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Öğe Alendronate Decreases Contractile Responses by Affecting ATP-Sensitive Potassium Channels in Human Left Internal Mammary Artery Rings(Asian Network Scientific Information-Ansinet, 2014) Arun, M. Z.; Reel, B.; Guzeloglu, M.; Albayrak, G.; Aykut, K.; Hazan, E.Bisphosphonates, including alendronate, are widely used for the treatment of osteoporosis, hypercalcemia and bone metastasis associated with cancer. However, recent evidence has demonstrated anti-atherosclerotic effects of bisphosphonates in animal models and atherosclerotic patients. Besides, some studies have shown that bisphosphonates change calcium homeostasis in cardiomyocytes and interfere L-type calcium channels in vascular smooth muscle cells. Therefore, in the present study it was aimed to investigate the effects of alendronate on contractile responses and ATP-sensitive potassium channels in vitro in human Left Internal Mammary Artery (LIMA). Human LIMA rings were placed into isolated organ chambers. After resting period, rings were kept for an hour in incubation medium which contains alendronate (10(-6) M) or not (control) and responses of the rings to the contractile agents were examined. The incubation of two rings was performed in the presence of glibenclamide which is ATP-sensitive potassium channel blocker (10(-6) M). Maximum contractile responses of LIMA rings to noradrenalin and serotonin decreased in the presence of alendronate. In concomitant incubation of LIMA with alendronate and glibenclamide reversed decreased contractions to noradrenalin or serotonin caused by alendronate. However, neither alendronate nor glibenclamide changed sensitivity to noradrenaline or serotonin. The present findings point out that alendronate may change intracellular calcium dynamics in human LIMA, due to the activation of ATP-sensitive potassium channels which have an important role on cardiovascular system.Öğe ALPHA LIPOIC ACID PRESERVES LONG-TERM PATENCY AND FUNCTIONAL PERFORMANCE OF THE HUMAN SAPHENOUS VEIN GRAFT BY PREVENTING VASOSPASM(Elsevier Ireland Ltd, 2022) Kalkan, T.; Reel, B.; Bintepe, C.; Yurekli, I.; Ersoy, N.; Bagriyanik, A.[No Abstract Available]Öğe Cathepsin K and survivin in a collar-induced early atherosclerosis model(Blackwell Publishing, 2006) Islekel, H.; Reel, B.; Oktay, G.; Ozkaya, A.; Sozer, G. Ozsarlak; Kerry, Z.Öğe The effects of calcium channel blockers are not related to their chemical structure in the collar model of the rabbit(Cambridge Med Publ, 2007) Yasa, M.; Kerry, Z.; Reel, B.; Anacak, G. Yetik; Ertuna, E.; Ozer, A.Placing a silicone collar around the rabbit carotid artery induces intimal thickening, an early stage in atherosclerosis and restenosis. We investigated whether treatment with oral pranidipine, a new potent, long lasting dihydropyridine calcium channel blocker (CCB), inhibited collar-induced intimal thickening in addition to the changes in vascular reactivity usually observed in this model. Pranidipine treatment did not inhibit collar-induced intimal thickening. Placing the collar around the carotid artery resulted in the characteristic changes in vascular reactivity, such as increased sensitivity to 5-hydroxytryptamine. Treatment with N-omega-nitro-L-arginine (100 mu M) and pranidipine, however, did not affect collarinduced changes in vascular reactivity. From results of this and previous studies, we conclude that pranidipine does not prevent collar-induced intimal thickening or collar-induced changes in vascular reactivity. Not all CCBs prevent collarinduced intimal thickening, suggesting that the effects of these agents are not related to their chemical structure and/or their calcium channel-blocking actions.Öğe Effects of carvedilol on vascular reactivity in human left internal mammary artery(Verduci Publisher, 2017) Guzeloglu, M.; Ertuna, E.; Arun, M. Z.; Reel, B.OBJECTIVE: Surgical treatment choice for coronary artery disease is coronary artery bypass grafting (CABG) surgery. Left internal mammary artery (LIMA) is frequently used as an arterial graft in CABG operations. Perioperative spasm of LIMA can result in increased morbidity and mortality. Pharmacological interventions are routinely used for prevention and treatment of LIMA spasm. In this study, we aimed to investigate the effects of carvedilol, an alpha-and beta-adrenergic receptor blocker, on responses to endogenous vasoconstrictors which play a role in graft spasm and the possible interaction between carvedilol and diltiazem/papaverine which are vasodilators commonly used in CABG surgery. PATIENTS AND METHODS: Isolated LIMA rings collected from patients undergoing CABG operation were suspended in an organ bath. Concentration-dependent responses to norepinephrine (NE), serotonin (5-HT) and diltiazem were examined before and after carvedilol incubation (10(-6) M, 1 hour). Maximum relaxation response to papaverine (10(-4) M) was compared in LIMA rings incubated with 0.05% dimethyl sulfoxide (DMSO, placebo) or carvedilol (10(-6) M). RESULTS: Carvedilol did not affect the maximal contractile response to NE; however, it significantly reduced the sensitivity of LIMA to NE. Carvedilol increased contractile response and sensitivity to 5-HT. Promisingly, carvedilol increased the vasodilatory effects of diltiazem and papaverine. CONCLUSIONS: Our study suggests that carvedilol may be administered perioperatively in combination with diltiazem or papaverine to prevent or resolve LIMA graft spasm.Öğe The effects of chronic ETA/ETB receptor blockade in the isolated rabbit aorta(Blackwell Publishing, 2006) Reel, B.; Oktay, G.; Sozer, G. Ozsarlak; Kerry, Z.Öğe Natural mineral zeolite (clinoptilolite) inhibits alpha v beta 1 integrin-mediated MMP-2 activity in PC3 human prostate cancer cells(Wiley, 2021) Reel, B.; Bintepe, C.; Onursal, C.; Ersoy, N.; Bagriyanik, A.[No Abstract Available]Öğe NEBIVOLOL PREVENTS RESTENOSIS BY INHIBITING INFLAMMATION, PROLIFERATION AND PLATELET AGGREGATION IN HIGH GLUCOSE-INDUCED HUMAN SAPHENOUS VEIN GRAFTS(Elsevier Ireland Ltd, 2022) Bintepe, C.; Reel, B.; Engin, C.; Ersoy, N.; Bagriyanik, H. A.[No Abstract Available]Öğe NEBIVOLOL REGULATES EXPRESSION OF NETRIN-1 AND SLIT-2, INHIBITS MATRIX METALLOPROTEINASE-2,-9 AND VASCULAR DYSFUNCTION IN HIGH GLUCOSE-TREATED HUMAN SAPHENOUS VEIN GRAFTS(Elsevier Ireland Ltd, 2021) Bintepe, C.; Reel, B.; Engin, C.; Ersoy, N.; Bagriyanik, A.[No Abstract Available]Öğe Telomeric restriction analysis of vascular smooth muscle cells following balloon angioplasty in rabbits(Springer, 2009) Ozsarlak-Sozer, G.; Kerry, Z.; Oran, I.; Gokce, G.; Tosun, M.; Bechard, L.; Reel, B.; Yasa, M.; Lebe, B.; Topcu, Z.G. OZSARLAK-SOZER, Z. KERRY, I. OR-AN, G. GOKCE, M. TOSUN, L. BECHARD, B. REEL, M. YASA, B. LEBE and Z. TOPCU. Telomeric restriction analysis of vascular smooth muscle cells following balloon angioplasty in rabbits. J Physiol Biochem, 65 (3), 243-250, 2009. Intimal hyperplasia due to smooth muscle cell proliferation and migration has been reported to be responsible for the pathogenesis of atherosclerosis and restenosis, manifested following balloon angioplasty. In this study, we employed the balloon angioplasty model to study telomere length regulation in proliferating vascular smooth muscle cells. Our results showed that balloon angioplasty in iliac arteries resulted in intimal hyperplasia due to proliferation of the smooth muscle cells and small size telomeric restrictional fragments were evident in injured arteries.Öğe Telomeric restriction analysis of vascular smooth muscle cells following balloon angioplasty in rabbits(Springer, 2009) Ozsarlak-Sozer, G.; Kerry, Z.; Oran, I.; Gokce, G.; Tosun, M.; Bechard, L.; Reel, B.; Yasa, M.; Lebe, B.; Topcu, Z.G. OZSARLAK-SOZER, Z. KERRY, I. OR-AN, G. GOKCE, M. TOSUN, L. BECHARD, B. REEL, M. YASA, B. LEBE and Z. TOPCU. Telomeric restriction analysis of vascular smooth muscle cells following balloon angioplasty in rabbits. J Physiol Biochem, 65 (3), 243-250, 2009. Intimal hyperplasia due to smooth muscle cell proliferation and migration has been reported to be responsible for the pathogenesis of atherosclerosis and restenosis, manifested following balloon angioplasty. In this study, we employed the balloon angioplasty model to study telomere length regulation in proliferating vascular smooth muscle cells. Our results showed that balloon angioplasty in iliac arteries resulted in intimal hyperplasia due to proliferation of the smooth muscle cells and small size telomeric restrictional fragments were evident in injured arteries.
