Yazar "Salih, B." seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Effects of Manisa propolis on telomerase activity in leukemia cells obtained from the bone marrow of leukemia patients
    (Taylor & Francis Ltd, 2009) Cogulu, O.; Biray, C.; Gunduz, C.; Karaca, E.; Aksoylar, S.; Sorkun, K.; Salih, B.; Özkınay, Ferda
    Propolis is a resinous material collected by honeybees and obtained from beehives that has anticancer effects by inducing apoptosis. The aim of this study is to investigate the effect of propolis on human telomerase reverse transcriptase (hTERT) in the leukemia cells obtained from leukemia patients. Four different bone marrow cell cultures from each of four leukemia cases were prepared. The 60 ng/ml, 30 ng/ml and 15 ng/ml working concentrations of propolis were administered to three cultures of each patient, while one culture contained only culture medium. hTERT mRNA expression levels of cells were detected at 24 h, 48 h and 72 h using the LightCycler 2.0 instrument. A significant decrease in hTERT expression levels was observed in the 60 ng/ml concentration of propolis. In conclusion, Manisa propolis may also have a potential effect on the expression of hTERT in leukemia-particularly owing to its constituent chrysin.
  • Küçük Resim Yok
    Öğe
    Thermal studies of Co(II), Ni(II) and Cu(II) complexes of N,N'-bis(3,5-Di-t-butylsalicylidene)ethylenediamine
    (Springer, 2009) Dogan, F.; Ulusoy, M.; Ozturk, O.-F.; Kaya, I.; Salih, B.
    The thermal decomposition kinetics of sterically hindered salen type ligand (L) and its metal complexes [M=Co(II), Ni(II), Cu(II)] were investigated by thermogravimetric analysis. A direct insertion probe-mass spectrometer (DIP-MS) was used for the characterization of metal complexes of L and all fragmentations and stable ions were characterized. The thermogravimetry and differential thermogravimetry (TG-DTG) plots of salen type salicylaldimine ligand and complexes showed a single step. The kinetic analysis of thermogravimetric data was performed by using the invariant kinetic parameter method (IKP). The values of the invariant activation energy, E (inv) and the invariant pre-exponential factor, A (inv), were calculated by using Coats-Redfern (CR) method. The thermal stabilities and activation energies of metal complexes of sterically hindered salen type ligand (L) were found as Co(II)> Cu(II)> Ni(II)> L and E (Cu)> E (Ni)> E (Co)> L. Also, the probabilities of decomposition functions were investigated. The diffusion functions (D (n)) are most probable for the thermal decomposition of all complexes.