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Öğe Acute effect of kinesiotaping applied to the first finger of the patients with rheumatoid hand(Anaesthesia Pain & Intensive Care, 2023) Copuroglu, Ozge Baykan; Narin, Selnur; Bayraktar, Dilek; Ozgul, Semiha; Inal, VedatBackground & Objective: Rheumatoid arthritis (RA) is a crippling disease characterized by joint pains and joint stiffness. Kinesiotaping (KT) has been advocated to reduce local pressure and increase circulation, resulting in decreased pain in various conditions. We aimed to evaluate the acute effect of KT on pain, function, range of motion (ROM) and grip strength parameters in patients with rheumatoid hand. Methodology: A total of 34 patients, 27 women and 7 men, diagnosed with RA were included in our study. All patients were divided into two groups; Kinesiotape group (Group KT) and control group (Group C), each consisting of 17 patients. Subjective pain intensity by Visual Analog Scale (VAS), ROM by goniometer, functional evaluation with the Grip Skill Test, hand grip strength by dynamometer, and finger grip strength by pinchmeter were evaluated. The patients in the Group KT were taped with the mechanical correction method and the patients in the Group C were taped with tensionless I tape. Applications were made on both dominant and non-dominant hands. Results: The mean age of the patients was 54 +/- 20 y. VAS score changes at the time of grasping were significant in both groups (P < 0.05), but Group KT was more effective for reducing pain and increasing grip strength. An increase was observed in the wrist and thumb metacarpophalangeal joint ROM in the Group KT (P < 0.05). No change was observed in the groups in hand grip strength and finger grip strength (P > 0.05). In the Grip Skill test, there was a significant difference after the application in both groups (P < 0.05), but there was no difference in between the groups (P > 0.05). Conclusion: Kinesiotaping applied in rheumatoid hand patients was found to be effective in increasing functionality and joint range of motion, as well as reducing pain during gripping.Öğe Anterior segment parameters after uveitic cataract surgery: A prospective study with 1-year results(Elsevier, 2022) Kumcu, Nur Doganay; Balikoglu-Yilmaz, Melike; Ozgul, Semiha; Imre, Seher SaritepePurpose: To determine the changes in anterior segment parameters in uveitic patients undergoing uncomplicated cataract surgery. Methods: The best corrected visual acuity (BCVA), intraocular pressure (IOP), central corneal thickness (CCT), anterior chamber angle (ACA), anterior chamber depth (ACD), and axial length (AXL) of the 38 eyes of 28 well-controlled uveitic patients who underwent cataract surgery were monitored for 12 months. Results: Mean BCVA improved significantly at the postoperative visits when compared to the baseline (all P<0.001). Mean CCT increased on the first day compared to the preoperative value (627.62 +/- 71.16 vs. 572.18 +/- 53.52 mu m, P=0.015) and then returned to the preoperative value at 3 months (572.27 +/- 49.93 mu m). ACA showed a significant increase postoperatively in the first month (54.65 +/- 5.52 vs. 43.50 +/- 9.13 degrees) and then decreased at 3 months (51.85 +/- 5.52 degrees), remaining stable afterwards (51.73 +/- 6.59 degrees at 12 months). ACD as measured by Sirius topography and IOLMaster 500 was higher at the follow-up times compared to the preoperative value (P<0.001). AXL at 1. month was significantly lower than the preoperative level (23.14 +/- 0.74 vs. 23.54 +/- 0.68 mm, P=0.003). Conclusion: Following successful cataract surgery in well-controlled uveitic eyes, the CCT showed a rapid increase on the first day and then decreased to the preoperative level at the third month. ACA increased in the postoperative first month and then decreased, but it was higher than the baseline at all postoperative visits. ACD increased in the postoperative first week.Öğe Deletions in SERPING1 Lead to Lower C1 Inhibitor Function: Lower C1 Inhibitor Function Can Predict Disease Severity(Karger, 2019) Gokmen, Nihal Mete; Gulbahar, Okan; Onay, Huseyin; Koc, Zeynep Peker; Ozgul, Semiha; Kose, Timur; Gelincik, Asli; Buyukozturk, Suna; Sin, Aytul ZerrinBackground: How genotype affects phenotype in hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) has not been totally clarified. In this study, we investigated the relationship between different types of mutations and various phenotypic characteristics. Methods: Clinical data from 81 patients from 47 families were recorded. Complement proteins were analyzed from 61 untreated patients. The coding exons and the exon-intron boundaries of the SERPING1 gene were sequenced, and deletion/duplication analysis with multiple ligation dependent probe amplification was performed. The relationship of complement protein with the mutation type was analyzed by using generalized estimating equations. Results: Thirty-five different mutations (15 novel and 2/15 homozygous) were identified. There was no causative mutation in 6 patients (7.4%). Patients with deletion and large deletion had the lowest (5.05%, 0-18.7; 5.8%, 0-16.5%, respectively), and the none mutation group had the highest C1 inhibitor function (23.3%, 11-78%, p < 0.001). C1 inhibitor function levels decreased as the age of the disease progressed (r = -0.352, p = 0.005). Lower C1 inhibitor function levels caused severer disease (r = -0.404, p = 0.001) and more frequent annual attacks (r = -0.289, p = 0.024). In the off-attack period, C1q levels were lower than normal in 9.8% of the patients. Conclusion: Deletion mutations may represent the most unfavorable effect on C1 inhibitor function. The earlier disease onset age could be a sign for lower C1 inhibitor function levels in adult life. C1q levels could also be low in C1-INH-HAE patients, as in acquired angioedema. Lower C1 inhibitor function can predict disease severity and may have negative impacts on the course of C1-INH-HAE. (c) 2018 S. Karger AG, BaselÖğe Exact traveling wave solutions of perturbed nonlinear Schrodinger's equation (NLSE) with Kerr law nonlinearity(Elsevier Gmbh, Urban & Fischer Verlag, 2012) Ozgul, Semiha; Turan, Meltem; Yildirim, AhmetBy using new solutions of nonlinear partial differential equation, a direct algebraic method is described to construct the exact traveling wave solutions for perturbed nonlinear Schrodinger's equation (NLSE). Exact traveling wave solutions are explicitly obtained by this method. (C) 2011 Elsevier GmbH. All rights reserved.Öğe Genital Attacks in Hereditary Angioedema and Their Effects on Sexual Life(MDPI, 2024) Camyar, Asuman; Bulut, Gokten; Ozisik, Melih; Altay, Sevgi; Tuncel, Ozlem Kuman; Ozgul, Semiha; Sin, Aytul Zerrin; Gokmen, Nihal MeteBackground and Objectives: Hereditary angioedema (HAE) is characterized by unpredictable skin and mucosal angioedema attacks. We aimed to find the frequency of sexual-activity-triggered attacks (STAs) and understand how the sexual life of HAE with C1-inhibitor deficiency (HAE-C1INH) patients is affected. Materials and Methods: Adult HAE-C1INH patients were included in this cross-sectional study, which started in March 2020. Demographic information, marriage properties, gender-specific sexual life characteristics, and the HAE-specific histories of the patients were collected. The Hospital Anxiety and Depression Scale (HADS) and the Turkish version of the New Sexual Satisfaction Scale (NSSS) were applied to all participants. Results: Among 42 symptomatic HAE patients, 33 (78.57%) had genital attacks and 17 (42.5%) had STAs. Ten (58.8%) had genital pain, tenderness, or swelling, and five (29.4%) had isolated abdominal and groin pain. Eight (47.1%) patients with STAs experienced a HAE attack during their first time engaging in sexual intercourse. Anxiety/depression scales, NSSS scores, and distribution of other HAE attack localizations were similar in patients with and without STAs, and no gender differences were observed. Compared to the patients without STAs, the ratio of patients who stated that their sexual lives were negatively affected and that they lost their sexual desire was higher in patients with STAs. Conclusions: Genital or abdominal attacks triggered by sexual activity may be more common than thought. Sexual activity should also be questioned for evaluating attack triggers. There is a possibility of triggering an attack with the first and ongoing sexual intercourse, and patients should be informed to keep their attack treatment medications ready in advance.Öğe High-flow nasal cannula oxygen in children with bronchiolitis: A randomized controlled trial(Wiley, 2022) Eski, Aykut; Ozturk, Gokcen Kartal; Turan, Caner; Ozgul, Semiha; Gulen, Figen; Demir, EsenObjective To determine whether high-flow nasal cannula oxygen (HFNCO) provided enhanced respiratory support in bronchiolitis than low-flow oxygen (LFO). Methods We conducted a prospective, randomized controlled trial in children between 1 and 24 months diagnosed with moderate-to-severe bronchiolitis requiring oxygen therapy. Participants received LFO via face mask (6-10 L/min) or HFNCO (2 L/kg/min). Primary outcomes were the time that heart rate (HR) and respiratory rate (RR) return to their normal range for age and the time that baseline clinical respiratory score (CRS) regress to a lower severity score. Secondary outcomes were changes in HR, RR, and CRS over time, length of stay (LOS), duration of oxygen requirement, treatment failure, and adverse event (AE). Results Eighty-seven children were enrolled (48 in LFO; 39 in HFNCO). The time that HR and RR baseline values reached their normal range for age was shorter in HFNCO therapy (2.0 h [1.0-4.0] vs. 12.0 h [2.0-24.0], and 4.0 h [2.0-12.0] vs. 24.0 h [4.0-48.0], respectively; p < 0.001); additionally, the improvement in CRS emerged more quickly in children treated with HFNCO (2.0 h [1.0-4.0] vs. 4.0 h [2.0-24.0]; p = 0.003). While the duration of oxygen requirement (19.0 h [4.0-30.0] vs. 29.5 h [14.0-45.7]; p = 0.009) and treatment failure (3% vs. 21%) was statistically lower in children who received HFNCO, there were no differences in LOS and AE between groups. Conclusion HFNCO may provide enhanced respiratory support with a notable improvement in HR, RR, and CRS than LFO. Comprehensive studies are needed to assess the clinical efficacy of HFNCO therapy.Öğe Investigation of possible associations of the BDNF, SNAP-25 and SYN III genes with the neurocognitive measures: BDNF and SNAP-25 genes might be involved in attention domain, SYN III gene in executive function(Taylor & Francis Ltd, 2022) Bolat, Hilmi; Unsel-Bolat, Gul; Ozgul, Semiha; Pariltay, Erhan; Tahillioglu, Akin; Rohde, Luis Augusto; Akin, HalukObjectives Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous disorder and Sluggish Cognitive Tempo (SCT) might be a second inattention disorder that might be even affected by different attention pathways. SCT is characterized by daydreaming, mental confusion, staring blankly and hypoactivity. In the present study, we evaluated 5 common variants (rs6265, rs3746544, rs1051312, rs133946 and rs133945) located in 3 candidate genes (BDNF, SNAP25 and SYN III) that are known to take part in synaptic plasticity and neurotransmitter transmission. Methods We tested the effects of these variants on neuropsychological findings assessed by a computer-based neuropsychological test battery in children with inattention symptoms (SCT and/or ADHD). Results BDNF (rs6265), SNAP25 (rs3746544 and rs1051312) and SYN III (rs133946 and rs133945) polymorphisms were associated with variable cognitive measures. BDNF gene (rs6265) polymorphism Met allele carriers and SNAP25 gene (rs3746544) T allele carriers had an association with the attention domain. SNAP25 gene (rs1051312) C allele carriers were only associated with reaction time scores. Cognitive flexibility, which is one of the key components of executive function evaluation and shifting attention test scores were associated with BDNF (rs6265) Met allele and SYN III (rs133946) gene G allele. SYN III (rs133945) gene C allele carriers had an association with verbal memory correct hit scores. Conclusions As a conclusion, BDNF, SNAP25 and SYN III genes were associated with specific neurocognitive outcomes in children with inattention symptoms. It is important to note that exploring genotyping effects on neurocognitive functions instead of a heterogeneous psychiatric diagnosis can improve our understanding of psychopathologies.Öğe May ganglion cell complex analysis be a marker for glaucoma susceptibility in unilateral Fuchs' uveitis syndrome?(Springer, 2021) Yilmaz, Melike Balikoglu; Kumcu, Nur Doganay; Daldal, Hatice; Imre, Seher Saritepe; Aydin, Erdinc; Ozgul, Semiha; Kose, TimurPurpose To compare retinal nerve fiber layer (RNFL) thickness and ganglion cell-inner plexiform layer thickness (GCIPLT) in the affected eyes to fellow unaffected eyes of patients with unilateral Fuchs' uveitis syndrome (FUS) and analyze their change over time. Methods Twenty seven unilateral FUS patients who did not have concomitant systemic or ocular disease were retrospectively enrolled. Central macular thickness (CMT), RNFL thickness, and GCIPLT measurements were evaluated. Data was analyzed using the non-parametric Brunner-Langer model (LD-F2 design) and Wilcoxon signed-rank test. Results The mean age of the patients was 40.2 +/- 10.2 years. The median disease duration was 11 (2-62) months. The median best-corrected visual acuity (BCVA) of the affected eyes and the fellow eyes was 0.22 (0.00-2.50) vs. 0.00 (0.0-0.10) logMAR at the initial visit and 0.05 (0.00-2.50) vs. 0.00 (0.0-0.30) logMAR at the final visit. The change in BCVA was found significant in the affected eyes, but not in the fellow eyes (p < 0.001 and p = 0.287, respectively). The median CMT in the affected eyes at the final visit was not statistically different from the value at the initial visit (255 (157-306) vs. 245 (140-310) mu m, p = 0.256). The change in RNFL thickness over time in the affected eyes was similar to the fellow unaffected eyes of the patients with unilateral FUS at all quadrants, with non-significant time and group effects (p > 0.05). However, median GCIPLT in all quadrants (except superonasal) in the affected eyes was statistically lower than the fellow eyes at the initial and final visits (p < 0.05). The most affected quadrant of the ganglion cell complex was inferonasal in the involved eyes (79 (42-97) vs. 75 (43-87) mu m) at initial and final visits (p = 0.033 for time effect and p < 0.001 for group effect, respectively). Conclusion Median CMT and RNFL thickness did not change during follow-up in the affected eyes of patients with unilateral FUS. Median GCIPLT in the affected eyes declined over time in all quadrants. Ganglion cell loss was also most prominent in the inferonasal quadrant in the affected eyes. FUS patients should be followed up long-term in terms of ganglion cell loss, especially in the inferonasal quadrant.Öğe Posterior segment parameters after uveitic cataract surgery: A prospective study with 1-year results(Elsevier, 2024) Kumcu, Nur Doganay; Balikoglu-Yilmaz, Melike; Ozgul, Semiha; Imre, Seher SaritepePurpose: To evaluate the changes in posterior segment after uncomplicated cataract surgery in uveitic patients. Methods: Retinal nerve fiber layer thickness (RNFLT), ganglion cell layer thickness (GCLT), central macular thickness (CMT), and choroidal thickness (CT) of 38 eyes of 28 patients were measured pre- and postoperatively on day 1, week 1, and month 1, 3, 6, 9, and 12. Results: The RNFLT increased after surgery. Although the measurements taken were higher than the baseline CMT at all postoperative times, no significant difference was detected between the paired comparisons. The GCLT was found to be higher than the baseline value in all quadrants at the 12th month. A decrease in CT was observed at 5 measured points on the 1st day compared to the baseline. Conclusion: During the 1 -year follow-up, the effect of cataract surgery on the retina and choroid in uveitic eyes was most evident at the postoperative month 1.Öğe Psychiatric Correlates of Internet Gaming Disorder in Children(Turkish Green Crescent Soc, 2021) Bolat, Gul Unsel; Celik, Didem; Ozgul, Semiha; Ercan, Eyup SabriThe Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria has included internet gaming disorder (IGD) as a condition, but it needs further research. Little is known about who is at risk of developing IGD. Efforts at prevention and early intervention are very important in childhood and adolescence when the first signs of IGD appear, especially in susceptible groups. However, in the results of studies investigating the relationship between psychopathologies and IGD, there are contradictions that may be the result of heterogeneity in the evaluation processes. Therefore, it is critical to use DSM-5 criteria or questionnaires regarding IGD. Ninety-two children were included in this study, which is a cross-sectional study evaluating the correlation between IGD and other possible comorbid conditions (inattention, hyperactivity/impulsivity, oppositional defiant disorder, conduct disorder, anxiety, depression, suicidality, and family dysfunction). IGD scores were significantly correlated with the scores of anxiety, hyperactivity/impulsivity, and suicidal ideation. However, we did not find a significant correlation between IGD and depression or family dysfunction. The mean time between the first internet gaming experience and the parents' recognition of the disorder was about 2 years. Children suffering from anxiety or hyperactivity/impulsivity should be evaluated for their screen time. Children with problematic gaming behavior are at risk for developing suicidal tendencies.
