Yazar "Oguz M.A." seçeneğine göre listele

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  • Küçük Resim Yok
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    Comparative venomics of the vipera ammodytes transcaucasiana and vipera ammodytes montandoni from turkey provides insights into kinship
    (MDPI AG, 2018) Hempel B.-F.; Damm M.; Göçmen B.; Karis M.; Oguz M.A.; Nalbantsoy A.; Süssmuth R.D.
    The Nose-horned Viper (Vipera ammodytes) is one of the most widespread and venomous snakes in Europe, which causes high frequent snakebite accidents. The first comprehensive venom characterization of the regional endemic Transcaucasian Nose-horned Viper (Vipera ammodytes transcaucasiana) and the Transdanubian Sand Viper (Vipera ammodytes montandoni) is reported employing a combination of intact mass profiling and bottom-up proteomics. The bottom-up analysis of both subspecies identified the major snake protein families of viper venoms. Furthermore, intact mass profiling revealed the presence of two tripeptidic metalloprotease inhibitors and their precursors. While previous reports applied multivariate analysis techniques to clarify the taxonomic status of the subspecies, an accurate classification of Vipera ammodytes transcaucasiana is still part of the ongoing research. The comparative analysis of the viper venoms on the proteome level reveals a close relationship between the Vipera ammodytes subspecies, which could be considered to clarify the classification of the Transcaucasian Nose-horned Viper. However, the slightly different ratio of some venom components could be indicating interspecific variations of the two studied subspecies or intraspecies alternations based on small sample size. Additionally, we performed a bioactivity screening with the crude venoms against several human cancerous and non-cancerous cell lines, which showed interesting results against a human breast adenocarcinoma epithelial cell line. Several fractions of Vipera a. transcaucasiana demonstrated a strong cytotoxic effect on triple negative MDA MB 231 breast cancer cells. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.
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    Genetic confirmation of the occurrence and notes on the ecology of the yellow-bellied toad, Bombina variegata (L., 1758) (Amphibia: Bombinatoridae) in the European part of Turkey
    (British Herpetological Society, 2017) Karis M.; Veith M.; Gocmen B.; Oguz M.A.; Sener D.; Kurt B.
    We confirmed the occurrence and report some ecological traits of the yellow-bellied toad, Bombina variegata from Turkish Thrace. The specimens were caught in April 2016 from ponds and several streams of Karacahasan Mountain, Enez District, Edirne Province. In order to determine and confirm its systematic position, we genetically analysed the tissue samples of caught specimens. We also present some behavioural data of the species.
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    A new locality record of caucasian parsley frog, pelodytes caucasicus boulenger, 1896 (Amphibia: Anura: Pelodytidae) in the eastern Black Sea region of Anatolia
    (2013) IgcI N.; Akman B.; Göçmen B.; Adakul A.; Oguz M.A.
    A new locality record for The Caucasian Parsley Frog, Pelodytes caucasicus from Hidirnebi Plateau (Akçaabat, Trabzon) is presented based on our fieldwork in Black Sea Region in July 2012. Our record is a western range extension of approximately 15 km from the nearest reliable published locality. ©Biharean Biologist, Oradea, Romania, 2013.