Yazar "Pekok, Abdullah Umut" seçeneğine göre listele

Listeleniyor 1 - 5 / 5
  • Küçük Resim Yok
    Öğe
    Mortality indicators in pneumococcal meningitis: therapeutic implications
    (Elsevier Sci Ltd, 2014) Erdem, Hakan; Elaldi, Nazif; Oztoprak, Nefise; Sengoz, Gonul; Ak, Oznur; Kaya, Selcuk; Inan, Asuman; Nayman-Alpat, Saygin; Ulu-Kilic, Aysegul; Pekok, Abdullah Umut; Gunduz, Alper; Gozel, Mustafa G.; Pehlivanoglu, Filiz; Yasar, Kadriye; Yilmaz, Hava; Hatipoglu, Mustafa; Cicek-Senturk, Gonul; Akcam, Fusun Z.; Inkaya, Ahmet C.; Kazak, Esra; Sagmak-Tartar, Ayse; Tekin, Recep; Ozturk-Engin, Derya; Ersoy, Yasemin; Sipahi, Oguz Resat; Guven, Tumer; Tuncer-Ertem, Gunay; Alabay, Selma; Akbulut, Ayhan; Balkan, Ilker I.; Oncul, Oral; Cetin, Birsen; Dayan, Saim; Ersoz, Gulden; Karakas, Ahmet; Ozgunes, Nail; Sener, Alper; Yesilkaya, Aysegul; Erturk, Ayse; Gundes, Sibel; Karabay, Oguz; Sirmatel, Fatma; Tosun, Selma; Turhan, Vedat; Yalci, Aysun; Akkoyunlu, Yasemin; Aydin, Emsal; Diktas, Husrev; Kose, Sukran; Ulcay, Asim; Seyman, Derya; Savasci, Umit; Leblebicioglu, Hakan; Vahaboglu, Haluk
    Background: The aim of this study was to delineate mortality indicators in pneumococcal meningitis with special emphasis on therapeutic implications. Methods: This retrospective, multicenter cohort study involved a 15-year period (1998-2012). Culture-positive cases (n = 306) were included solely from 38 centers. Results: Fifty-eight patients received ceftriaxone plus vancomycin empirically. The rest were given a third-generation cephalosporin alone. Overall, 246 (79.1%) isolates were found to be penicillin-susceptible, 38 (12.2%) strains were penicillin-resistant, and 22 (7.1%) were oxacillin-resistant (without further minimum inhibitory concentration testing for penicillin). Being a critical case (odds ratio (OR) 7.089, 95% confidence interval (CI) 3.230-15.557) and age over 50 years (OR 3.908, 95% CI 1.820-8.390) were independent predictors of mortality, while infection with a penicillin-susceptible isolate (OR 0.441, 95% CI 0.195-0.996) was found to be protective. Empirical vancomycin use did not provide significant benefit (OR 2.159, 95% CI 0.949-4.912). Conclusions: Ceftriaxone alone is not adequate in the management of pneumococcal meningitis due to penicillin-resistant pneumococci, which is a major concern worldwide. Although vancomycin showed a trend towards improving the prognosis of pneumococcal meningitis, significant correlation in statistical terms could not be established in this study. Thus, further studies are needed for the optimization of pneumococcal meningitis treatment. (C) 2013 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. All rights reserved.
  • Küçük Resim Yok
    Öğe
    Portraying infective endocarditis: results of multinational ID-IRI study
    (Springer, 2019) Erdem, Hakan; Puca, Edmond; Ruch, Yvon; Santos, Lurdes; Ghanem-Zoubi, Nesrin; Argemi, Xavier; Hansmann, Yves; Guner, Rahmet; Tonziello, Gilda; Mazzucotelli, Jean-Philippe; Como, Najada; Kose, Sukran; Batirel, Ayse; Inan, Asuman; Tulek, Necla; Pekok, Abdullah Umut; Khan, Ejaz Ahmed; Iyisoy, Atilla; Meric-Koc, Meliha; Kaya-Kalem, Ayse; Martins, Pedro Palma; Hasanoglu, Imran; Silva-Pinto, Andre; Oztoprak, Nefise; Duro, Raquel; Almajid, Fahad; Dogan, Mustafa; Dauby, Nicolas; Gunst, Jesper Damsgaard; Tekin, Recep; Konopnicki, Deborah; Petrosillo, Nicola; Bozkurt, Ilkay; Wadi, Jamal; Popescu, Corneliu; Balkan, Ilker Inanc; Ozer-Balin, Safak; Zupanc, Tatjana Lejko; Cascio, Antonio; Dumitru, Irina Magdalena; Erdem, Aysegul; Ersoz, Gulden; Tasbakan, Meltem; Ajamieh, Oday Abu; Sirmatel, Fatma; Florescu, Simin; Gulsun, Serda; Ozkaya, Hacer Deniz; Sari, Sema; Tosun, Selma; Avci, Meltem; Cag, Yasemin; Celebi, Guven; Sagmak-Tartar, Ayse; Karakus, Sumeyra; Sener, Alper; Dedej, Arjeta; Oncu, Serkan; Del Vecchio, Rosa Fontana; Ozturk-Engin, Derya; Agalar, Canan
    Infective endocarditis is a growing problem with many shifts due to ever-increasing comorbid illnesses, invasive procedures, and increase in the elderly. We performed this multinational study to depict definite infective endocarditis. Adult patients with definite endocarditis hospitalized between January 1, 2015, and October 1, 2018, were included from 41 hospitals in 13 countries. We included microbiological features, types and severity of the disease, complications, but excluded therapeutic parameters. A total of 867 patients were included. A total of 631 (72.8%) patients had native valve endocarditis (NVE), 214 (24.7%) patients had prosthetic valve endocarditis (PVE), 21 (2.4%) patients had pacemaker lead endocarditis, and 1 patient had catheter port endocarditis. Eighteen percent of NVE patients were hospital-acquired. PVE patients were classified as early-onset in 24.9%. A total of 385 (44.4%) patients had major embolic events, most frequently to the brain (n = 227, 26.3%). Blood cultures yielded pathogens in 766 (88.4%). In 101 (11.6%) patients, blood cultures were negative. Molecular testing of vegetations disclosed pathogens in 65 cases. Overall, 795 (91.7%) endocarditis patients had any identified pathogen. Leading pathogens (Staphylococcus aureus (n = 267, 33.6%), Streptococcus viridans (n = 149, 18.7%), enterococci (n = 128, 16.1%), coagulase-negative staphylococci (n = 92, 11.6%)) displayed substantial resistance profiles. A total of 132 (15.2%) patients had cardiac abscesses; 693 (79.9%) patients had left-sided endocarditis. Aortic (n = 394, 45.4%) and mitral valves (n = 369, 42.5%) were most frequently involved. Mortality was more common in PVE than NVE (NVE (n = 101, 16%), PVE (n = 49, 22.9%), p = 0.042).
  • Küçük Resim Yok
    Öğe
    Results of a Multinational Study Suggest the Need for Rapid Diagnosis and Early Antiviral Treatment at the Onset of Herpetic Meningoencephalitis
    (Amer Soc Microbiology, 2015) Erdem, Hakan; Cag, Yasemin; Ozturk-Engin, Derya; Defres, Sylviane; Kaya, Selcuk; Larsen, Lykke; Poljak, Mario; Barsic, Bruno; Argemi, Xavier; Sorensen, Signe Maj; Bohr, Anne Lisbeth; Tattevin, Pierre; Gunst, Jesper Damsgaard; Bastakova, Lenka; Jereb, Matjaz; Johansen, Isik Somuncu; Karabay, Oguz; Pekok, Abdullah Umut; Sipahi, Oguz Resat; Chehri, Mahtab; Beraud, Guillaume; Shehata, Ghaydaa; Del Vecchio, Rosa Fontana; Maresca, Mauro; Karsen, Hasan; Sengoz, Gonul; Sunbul, Mustafa; Yilmaz, Gulden; Yilmaz, Hava; Sharif-Yakan, Ahmad; Kanj, Souha Shararah; Parlak, Emine; Pehlivanoglu, Filiz; Korkmaz, Fatime; Komur, Suheyla; Kose, Sukran; Ulug, Mehmet; Bolukcu, Sibel; Coskuner, Seher Ayten; Ince, Nevin; Akkoyunlu, Yasemin; Halac, Gulistan; Sahin-Horasan, Elif; Tireli, Hulya; Kilicoglu, Gamze; Al-Mandawi, Akram; Nemli, Salih Atakan; Inan, Asuman; Senbayrak, Seniha; Stahl, Jean Paul; Vahaboglu, Haluk
    Data in the literature regarding the factors that predict unfavorable outcomes in adult herpetic meningoencephalitis (HME) cases are scarce. We conducted a multicenter study in order to provide insights into the predictors of HME outcomes, with special emphasis on the use and timing of antiviral treatment. Samples from 501 patients with molecular confirmation from cerebrospinal fluid were included from 35 referral centers in 10 countries. Four hundred thirty-eight patients were found to be eligible for the analysis. Overall, 232 (52.9%) patients experienced unfavorable outcomes, 44 died, and 188 survived, with sequelae. Age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.02 to 1.05), Glasgow Coma Scale score (OR, 0.84; 95% CI, 0.77 to 0.93), and symptomatic periods of 2 to 7 days (OR, 1.80; 95% CI, 1.16 to 2.79) and >7 days (OR, 3.75; 95% CI, 1.72 to 8.15) until the commencement of treatment predicted unfavorable outcomes. The outcome in HME patients is related to a combination of therapeutic and host factors. This study suggests that rapid diagnosis and early administration of antiviral treatment in HME patients are keys to a favorable outcome.
  • Küçük Resim Yok
    Öğe
    Results of a Multinational Study Suggest the Need for Rapid Diagnosis and Early Antiviral Treatment at the Onset of Herpetic Meningoencephalitis
    (Amer Soc Microbiology, 2015) Erdem, Hakan; Cag, Yasemin; Ozturk-Engin, Derya; Defres, Sylviane; Kaya, Selcuk; Larsen, Lykke; Poljak, Mario; Barsic, Bruno; Argemi, Xavier; Sorensen, Signe Maj; Bohr, Anne Lisbeth; Tattevin, Pierre; Gunst, Jesper Damsgaard; Bastakova, Lenka; Jereb, Matjaz; Johansen, Isik Somuncu; Karabay, Oguz; Pekok, Abdullah Umut; Sipahi, Oguz Resat; Chehri, Mahtab; Beraud, Guillaume; Shehata, Ghaydaa; Del Vecchio, Rosa Fontana; Maresca, Mauro; Karsen, Hasan; Sengoz, Gonul; Sunbul, Mustafa; Yilmaz, Gulden; Yilmaz, Hava; Sharif-Yakan, Ahmad; Kanj, Souha Shararah; Parlak, Emine; Pehlivanoglu, Filiz; Korkmaz, Fatime; Komur, Suheyla; Kose, Sukran; Ulug, Mehmet; Bolukcu, Sibel; Coskuner, Seher Ayten; Ince, Nevin; Akkoyunlu, Yasemin; Halac, Gulistan; Sahin-Horasan, Elif; Tireli, Hulya; Kilicoglu, Gamze; Al-Mandawi, Akram; Nemli, Salih Atakan; Inan, Asuman; Senbayrak, Seniha; Stahl, Jean Paul; Vahaboglu, Haluk
    Data in the literature regarding the factors that predict unfavorable outcomes in adult herpetic meningoencephalitis (HME) cases are scarce. We conducted a multicenter study in order to provide insights into the predictors of HME outcomes, with special emphasis on the use and timing of antiviral treatment. Samples from 501 patients with molecular confirmation from cerebrospinal fluid were included from 35 referral centers in 10 countries. Four hundred thirty-eight patients were found to be eligible for the analysis. Overall, 232 (52.9%) patients experienced unfavorable outcomes, 44 died, and 188 survived, with sequelae. Age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.02 to 1.05), Glasgow Coma Scale score (OR, 0.84; 95% CI, 0.77 to 0.93), and symptomatic periods of 2 to 7 days (OR, 1.80; 95% CI, 1.16 to 2.79) and >7 days (OR, 3.75; 95% CI, 1.72 to 8.15) until the commencement of treatment predicted unfavorable outcomes. The outcome in HME patients is related to a combination of therapeutic and host factors. This study suggests that rapid diagnosis and early administration of antiviral treatment in HME patients are keys to a favorable outcome.
  • Küçük Resim Yok
    Öğe
    Results of a Multinational Study Suggest the Need for Rapid Diagnosis and Early Antiviral Treatment at the Onset of Herpetic Meningoencephalitis
    (Amer Soc Microbiology, 2015) Erdem, Hakan; Cag, Yasemin; Ozturk-Engin, Derya; Defres, Sylviane; Kaya, Selcuk; Larsen, Lykke; Poljak, Mario; Barsic, Bruno; Argemi, Xavier; Sorensen, Signe Maj; Bohr, Anne Lisbeth; Tattevin, Pierre; Gunst, Jesper Damsgaard; Bastakova, Lenka; Jereb, Matjaz; Johansen, Isik Somuncu; Karabay, Oguz; Pekok, Abdullah Umut; Sipahi, Oguz Resat; Chehri, Mahtab; Beraud, Guillaume; Shehata, Ghaydaa; Del Vecchio, Rosa Fontana; Maresca, Mauro; Karsen, Hasan; Sengoz, Gonul; Sunbul, Mustafa; Yilmaz, Gulden; Yilmaz, Hava; Sharif-Yakan, Ahmad; Kanj, Souha Shararah; Parlak, Emine; Pehlivanoglu, Filiz; Korkmaz, Fatime; Komur, Suheyla; Kose, Sukran; Ulug, Mehmet; Bolukcu, Sibel; Coskuner, Seher Ayten; Ince, Nevin; Akkoyunlu, Yasemin; Halac, Gulistan; Sahin-Horasan, Elif; Tireli, Hulya; Kilicoglu, Gamze; Al-Mandawi, Akram; Nemli, Salih Atakan; Inan, Asuman; Senbayrak, Seniha; Stahl, Jean Paul; Vahaboglu, Haluk
    Data in the literature regarding the factors that predict unfavorable outcomes in adult herpetic meningoencephalitis (HME) cases are scarce. We conducted a multicenter study in order to provide insights into the predictors of HME outcomes, with special emphasis on the use and timing of antiviral treatment. Samples from 501 patients with molecular confirmation from cerebrospinal fluid were included from 35 referral centers in 10 countries. Four hundred thirty-eight patients were found to be eligible for the analysis. Overall, 232 (52.9%) patients experienced unfavorable outcomes, 44 died, and 188 survived, with sequelae. Age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.02 to 1.05), Glasgow Coma Scale score (OR, 0.84; 95% CI, 0.77 to 0.93), and symptomatic periods of 2 to 7 days (OR, 1.80; 95% CI, 1.16 to 2.79) and >7 days (OR, 3.75; 95% CI, 1.72 to 8.15) until the commencement of treatment predicted unfavorable outcomes. The outcome in HME patients is related to a combination of therapeutic and host factors. This study suggests that rapid diagnosis and early administration of antiviral treatment in HME patients are keys to a favorable outcome.