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    A comparison of four disability scales for Turkish patients with neck pain
    (Foundation Rehabilitation Information, 2007) Kose, Gulsah; Hepguler, Simin; Atamaz, Funda; Oder, Gonca
    Objective: The Neck Disability Index, the Northwick Park Pain Questionnaire, the Copenhagen Neck Functional Disability Scale and the Neck Pain and Disability Scale are widely used scales for assessing neck pain or disability. The aim of this study was to determine the most suitable scale for Turkish patients with neck pain. Methods: All scales were translated into Turkish, administered to 102 patients with neck pain, then compared with regard to their construct validity, reliability, responsiveness, acceptability and usefulness. Results: The scales were similar in their high validity, reliability standards and sensitivity to change, but differed in their acceptability and usefulness. The item about driving in the Neck Disability Index and the Northwick Park Pain Questionnaire was omitted by 69.6% of patients for reasons other than a neck problem. Conclusion: All scales were reliable, valid and sensitive instruments, with similar psychometric properties. The scale that most adequately reflects the patient should be chosen.
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    Hodgkin's lymphoma following treatment with etanercept in ankylosing spondylitis
    (Springer, 2007) Aksu, Kenan; Donmez, Ayhan; Ertan, Yesim; Keser, Gokhan; Inal, Vedat; Oder, Gonca; Tombuloglu, Murat; Kabasakal, Yasemin; Doganavsargil, Eker
    It has been well known that anti-TNF drugs might increase lymphoma risk in rheumatoid arthritis (RA), where the rate of lymphoma has already been increased. However, unlike RA, an increased rate of lymphoma has not been reported in ankylosing spondylitis (AS). Hereby, we present a case with AS developing Hodgkin's lymphoma (HL) following 6 months of etanercept treatment. Pathological analysis revealed mixed cellular type of HL. Although we report a single case, it should be kept in mind that anti-TNF drugs might cause lymphoma development not only in RA, but also in AS.
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    Isokinetic ankle plantarflexion and dorsiflexion strength in patients with rheumatoid arthritis
    (Ios Press, 2008) Eyigor, Sibel; Kirazli, Yesim; Capaci, Kazim; Oder, Gonca; Tarhan, Figen; Inal, Vedat
    Backgroud and objectives: In patients with rheumatoid arthritis ( RA), some muscle groups are affected in different stages of disease, especially those related to the affected joint. However, data on associations between functional performance and muscle strength in RA are few. Therefore we sought to determine whether isokinetic ankle plantarflexion ( PF) and dorsiflexion (DF) strength was affected in RA patients and to study the association between isokinetic strength and other clinical indicators of disability such as walking and stair-climbing time and disease activity in patients with RA. Methods: Thirty three patients diagnosed with RA in the chronic phase were selected from a rheumatology outpatient clinic and matched for age and gender with 33 healthy subjects. Isometric and isokinetic muscle strength was measured in DF and PF. The subjects were also evaluated through the Stanford Health Assessment Questionaire ( HAQ), walking and stair-climbing time. Cumulative and current steroid doses (CSD) were calculated. Results: No significant correlations were found between muscle strength and visual analogue scale ( VAS) scores, HAQ, ankle involvement, CSD ( p > 0.05). With respect to the isokinetic parameters, no differences have been been observed between RA and control groups ( p > 0.05). Walking and stair-climbing time increased significantly ( p < 0.05) in patients with RA. Conclusions: Ankle isokinetic muscle strength is not affected in inactive RA patients while negative effects of steroids on muscle strength were not demonstrated. Important determinators of walking ability in RA patients should be defined in future studies.
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    Multimodal Evoked Potentials in Primary Sjogren's Syndrome Without Neurological Manifestations
    (Journal Neurological Sciences, 2009) Gokcay, Figen; Celebisoy, Nese; Gokcay, Ahmet; Oder, Gonca; Kabasakal, Yasemin; Aksu, Kenan; Kose, Timur
    We evaluated multimodal evoked potentials in patients with primary Sjogren's syndrome without clinical neurological manifestations. While brainstem auditory evoked potentials (BAEP) were performed in ninety patients visual (VEP) and somatosensory evoked potentials (SEP) could be evaluated in fifty-eight patients. The control group included 20 healthy adults matched for sex and chronological age. VEP and AEP studies did not reveal any abnormality. In SEP; N9-N13 interpeak latencies were significantly prolonged in the patients group. However, the latency of N9 potentials recorded from Erb's point was normal as well as the N13-N20 interpeak latencies. This result indicates that central branches of the primary sensory neurons are involved in Sjogren's syndrome.
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    Nasal and paranasal involvement in primary Sjogren's syndrome
    (Int Rhinologic Soc, 2013) Midilli, Rasit; Gode, Sercan; Oder, Gonca; Kabasakal, Yasemin; Karci, Buleot
    Background: The aim of this study is to investigate nasal and paranasal signs and symptoms of the primary Sjogren's syndrome patients and compare them with healthy controls. Methodology: Seventy-seven (7 M, 70 F) primary Sjogren's syndome patients and 77 healthy controls were included in the study. Anterior rhinoscopy, nasal endoscopy, 5 component smell discrimination test, nasal clearance analysis with saccharin test and electrorhinomanometer were performed. Results: Nasal crusting was present in 31 and 24 individuals in patient and Control groups, respectively. Sinusitis was present in 2 and 1 individuals in patient and control groups, respectively. Nasal polyposis was present in 7 and 1 individuals in patient and control groups, respectively.These differences were not statistically different. Conclusion: Although there were some findings in a few patients, nasal findings were insignificant and-mild even in patients with severe oral or ocular findings. Rhinomanometry, nasal clearance determination Or smell discrimination tests have very little value in the diagnosis or management of primary Sjogren's syndrome. Nasal polyposis was higher in the patient group, though it did not reach a significant level. Nasal glandular involvement is mild and insignificant in primary Sjogren's syndrome.
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    Primary Sjogren's syndrome presenting as neuromyelitis optica
    (Elsevier Science Inc, 2007) Gokcay, Figen; Celebisoy, Nese; Gokcay, Ahmet; Kabasakal, Yasemin; Oder, Gonca
    This report presents a patient with Devic's neuromyelitis optica associated with primary Sjogren's syndrome. Her first attack was right-sided optic neuritis at age 10 years. Attacks involving both optic nerves and medulla spinalis were recorded during the ensuing years. The diagnosis of Sjogren's syndrome could not be made until the second decade because it was not suspected. (c) 2007 by Elsevier Inc. All rights reserved.
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    Telomerase activity in connective tissue diseases: elevated in rheumatoid arthritis, but markedly decreased in systemic sclerosis
    (Springer, 2008) Tarhan, Figen; Vural, Filiz; Kosova, Buket; Aksu, Kenan; Cogulu, Ozgur; Keser, Gokhan; Gunduz, Cumhur; Tombuloglu, Murat; Oder, Gonca; Karaca, Emin; Doganavsargil, Eker
    Telomerase is a reverse transcriptase enzyme contributing to the maintenance of the telomeric structure by adding telomere repeat sequences to chromosomal ends, thus compensating for its shortening. Telomerase activity which is common in cancers and human germ line tissue, may also be increased, although to a lesser extent, in systemic autoimmune diseases. We aimed to evaluate telomerase activity in a group of Turkish patients with various connective tissue diseases. In this cross sectional study, 19 patients with systemic sclerosis (SSc), 15 with systemic lupus erythematosus (SLE), 10 with rheumatoid arthritis (RA) and 14 with primary Sjogren's syndrome (pSjS) were studied. As the control group, 29 healthy subjects were also included. Human telomerase-specific reverse transcriptase (hTERT) was measured in peripheral blood lymphocytes, using online real-time reverse-transcriptase polymerase chain reaction (PCR). We also investigated if hTERT values in each patient group were correlated with clinical parameters and disease activity. Highest hTERT values were observed in RA group (21.24 +/- 28.54), followed by SLE (13.38 +/- 26.05) and pSjS (11.73 +/- 10.59) groups. Only hTERT values in RA group was significantly higher than the healthy control group (7.62 +/- 4.21) (p < 0.05). Interestingly, hTERT values in SSc were very low (2.09 +/- 3.18), even less than the healthy control group. In consistent with previous studies, telomerase activity was increased in SLE and RA. Very low telomerase activity in SSc group was rather surprising. Since existing telomerase data in SSc was limited and telomere shortening was previously reported in SSc, our finding of low telomerase activity in SSc group deserves relevant discussion and further studies.