuna, Burcin; Sarsik, Banu; Tepeli, EmreÖğe Acinar Adenocarcinoma of Prostate with Predominant Ttf-1 Positive Intraductal Component(De Gruyter Open Ltd, 2017) Sarsik, Banu; Karadeniz, Nisar; Simsir, Adnan; Akyol, Rahmi; Yorukoglu, Kutsal; Sen, SaitIntraductal carcinoma of prostate has been previously described in radical prostatectomies. It's rarely encountered in needle biopsies in the absence of infiltrative carcinoma. But, both histogenesis and nomenclature of the lesion is still controversial. Among the pure intraductal carcinoma of prostate cases, a different solid patern was described with smaller nuclei at the center of the ducts. However, there is a lack of information about the association of those cases with acinar prostate adenocarcinoma. Herein, we describe a case of acinar adenocarcinoma with predominant non-neuroendocrine TTF-1 positive small cell intraductal component.Öğe Acoustic Radiation Force Impulse Elastography May Predict Acute Rejection in Kidney Transplantation(Elsevier Science Inc, 2020) Gokalp, Cenk; Oytun, Merve Guner; Gunay, Emrah; Tamsel, Sadik; Sen, Sait; Sezer, Taylan Ozgur; Toz, HuseyinBackground. Allograft biopsy that is done as indicated by clinical and laboratory clues about graft rejection provides a definitive diagnosis. Noninvasive methods that may be useful for predicting or diagnosing rejection are important for early diagnosis of possible rejection. Purpose. The aim of this study is to investigate the relationship between changes in shear wave velocity (SWV) values and renal allograft kidney biopsy findings. Material and Methods. Thirty-four end-stage renal failure patients who underwent living donor renal transplantation between January 2015 and July 2015 were enrolled in this prospective cohort study. Implantation, sixth-month protocol, and biopsies that were performed with suspicion of acute rejection were evaluated with renal Doppler ultrasound and elastography findings of recipients' preimplantation donor ultrasonography findings. Results. Comparison of renal ultrasound and elastography findings of 2 groups revealed a significant elevation in the resistive index (0.81 vs 0.63, P = .005) and pulsatility index (2.08 vs 1.20, P = .008) values in the rejection group, and no significant difference in the SWV values between the 2 groups. Delta (Delta)-SWV was calculated using the difference between acute rejection values and preimplantation, implantation, and sixth-month values showed a positive correlation between acute rejection (Delta-sixth month, r = 0.498, P = .030), tubulitis (Delta-pretransplant, r = 0.509, P = .037), and inflammation (Delta-pretransplant, r = 0.657, P = .004) scores. However, there were no correlations between Delta-SWV values and glomerulitis and peritubular capillaritis score. Conclusion. Changes in SWV may predict acute rejection in kidney transplantation pa-tients if the reference measurements were done at a more stable time after the transplantation.Öğe Adult primary glomerular diseases due to podocytopathies: a single center experience on patient characteristics, treatment and outcomes(Cukurova Univ, Fac Medicine, 2024) Bulgur, Ismail; Sen, Sait; Kumbaraci, Banu Sarsik; Demirci, Meltem Sezis; Yilmaz, Mumtaz; Asci, GulayPurpose: This study aims to evaluate the demographic, clinical, and pathologic characteristics and response to immunosuppressive therapy, particularly corticosteroids, in adult patients with primary focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD), which are classified as podocytopathies. Materials and Methods: Between January 1998 and December 2014, this study included 44 patients (27 with primary FSGS and 17 with MCD) aged older than 18 years with a histopathologic diagnosis, symptoms of nephrotic syndrome, and a minimum follow-up of six months. Patients were divided into two groups according to the treatment they received and three groups according to their response to treatment. Patients diagnosed with primary FSGS and MCD were evaluated based on clinical, demographic, and laboratory findings, as well as response to treatment, and a comparison was conducted between the two groups. Results: 59.1% of the patients were male with a mean age of 44.8 +/- 17.7 years. At the time of diagnosis, there were no statistically significant differences in clinical and demographic characteristics between MCD and primary FSGS patients. However, in patients with MCD, the mean creatinine clearance (118.0 +/- 46.7 ml/min) was higher and the rate of microscopic hematuria (11.8%) was lower at the time of diagnosis. There was an increased need for alternative immunosuppressive treatments besides corticosteroids in patients with primary FSGS to achieve partial or complete remission. At both the third and sixthmonth follow-ups, MCD patients achieved a higher rate of complete remission (proteinuria <0.3 g/day) than FSGS patients. Conclusion: Compared to MCD, primary FSGS is more likely to progress, requires more immunosuppressive therapy beyond corticosteroids to achieve partial or complete remission, and has a lower treatment response rate.Öğe AL Amyloidosis Presenting with Yellow Discolouration of the Skin with Dermoscopic Findings(Wolters Kluwer Medknow Publications, 2023) Acar, Ayda; Baklan, Ecem; Yaman, Banu; Turk, Bengu Gerceker; Sen, Sait; Keser, Gokhan[No abstract available]Öğe Amyloidosis of seminal vesicles; incidence and pathologic characteristics.(2012) Argon, Asuman; Şimşir, Adnan; Sarsik, Banu; Tuna, B; Yorukoglu, K; Niflioğlu, Gg; Sen, Sait…Öğe Analysis of Prognostic Factors Affecting Cancer-specific Survival in Renal Tumors Larger than Ten Centimeters(Galenos Yayincilik, 2019) Kizilay, Fuat; Simsir, Adnan; Akincioglu, Emir; Kalemci, Serdar; Sen, Sait; Sarsik, Banu; Cal, Cag; Cureklibatir, IbrahimObjective: The aim of this study was to evaluate the relationship between prognostic factors and cancer-specific survival (CSS) in renal tumors larger than ten centimeters. Materials and Methods: We evaluated the data of 126 patients who underwent open radical nephrectomy due to a renal mass larger than 10 cm between January 2010 and June 2016. Kaplan-Meier analysis or Cox regression was used to analyze the relationship between CSS and variables. Pairwise group comparisons were also evaluated with the Log-Rank test. A p-value <0.05 was considered statistically significant. Results: Mean follow-up was 68.5 months and mean survival was 39.2 months. The relationships between tumor histopathology, stage and CSS were significant. Tumor size negatively affected CSS, but the relationship was not significant. Tumor stage (T2b, T3b), tumor thrombus, lymph node metastasis and adjuvant therapy were the most effective independent factors affecting CSS according to Cox regression analysis results. Conclusion: Although tumor size is an important prognostic factor for T2b and lower stage kidney tumors, this effect is less in larger tumors and other clinicopathological features should be considered further to predict prognosis.Öğe ARE THE PAIRED IMPLANT BIOPSIES FROM CADAVERIC DONORS NECESSARY?(Wiley-Blackwell, 2005) Sen, Sait; Nalbantoglu, Ilke; Toz, Huseyin; Doganavsargil, Basak; Sozbilen, Murat; Ertilav, Muhittin; Hoscoskun, CuneytÖğe Atorvastatin ameliorates morphological changes in encapsulated peritoneal sclerosis rat models(Oxford Univ Press, 2006) Sipahi, Savas; Sezak, Murat; Duman, Soner; Ozkan, Sultan; Sen, Sait; Ok, ErcanÖğe Autopsy Findings of a Case with Oxalosis(Alliance Communications Group Division Allen Press, 2009) Doganavsargil, Basak; Akil, Ipek; Sen, Sait; Mir, Sevg; Basdemir, GulcinOxalosis, deposition of calcium oxalate in tissues, is the final stage of hyperoxaluric syndromes. Being a rare entity, it is often missed, or the diagnosis is delayed, since the definitive diagnosis requires special laboratory tests. Kidneys, the walls of blood vessels, and bones are the major sites for crystal deposition. We report the autopsy findings of a 4-year-old girl who presented with end-stage renal disease in which the clinical presentation was consistent with primary hyperoxaluria Type 1. The case is unusual, as there was extensive crystal deposition throughout the body, including in tissues that are rarely involved, such as ovaries, fallopian tubes, uterus, thymus, salivary glands, pancreas, and bladder.Öğe Böbreğin müsinöz tübüler iğsi hücreli karsinomu ve tanı sorunları(2011) Sarsik, Banu; Şimşir, Adnan; Sen, Sait…Öğe Böbrekte kitle nedeniyle yapılan iğne kor biyopsileri ve tanı zorlukları(2009) Sen, Sait; Sarsık, B; Şimşir, Adnan; Kısmalı, Erkan; Gokmen, E…Öğe C4d as a Practical Marker for Cutaneous Amyloidosis(Lippincott Williams & Wilkins, 2022) Yaman, Banu; Kumbarac, Banu Sarsik; Gonzalez, Claudia A. Gomez; Akalin, Taner; Sen, SaitCutaneous amyloidosis (CA) is defined by the accumulation of amyloid in the dermis; it might be primary or secondary. The diagnosis is based on histopathological findings with the demonstration of amyloid deposits, confirmed by Congo red stain under the polarized light. Studies on other diagnostic markers are ongoing in the literature. The aim of this study was to demonstrate the utility of C4d staining in the recognition of amyloid in CA and using it as an alternative or substitute marker for the diagnosis. In this retrospective study, 199 skin biopsies with a clinical provisional diagnosis of CA were analyzed, the Congo red stain was performed, and, in a subgroup (n = 97) with histopathological findings probably for CA, C4d immunohistochemistry was assessed. Forty-eight cases of CA were detected. Congo red birefringence was positive in all cases, whereas in 14 cases, it was faded. In these 14 cases, the diagnosis of CA was made by means of Congo red fluorescence and Thioflavin T because the histopathological findings were highly suggestive for CA. All CA cases were positive with C4d, and in 12 of the 49 inflammatory dermatoses, C4d was positive. The interpretation of C4d immunohistochemistry can be performed more easily and rapidly than Congo red evaluation. The sensitivity and specificity of C4d were 100% and 75.5%, respectively. In our experience, C4d staining was a useful method for detecting amyloid deposits in CA. Although Congo red staining is the gold standard for amyloid detection, we propose C4d immunohistochemistry as a routine screening method or hybrid transition while further investigations are completed.Öğe Calcineurin inhibitor-based and free regimens have distinct gene expression patterns in subclinical graft fibrosis(Int Scientific Literature, Inc, 2011) Toz, Huseyin; Sen, Sait; Celik, Handan Ak; Yilmaz, Mumtaz; Hur, Ender; Hoscoskun, Cuneyt; Ozkahya, Mehmet; Aydin, Hikmet HakanBackground: Chronic nephrotoxic effects of calcineurin inhibitors may be responsible for late allograft dysfunction and reduced allograft half-life. Mammalian target of rapamycin inhibitors (mTOR-i's), a newer class of immunosuppressant, do not have the chronic nephrotoxic effects shown with calcineurin inhibitors (CNI). Whether these drug classes have distinct features at the molecular level is not clear. Material/Methods: Difference in gene expression profiles of kidney graft protocol biopsies from patients treated with CNI or mTOR-i's were investigated. Biopsies from patients using CNI (n=4) and mTOR-i-based treatments (n=4) were analyzed. The control group consisted of 5 biopsies obtained at the time of implantation (zero hour). Microarray hybridization was performed using the Affymetrix (R) GeneChip U133 plus 2.0 Array. Results: In the CNI and mTOR-i groups, 64 up-regulated and 119 down-regulated genes were found compared to control subjects. A total of 29 genes in the CNI group and 101 genes in the mTOR-i group were up-regulated compared to each other. Conclusions: Despite similar clinical courses and histopathological appearances, different treatment strategies cause different gene expression profiles in kidney transplantation.Öğe CAN N-ACETYLCYSTEINE PRESERVE PERITONEAL FUNCTION AND MORPHOLOGY IN ENCAPSULATING PERITONEAL SCLEROSIS?(Multimed Inc, 2009) Bozkurt, Devrim; Hur, Ender; Ulkuden, Burcu; Sezak, Murat; Nar, Hasim; Purclutepe, Ozlem; Sen, Sait; Duman, SonerLong-term use of the peritoneum as a dialysis membrane results in progressive irreversible dysfunction, described as peritoneal fibrosis. Oxidative stress during peritoneal dialysis has been established in many studies. Generation of reactive oxygen species (ROS) by conventional peritoneal dialysis solutions, regardless of whether produced by high glucose, angiotensin II, or glucose degradation products may be responsible for progressive membrane dysfunction. The well-known antioxidant molecule N-acetylcysteine (NAC) is capable of direct scavenging of ROS. The aim of the present study was to investigate the effect of NAC therapy on both progression and regression of encapsulating peritoneal sclerosis (EPS). We divided 49 nonuremic Wistar albino rats into four groups: Control group-2 mL isotonic saline intraperitoneally (IP) daily for 3 weeks; CG group-2 mL/200 g 0.1% chlorhexidine gluconate (CG) and 15% ethanol dissolved in saline injected IP daily for a total of 3 weeks; Resting group CG (weeks 1-3), plus peritoneal resting (weeks 4-6); NAC-R group-CG (weeks 1-3), plus 2 g/L NAC (weeks 4-6). At the end of the experiment, all rats underwent a 1-hour peritoneal equilibration test with 25 mL 3.86% PD solution. Dialysate-to-plasma ratio (D/P) urea, dialysate white blood cell count (per cubic milliliter), ultrafiltration (UF) volume, and morphology changes of parietal peritoneum were examined. The CG group progressed to encapsulating peritoneal sclerosis, characterized by loss of UF, increased peritoneal thickness, inflammation, and ultimately, development of fibrosis. Resting produced advantages only in dialysate cell count; with regard to vascularity and dialysate cell count, NAC was more effective than was peritoneal rest. Interestingly, we observed no beneficial effects of NAC on fibrosis. That finding may be a result of our experimental severe peritoneal injury model. However, decreased inflammation and vascularity with NAC therapy were promising results in regard to membrane protection.Öğe Can Neutrophil/Lymphocyte and Platelet/Lymphocyte Rates Predict Bone Metastasis in Prostate Cancer Patients?(Galenos Yayincilik, 2019) Ceylan, Yesim; Tatlidil, Sevil; Sen, Sait; Sarsik, Banu; Ozcan, ZehraObjective: Bone metastasis is common in advanced prostate cancer (PCa). Recently, there has been a growing interest in the potential role of inflammatory markers, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and neutrophil-to-monocyte ratio (NMR), in predicting advanced disease in patients with solid tumors. In the current study, we aimed to assess the relationship of bone metastasis detected on bone scintigraphy (BS) with NLR, PLR, and NMR in patients with Pca. Materials and Methods: The study group included 85 PCa patients. Patient characteristics, prostate-specific antigen (PSA) values, Gleason score, histopathological features, presence of metastatic focus on BS and complete blood count values were retrospectively evaluated. The relationship of the presence of bone metastasis on BS with clinicopathological features such as PSA, Gleason score, histopathological findings and NLR, PLR and NMR values were investigated. Results: Median NLR, PLR and NMR were 2.90, 125.69 and 8.38, respectively. Thirty-six patients had metastatic disease on BS. Our findings showed a statistically significant relationship between high NLR value and the presence of bone metastasis (p=0.018) and high Gleason score (p=0.034). However, no significant statistical relationship was found between clinicopathological features and PLR and NMR values (p>0.05). Conclusion: Despite the limited number of patients, a significant relationship between high NLR and metastatic bone disease was found. While high NLR has been generally considered an independent risk factor for poor PCa prognosis, we assume that larger scale studies are warranted to assess its value as a prognostic indicator in PCa patients.Öğe Classification and scoring system of renal amyloidosis; experience with 288 cases(Springer, 2007) Sen, Sait; Sarsik, Banu; Yazici, AyseÖğe Coexistence of Sjogren's syndrome and pulmonary nodular amyloidosis(Wiley, 2023) Tastekin, Fatih; Kerim, Duygu; Sen, Sait; Kabasakal, YaseminThere are very few cases in the literature on the coexistence of Sjogren's syndrome and pulmonary nodular amyloidosis being treated with rituximab. When nodules with central calcification and cystic lesions are seen on computed tomography, amyloid lung should be considered. Biopsy is recommended as it can be confused with malignancies. In this article, we present a 66-year-old female patient who has been followed up for Sjogren's syndrome for 26 years. Multiple cystic lesions with central calcification in the lung were detected and it was evaluated as amyloid nodule in the biopsy performed. The patient is being followed and is stable under rituximab treatment. Pulmonary noduler amyloidosis is very rare in Sjogren patients and there are very few cases where rituximab is used for treatment. We decided to publish in order to guide clinicians who will encounter similar cases.Öğe Design and evaluation of an intravesical delivery system for superficial bladder cancer: preparation of gemcitabine HCl-loaded chitosan-thioglycolic acid nanoparticles and comparison of chitosan/poloxamer gels as carriers(Dove Medical Press Ltd, 2015) Senyigit, Zeynep Ay; Karavana, Sinem Yaprak; Ilem-Ozdemir, Derya; Caliskan, Cagri; Waldner, Claudia; Sen, Sait; Bernkop-Schnurch, Andreas; Baloglu, EsraThis study aimed to develop an intravesical delivery system of gemcitabine HCl for superficial bladder cancer in order to provide a controlled release profile, to prolong the residence time, and to avoid drug elimination via urination. For this aim, bioadhesive nanoparticles were prepared with thiolated chitosan (chitosan-thioglycolic acid conjugate) and were dispersed in bioadhesive chitosan gel or in an in situ gelling poloxamer formulation in order to improve intravesical residence time. In addition, nanoparticle-loaded gels were diluted with artificial urine to mimic in vivo conditions in the bladder and were characterized regarding changes in gel structure. The obtained results showed that chitosan-thioglycolic acid nanoparticles with a mean diameter of 174.5 +/- 3.762 nm and zeta potential of 32.100 +/- 0.575 mV were successfully developed via ionotropic gelation and that the encapsulation efficiency of gemcitabine HCl was nearly 20%. In vitro/ex vivo characterization studies demonstrated that both nanoparticles and nanoparticle-loaded chitosan and poloxamer gels might be alternative carriers for intravesical administration of gemcitabine HCl, prolonging its residence time in the bladder and hence improving treatment efficacy. However, when the gel formulations were diluted with artificial urine, poloxamer gels lost their in situ gelling properties at body temperature, which is in conflict with the aimed formulation property. Therefore, 2% chitosan gel formulation was found to be a more promising carrier system for intravesical administration of nanoparticles.Öğe Digitally reinforced hematoxylin-eosin polarization technique in diagnosis of rectal amyloidosis(Baishideng Publishing Group Inc, 2015) Doganavsargil, Basak; Buberal, Gulruh Emiroglu; Toz, Huseyin; Sarsik, Banu; Pehlivanoglu, Burcin; Sezak, Murat; Sen, SaitAIM: To investigate the efficacy of the digitally reinforced hematoxylin-eosin polarization (DRHEP) technique for detection of amyloidosis in rectal biopsies. METHODS: One hundred hematoxylin-eosin (HE) stained rectal biopsies with Congo-red (CR)-positive amyloid depositions and 50 control cases with CR-negative amyloid-mimicking areas were scanned blinded to the CR results for amyloid depositions under both bright and polarized light, and digitally photographed using the DRHEP technique, to accentuate the faint birefringence observed in HE slides under polarization. The results of DRHEP and HE evaluation were statistically correlated with CR polarization results with respect to presence and localization of amyloid deposits as well as amyloid types. RESULTS: Amyloid deposits showed yellowish-green birefringence by DRHEP, which allowed identification of amyloidosis in 41 HE-unsuspected cases (P = 0.016), 31 of which only had vascular deposits. True positivity was higher, and false negativity and positivity were lower by DRHEP, compared to evaluation by HE (69%, 31%, and 0.8% vs 33%, 67%, and 33%, respectively; P < 0.0001). The sensitivity, specificity, accuracy, and positive and negative predictive values for DRHEP were 69%, 98%, 78.6%, 98.5%, and 61.25%, respectively. Reasons for DRHEP false negativity were presence of extensive background birefringence in 12 cases, absence of CR birefringent vessel in 3 cases, and missing of the tiny deposits in 9 cases, which could be improved by experience, especially in the latter case. No correlation was found between age, gender, sites of deposits, or amyloid types. CONCLUSION: The DRHEP technique improves diagnostic accuracy when used as an adjunct or a prior step to CR staining, especially for cases with limited tissues for further analysis.