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Öğe Comparison of montelukast and cabergoline for prevention of ovarian hyperstimulation syndrome: In an experimental rat model(Informa Healthcare, 2015) Akman L.; Sahin G.; Erbas O.; Aktug H.; Akdogan A.; Goker E.N.T.; Taskiran D.; Tavmergen E.Ovarian hyperstimulation syndrome (OHSS) is a serious iatrogenic complication that can occur during assisted reproductive techniques. The aim of this study is to investigate the effects of the leukotriene receptor antagonist (montelukast) treatment in prevention of OHSS and compare to cabergoline treatment. Twenty-four immature female Wistar rats were assigned to four groups. Group 1 was the control group. In the remaning three groups, OHSS was induced through ovarian stimulation with gonadotropins. No treatment was given to Group 2. Group 3 was administered a low-dose 100 mg/kg cabergoline treatment and Group 4 was received 20 mg/kg montelukast. Body weight, ovarian weight, vasculary permability (VP), peritoneal fluid vascular endothelial growth factor (VEGF) values and VEGF immune-expression were compared between the groups. Both cabergoline and montelukast prevented progression of OHSS compared to the OHSS group. Body weight, ovarian weight, VP, peritoneal fluid VEGF values and VEGF expression were significantly lower in both cabergoline- and montelukast-treated rats than in those not treated OHSS group. In conclusion, montelukast is an effective option for prevention of OHSS, as well as cabergoline. Montelukast may be a new treatment option to prevent and control the OHSS. © 2015 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted.Öğe Effect of high-intensity interval training vs. moderate-intensity continuous training in young trained cyclists(Editura Universitatii din Pitesti, 2022) Yalcin E.; Sahin G.; Coskun A.; Yalcin O.Purpose: The aim of this study was to determine the effect of high intensity interval training (HIIT) vs moderate-intensity continuous training (MICT) on VO2max and anaerobic power in trained young cyclists in short period. Methods: Eighteen cyclists (between 15 and 20 years, n= 7 women, n= 11 men) were included in this study (age:17.50 years, height: 173.22 cm, body mass: 63.38 kg and body-mass index: 20.95 kg/m2). The cyclists were randomly divided into two groups. The training group (GHIIT, n= 9) participated in high intensity interval training two times per week for 6 weeks, while the Control Group (GCON, n= 9) completed moderate intensity continuous training (MICT). The training’ HR was conducted at 80%-95% HRmax for the first four weeks. In the last two weeks, the training’ HR was increased to %100 HRmax. The height, body mass, body fat %, aerobic and anaerobic power were measured. The maximal oxygen consumption (VO2max) was measured using a portable metabolic analyzer and, the traditional VO2max test followed a standard incremental design. Anaerobic capacity was evaluated by Wingate Anaerobic Test (WAnT) in 30sec. Results: There was no significant difference in body fat %, body mass, BMI, powerpeak, powermean, and powermin between GHIIT and GCON at the end of the training program (p>0.05). However, there was a significant difference in VO2max (p= 0.001) between GHIIT and GCON at the end of training (p<0.05). Conclusion: The high intensity interval training occurred a significant increase in VO2max. Anaerobic power improved but this result was not significant. Nevertheless, HIIT may use to improve in VO2max in young trained cyclists in short period. © JPES.Öğe The effect of thickness of silver thin film on structural and optical properties of porous silicon(World Scientific Publishing Co. Pte Ltd, 2017) Cetinel A.; Ozdogan M.; Utlu G.; Artunc N.; Sahin G.; Tarhan E.In this study, porous silicon (PS) samples were prepared on n-type silicon (100) wafers by electrochemical etching method, varying the current density from 20 to 100mA/cm2 and keeping constant HF concentration (10%) and etching time of 15min. Then, Ag thin films, which have 10, 50 and 100nm film thicknesses, were deposited on PS layers by using thermal evaporation to investigate the influence of Ag film thickness on structural and optical properties of PS. The structural and optical properties of PS and Ag deposited PS layers have been investigated by XRD, FE-SEM, Raman and photoluminescence (PL) spectroscopy. FE-SEM XRD and Raman analyzes indicate that average pore size and porosity of PS layers increase with the increasing current density. Further, Ag nanoparticles have embedded in pore channel. PL measurement reveals that higher porosity of PS would be better to form the Ag-PS nano-composite material leading to stronger PL band. The PL spectra of PS and Ag-PS samples indicate that PL bands show blue shift with increasing current density and film thickness. Consequently, it has been found that the structural and optical properties of PS depend on current density and Ag film thickness individually. © 2017 World Scientific Publishing Company.Öğe In vitro fertilization-induced pregnancies predispose to gastroesophageal reflux disease(SAGE Publications Ltd, 2016) Turan I.; Kitapcioglu G.; Goker E.T.; Sahin G.; Bor S.Background: Women conceiving following in vitro fertilization (IVF) likely have a variety of risk factors that predispose them to gastroesophageal reflux disease (GERD) in the future. Objective: We aimed to investigate whether pregnancy through IVF may predispose to subsequent GERD compared with pregnancies without IVF. We also evaluate whether twin IVF pregnancies lead to additional risk for having GERD compared with singleton IVF pregnancies. Methods: A validated reflux questionnaire was administered to 156 women with singleton (n=102) or twin (n=54) IVF birth (IVF group) and 111 women with a naturally conceived singleton birth (control group). All women included in the study were primiparas who had given birth at least 1 year prior to data collection. The diagnosis of GERD was based on the occurrence of typical symptoms (heartburn, regurgitation, or both) at least once a week. Results: The prevalence of GERD was 13.5% and 4.5% in IVF and control groups (p=0.015); in the IVF group, this was slightly higher, but not statistically significant, in women with twin compared with singleton pregnancies (14.8% vs. 12.7%, p=0.749). Logistic regression analysis showed that IVF was strongly associated with subsequent GERD (OR, 3.30; 95% CI 1.20–9.04; p=0.02). Conclusion: The risk of developing GERD at least 1 year after delivery increased following IVF. Long-term follow-up studies are required to determine whether therapy during pregnancy can prevent this risk. © Author(s) 2016.Öğe In-vitro fertilization outcome predictors in women with high baseline follicle-stimulating hormone levels: Analysis of over 1000 cycles from a tertiary center(Sociedade Brasileira de Reproducao Assistida, 2021) Sahin G.; Akdogan A.; Aydın M.H.; Tekindal M.A.; Göker E.N.T.; Tavmergen E.Objective: The present study aimed to evaluate reproductive outcomes and determine the predictors of clinical pregnancy and live birth in women with elevated baseline follicle-stimulating hormone (FSH) levels, who have undergone intracytoplasmic sperm injection (ICSI) treatment. Methods: This retrospective study included 1011 ICSI cycles of women with high baseline FSH levels (> 10 IU/L), from a tertiary university IVF center between 2010 and 2015. Logistic regression analysis was performed to evaluate the prognostic factors of clinical pregnancy and live birth. Results: Among the 1011 ICSI cycles, the clinical pregnancy and live birth rates per oocyte retrieval were 19.5% and 14.3%, respectively. The live birth rates were 21.1% and 1.7% in women aged ?30 years and those aged ?40 years, respectively. In addition, the live birth rate was 1.47-fold higher in women from whom >3 oocytes were retrieved, compared to those from whom ?3 oocytes were retrieved (p=0.047). Logistic regression analysis indicated that the age categories ?30y, 36-39y and ?40y, level of baseline FSH (?20 IU/L) and the ovarian response (?3 or >3 oocytes retrieved) were significantly associated with live birth. Conclusions: Our study indicated that age, baseline FSH level, and ovarian response are independent predictive factors for clinical pregnancy and live birth among women with baseline FSH levels >10 IU/L. © 2021, Sociedade Brasileira de Reproducao Assistida. All rights reserved.Öğe Ligneous cervicovaginitis associated with plasminogen deficiency: A rare cause of infertility(UHOD - Uluslararasi Hematoloji Onkoloji Dergisi, 2015) Akdogan A.; Sahin G.; Akman L.; Simsek D.; Zekioglu O.; Goker E.N.; Tavmergen E.[No abstract available]
