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Öğe Complete response after chemotherapy in metastatic involvement of the orbita in breast cancer(2009) Makay O.; Gurcu B.; Sanli U.A.; Zekioglu O.; Oktay A.; Goker E.; Kapkac M.[No abstract available]Öğe Design of a new generation wound dressing with pine bark extract(SAGE Publications Ltd, 2019) Karakaya P.S.; Oktay A.; Seventekin N.; Yesil-Celiktas O.Medical textiles are one of the fastest growing sectors in the technical textile market. Wound dress is one of the significant applications with the largest share in medical textiles. Active molecules doped in the dressings may be therapeutic agents, vitamins, antibiotics, minerals, and growth factors, which contribute to wound healing. Medical plants have a great potential with positive effects in wound care and accelerate the rate of wound healing. Pine bark, which is known to exhibit wound healing properties, is also used in the medical field. The purpose of this study is to design a new wound dressing enriched with Pinus brutia extract. Microwave-assisted extraction which is an environmentally friendly method was carried out at 70?, 900 W for 10 min to obtain the extracts. Subsequently, P. brutia bark extract was embedded to the alginate gel dressing and characterized and evaluated by in vivo studies on rats. According to the results, the extract was rapidly released from the alginate gel in the first 6 h, whereas the release was slowly increased to 24 h and then reached a steady state. Therefore, P. brutia extract-embedded alginate gel dressings applied for in vivo studies were changed every 24 h, reaching a healing rate of 75.7%, whereas the control group showed a healing rate of 48.6% indicating the superiority of the newly designed wound healing dress enriched with pine bark extract. © The Author(s) 2019.Öğe Design of a new generation wound dressing with pine bark extract(SAGE Publications Ltd, 2021) Karakaya P.S.; Oktay A.; Seventekin N.; Yesil-Celiktas O.Medical textiles are one of the fastest growing sectors in the technical textile market. Wound dress is one of the significant applications with the largest share in medical textiles. Active molecules doped in the dressings may be therapeutic agents, vitamins, antibiotics, minerals, and growth factors, which contribute to wound healing. Medical plants have a great potential with positive effects in wound care and accelerate the rate of wound healing. Pine bark, which is known to exhibit wound healing properties, is also used in the medical field. The purpose of this study is to design a new wound dressing enriched with Pinus brutia extract. Microwave-assisted extraction which is an environmentally friendly method was carried out at 70?, 900 W for 10 min to obtain the extracts. Subsequently, P. brutia bark extract was embedded to the alginate gel dressing and characterized and evaluated by in vivo studies on rats. According to the results, the extract was rapidly released from the alginate gel in the first 6 h, whereas the release was slowly increased to 24 h and then reached a steady state. Therefore, P. brutia extract-embedded alginate gel dressings applied for in vivo studies were changed every 24 h, reaching a healing rate of 75.7%, whereas the control group showed a healing rate of 48.6% indicating the superiority of the newly designed wound healing dress enriched with pine bark extract. © The Author(s) 2019.Öğe Intraosseous lipoma: Radiological findings(2008) Öztekin Ö.; Argin M.; Oktay A.; Arkun R.OBJECTIVE: Intraosseous lipomas may be less rare lesions than previously suggested in the literature. They have frequently been misdiagnosed as other benign bone lesions. A combination of computed tomography, magnetic resonance imaging and radiography is essential for decreasing misdiagnosis rates. MATERIALS AND METHODS: This retrospective study presents ten cases of intraosseous lipoma. The patients' ages ranged from 25 to 80 years, and six of them were female. Six patients presented with bone pain, whereas four patients were asymptomatic with incidentally discovered lesions. The involved bones were: femur (four patients), tibia (two patients), calcaneus (one patient), sacrum (one patient), iliac bone (one patient), navicular bone (one patient). All of the patients were assessed by means of conventional radiography, computed tomography and magnetic resonance imaging of the affected region. RESULTS: In all of the cases, plain films revealed well-defined lytic lesions. Both computed tomography and magnetic resonance imaging were quite useful in demonstrating fat within the femur. The histologic pattern of all tumors was that of mature adipose tissue. CONCLUSION: Intraosseous lipoma is a well-defined entity that may develop with varying presentations. Plain radiographs alone cannot establish the diagnosis of this lesion. However, both computed tomography and magnetic resonance imaging are quite useful methods in these cases. © Colégio Brasileiro de Radiologia e Diagnóstico por Imagem.Öğe Radioisotope synovectomy with rhenium186 in haemophilic synovitis for elbows, ankles and shoulders(2008) Kavakli K.; Aydogdu S.; Taner M.; Duman Y.; Balkan C.; Karapinar D.Y.; Saydam, G..; Capaci K.; Oktay A.We have performed 221 radioisotope synovectomy (RS) in more than 150 children and young adults with haemophilia, age ranging 3-30years (mean 15) in Ege Hemophilia Center, Izmir, Turkey for last 7years. We always preferred to use Yttrium 90 (Y90) for knees; however, since 2005, we started using rhenium 186 (Re186) for medium-sized joints with respect to safety. In this article, we have evaluated long-term experience ranging from 6months to 3years (mean 18months) with Re186 for elbows (n = 35), ankles (n = 26) and shoulders (n = 2) in total of 63 RS procedures for 49 patients. Their age range was 3-30 years and mean age was 15.5. Two mCi of Re186 intra-articularly injected for treating target joints and chronical synovitis. After RS, joint bleedings were decreased for all patients. The best results were obtained for all joints in patients with grade-II synovitis as like earlier experience with Y90. Excellent rates (no bleeding) were observed in grade-II synovitis in 81% and 46% for elbows vs. 86% and 57% for ankles after 6months and after 1 year follow-up of patients, respectively. In grade-III synovitis, excellent rates were 53% and 25% for elbows and 44% and 29% for ankles, respectively. In five joints for five patients, repeated injections were needed for better outcome. No adverse events such as radioisotope leakage, local inflamatory reactions or malignancy development were observed during and after RS. For medium-sized joints, RS with Re186 seems to be either effective or safe treatment method. Our results confirm those previously published by others on the value of Re186 synoviorthesis in medium-sized joints in haemophilia patients. After this experience, we changed our protocol and we use Re 186 for all medium-sized joints for treating chronical synovitis. © 2008 Blackwell Publishing Ltd.Öğe The role of breast MRI in planning the surgical treatment of breast cancer(2012) Duygulu G.; Oktay A.; Bilgen I.G.; Kapkaç M.; Zekioglu O.Purpose To determine the frequency by which breast magnetic resonance imaging (MRI) provides information that influences the surgical management of patients with breast cancer. Materials and Methods From August 2006 to December 2008, contrast-enhanced bilateral breast MRI was performed on 68 patients, all of whom exhibited highly suspicious imaging findings (BI-RADS category 4 or 5). Patients were grouped according to their histopathological diagnosis and type of breast parenchyma. All of the enrolled patients were believed to be candidates for breast conservation on the basis of physical examination, mammography, and ultrasonography. The patients were reevaluated with the MRI examination as to whether they were still candidates for breast conservation therapy. Results The MRI findings changed the previous management plans in 19.1% of the 68 patients. With respect to the surgical approach, no statistically significant difference was observed between the histopathology groups (P = 0.403). In terms of the breast parenchymal pattern, however, surgical planning was changed in 53.8% of the patients who exhibited a dense pattern, which was significantly different from the rates of the other groups (P = 0.006). The sensitivity, specificity, positive predictive value, and negative predictive value of the MRI for additional malignant lesion detection and identification were 85%, 98%, 92%, and 96%, respectively. The agreement test revealed 86% agreement (very good) between the additional findings observed on the MRI and the histopathological results. Conclusion If breast-conserving surgery is planned, an MRI should be performed in all women with suspected breast cancer, especially those exhibiting dense or heterogeneously dense breast parenchyma, for which the sensitivity of both ultrasonography and mammography is low. © Turkish Society of Radiology 2012.Öğe Screening for metastasis in primary breast cancer patients having four or more axillary lymph node involvement: Is it really necessary?(2010) Uslu R.; Kapkac M.; Karaca B.; Camyar H.; Durusoy R.; Ozdemir N.; Aras A.B.; Oktay A.; Ozkilic H.; Yilmaz R.Purpose: To evaluate the necessity and direct cost effectiveness of screening and staging procedures in breast cancer patients having >4 positive axillary lymph nodes and to identify further possible biopathological risk factors associated with increased risk of metastasis. Methods: We reviewed the demographic and clinicopathological data from the medical records of 1897 newly diagnosed breast cancer patients. Patients having >4 positive axillary lymph nodes after primary surgery for breast cancer and who had staging examinations for metastasis were eligible. The impact of staging procedures (thoracoabdominal CT, bone scan etc.) for detecting metastasis, decision of adjuvant treatment and direct costs were analyzed in 329 patients with operable breast cancer. Results: Thirty-five (10.6%) patients were found with metastasis at diagnosis. Seven (20.0%) among them had multiple metastases. Eighteen (51.4%) had lung, 17(48.6%) bone, and 7 (20.0%) liver metastasis. Twenty-one (60.0%) patients needed further radiological investigation for metastasis confirmation. Treatment decision was changed in 27 (77.1%) patients. No statistically significant risk factor was identified among the metastatic patients by means of conventional demographic and biopathological parameters. The cost of screening was lower when compared to the cost of treatment without any screening procedure. Conclusion: Since the conventional clinicopathological data seems not sufficient to define the risk of developing metastasis in breast cancer patients with >4 axillary lymph node involvement, all of them should undergo full staging examinations until new parameters based on genomic level are defined. Staging procedures need modification for high risk breast cancer patients. © 2010 Zerbinis Medical Publications.Öğe Ultrasound-Guided Breast Biopsies and Aspirations(2008) Oktay A.Ultrasonography is an efficient modality for guidance in interventional procedures in the breast. It is inexpensive and well tolerated by patients, and the risks are rare. Ultrasonographically guided breast core biopsy is commonly used in many centers as an accurate alternative to surgical biopsy for suspicious lesions. The advantages include decreased cost, absence of surgical scarring, no need for general anesthesia, and speed of the procedure. A good imaging-histologic correlation is necessary to decrease false-negative results. Other interventional procedures like cyst aspiration and needle localization can also be performed easily under ultrasound guidance. © 2008 Elsevier Inc. All rights reserved.
