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    Incidence of cyclophosphamide-induced urotoxicity and protective effect of mesna in rheumatic diseases
    (Journal of Rheumatology, 2015) Yilmaz N.; Emmungil H.; Gucenmez S.; Ozen G.; Yildiz F.; Balkarli A.; Kimyon G.; Coskun B.N.; Dogan I.; Pamuk O.N.; Yasar S.; Cetin G.Y.; Yazici A.; Esmen S.E.; Cagatay Y.; Yilmaz S.; Cefle A.; Sayarlioglu M.; Kasifoglu T.; Karadag O.; Pehlivan Y.; Dalkilic E.; Kisacik B.; Cobankara V.; Erken E.; Direskeneli H.; Aksu K.; Yavuz S.
    Objective. To assess bladder toxicity of cyclophosphamide (CYC) and uroprotective effect of mesna in rheumatic diseases. Methods. Data of 1018 patients (725 women/293 men) treated with CYC were evaluated in this retrospective study. All of the following information was obtained: the cumulative CYC dose, route of CYC administration, duration of therapy, concomitant mesna usage, and hemorrhagic cystitis. Cox proportional hazard model was used for statistics. Results. We identified 17 patients (1.67%) with hemorrhagic cystitis and 2 patients (0.19%) with bladder cancer in 4224 patient-years. The median time for diagnosis to hemorrhagic cystitis was 10 months (4-48) and bladder cancer was 8 years (6-10.9). There were 583 patients (57.2%) who received mesna with intravenous CYC therapy. We observed similar incidence rate for hemorrhagic cystitis in both patient groups concomitantly treated with or without mesna [9/583 (1.5%) vs 8/425 (1.8%) respectively, p = 0.08]. Cumulative CYC dose (HR for 10-g increments 1.24, p < 0.001) was associated with hemorrhagic cystitis. Conclusion. Cumulative dose was the only risk factor for hemorrhagic cystitis in patients treated with CYC. No proof was obtained for the uroprotective effect of mesna in our cohort. © 2015 All rights reserved.
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    Spectroscopy of chromium doped garnets in a wide temperature range
    (2008) Orucu H.; Ozen G.; Collins J.; Bartolo B.D.
    Chromium doped garnets are tunable solid state laser materials which emit in the red and near infrared. We have studied the emission spectra of Y 3Al 5O 12:Cr 3+ (YAG:Cr), Gd 3Ga 5O 12:Cr 3+ (GGG:Cr) and Gd 3Sc 2Ga 3O 12:Cr 3+ (GSGGrCr) in a wide range of temperatures 25-800 K and have related their spectroscopic properties to the interaction between the 2E and 4T 2 energy levels of the chromium ion. The measurements included absorption, lifetime, luminescence under continuous and pulsed excitations, and thermal effects on sharp lines. © 2008 Materials Research Society.