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    Infectious complications in pediatric liver transplantation candidates
    (Blackwell Publishing Inc., 2010) Cakir M.; Arikan C.; Akman S.A.; Baran M.; Saz U.E.; Yagci R.V.; Zeytunlu M.; Kilic M.; Aydogdu S.
    We analyzed infections that occurred within one month prior to LT, identified factors associated with their occurrence and effect of infections on post-transplant mortality. The study group included 40 consecutive children who underwent LT. Sites and types of infection and culture results were recorded prospectively. IID was assessed. Risk factors for the infectious events were analyzed. Forty infection episodes were found in 24 patients (60%); 90% were bacterial, 7.5% fungal, and 2.5% viral. Overall, IID was 38.2 per 1000 patient days. Sites of bacterial infection were urinary tract in 13 events (36.1%) and blood stream in 11 events (30.5%). Bacteremia (culture positive infection episodes) was identified in 19 events (52.7%). Gram-negative isolates were twice as frequent as Gram-positive infections (63.1% vs. 36.9%). Risk factors for the infectious complications were young age, low body weight, prior abdominal surgery, chronic liver disease related to biliary problems, presence of ascites, portal hypertension and cirrhosis, and high PELD score (p < 0.05 for all). Infectious complications in pediatric LT candidates are common. Preventive measures are important not only to reduce the infectious complications but also to prevent the post-operative mortality. © 2009 John Wiley & Sons A/S.
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    Suicides in adolescents: Benefit/harm balance of antidepressants
    (2007) Saz U.E.; Arslan M.T.; Egemen A.
    Introduction: Depression is an important cause of suicide in adolescents. It has been speculated that antidepressants themselves can increase the risk of suicide. Method: Cases of adolescents admitted to the Ege University Pediatric Emergency Department in Turkey due to suicide attempt were assessed. Results: Nine of 13 suicide attempts during June 2005 were due to overdose of antidepressants prescribed for major depressive disorder. Conclusion: Well-designed studies are needed to elucidate the role of antidepressant drugs in suicide.