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Öğe Can Ursodeoxycholic acid be an alternative of N-acetylcystein in acute acetaminophen intoxication?(2016) Savran, Yusuf; Çavuşoğlu, Türker; Tumer, Mehmet Kemal; Yiğittürk, Gürkan; Cıftcı, Oznur Dılek; Acara, Ahmet Çağdaş; Uyanıkgil, Yiğit…Öğe Current Statement of Intensive Care Units in Turkey: Data obtained from 67 Centers(Bilimsel Tip Publishing House, 2018) Ediboglu, Ozlem; Mocin, Ozlem Yazicioglu; Ozyilmaz, Ezgi; Salturk, Cuneyt; Onalan, Tugba; Seydaoglu, Gulsah; Celikel, Turgay; Arikan, Huseyin; Ataman, Sena; Kirakli, Cenk; Ozcelik, Zerrin; Kultufan, Sema; Kara, Iskender; Kara, Atilla; Dagli, Emine; Bulbul, Selma Duru; Kahveci, Kadriye; Dincer, Metin; Senoglu, Nimet; Ozkarakas, Huseyin; Bahar, Ilhan; Cengiz, Melike; Ramazanoglu, Atilla; Celik, Burcu; Gaygisiz, Ummugulsun; Kir, Gulay; Bindal, Ahmet; Akan, Belgin; Turan, Isil Ozkocak; Yildirim, Fatma; Basarik, Burcu; Ulukan, Zeliha Arslan; Efe, Serdar; Sungur, Murat; Temel, Sahin; Izdes, Seval; Hosgun, Derya; Karadeniz, Nurhan; Tuncay, Eylem; Goksenoglu, Nezihe Ciftarslan; Irmak, Ilim; Datli, Utku; Zerman, Avsar; Akdag, Devrim; Ozdemir, Levent; Elay, Gulseren; Karacayir, Yucel; Topeli, Arzu; Hanci, Pervin; Kaya, Esat Kivanc; Guven, Pinar; Sazak, Hilal; Aydemir, Semih; Aygencel, Gulbin; Aydemir, Yusuf; Doganay, Zahide; Komurcu, Ozgur; Hanci, Volkan; Karakoc, Emre; Sozutek, Didem; Coskun, Guven; Ates, Gungor; Tiryaki, Civan; Soyturk, Ayse Nur; Girgin, Nermin Kelebek; Caliskan, Gulbahar; Biyikli, Oben; Gokmen, Necati; Koca, Ugur; Ciledag, Aydin; Suner, Kezban Ozmen; Cinel, Ismail; Arslantas, Mustafa Kemal; Gul, Fethi; Ergun, Recai; Yilmaz, Nafiye; Altintas, Defne; Talan, Leyla; Yalcinsoy, Murat; Gullu, Mehmet Nezir; Ozcan, Perihan Ergin; Orhun, Gunseli; Savran, Yusuf; Tokur, Murat Emre; Akpinar, Serdar; Sen, Pelin; Gursel, Gul; Serifoglu, Irem; Gedik, Ender; Balbay, Oner Abidin; Akbas, Turkay; Cesur, Sinem; Yolacan, Hulya; Sagmen, Seda Beyhan; Ekren, Pervin Korkmaz; Bacakoglu, Feza; Ergan, Begum; Gunay, Ersin; Sariaydin, Muzaffer; Saglam, Dursun Ali; Karakurt, Sait; Eryuksel, Emel; Oztuna, Funda; Murtezaoglu, Emine Sevil Ayaydin; Cinemre, Hakan; Nalbant, Ahmet; Yagmurkaya, Oznur; Mandal, Tugba; Ikidag, BelginOBJECTIVES: We aimed to obtain information about the characteristics of the ICUs in our country via a point prevalence study. MATERIAL AND METHODS: This cross-sectional study was planned by the Respiratory Failure and Intensive Care Assembly of Turkish Thoracic Society. A questionnaire was prepared and invitations were sent from the association's communication channels to reach the whole country. Data were collected through all participating intensivists between the October 26, 2016 at 08:00 and October 27, 2016 at 08:00. RESULTS: Data were collected from the 67 centers. Overall, 76.1% of the ICUs were managed with a closed system. In total, 35.8% (n=24) of ICUs were levels of care (LOC) 2 and 64.2% (n=43) were LOC 3. The median total numbers of ICU beds, LOC 2, and LOC 3 beds were 12 (8-23), 14 (10-25), and 12 (8-20), respectively. The median number of ventilators was 12 (7-21) and that of ventilators with non-invasive ventilation mode was 11 (6-20). The median numbers of patients per physician during day and night were 3.9 (2.3-8) and 13 (9-23), respectively. The median number of patients per nurse was 2.5 (2-3.1); 88.1% of the nurses were certified by national certification corporation. CONCLUSION: In terms of the number of staff, there is a need for specialist physicians, especially during the night and nurses in our country. It was thought that the number of ICU-certified nurses was comparatively sufficient, yet the target was supposed to be 100% for this rate.Öğe Oxytocin Effect on Sepsis-induced Experimental Rat Renal Failure Model: A Histological and Biochemical study(2018) Çavuşoğlu, Türker; Savran, Yusuf; Uyanıkgil, Yiğit; Gülle, Kanat; Acara, Ahmet Çağdaş; Yiğittürk, Gürkan; Erbaş, OytunObjective: We aimed to investigate the therapeutic role of Oxytocin (OT) in sepsis induced rats and its effects on kidneys. Sepsis was induced in 24 of them by cecal ligation-perforation (CLP) method. Material-Method: One of the groups of CLP did not recieve any treatment while either saline 1 ml/kg or OT 0.4 mg/kg was applied intraperitoneally to the other groups within the first hour of surgery. 8 rats were sham-operated and 8 rats were spared as control group. Plasma TNF-? ? (Tumor necrosis factor- ?), CRP (C reactive Protein), MDA (Malondialdehyde) levels, total antioxidant capacity (TAC), creatinine level and peripheral leukocyte (WBC) counts were measured. Results: TNF-?, CRP, MDA, TAC levels and WBC counts were significantly increased in CLP and CLP-saline groups, on the contrary they are decreased in CLP-OT group. Histopathologically loss of brush border, tubular dilatation and mononuclear cell infiltration was significantly decreased in CLP-OT group but there was no significant difference in erytrocyte extravasation and cast formation when compared to CLP and CLP-saline groups. Conclusions: Our results indicate that OT may have a therapeutic value in limiting sepsis induced inflammation and organ damage.Öğe Risk Factors for Resistant Gram Negative Infections in Intensive Care Unit(2020) Sahutoglu, Sercan; Savran, Yusuf; Comert, BilginObjective: The most common resistant gram negative bacteria isolated in hospital-acquired blood stream infections are Pseudomonas aeruginosa, Acinetobacter species and Klebsiella pneumoniae. These infections are associated with increased mortality rates. In this study, we aimed to identify the risk factors for emerging resistant gram negative bacterial infections. Methods: Data of 280 patients hospitalized in Medical Intensive Care Unit (ICU) between September 1st, 2013 and September 30th, 2014 were reviewed retrospectively. Results: Resistant gram negative bacterial infections were detected in 80 patients. Acinetobacter baumannii, Klebsiella pneumoniae and Pseudomonas aeruginosa were the most resistant strains, respectively. APACHE II score, duration of mechanical ventilation, length of ICU stay and length of hospital stay were independent risk factors for resistant gram negative bacteria isolation. Mechanical ventilation and central venous catheterization were related with increased mortality rates. Length of ICU stay was an independent risk factor for resistant A.baumannii isolation. Prolonged mechanical ventilation, hospital and ICU stay were common risk factors for resistant K.pneumoniae and P.aeruginosa isolation. Total parenteral nutrition was an additional risk factor for resistant K.pneumoniae isolation and mortality rates for K.pneumoniae were higher than the other bacteriae. Conclusion: In the management of critical patients; prolonged ICU and hospital stays should be avoided as much as possible and central venous catheterization should only be used for appropriate indications and removed as soon as possible to prevent resistant gram negative bacterial infections. In addition, mechanically ventilated patients should be weaned from the ventilator as soon as possible, parenteral nutrition products should not be used instead of enteral nutrition if it’s not necessary and antibiotics must be used appropriately.Öğe Risk Factors for Resistant Gram Negative Infections in Intensive Care Unit(Turkish Soc Medical & Surgical Intensive Care Medicine, 2020) Sahutoglu, Sercan; Savran, Yusuf; Comert, BilginObjective: The most common resistant gram negative bacteria isolated in hospital-acquired blood stream infections are Pseudomonas aeruginosa, Acinetobacter species and Klebsiella pneumoniae. These infections are associated with increased mortality rates. In this study, we aimed to identify the risk factors for emerging resistant gram negative bacterial infections. Methods: Data of 280 patients hospitalized in Medical Intensive Care Unit (ICU) between September 1st, 2013 and September 30th, 2014 were reviewed retrospectively. Results: Resistant gram negative bacterial infections were detected in 80 patients. Acinetobacter baumannii, Klebsiella pneumoniae and Pseudomonas aeruginosa were the most resistant strains, respectively. APACHE II score, duration of mechanical ventilation, length of ICU stay and length of hospital stay were independent risk factors for resistant gram negative bacteria isolation. Mechanical ventilation and central venous catheterization were related with increased mortality rates. Length of ICU stay was an independent risk factor for resistant A.baumannii isolation. Prolonged mechanical ventilation, hospital and ICU stay were common risk factors for resistant K.pneumoniae and P.aeruginosa isolation. Total parenteral nutrition was an additional risk factor for resistant K.pneumoniae isolation and mortality rates for K.pneumoniae were higher than the other bacteriae. Conclusion: In the management of critical patients; prolonged ICU and hospital stays should be avoided as much as possible and central venous catheterization should only be used for appropriate indications and removed as soon as possible to prevent resistant gram negative bacterial infections. In addition, mechanically ventilated patients should be weaned from the ventilator as soon as possible, parenteral nutrition products should not be used instead of enteral nutrition if it's not necessary and antibiotics must be used appropriately.Öğe Sepsis Kaynaklı Deneysel Sıçan Böbrek Hasarı Modeli Üzerine Oksitosin Etkisi: Histolojik ve Biyokimyasal Bir Çalışma(2018) Çavuşoğlu, Türker; Savran, Yusuf; Uyanıkgil, Yiğit; Gülle, Kanat; Acara, Ahmet; Yiğittürk, Gürkan; Kılıç, Kubilay Doğan…
