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    Radiolabeling of folate targeted multifunctional conjugate with Technetium-99m and biodistribution studies in rats
    (2012) Ak G.; Yurt Lambrecht F.; Sanlier S.H.
    Despite the progress in the diagnosis and management of early stage disease, the management of advanced prostate cancer remains an important problem. Prostate tissue expresses folate receptor (FR) which binds both folic acid and folate-linked drugs or imaging agents. Doxorubicin is the best known and most widely used member of the anthracycline antibiotic group of anticancer agents. The aim of this work is to develop a multifunctional nanoconjugate, 99mTc-folatePEGdoxorubicin, in order to investigate its radiopharmaceutical potential as a prostate cancer imaging and real-time drug location imaging agent. Through this aim, biodistribution studies of 99mTc-folatePEGdoxorubicin and control groups ( 99mTcdoxorubicin and 99mTcPEGdoxorubicin) in male rats were carried out. Obtained data showed that uptake of 99mTc- folatePEGdoxorubicin in prostate was significantly higher than that of the control groups due to the affinity of folate ligand to folate receptor. As a consequence, it was indicated that 99mTc-FOLPEGDOX radiolabeled conjugate which has a great target/non-target organ ratio, is specific for target organ and has a high radiopharmaceutical potential as a prostate cancer and real-time drug location imaging agent. © 2012 Informa UK, Ltd.
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    Removal of textile dye, direct red 23, with glutaraldehyde cross-linked magnetic chitosan beads
    (2013) Sanlier S.H.; Ak G.; Yilmaz H.; Ozbakir G.; Cagliyan O.
    One of the most important classes of pollutants is dyes, and today there are more than 100,000 commercial dyes. Conventional treatment processes are very expensive, so it is essential to develop low-cost sorbent materials with high adsorption capacities. The aim of this study is to prepare magnetic microsized adsorbents that have high adsorption capacity for removal of direct red 23. Through this objective, glutaraldehyde cross-linked magnetic chitosan beads were formed in order to remove the textile dye direct red 23. Barium ferrite was used to give a magnetic property so that the beads could easily be separated from the water after treatment. The effects of barium ferrite, pH, incubation time, dye concentration, and glutaraldehyde amounts were investigated. The Langmuir and Freundlich adsorption models were applied to describe the equilibrium isotherms. The adsorption capacity had a very large value: 1250 mg/g at pH 4.0, at room temperature. Compared with activated carbon, magnetic cross-linked chitosan exhibits excellent performance in the adsorption of anionic dyes and the magnetic properties of beads enable us to remove the beads from the water after treatment. Pseudo-second-order and intraparticle diffusion kinetic models were applied. © 2013 Taylor & Francis Group, LLC.