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Öğe Effects of everolimus as an antiproliferative agent on regression of encapsulating peritoneal sclerosis in a rat model.(2008) Duman S.; Bozkurt D.; Sipahi S.; Sezak M.; Ozkan S.; Ertilav M.; Sen S.; Ok E.The most serious complication of peritoneal dialysis is encapsulating peritoneal sclerosis (EPS). The prolonged inflammatory stimuli, fibrogenic cytokine overexpression, and angiogenesis that underlie EPS ultimately result in increased production of fibrous tissue, encapsulating the bowel loops. In recent years, inhibitors of mammalian target of rapamycin (mTOR) as an alternative agent for calcineurin inhibitor toxicity have been widely used in organ transplantation. These agents have also been used since the 1990s in endovascular medicine for drug-eluting stents because of antiproliferative effects on vascular smooth muscle cells and potent anti-inflammatory properties by direct action on human immune cells. Because of the shared characteristics of EPS and other fibrotic processes, we hypothesized that everolimus, an mTOR inhibitor can reverse the process responsible for the eventual development of EPS. We allocated 32 non-uremic albino Wistar rats to 4 groups: control group, 2 mL isotonic saline injected intraperitoneally (IP) daily for 3 weeks; CG group, 2 mL/200 g (0.1%) chlorhexidine gluconate (CG) injected IP daily and ethanol (15%) dissolved in saline, for 3 weeks; resting group, CG (weeks 0 - 3), plus peritoneal rest (weeks 3 - 6); and Evo-R, CG (weeks 0 - 3), plus 0.3 mg/L everolimus in drinking water (weeks 3 - 6). At the end of the study, we performed a 1-hour peritoneal equilibration test with 25 mL 3.86% PD solution, and examined the dialysate-to-plasma ratio of urea (D/P urea), dialysate white blood cell count, ultrafiltration (UF) volume, and morphologic change in the parietal peritoneum. Exposure to CG for 3 weeks resulted in alterations in peritoneal transport (increased D/P urea, decreased UF volume, p < 0.05) and morphology (increased inflammation, neovascularization, fibrosis, and peritoneal thickness, p < 0.05). Peritoneal rest has some beneficial effect only on UF failure and dialysate cell count (p < 0.05). However; everolimus was more effective than peritoneal rest with regard to vascularity and peritoneal thickness (p < 0.05). Everolimus has beneficial effects on UF failure, inflammation, and fibrosis. Everolimus may have therapeutic value in the management of EPS.Öğe Evaluation of quality of life of breast cancer patient nextof-kin in turkey(Asian Pacific Organization for Cancer Prevention, 2013) Ogce F.; Ozkan S.; Okcin F.; Yaren A.; Demiray G.Introduction: Quality of life (QoL) issues are of importance in relatives of women with breast cancer (BC)as caregivers in neglecting their own needs due to care of a patient and also as women regarding the potential risk of themselves developing BC. The objectives in the present study were to compare the QoL of female relatives of women in treatment for breast cancer. To date, no study had examined multi-dimensional QoL in accompanying people as compared them into two groups of female relatives whose first degree and second degree. Methods: QoL of female relatives was assessed using the Quality of Life-Family Version (QOL-FV) scale. Relationships between socio-demographic characteristics and QoL scores were analyzed using the Mann-Whitney U, Kruskal Wallis and Crosstabs tests. Results: The mean age of the female relatives was 37.6 years, and nearly 48% had a university education. It was found that first degree relatives had worse QoL in all domains except physical wellbeing than second degree relatives. Conclusion: This study showed that being female relatives of BC, especially first-degree, affect QoL negatively. Health care providers are of an important role in the stage of information related to genetic influence of BC.Öğe Meningitis caused by neisseria meningitidis, hemophilus influenzae type b and streptococcus pneumoniae during 2005-2012 in Turkey: A multicenter prospective surveillance study(Landes Bioscience, 2014) Ceyhan M.; Gürler N.G.; Ozsurekci Y.; Keser M.; Aycan A.E.; Gurbuz V.; Salman N.; Camcioglu Y.; Dinleyici E.C.; Ozkan S.; Sensoy G.; Belet N.; Alhan E.; Hacimustafaoglu M.; Celebi S.; Uzun H.; Oner A.F.; Kurugol Z.; Ali M.; Aygun D.; Oncel E.K.; Celik M.; Yasa O.; Akin F.; Coşkun Y.Successful vaccination policies for protection from bacterial meningitis are dependent on determination of the etiology of bacterial meningitis. Cerebrospinal fluid (CSF) samples were obtained prospectively from children from 1 month to ? 18 years of age hospitalized with suspected meningitis, in order to determine the etiology of meningitis in Turkey. DNA evidence of Neisseria meningitidis (N. meningitidis ), Streptococcus pneumoniae ( S. pneumoniae), and Hemophilus influenzae type b (Hib) was detected using multiplex polymerase chain reaction (PCR). In total, 1452 CSF samples were evaluated and bacterial etiology was determined in 645 (44.4%) cases between 2005 and 2012; N. meningitidis was detected in 333 (51.6%), S. pneumoniae in 195 (30.2%), and Hib in 117 (18.1%) of the PCR positive samples. Of the 333 N. meningitidis positive samples 127 (38.1%) were identified as serogroup W-135, 87 (26.1%) serogroup B, 28 (8.4%) serogroup A and 3 (0.9%) serogroup Y; 88 (26.4%) were non-groupable. As vaccines against the most frequent bacterial isolates in this study are available and licensed, these results highlight the need for broad based protection against meningococcal disease in Turkey. © 2014 Taylor & Francis Group, LLCÖğe Pregnancy-associated plasma protein A gene polymorphism in pregnant women with preeclampsia and intrauterine growth restriction(Elsevier (Singapore) Pte Ltd, 2015) Ozkan S.; Sanhal C.Y.; Yeniel O.; Arslan Ates E.; Ergenoglu M.; Binbir B.; Onay H.; Özkınay F.; Sagol S.Preeclampsia (PE) and intrauterine growth restriction (IUGR) are still among the most commonly researched titles in perinatology. To shed light on their etiology, new prevention and treatment strategies are the major targets of studies. In this study, we aimed to investigate the relation between gene polymorphism of one of the products of trophoblasts, pregnancy-associated plasma protein A (PAPP-A) and PE/IUGR.A total of 147 women (IUGR, n = 61; PE, n = 47; IUGR + PE, n = 37; eclampsia, n = 2) were compared with 103 controls with respect to the sequencing of exon 14 of the PAPP-A gene to detect (rs7020782) polymorphism. Genotypes "AA" and "CC" were given in the event of A or C allele homozygosity and "AC" in A and C allele heterozygosity. Our findings revealed that the rate of AA, CC homozygotes, and AC heterozygotes did not differ between groups. Moreover, there was no difference in the distribution of PAPP-A genotypes among the patients with IUGR, PE, IUGR + PE, or eclampsia. Finally, birth weight, rate of the presence of proteinuria, and total protein excretion on 24-hour urine were similar in the subgroups of AA, AC, and CC genotypes in the study group. Our study demonstrated no association between PAPP-A gene rs7020782 polymorphism and PE/IUGR. © 2015, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. All rights reserved.Öğe Psychometric Analysis of the Inventory of Functional Status'Cancer (IFS-CA) in Turkish Women(2009) Ozkan S.; Ogce F.The aim of this study was to test the reliability and validity of the Turkish version of the Inventory of Functional Status’ Cancer (IFS-CA). The questionnaire was composed of four subscales that measured to what extent a woman maintained her usual household and family, social and community, personal care, and occupational activities. Internal consistency reliability using average correlations for the subscale item to subscale total scores ranged from.21 to.97. Construct validity was accomplished by examination of subscale correlations, which ranged from ’.10 to.70. The Turkish version of the IFS-CA is found to be psychometrically reliable and valid. © 2009, SAGE Publications. All rights reserved.Öğe Serotype distribution of Streptococcus pneumoniae in children with invasive diseases in Turkey: 2008–2014(Taylor and Francis Inc., 2016) Ceyhan M.; Ozsurekci Y.; Gürler N.; Öksüz L.; Aydemir S.; Ozkan S.; Yuksekkaya S.; Keser Emiroglu M.; Gültekin M.; Yaman A.; Kiremitci A.; Yanık K.; Karli A.; Ozcinar H.; Aydin F.; Bayramoglu G.; Zer Y.; Gulay Z.; Gayyurhan E.D.; Gül M.; Özakın C.; Güdücüoğlu H.; Perçin D.; Akpolat N.; Ozturk C.; Camcıoğlu Y.; Karadağ Öncel E.; Çelik M.; Şanal L.; Uslu H.Successful vaccination policies for protection from invasive pneumococcal diseases (IPD) dependent on determination of the exact serotype distribution in each country. We aimed to identify serotypes of pneumococcal strains causing IPD in children in Turkey and emphasize the change in the serotypes before and after vaccination with 7-valent pneumococcal conjugate vaccine (PCV-7) was included and PCV-13 was newly changed in Turkish National Immunization Program. Streptococcus pneumoniae strains were isolated at 22 different hospitals of Turkey, which provide healthcare services to approximately 65% of the Turkish population. Of the 335 diagnosed cases with S. pneumoniae over the whole period of 2008–2014, the most common vaccine serotypes were 19F (15.8%), 6B (5.9%), 14 (5.9%), and 3 (5.9%). During the first 5 y of age, which is the target population for vaccination, the potential serotype coverage ranged from 57.5 % to 36.8%, from 65.0% to 44.7%, and from 77.4% to 60.5% for PCV-7, PCV-10, and PCV-13 in 2008–2014, respectively. The ratio of non-vaccine serotypes was 27.2% in 2008–2010 whereas was 37.6% in 2011–2014 (p=0.045). S. penumoniae serotypes was less non-susceptible to penicillin as compared to our previous results (33.7 vs 16.5 %, p=0.001). The reduction of those serotype coverage in years may be attributed to increasing vaccinated children in Turkey and the increasing non-vaccine serotype may be explained by serotype replacement. Our ongoing IPD surveillance is a significant source of information for the decision-making processes on pneumococcal vaccination. © 2016 Taylor & Francis Group, LLC.Öğe Serotypes of Streptococcus pneumoniae isolates from children with invasive pneumococcal disease in Turkey: Baseline evaluation of the introduction of the pneumococcal conjugate vaccine nationwide(2011) Ceyhan M.; Gurler N.; Yaman A.; Ozturk C.; Oksuz L.; Ozkan S.; Keser M.; Salman N.; Alhan E.; Esel D.; Gultekin M.; Camcioglu Y.; Gul M.; Sorguc Y.; Aydemir S.; Gunaydin M.; Yakupogullari Y.; Kizirgil A.Before use of the pneumococcal conjugate vaccine PCV7 became widespread in Turkey, 202 invasive pneumococcus isolates were analyzed. The most common serotypes were 19F and 6B. In children ?2 years of age, the potential coverage rate of PCV7 was 69.5%. The most frequent non-PCV7 serotypes were 19A, 3, 1, 6A, and 8. Copyright © 2011, American Society for Microbiology. All Rights Reserved.
