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Öğe Autoantibodies in Patients with Fasciolosis(Iranian Scientific Society Medical Entomology, 2009) Kaya, S.; Demirci, M.; Cetin, E. Sesli; Aridogan, B. Cicioglu; Sahin, M.; Korkmaz, M.Background: Antiself humoral immune responses have been detected not only in classical autoimmune diseases, but autoantibodies have also been found in sera of patients suffering from chronic parasitic diseases. We aimed to investigate the role of fasciolosis as a trigger factor of autoimmune reactivity by searching some antibodies related to hepatobiliary systems, in patients with fasciolosis. Methods: Thirty-two patients (17 males, 15 females) with fasciolosis were included in this case-control study. Anti-nuclear antibodies (ANA) Screen (antigen mixture of dsDNA, histones, nRNP/Sm, Sm, SS-A, SS-B, Scl-70, Jo-1, ribosomal P-proteins, centromere) ELISA and single-antigen ELISAs for detection of some antibodies (dsDNA, Anti-M2. Anti-liver-kidney microsomes type 1 (LKM-1) and Myeloperoxidase (MPO) were carried out. Results: ANA-screen, M-2, LKM-1, MPO and anti-dsDNA positivity were detected with ELISA in 7,7,4,2 and 2 of 32 patients with fasciolosis, consecutively. No statistically significant difference was detected for any of the autoantibodies' frequency between patients with fasciolosis and control group. However, autoantibody positivity rate was significantly higher in patients with fasciolosis (50 %) than control group (12.5 %). Absorbance values of all autoantibodies in patients with fasciolosis were statistically significant higher than controls. Conclusion: These results lent support to the role of fasciolosis as a trigger factor of autoimmune reactivity by the breakdown of tolerance. In spite of the extensive knowledge that has accumulated, the specific relationship between fasciolosis and autoimmunity is still obscure.Öğe Autoantibodies in Patients with Fasciolosis(Iranian Scientific Society Medical Entomology, 2009) Kaya, S.; Demirci, M.; Cetin, E. Sesli; Aridogan, B. Cicioglu; Sahin, M.; Korkmaz, M.Background: Antiself humoral immune responses have been detected not only in classical autoimmune diseases, but autoantibodies have also been found in sera of patients suffering from chronic parasitic diseases. We aimed to investigate the role of fasciolosis as a trigger factor of autoimmune reactivity by searching some antibodies related to hepatobiliary systems, in patients with fasciolosis. Methods: Thirty-two patients (17 males, 15 females) with fasciolosis were included in this case-control study. Anti-nuclear antibodies (ANA) Screen (antigen mixture of dsDNA, histones, nRNP/Sm, Sm, SS-A, SS-B, Scl-70, Jo-1, ribosomal P-proteins, centromere) ELISA and single-antigen ELISAs for detection of some antibodies (dsDNA, Anti-M2. Anti-liver-kidney microsomes type 1 (LKM-1) and Myeloperoxidase (MPO) were carried out. Results: ANA-screen, M-2, LKM-1, MPO and anti-dsDNA positivity were detected with ELISA in 7,7,4,2 and 2 of 32 patients with fasciolosis, consecutively. No statistically significant difference was detected for any of the autoantibodies' frequency between patients with fasciolosis and control group. However, autoantibody positivity rate was significantly higher in patients with fasciolosis (50 %) than control group (12.5 %). Absorbance values of all autoantibodies in patients with fasciolosis were statistically significant higher than controls. Conclusion: These results lent support to the role of fasciolosis as a trigger factor of autoimmune reactivity by the breakdown of tolerance. In spite of the extensive knowledge that has accumulated, the specific relationship between fasciolosis and autoimmunity is still obscure.Öğe DATA ON SMOKING IN TURKEY: SYSTEMATIC REVIEW, META-ANALYSIS AND META-REGRESSION OF EPIDEMIOLOGICAL STUDIES ON CARDIOVASCULAR RISK FACTORS(Elsevier Ireland Ltd, 2019) Ozer, N.; Kilickap, M.; Tokgozoglu, L.; Goksuluk, H.; Karaaslan, D.; Kayikcioglu, M.; Yilmaz, M. B.; Barcin, C.; Abaci, A.; Sahin, M.Öğe Design of web based dynamic assessment system for solving two sigma problem(IADIS Press, 2019) Tuluk, A.; Sahin, M.; Yurdugül, H.In 1984 Benjamin Bloom stated that one-to-one tutorial support increased students' achievement by two standard deviations (two sigma problem). In the literature for solving two sigma problem (in order to increase student achievement), many systems were developed as intelligent tutoring systems, adaptive hypermedia systems, recommender systems and etc. In addition to this, it can be said that dynamic assessment increases the students' achievement. Because one of the main objectives of the dynamic assessment is to improve the performance of learners by providing instructional aids with assessment tasks. Within the scope of this research, a web-based dynamic assessment system was designed and developed. Then, the effectiveness of the system tested with actual users. One group pretest-posttest design was used. A total of 322 secondary school 5th-grade students participated in this study. The findings were discussed in the context of two sigma problems. According to the findings, it can be said that the web-based dynamic assessment system increases student achievement approximately two standard deviations. © 2019 16th International Conference on Cognition and Exploratory Learning in Digital Age, CELDA 2019. All rights reserved.Öğe Effect of Rhizobacteria on Yield of Hydroponically Grown Tomato Plants(Int Soc Horticultural Science, 2012) Gul, A.; Ozaktan, H.; Yolageldi, L.; Cakir, B.; Sahin, M.; Akat, S.; Kittas, C; Katsoulas, N; Bartzanas, TIn this study, plant growth-promoting rhizobacteria (PGPR), selected for their ability to promote plant growth and for the biological control of crown and root rot caused by Fusarium oxysporum f. sp. radicis-lycopersici (FORL), were tested on tomato production in perlite under greenhouse conditions. Four PGPR isolates (TR 2/1: Pseudomonas fluorescens bv3, TR 18/1: Pseudomonas fluorescens, TR 21/1: Pseudomonas putida, 14/1y: Pseudomonas fluorescens bv5) selected based on the results of in vitro and in vivo tests from a collection of fifty PGPR strains, were compared with non PGPR inoculated control treatment. A resistant and a sensitive to FORL tomato variety were used. Plants were grown under healthy conditions without FORL inoculation. Seeds were sown on 11 January 2010 and transplanting was realised on 26 February 2010. Harvest period lasted six weeks from 24 May to 2 July. Cumulative fruit weight and number were measured weekly. Tomato plants inoculated with rhizobacteria gave significantly higher yield compared to the control treatment in the first 4 weeks of harvesting period.Öğe Evaluation of Turkey quince genebank for resistance breeding to fire blight disease(International Society for Horticultural Science, 2020) Sahin, M.; Misirli, A.; Ozaktan, H.; Kucuk, E.; Gokkur, S.; Aksoy, D.; Cavdar, A.Turkey, which is one of the major quince producer countries in the world, has an important role in the export of quince. Studies on protection of quince genetic resources are being conducted in Institutes, located in Izmir, Isparta and Erzincan locations, within the scope of General Directorate of Agricultural Researches and Politics (GDAR). Aegean Agricultural Research Institute (AARI) is the first responsible institute for the conservation of quince genetic resources and 61 genotypes are protected in the field gene bank at Menemen/Izmir location in Turkey. Fire blight is the leading cause of disease that restricting production and causing significant economic losses. Quince is described as one of the most susceptible hosts to the disease, the extensive breeding studies; the world was launched for the first time with the project of "Fire Blight Resistant Quince Breeding" funded by GDAR in 2016 under the leadership of AARI. In this context, genetic resources and cultivars (total 56) are tested with a mixture of 3 virulent strains in 3 different periods for the evaluation of disease tolerance. In addition, selection breeding studies carried out Manisa, Sakarya, Bursa, Izmir and Denizli locations for determining the tolerant genotypes under natural epidemic conditions in two consecutive years. As a result of the artificial inoculations, 50 genotypes took place in medium susceptible group, whereas susceptible group included 6 genotypes. Under natural infection conditions 15 genotypes were selected as tolerant to the disease with the range of 0-12% disease index. The possibility of using as a cultivar or genitor in the breeding studies and the importance of Turkey quince genetic resources in terms of tolerance to disease were determined. © 2020 International Society for Horticultural Science. All rights reserved.Öğe Investigations on fertilization biology of important dried apricot cultivars(Int Soc Horticultural Science, 2006) Misirli, A.; Saglam, H.; Gulcan, R.; Olmez, H. A.; Sahin, M.; Audergon, JMIn this study, self and cross pollination were carried out in important dried apricot cultivars ('Hacihaliloglu', 'Hasanbey', 'Cataloglu', 'Kabaasi' and 'Soganci') during two years. Pollen viability and germination tests were performed. Pollen production/anther and flower was determined. Pollen tube development in style was investigated. The highest germination values were obtained from in 15% sucrose medium. 'Hasanbey' and 'Soganci' had the highest viability in TTC and IKI tests. 'Hasanbey' and 'Kabaasi' can be used as pollinizers for all investigated varieties.Öğe Novel esophageal speech therapy method in total laryngectomized patients: biofeedback by intraesophageal impedance(Oxford Univ Press Inc, 2016) Sahin, M.; Ogut, M. F.; Vardar, R.; Kirazli, T.; Engin, E. Z.; Bor, S.The loss of the best communication port after total laryngectomy surgery makes speech rehabilitation an important goal. Our aim was to improve the quality of esophageal speech (ES) using online esophageal multichannel intra-luminal impedance (MII) as a new biofeedback method. Twenty-six total laryngectomized patients were included. Before ES therapy, an esophageal motility test was carried out. MII catheters were placed in all subjects who were then randomized into two groups. Group 1 included 13 cases, who were retrained according to the classical method. Group 2 included 13 cases, who were retrained according to the simplified animation of air movements within the esophagus and upper stomach resulting from the modifications of intra-esophageal air kinetics gained by MII. The level of speech proficiency was evaluated relative to pretraining levels using perceptual scales in the third and sixth months. Acoustic voice was analyzed. The number of syllables read per minute and the intelligibility of monosyllabic and dissyllabic words were calculated. In this study, MII was used for the first time in alaryngeal speech rehabilitation as a biofeedback method; an overall sufficient speech level was achieved by 68.4% at the end of therapy, whereas attendance was 90%. A statistically significant improvement was found in both groups in terms of ES level compared with the pretraining period although there was no significant difference between groups. Although we did not observe the expected difference between groups suggested by our hypothesis, MII may be used as an objective tool to show patients how to swallow and regurgitate air during training, and may thus expedite ES theraphy both for the speech therapist and the patient in the future.Öğe Predictive value of esophageal motility test in the proficiency of esophageal speech(Oxford Univ Press Inc, 2015) Sahin, M.; Vardar, R.; Kirazli, T.; Ogut, F.; Akyildiz, S.; Bor, S.One method of speech rehabilitation following total laryngectomy surgery is esophageal speech therapy (EST). In this method, which has witnessed relatively low success rates at the end of therapy, identification of patients who can benefit from EST beforehand will be important for determining the appropriate method for alaryngeal speech rehabilitation and might be cost-effective, saving time and labor. To this end, this study conducted research on the feasibility of manometric data measured prior to therapy using an esophageal motility test (EMT) in order to determine the candidates most suitable for esophageal speech (ES) beforehand. A total of 51 total laryngectomy male patients who had never been subject to any kind of speech rehabilitation and had always been articulate were included in the study. Data were collected from 44 patients who completed EST, lasting for 6 months in total and consisting of 11 sessions. Manometric measures were obtained through EMT using a water-perfusion system with a Dent sleeve catheter on the patients prior to the therapy. Wepman's scale was used in order to evaluate ES proficiency. Following the therapy, in accordance with this scale, while patients whose scores was 1, 2, or 3 were considered as adequate, those whose scores were 4, 5, 6, or 7 were considered inadequate and were divided into two groups. Manometric correlations were analyzed between 17 patients (group I) who were able to perform ES at an adequate level and 27 patients (group II) who could not. No statistically significant difference between the groups could be observed in terms of average pressure generated within the upper and lower esophageal sphincters obtained through EMT, peak amplitude of esophageal body contraction pressure, contraction duration time, onset velocity, or peak velocity values. EMT conducted prior to application of EST to total laryngectomized patients did not have any value in determining the level of ES that a patient could reach. Our results also suggest that sphincter pressures or esophageal motility patterns do not have any predictive value and should not be performed.Öğe Recurrence and occurrence of hepatocellular carcinoma following ledipasvir and sofosbuvir treatment for chronic hepatitis C in patients with advanced liver disease: Turkish multi-center early access program(Elsevier Science Bv, 2018) Idilman, R.; Demir, M.; Aladag, M.; Kaymakoglu, S.; Erol, C.; Cavus, B.; Iliaz, R.; Akarca, U. S.; Koklu, S.; Cakaloglu, Y.; Sahin, M.; Koksal, I.; Ozgenel, M.; Toka, B.; Karasu, Z.; Ersoz, G.; Kiyici, M.; Akdogan, M.; Turkey, E. A. P.
