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    Cathepsin K and survivin in a collar-induced early atherosclerosis model
    (Blackwell Publishing, 2006) Islekel, H.; Reel, B.; Oktay, G.; Ozkaya, A.; Sozer, G. Ozsarlak; Kerry, Z.
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    Dietary vitamin E (alpha-tocopherol acetate) and selenium supplementation from different sources: performance, ascites-related variables and antioxidant status in broilers reared at low and optimum temperatures
    (Taylor & Francis Ltd, 2007) Oezkan, S.; Malayoglu, H. Basmacioglu; Yalcin, S.; Karadas, F.; Koctuerk, S.; Cabuk, M.; Oktay, G.; Oezdemir, S.; Oezdemir, E.; Erguel, M.
    1. This study compared the effect of dietary supplementation with organic or inorganic selenium (Se) sources plus control amounts or large amounts of vitamin E (alpha- tocopherol acetate) in broilers raised at control ( 20 to 24 degrees C) or low ( 14 center dot 5 to 16 center dot 8 degrees C) temperatures after 2 weeks of age. 2. The following dietary treatments were used from one day old. Diet 1, the control diet, comprised a commercial diet containing 0 center dot 15 mg/ kg inorganic Se and 50 mg vitamin E/kg feed. Diet 2 was the same as diet 1, supplemented with 0 center dot 15 mg/ kg inorganic Se. Diet 3 was the same as diet 2 but was supplemented with 200 mg/ kg vitamin E. Diet 4 was the same as diet 1, but inorganic Se was replaced with 0 center dot 30 mg/ kg organic Se. Diet 5 was the same as diet 4, supplemented with 200 mg/ kg vitamin E. 3. Low temperature reduced the growth rate of broilers; however, at 6 weeks, there were no differences in the body weights of birds fed on organic Se supplemented diets housed at low or control temperature. The feed conversion ratio was significantly affected by low temperature but not by diet. The heterophil/ lymphocyte ratio was higher in chicks after one week in the cold, indicating mild stress. Blood triiodothyronine levels were significantly higher in birds after 1 and 4 weeks in the cold but thyroxin was not affected. 4. Organic Se supplementation increased relative lung weight at the control temperature, which might lead to greater respiratory capacity. Relative spleen weight significantly decreased in broilers fed diets supplemented with inorganic Se under cold conditions, a possible indication of chronic oxidative stress. 5. At the low temperature, supplementation with organic Se alone, or with inorganic Se and vitamin E increased glutathione peroxidase ( GSHPx) activity and glutathione ( GSH) concentration in the liver of broilers, which may indicate increased activity of birds' antioxidant defence against suboptimal environments.
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    Dietary vitamin E (alpha-tocopheryl acetate) and organic selenium supplementation: performance and antioxidant status of broilers fed n-3 PUFA-enriched feeds
    (South African Journal Of Animal Sciences, 2009) Malayoglu, H. Basmacioglu; Ozkan, S.; Kocturk, S.; Oktay, G.; Ergul, M.
    The experiment was conducted to study the effects of organic selenium (Se-enriched yeast) and vitamin E (alpha-tocopheryl acetate) supplementation, alone or together, on the performance and antioxidant status of broilers fed diets enriched in n-3 PUFAs using fish oil. Day-old Hubbard-JV strain broiler chicks allocated to one of the following treatments: (1) a commercial basal diet containing 0.15 mg inorganic Se/kg as sodium selenite and 50 mg alpha-tocopheryl acetate (alpha-TA)/kg feed acted as the control; (2) VE200: Control diet supplemented with 200 mg alpha-TA/kg feed; (3) OrgSe0.15: Control with inorganic Se replaced with 0.15 mg organic Se/kg; (4) OrgSe0.30: Control with inorganic Se replaced with 0.30 mg organic Se/kg feed; (5) VE200+OrgSe0.15, (6) VE200+OrgSe0.30. Body weight (BW) and body weight gain (BWG) to 42 d were significantly improved with vitamin E or organic Se at 0.20 mg/kg (but not at 0.15 mg/kg) when supplemented individually, but not in combination, except that VE200+OrgSe0.15 improved 28 and 35-d body weights significantly compared with the control. Feed intake (FI), feed conversion ratio (FCR), mortality, carcass characteristics and relative organ weights, except for the spleen, were unaffected by any of the supplementation treatments. The significant positive effect of VE200 on BWG was observed after 21 d. Relative spleen weight was significantly higher in broilers fed VE200 compared to the other treatments. The antioxidative effects of organic Se and vitamin E, alone or together, were not evident in diets enriched in n-3 PUFAs using 1.5% fish oil.
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    The effects of chronic ETA/ETB receptor blockade in the isolated rabbit aorta
    (Blackwell Publishing, 2006) Reel, B.; Oktay, G.; Sozer, G. Ozsarlak; Kerry, Z.
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    The report of the 1st Turkey in vitro diagnostic symposium results
    (Wiley-Blackwell, 2016) Kocdor, H.; Sezer, E.; Erbayraktar, Z.; Pabuccuoglu, A.; Onat, T.; Oktay, G.; Akdogan, G. Guner; Yener, N.; Sagin, F.; Aslan, D.
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    Taurine suppresses oxidative stress-potentiated expression of lectin-like oxidized low-density lipoprotein receptor and restenosis in balloon-injured rabbit iliac artery
    (Wiley-Blackwell, 2011) Gokce, G.; Ozsarlak-Sozer, G.; Oran, I.; Oktay, G.; Ozkal, S.; Kerry, Z.
    1. In endothelial cells, the major receptor for the binding and internalization of oxidized low-density lipoprotein (LDL) is the lectin-like oxidized LDL receptor (LOX-1). The aim of the present study was to investigate the effects of taurine on intimal thickening and LOX-1 expression under normal and oxidative conditions.