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Öğe Effect of azithromycin, as an adjunct to nonsurgical periodontal treatment, on microbiological parameters and gingival crevicular fluid biomarkers in generalized aggressive periodontitis(Wiley, 2012) Emingil, G.; Han, B.; Ozdemir, G.; Tervahartiala, T.; Vural, C.; Atilla, G.; Baylas, H.; Sorsa, T.Emingil G, Han B, ozdemir G, Tervahartiala T, Vural C, Atilla G, Baylas H, Sorsa T. The effect of azithromycin, as an adjunct to nonsurgical periodontal treatment, on microbiological parameters and gingival crevicular fluid biomarkers in generalized aggressive periodontitis. J Periodont Res 2012; 47: 729739. (c) 2012 John Wiley & Sons A/S Background and Objective: To study the effectiveness of azithromycin in combination with nonsurgical periodontal therapy on clinical and microbiological parameters, and on the MMP-8 and TIMP-1 levels in gingival crevicular fluid, over a 6-mo time-period in patients with generalized aggressive periodontitis. Material and Methods: Thirty-two patients with generalized aggressive periodontitis were included in this randomized, double-blind, placebo-controlled, parallel-arm study. They were randomly assigned to azithromycin or placebo groups (500 mg once daily for 3 d). Probing depth, clinical attachment levels, presence of bleeding on probing and plaque were recorded. Gingival crevicular fluid samples were obtained from one single-rooted tooth, while microbiological samples were obtained from two single-rooted teeth, all with a probing depth of = 6 mm. Microbiological parameters were analyzed by quantitative real-time PCR for Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Fusobacterium nucleatum, Prevotella intermedia and total bacteria. Gingival crevicular fluid biomarkers were determined by immunofluorometric assay and ELISA. Results: All clinical parameters improved, and microbiological parameters and gingival crevicular fluid MMP-8 levels significantly decreased, over the 6-mo period (p < 0.05); both groups demonstrated similar improvements. The azithromycin group presented a higher percentage of deep pockets resolved (probing depth reduction of = 3 mm from baseline) compared with the placebo group at 1 mo (p < 0.05). Conclusion: Adjunctive azithromycin therapy provides no additional benefit over nonsurgical periodontal treatment on clinical parameters, microbiological parameters and gingival crevicular fluid biochemical markers investigated in patients with generalized aggressive periodontitis.Öğe Efficacy of Various Biocides Against Biofilm Bacteria Isolated from Cooling Waters of a Petrochemical Industry(Asian Journal Of Chemistry, 2010) Ozdemir, G.; Ceyhan, N.Cooling water is essential in many industries, including power generation, chemical manufacture and petroleum refineries Microbial fouling, the formation of biofilms in cooling water systems can lead to reduced heat transfer in condensers and heat exchangers. In order to prevent biofilms from creating these problems, a number of biocides are being used. In this study, the minimal inhibition concentrations (MIC) against 18 biofilm bacteria (8 g-negative and 10 g-positive), isolated at different times from cooling waters of a petrochemical industry, with increasing amounts (4-64 ppm) of 10-different biocides were investigated. The experiments were earned out at pH 7.9 and at 30 degrees C Henkel P3 Ferrocid 8583 and Concorde chem Hydrobio 620 exhibited the greatest antimicrobial effect against isolated biofilm bacteria. In addition. the reduction of the numbers of viable microorganisms count in the samples taking from cooling solution by selected biocides is determined Interestingly, the results of this study clearly demonstrate that the most effective biocides against isolated bacteria did not have the same level when they were tried with cooling solutionÖğe Enhanced biodegradation of crude oil in soil by a developed bacterial consortium and indigenous plant growth promoting bacteria(Wiley, 2020) Diallo, M. M.; Vural, C.; Cay, H.; Ozdemir, G.Aims This study aimed to develop an efficient, cost-effective and eco-friendly bacterial consortium to degrade petroleum sludge. Methods and Results Four bacterial strains belonging to generaAcinetobacterandPseudomonaswere selected to constitute three different consortia based on their initial concentration. the highest degradation rate (78%) of 1% (v/v) crude oil after 4 weeks of incubation was recorded when the concentration of biosurfactant (BS) producing isolate was high. Genes, such asalkB, almA,cyp153,pah-rhdGN, nah, phnACandcat23were detected using the polymerase chain reaction method and their induction levels were optimal at pH 7 center dot 0. A crude oil sludge was artificially constituted, and its bacterial composition was investigated using 16S rRNA gene amplicon sequencing. the results showed that the soil bacterial community was dominated by plant growth-promoting bacteria (PGPB) after crude oil treatment. Conclusions Our findings indicate the decontamination of the crude oil contaminated soil was more effective in the presence of both the constituted consortium and PGPB compared to the presence of PGPB alone. Significance and Impact of the Study This study showed that the PGPB (Taibaiella) present in petroleum uncontaminated soil can promote the soil decontamination. the addition of both efficient hydrocarbon-degrading and BS producing bacteria is also necessary to improve the decontamination.Öğe Keratin-rhamnolipids and keratin-sodium dodecyl sulfate interactions at the air/water interface(Elsevier Science Bv, 2006) Ozdemir, G.; Sezgin, O. E.Keratin-surfactant interactions at the air/solution interface may be indicative for skin irritation by surfactants. In this study pure keratin was extracted from chicken feathers as described by Schrooyen at al. [1,2] and the adsorption properties of biologically produced rhamnolipids (RL) and sodium dodecyl sulfate (SDS) mixed with keratin molecules were investigated by surface tension measurements. Keratin was added in three specific amounts to RL and SDS aqueous solutions of varying concentrations, respectively, and keratin-RL and keratin-SDS interactions were investigated at pH 6.2 and 5.0. The surface tension measurements showed that surfactant-keratin complexes were formed in the solutions at pH 6.2. At low RL concentrations the added amount of keratin decreased the surface tension as a result of the hydrophobic keratin-RL complexes formed, which have covered the air/solution interface. Beginning from moderate RL concentrations, less surface active keratin-RL complexes were formed due to hydrophilization of the former complexes and they were removed from the interface to the bulk phase as a result of the competitive adsorption mechanism and pure RL molecules covered the interface gradually. At low SDS concentrations surface tension decrease was also observed by the covering of the air/solution inter-face with keratin-SDS complexes. At moderate SDS concentrations the keratin-SDS complexes exhibited a more surface active feature. Unlike the keratin-RL complexes, they have remained at the interface until the higher SDS concentrations and keratin ratios. However, at the minimum surface tension value of the pure SDS at its CMC value, the surface tension of the keratin-SDS mixture reached the value of pure SDS solution and the air/solution interface has been covered again only with pure SDS monomers. The keratin-surfactant solutions prepared at pH 5 showed lower surface tension values compared to that measured at pH 6.2 and the surface tension behavior of RL and SDS resembled each other. Above a certain surfactant concentration the addition of keratin to surfactant solutions rendered the surface less surface active compared to their pure surfactant solutions at pH 5.0. The consideration of the surface tension behavior of two anionic surfactants has shown that the RL-keratin interactions are milder than SDS-keratin interactions at pH 6.2 and 5.0. (c) 2006 Elsevier B.V. All rights reserved.Öğe REAL TIME BACTERIAL MONITORING DURING THE BIODEGRADATION OF SELECTED PAHs IN INDUSTRY-BORNE ACTIVATED SLUDGE(Scibulcom Ltd, 2014) Vural, C.; Karabey, B.; Bayrak, D. E.; Ozdemir, G.Selected polyaromatic hydrocarbons (PAHs) were evaluated for their degradation potentials in aerobic completely stirred tank reactor (CSTR) and bacterial monitoring was performed with using real time polymerase chain reaction (real time PCR). For this, identified bacteria were inoculated to continuous stirred tank reactor (CSTR) for degradation of selected PAHs. During the degradation process, bacterial existences and numbers were monitored with using designed primer-probe sets in real time PCR. As a mean of the ageing period, 55 days, pH was 7.5 and the dissolved oxygen (DO) was 4 mg/l. Mean of the chemical oxygen demand (COD) and mixed liquor suspended solids (MLSS) rates in effluent 282 and 219 mg/l, respectively, and sludge volume was 373 ml/l. All selected isolates have shown stable results. As a mean of 36 days of biodegradation, Acinetobacter sp., Burkholderia cepacia, Chryseobacterium sp. and Pseudomonas fluorescens were calculated as 2.3 x 10(5), 2.9 x 10(5), 1.5 x 10(6) and 3.6 x 10(7), respectively.
