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    Is there an association between migraine and atopic disorders? The results of multicenter migraine attack study
    (Journal Neurological Sciences, 2008) Ozge, Aynur; Ozturk, Candan; Dora, Babuer; Inan, Levent; Saip, Sebahattin; Ozturk, Musa; Vanli, Ebru Nur; Gokcay, Figen; Ozturk, Vesile; Erdemoglu, Ali Kemal; Tasmertek, Fazilet; Yilmaz, Nurguel; Ozer, Gokhan; Siva, Aksel; Demir, Nurhak; Baykan, Betuel; Guler, Ayse; Poyraz, Turan; Doner, Hatice; Sirin, Hadiye
    We designed this multicenter study to evaluate the abnormalities related to the mast cell activation during attacks in a large group of migraineurs and to compare the findings both with episodic tension type headache (ETTH) and matched healthy control subjects. After the evaluation of diagnostic criteria, 213 subjects were included in this study after giving consent. Of all 146 subjects (67.8%) were migraineurs, 38 (19.4%) were ETTH patients and 29 others were healthy controls matched according to age and sex. Immunological screening showed significantly high ratios of IL-beta, IL-2, IL-6 and TNF-alpha in the migraine group compared to ETTH (16.6% vs 10.5%, 20.0% vs 5.3%, 13.8% vs 2.6% and 15.9% vs 5.3%, respectively) and to the healthy controls. Logistic regression analysis showed that only duration of headache has an important effect on having IL-2 abnormality (Exp-B: 0.322, 95% CI: 0.151-0.688, p=0.003) in patients with migraine. There was no important effect of clinical variables on serological abnormalitites or each other. In conclusion, our multicenter clinical and laboratory based study suggests that primary headache disorders (migraine and ETTH) are associated with atopic changes and they might share the inflammatory mechanism (pro-inflammatory as well as anti-inflammatory cytokine abnormalities) during headache attacks.
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    Serotype distribution of Streptococcus pneumoniae in children with invasive diseases in Turkey: 2008-2014
    (Taylor & Francis Inc, 2016) Ceyhan, Mehmet; Ozsurekci, Yasemin; Gurler, Nezahat; Oksuz, Lutfiye; Aydemir, Sohret; Ozkan, Sengul; Yuksekkaya, Serife; Emiroglu, Melike Keser; Gultekin, Meral; Yaman, Akgun; Kiremitci, Abdurrahman; Yanik, Keramettin; Karli, Arzu; Ozcinar, Hatice; Aydin, Faruk; Bayramoglu, Gulcin; Zer, Yasemin; Gulay, Zeynep; Gayyurhan, Efgan Dogan; Gul, Mustafa; Ozakin, Cuneyt; Guducuoglu, Huseyin; Percin, Duygu; Akpolat, Nezahat; Ozturk, Candan; Camcioglu, Yildiz; Oncel, Eda Karadag; Celik, Melda; Sanal, Laser; Uslu, Hakan
    Successful vaccination policies for protection from invasive pneumococcal diseases (IPD) dependent on determination of the exact serotype distribution in each country. We aimed to identify serotypes of pneumococcal strains causing IPD in children in Turkey and emphasize the change in the serotypes before and after vaccination with 7-valent pneumococcal conjugate vaccine (PCV-7) was included and PCV-13 was newly changed in Turkish National Immunization Program. Streptococcus pneumoniae strains were isolated at 22 different hospitals of Turkey, which provide healthcare services to approximately 65% of the Turkish population. Of the 335 diagnosed cases with S. pneumoniae over the whole period of 2008-2014, the most common vaccine serotypes were 19F (15.8%), 6B (5.9%), 14 (5.9%), and 3 (5.9%). During the first 5y of age, which is the target population for vaccination, the potential serotype coverage ranged from 57.5 % to 36.8%, from 65.0% to 44.7%, and from 77.4% to 60.5% for PCV-7, PCV-10, and PCV-13 in 2008-2014, respectively. The ratio of non-vaccine serotypes was 27.2% in 2008-2010 whereas was 37.6% in 2011-2014 (p=0.045). S. penumoniae serotypes was less non-susceptible to penicillin as compared to our previous results (33.7vs 16.5 %, p=0.001). The reduction of those serotype coverage in years may be attributed to increasing vaccinated children in Turkey and the increasing non-vaccine serotype may be explained by serotype replacement. Our ongoing IPD surveillance is a significant source of information for the decision-making processes on pneumococcal vaccination.
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    Serotypes of Streptococcus pneumoniae Isolates from Children with Invasive Pneumococcal Disease in Turkey: Baseline Evaluation of the Introduction of the Pneumococcal Conjugate Vaccine Nationwide
    (Amer Soc Microbiology, 2011) Ceyhan, Mehmet; Gurler, Nezahat; Yaman, Akgun; Ozturk, Candan; Oksuz, Lutfiye; Ozkan, Sengul; Keser, Melike; Salman, Nuran; Alhan, Emre; Esel, Duygu; Gultekin, Meral; Camcioglu, Yildiz; Gul, Mustafa; Sorguc, Yelda; Aydemir, Sohret; Gunaydin, Murat; Yakupogullari, Yusuf; Kizirgil, Ahmet
    Before use of the pneumococcal conjugate vaccine PCV7 became widespread in Turkey, 202 invasive pneumococcus isolates were analyzed. The most common serotypes were 19F and 6B. In children <= 2 years of age, the potential coverage rate of PCV7 was 69.5%. The most frequent non-PCV7 serotypes were 19A, 3, 1, 6A, and 8.