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Öğe BCR-ABL1–Negative Chronic Myeloproliferative Neoplasms and Pulmonary Hypertension: A Prospective Long-Term Follow-up Study of the Impact of Pulmonary Hypertension on Survival(Elsevier Inc., 2020) Payzin, K.B.; Savasoglu, K.; Alacacioglu, I.; Dalgic, E.E.; Kucukzeybek, B.B.; Calli, A.O.; Payzin, S.This prospective study assessed the prevalence of pulmonary hypertension (PHT) related to chronic myeloproliferative neoplasms (CMPNs) and evaluated the impact of PHT on survival during long-term follow-up. In a large group of BCR-ABL1–negative CMPN patients, there was a low prevalence of PHT. The impact of PHT on survival was negligible. © 2020 Elsevier Inc.Purpose: To assess the prevalence of PHT in patients with BCR-ABL1–negative CMPN and to evaluate impact of PHT on survival during long-term follow-up. Patients and Methods: A total of 122 patients with BCR-ABL1–negative CMPN underwent transthoracic echocardiographic (TTE) evaluation at the beginning of study. Patients undergoing PHT on TTE examination were also evaluated by a pulmonologist. Patients were divided into 3 groups. Group A comprised patients with CMPN-related PHT; group B, patients with no PHT; and group C, patients with PHT due to secondary causes. Patients were evaluated again every 3 to 6 months. Results: PHT was detected in 33 (27%) of 122 patients. Eight (6.5%) had CMPN-related PHT and the remaining 25 (20.5%) had non–CMPN-related PHT. Positivity for JAK2 V617F mutation in the study population was 72.9%. Groups were similar with respect to hematologic parameters and gender. Follow-up times were as follows: median (range) time from diagnosis to TTE and study end were 34 (1-158) months and 107 (16-251) months, respectively, and from TTE to study end was 88 (7-110) months. No significant differences found among the groups in terms of median time from diagnosis to TTE, follow-up, and overall survival. Conclusion: BCR-ABL1–negative CMPN patients had a lower prevalence of PHT compared to earlier studies. There was no statistically significant difference in median overall survival between patients with or without PHT. This may be because patients with PHT were asymptomatic and PHT was mild. The impact of PHT on survival was negligible. © 2020 Elsevier Inc.Öğe A circadian rhythm of syncope in patients with vasovagal syncope(Oxford Univ Press, 2006) Zoghi, M.; Duygu, H.; Nalbantgil, S.; Yavuzgil, O.; Akin, M.; Payzin, S.; Akilli, A.Öğe D374Y MUTATION IN THE PCSK-9 GENE IN TURKISH PATIENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA: LONG TERM FOLLOW-UP WITH GOOD CLINICAL COURSE(Elsevier Ireland Ltd, 2016) Kayikcioglu, M.; Kocabas, E. K.; Vardarli, A. T.; Eroglu, Z.; Dokmen, H.; Salman, N.; Payzin, S.; Can, L. H.Öğe Long term follow-up in patients with homozygous familial hypercholesterolemia; 13-year xperience of an university hospital lipid clinic(Oxford Univ Press, 2014) Kayikcioglu, M.; Kismali, E.; Can, L. H.; Payzin, S.Öğe OUR RESULTS OF ALCOHOL SEPTAL ABLATION IN SYMPTOMATIC PATIENTS WITH HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY(Elsevier Ireland Ltd, 2011) Yavuzgil, O.; Tuluce, K.; Gurgun, C.; Kultursay, H.; Payzin, S.; Hasdemir, C.; Can, L. H.; Turkoglu, C.Öğe The relationship between lipoprotein a and aortic calcification in familial hypercholesterolemia(Oxford Univ Press, 2017) Kayikcioglu, M.; Huseynov, R.; Bayraktaroglu, S.; Can, L. H.; Payzin, S.
