Yazar "Oksuz, Lutfiye" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim Yok
    Öğe
    Serotype distribution of Streptococcus pneumoniae in children with invasive diseases in Turkey: 2008-2014
    (Taylor & Francis Inc, 2016) Ceyhan, Mehmet; Ozsurekci, Yasemin; Gurler, Nezahat; Oksuz, Lutfiye; Aydemir, Sohret; Ozkan, Sengul; Yuksekkaya, Serife; Emiroglu, Melike Keser; Gultekin, Meral; Yaman, Akgun; Kiremitci, Abdurrahman; Yanik, Keramettin; Karli, Arzu; Ozcinar, Hatice; Aydin, Faruk; Bayramoglu, Gulcin; Zer, Yasemin; Gulay, Zeynep; Gayyurhan, Efgan Dogan; Gul, Mustafa; Ozakin, Cuneyt; Guducuoglu, Huseyin; Percin, Duygu; Akpolat, Nezahat; Ozturk, Candan; Camcioglu, Yildiz; Oncel, Eda Karadag; Celik, Melda; Sanal, Laser; Uslu, Hakan
    Successful vaccination policies for protection from invasive pneumococcal diseases (IPD) dependent on determination of the exact serotype distribution in each country. We aimed to identify serotypes of pneumococcal strains causing IPD in children in Turkey and emphasize the change in the serotypes before and after vaccination with 7-valent pneumococcal conjugate vaccine (PCV-7) was included and PCV-13 was newly changed in Turkish National Immunization Program. Streptococcus pneumoniae strains were isolated at 22 different hospitals of Turkey, which provide healthcare services to approximately 65% of the Turkish population. Of the 335 diagnosed cases with S. pneumoniae over the whole period of 2008-2014, the most common vaccine serotypes were 19F (15.8%), 6B (5.9%), 14 (5.9%), and 3 (5.9%). During the first 5y of age, which is the target population for vaccination, the potential serotype coverage ranged from 57.5 % to 36.8%, from 65.0% to 44.7%, and from 77.4% to 60.5% for PCV-7, PCV-10, and PCV-13 in 2008-2014, respectively. The ratio of non-vaccine serotypes was 27.2% in 2008-2010 whereas was 37.6% in 2011-2014 (p=0.045). S. penumoniae serotypes was less non-susceptible to penicillin as compared to our previous results (33.7vs 16.5 %, p=0.001). The reduction of those serotype coverage in years may be attributed to increasing vaccinated children in Turkey and the increasing non-vaccine serotype may be explained by serotype replacement. Our ongoing IPD surveillance is a significant source of information for the decision-making processes on pneumococcal vaccination.
  • Küçük Resim Yok
    Öğe
    Serotype distribution ofStreptococcus pneumoniain children with invasive disease in Turkey: 2015-2018
    (Taylor & Francis Inc, 2020) Ceyhan, Mehmet; Aykac, Kubra; Gurler, Nezahat; Ozsurekci, Yasemin; Oksuz, Lutfiye; Altay Akisoglu, Ozlem; Birinci, Asuman
    Objectives To determine the serotype distribution of pneumococcus causing invasive pneumococcal disease (meningitidis, bacteremia and empyema) in children in Turkey, and to observe potential changes in this distribution in time to guide effective vaccine strategies. Methods We surveyedS. pneumoniaewith conventional bacteriological techniques and with real-time polymerase chain reaction (RT-PCR) in samples of cerebrospinal fluid (CSF), blood and pleural fluid.S. pneumoniaestrains were isolated from 33 different hospitals in Turkey, which are giving health services to approximately 60% of the Turkish population. Results A total of 167 cases were diagnosed with invasive pneumococcal disease between 2015 and 2018. We diagnosed 52 (31.1%) patients with meningitis, 104 (62.2%) patients with bacteremia, and 11 (6.6%) patients with empyema. Thirty-three percent of them were less than 2 years old and 56% less than 5 years old. Overall PCV13 serotypes accounted for 56.2% (94/167). the most common serotypes were 19 F (11.9%), 1 (10.7%) and 3 (10.1%). Conclusions Besides the increasing frequency of non-vaccine serotypes, vaccine serotypes continue to be a problem for Turkey despite routine and high-rate vaccination with PCV13 and significant reduction reported for the incidence of IPD in young children. Since new candidate pneumococcal conjugate vaccines with more serotype antigens are being developed, continuing IPD surveillance is a significant source of information for decision-making processes on pneumococcal vaccination.
  • Küçük Resim Yok
    Öğe
    Serotypes of Streptococcus pneumoniae Isolates from Children with Invasive Pneumococcal Disease in Turkey: Baseline Evaluation of the Introduction of the Pneumococcal Conjugate Vaccine Nationwide
    (Amer Soc Microbiology, 2011) Ceyhan, Mehmet; Gurler, Nezahat; Yaman, Akgun; Ozturk, Candan; Oksuz, Lutfiye; Ozkan, Sengul; Keser, Melike; Salman, Nuran; Alhan, Emre; Esel, Duygu; Gultekin, Meral; Camcioglu, Yildiz; Gul, Mustafa; Sorguc, Yelda; Aydemir, Sohret; Gunaydin, Murat; Yakupogullari, Yusuf; Kizirgil, Ahmet
    Before use of the pneumococcal conjugate vaccine PCV7 became widespread in Turkey, 202 invasive pneumococcus isolates were analyzed. The most common serotypes were 19F and 6B. In children <= 2 years of age, the potential coverage rate of PCV7 was 69.5%. The most frequent non-PCV7 serotypes were 19A, 3, 1, 6A, and 8.