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Öğe Central core disease: A typical case with respiratory insufficiency in an intensive care unit(2006) Polat M.; Tosun A.; Ay Y.; Ozer E.; Serdaroglu G.; Aydogdu S.; Gokben S.; Tekgul H.Central core disease is a rare congential myopathy characterized by formation of typical cores in myofibrils. We report an atypical case of central core disease with respiratory insufficiency in the late stage of congenital myopathy. A 13-year-old girl was admitted to the intensive care unit with the diagnosis of respiratory distress syndrome. Ventilatory support was initiated. After 2 weeks of follow-up, the Division of Pediatric Neurology was consulted owing to the failure to wean her from the ventilator. Clinical and electromyographic features were in favor of primary muscle disease. Muscle biopsy revealed typical cores in type 1 muscle fibers, which were diagnostic for central core disease. This case was presented to emphasize that patients with respiratory distress who cannot be weaned from the ventilator should be evaluated for central core disease with an atypical presentation.Öğe Enrichment of probiotic ice cream with different dietary fibers: Structural characteristics and culture viability(Elsevier Inc., 2018) Akalın A.S.; Kesenkas H.; Dinkci N.; Unal G.; Ozer E.; Kınık O.This study evaluated the effect of 5 dietary fibers (apple, orange, oat, bamboo, and wheat) on the physicochemical, rheological, and textural characteristics; sensory properties; and culture viability of probiotic ice cream stored at -18°C for 180 d. The presence of orange and apple fibers increased the titratable acidity, decreased the lightness (color) value of the ice creams, and enhanced the red and yellow coloration. Compared with the control sample, the consistency indices and apparent viscosities of the experimental samples increased with the addition of all dietary fibers except oat fiber. The highest viscosity was obtained in the sample fortified with apple fiber, whereas the ice cream containing orange fiber showed the highest hardness after d 60 of storage. The addition of orange and apple fibers significantly increased melting resistance; however, panelists did not generally like these samples in terms of taste-flavor. All ice creams had viable counts of Lactobacillus acidophilus of ?7 log cfu/g during storage except the samples with orange and bamboo fiber. Bifidobacterium lactis counts were also found to be >6 log cfu/g in those samples until d 150 of storage. © 2018 American Dairy Science AssociationÖğe Influence of fortification with inulin and Hi-maize on textural and sensory properties of set-type probiotic yoghurt [Utjecaj dodatka inulina i rezistentnog škroba na teksturu i senzorska svojstva probioti?kog jogurta](Hrvatska Mljekarska Udruga, 2018) Una G.; Ozer E.The aim of this research was to investigate the effect of fortification with inulin and resistant starch (Hi-maize) on textural and sensory properties of set-type probiotic yoghurt containing Lactobacillus acidophilus during 21 days of storage. Textural characteristics were evaluated by determining firmness, adhesiveness and apparent viscosity parameters. Milk was fortified with inulin or Hi-maize at 2 % or 4 % ratios, whereas the control group had no supplement. Probiotic yoghurt supplemented with 2 % Hi-maize was firmer than that supplemented with 2 % inulin, except at the beginning of storage. There were no significant differences among the firmness values of yoghurt samples fortified by inulin and Hi-maize when the ratio increased to 4 %. The addition ratio of inulin or Hi-maize did not significantly affect adhesiveness. Supplementation with 2 % inulin or Hi-maize did not alter viscosity of yoghurts at most of the storage days. Sensory attributes were evaluated as taste, appearance, aroma, texture and overall acceptability. In general, there were no significant differences in sensorial parameters between yoghurts added with inulin or Hi-maize. Neither the addition rate nor the storage period affected the sensory scores of the samples. Significant reductions (P<0.05) of taste, appearance, aroma and overall acceptability scores of the control probiotic yoghurt were determined at the end of storage when compared to the 1stday. © 2018, Hrvatska Mljekarska Udruga. All rights reserved.Öğe Influence of fortification with inulin and Hi-maize on textural and sensory properties of set-type probiotic yoghurt [Utjecaj dodatka inulina i rezistentnog škroba na teksturu i senzorska svojstva probiotickog jogurta](Hrvatska Mljekarska Udruga, 2018) Una G.; Ozer E.The aim of this research was to investigate the effect of fortification with inulin and resistant starch (Hi-maize) on textural and sensory properties of set-type probiotic yoghurt containing Lactobacillus acidophilus during 21 days of storage. Textural characteristics were evaluated by determining firmness, adhesiveness and apparent viscosity parameters. Milk was fortified with inulin or Hi-maize at 2 % or 4 % ratios, whereas the control group had no supplement. Probiotic yoghurt supplemented with 2 % Hi-maize was firmer than that supplemented with 2 % inulin, except at the beginning of storage. There were no significant differences among the firmness values of yoghurt samples fortified by inulin and Hi-maize when the ratio increased to 4 %. The addition ratio of inulin or Hi-maize did not significantly affect adhesiveness. Supplementation with 2 % inulin or Hi-maize did not alter viscosity of yoghurts at most of the storage days. Sensory attributes were evaluated as taste, appearance, aroma, texture and overall acceptability. In general, there were no significant differences in sensorial parameters between yoghurts added with inulin or Hi-maize. Neither the addition rate nor the storage period affected the sensory scores of the samples. Significant reductions (P<0.05) of taste, appearance, aroma and overall acceptability scores of the control probiotic yoghurt were determined at the end of storage when compared to the 1stday. © 2018, Hrvatska Mljekarska Udruga. All rights reserved.Öğe Outcome of the Respiratory Syncytial Virus related acute lower respiratory tract infection among hospitalized newborns: A prospective multicenter study(Taylor and Francis Ltd, 2016) Alan S.; Erdeve O.; Cakir U.; Akduman H.; Zenciroglu A.; Akcakus M.; Tunc T.; Gokmen Z.; Ates C.; Atasay B.; Arsan S.; Anik A.; Turkmen M.K.; Erdogan Y.; Oygur N.; Kahvecioglu D.; Yildiz D.; Caner I.; Tekgunduz K.S.; Kurt A.; Yigit Y.; Bilgili G.; Bolat F.; Cevit O.; Ozlu F.; Satar M.; Ertugrul S.; Cakir B.; Unal S.; Iscan B.; Duman N.; Ergor S.N.; Yalaz M.; Celik I.; Celik U.; Hirfanoglu I.M.; Koc E.; Sivasli E.; Melekoglu N.A.; Kiray Bas E.; Bozkaya D.; Korkmaz A.; Ozdemir R.; Karadag A.; Ozer E.; Ilhan O.; Mutlu M.; Aslan Y.; Erener- Ercan T.; Cetinkaya M.; Sahin O.; Akin M.A.; Okumus N.; Demirel G.; Kilic A.; Turkoglu-Unal E.; Bulbul A.; Takci S.; Anuk-Ince D.; Ciftdemir N.A.; Acunas B.; Ozkan H.; Koksal N.; Okulu E.; Demir N.; Tuncer O.; Dizdar E.A.; Oguz S.; Dilmen U.Aim: To determine the incidence and outcomes of respiratory syncytial virus (RSV)-related acute lower respiratory tract infection (ALRI) including morbidity, nosocomial infection and mortality among newborn infants who were admitted to the neonatal intensive care units (NICUs).Methods: A multicenter, prospective study was conducted in newborns who were hospitalized with community acquired or nosocomial RSV infection in 44 NICUs throughout Turkey. Newborns with ALRI were screened for RSV infection by Respi-Strip®-test. Main outcome measures were the incidence of RSV-associated admissions in the NICUs and morbidity, mortality and epidemics results related to these admissions.Findings: The incidence of RSV infection was 1.24% (n: 250) and RSV infection constituted 19.6% of all ALRI hospitalizations, 226 newborns (90.4%) had community-acquired whereas 24 (9.6%) patients had nosocomial RSV infection in the NICUs. Of the 250 newborns, 171 (68.4%) were full-term infants, 183 (73.2%) had a BW >2500 g. RSV-related mortality rate was 1.2%. Four NICUs reported seven outbreaks on different months, which could be eliminated by palivizumab prophylaxis in one NICU.Conclusion: RSV-associated ALRI both in preterm and term infants accounts an important percent of hospitalizations in the season, and may threat other high-risk patients in the NICU. © 2015 Taylor & Francis.Öğe The role of endothelin receptor antagonism in collar-induced intimal thickening and vascular reactivity changes in rabbits(2005) Reel B.; Ozkal S.; Islekel H.; Ozer E.; Oktay G.; Sozer G.O.; Tanriverdi S.; Turkseven S.; Kerry Z.Intimal thickening, due to smooth muscle cell migration and proliferation, is considered to be one of the major components of vascular proliferative disorders such as atherosclerosis and restenosis. One experimental model, resulting in intimal thickening in the rabbit, involves placing a silicon collar around the carotid artery, and is used in this study. Endothelin is known to act as a strong mitogen and to stimulate smooth muscle cell proliferation and migration. We investigated the contribution of endothelin to the development of collar-induced intimal thickening and the effects of TAK-044, (5mg kg -1 daily, s.c), a non-selective ETA/ETB receptor antagonist, on intimal thickening and vascular reactivity changes in the collared rabbit carotid artery. Endothelin levels and the intimal cross-sectional area, as well as the ratio of intimal area to media (index), increased significantly in collared arteries as compared with those in sham-operated arteries. TAK-044 significantly inhibited intimal thickening and also decreased the index without affecting increased endothelin levels in collared arteries. Vascular reactivity changes in response to collaring produced predictable effects, such as decreased contractile responses to vasoconstrictor agents and increased sensitivity to serotonin (5-hydroxytryptamine, 5-HT). In terms of contractile responses in this model, TAK-044, in particular, did not affect collar-induced vascular reactivity changes. These results suggest that endothelin may be involved in the pathogenesis of collar-induced intimal thickening. As an endothelin receptor antagonist, TAK-044 may potentially be beneficial in the treatment of atherosclerosis. © 2005 The Authors.
