Yazar "Pehlivanoglu F." seçeneğine göre listele
Listeleniyor 1 - 4 / 4
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Central nervous system infections in the absence of cerebrospinal fluid pleocytosis(Elsevier B.V., 2017) Erdem H.; Ozturk-Engin D.; Cag Y.; Senbayrak S.; Inan A.; Kazak E.; Savasci U.; Elaldi N.; Vahaboglu H.; Hasbun R.; Nechifor M.; Tireli H.; Kilicoglu G.; Defres S.; Gulsun S.; Ceran N.; Crisan A.; Johansen I.S.; Namiduru M.; Dayan S.; Kayabas U.; Parlak E.; Khalifa A.; Kursun E.; Sipahi O.R.; Yemisen M.; Akbulut A.; Bitirgen M.; Popovic N.; Kandemir B.; Luca C.; Parlak M.; Stahl J.P.; Pehlivanoglu F.; Simeon S.; Ulu-Kilic A.; Yasar K.; Yilmaz G.; Yilmaz E.; Beovic B.; Catroux M.; Lakatos B.; Sunbul M.; Oncul O.; Alabay S.; Sahin-Horasan E.; Kose S.; Shehata G.; Andre K.; Dragovac G.; Gul H.C.; Karakas A.; Chadapaud S.; Hansmann Y.; Harxhi A.; Kirova V.; Masse-Chabredier I.; Oncu S.; Sener A.; Tekin R.; Deveci O.; Ozkaya H.D.; Karabay O.; Agalar C.; Gencer S.; Karahocagil M.K.; Karsen H.; Kaya S.; Pekok A.U.; Celen M.K.; Deniz S.; Ulug M.; Demirdal T.; Guven T.; Bolukcu S.; Avci M.; Nayman-Alpat S.; Yaşar K.; Pehlivano?lu F.; Ates-Guler S.; Mutlu-Yilmaz E.; Tosun S.; Sirmatel F.; Batirel A.; Öztoprak N.; Kadanali A.; Turgut H.; Baran A.I.; Karaahmetoglu G.; Sunnetcioglu M.; Haykir-Solay A.; Denk A.; Ayaz C.; Gorenek L.; Larsen L.; Poljak M.; Barsic B.; Argemi X.; Sørensen S.M.; Bohr A.L.; Tattevin P.; Gunst J.D.; Baštáková L.; Jereb M.; Johansen I.S.; Chehri M.; Beraud G.; Del Vecchio R.F.; Maresca M.; Yilmaz H.; Sharif-Yakan A.; Kanj S.S.; Korkmaz F.; Komur S.; Coskuner S.A.; Ince N.; Akkoyunlu Y.; Halac G.; Nemli S.A.; Ak O.; Kaya S.; Gunduz A.; Gozel M.G.; Hatipoglu M.; Cicek-Senturk G.; Akcam F.Z.; Inkaya A.C.; Sagmak-Tartar A.; Ersoy Y.; Tuncer-Ertem G.; Balkan I.I.; Cetin B.; Ersoz G.; Ozgunes N.; Yesilkaya A.; Erturk A.; Gundes S.; Turhan V.; Yalci A.; Aydin E.; Diktas H.; Ulcay A.; Seyman D.; Leblebicioglu H.Previous multicenter/multinational studies were evaluated to determine the frequency of the absence of cerebrospinal fluid pleocytosis in patients with central nervous system infections, as well as the clinical impact of this condition. It was found that 18% of neurosyphilis, 7.9% of herpetic meningoencephalitis, 3% of tuberculous meningitis, 1.7% of Brucella meningitis, and 0.2% of pneumococcal meningitis cases did not display cerebrospinal fluid pleocytosis. Most patients were not immunosuppressed. Patients without pleocytosis had a high rate of unfavorable outcomes and thus this condition should not be underestimated. © 2017 The Author(s)Öğe The course of spinal tuberculosis (Pott disease): Results of the multinational, multicentre Backbone-2 study(Elsevier B.V., 2015) Batirel A.; Erdem H.; Sengoz G.; Pehlivanoglu F.; Ramosaco E.; Gülsün S.; Tekin R.; Mete B.; Balkan I.I.; Sevgi D.Y.; Giannitsioti E.; Fragou A.; Kaya S.; Cetin B.; Oktenoglu T.; Celik A.D.; Karaca B.; Horasan E.S.; Ulug M.; Senbayrak S.; Kaya S.; Arslanalp E.; Hasbun R.; Ates-Guler S.; Willke A.; Senol S.; Inan D.; Güclü E.; Ertem G.T.; Koc M.M.; Tasbakan M.; Ocal G.; Kocagoz S.; Kusoglu H.; Güven T.; Baran A.I.; Dede B.; Karadag F.Y.; Yilmaz H.; Aslan G.; Al-Gallad D.A.; Cesur S.; El-Sokkary R.; Sirmatel F.; Savasci U.; Karaahmetoglu G.; Vahaboglu H.We aimed to describe clinical, laboratory, diagnostic and therapeutic features of spinal tuberculosis (ST), also known as Pott disease. A total of 314 patients with ST from 35 centres in Turkey, Egypt, Albania and Greece were included. Median duration from initial symptoms to the time of diagnosis was 78 days. The most common complications presented before diagnosis were abscesses (69%), neurologic deficits (40%), spinal instability (21%) and spinal deformity (16%). Lumbar (56%), thoracic (49%) and thoracolumbar (13%) vertebrae were the most commonly involved sites of infection. Although 51% of the patients had multiple levels of vertebral involvement, 8% had noncontiguous involvement of multiple vertebral bodies. The causative agent was identified in 41% of cases. Histopathologic examination was performed in 200 patients (64%), and 74% were consistent with tuberculosis. Medical treatment alone was implemented in 103 patients (33%), while 211 patients (67%) underwent diagnostic and/or therapeutic surgical intervention. Ten percent of the patients required more than one surgical intervention. Mortality occurred in 7 patients (2%), and 77 (25%) developed sequelae. The distribution of the posttreatment sequelae were as follows: 11% kyphosis, 6% Gibbus deformity, 5% scoliosis, 5% paraparesis, 5% paraplegia and 4% loss of sensation. Older age, presence of neurologic deficit and spinal deformity were predictors of unfavourable outcome. ST results in significant morbidity as a result of its insidious course and delayed diagnosis because of diagnostic and therapeutic challenges. ST should be considered in the differential diagnosis of patients with vertebral osteomyelitis, especially in tuberculosis-endemic regions. Early establishment of definitive aetiologic diagnosis and appropriate treatment are of paramount importance to prevent development of sequelae. © 2015 European Society of Clinical Microbiology and Infectious Diseases.Öğe Management of Brucella endocarditis: Results of the Gulhane study(2012) Koruk S.T.; Erdem H.; Koruk I.; Erbay A.; Tezer-Tekce Y.; Erbay A.Ri.; Dayan S.; Deveci O.; Inan A.; Engin D.O.; Guner R.; Dikici N.; Doyuk-Kartal E.; Kurtaran B.; Pehlivanoglu F.; Sipahi O.R.; Yalci A.; Yemisen M.; Alp-Cavus S.; Gencer S.; Guzel G.; Oncul O.; Parlak M.; Kazak E.; Tulek N.; Ulcay A.; Savasci U.Brucella endocarditis (BE) is a rare but life-threatening complication of human brucellosis. The aim of this study was to investigate the course of BE along with the therapeutic interrelations. A total of 53 patients with BE hospitalised in 19 health institutions between 2006 and 2011 were included in the Gulhane study. Diagnosis of brucellosis was established by either isolation of Brucella sp. or the presence of antibodies, and the definition of endocarditis was made according to Duke's criteria. There were four treatment groups: ceftriaxone combined with oral antibiotics (Group 1); aminoglycosides combined with oral antibiotics (Group 2); oral antibiotic combinations (Group 3); and aminoglycoside plus ceftriaxone combined with an oral antibiotic (Group 4). Involvement rates of the aortic, mitral and tricuspid valves were 49.1%, 43.4% and 5.7%, respectively. Thirty-two patients (60.4%) had an underlying cardiac valvular problem, including previous prosthetic valve replacement (n = 18). Medical treatment was provided to 32 patients (60.4%), whilst concordant medical and surgical approaches were provided to 21 patients (39.6%). Mortality in Group 1 was 15% (3/20), whilst in Group 2 it was 5.3% (1/19). In Group 3, 25.0% (3/12) of the cases died, whereas none of the cases in Group 4 died. In conclusion, mortality increased 47-fold with pericardial effusion and 25-fold due to congestive heart failure that developed after BE. Although mortality was lower in the aminoglycoside-containing arm (Groups 2 and 4), statistical analysis could not be performed owing to the small number of patients. © 2012 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.Öğe Miliary tuberculosis(Lippincott Williams and Wilkins, 2017) Mert A.; Arslan F.; Kuyucu T.; Koç E.N.; Yilmaz M.; Turan D.; Altin S.; Pehlivanoglu F.; Sengoz G.; Yildiz D.; Dokmetas I.; Komur S.; Kurtaran B.; Demirdal T.; Erdem H.A.; Sipahi O.R.; Batirel A.; Parlak E.; Tekin R.; Tunçcan Ö.G.; Balkan I.I.; Hayran O.; Ceylan B.The aim of this study was to determine the clinical features, and outcome of the patients with miliary tuberculosis (TB). We retrospectively evaluated 263 patients (142 male, 121 female, mean age: 44 years, range: 16-89 years) with miliary TB. Criteria for the diagnosis of miliary TB were at least one of the followings in the presence of clinical presentation suggestive of miliary TB such as prolonged fever, night sweats, anorexia, weight loss: Radiologic criterion and pathological criterion and/or microbiological criterion; pathological criterion and/or microbiological criterion. The miliary pattern was seen in 88% of the patients. Predisposing factors were found in 41% of the patients. Most frequent clinical features and laboratory findings were fever (100%), fatigue (91%), anorexia (85%), weight loss (66%), hepatomegaly (20%), splenomegaly (19%), choroid tubercules (8%), anemia (86%), pancytopenia (12%), and accelerated erythrocyte sedimentation rate (89%). Tuberculin skin test was positive in 29% of cases. Fifty percent of the patients met the criteria for fever of unknown origin. Acid-fast bacilli were demonstrated in 41% of patients (81/195), and cultures for Mycobacterium tuberculosis were positive in 51% (148/292) of tested specimens (predominantly sputum, CSF, and bronchial lavage). Blood cultures were positive in 20% (19/97). Granulomas in tissue samples of liver, lung, and bone marrow were present in 100% (21/21), 95% (18/19), and 82% (23/28), respectively. A total of 223 patients (85%) were given a quadruple anti-TB treatment. Forty-four (17%) patients died within 1 year after diagnosis established. Age, serum albumin, presence of military pattern, presence of mental changes, and hemoglobin concentration were found as independent predictors of mortality. Fever resolved within first 21 days in the majority (90%) of the cases. Miliary infiltrates on chest X-ray should raise the possibility of miliary TB especially in countries where TB is endemic. Although biopsy of the lungs and liver may have higher yield rate of organ involvement histopathologicaly, less invasive procedures including a bone marrow biopsy and blood cultures should be preferred owing to low complication rates. © 2017 the Author(s). Published by Wolters Kluwer Health, Inc.
