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Öğe The acquisition time of infection: a determinant of the severity of hepatitis C virus-related liver disease in renal transplant patients(Wiley-Blackwell Publishing, Inc, 2009) Toz, H.; Nart, D.; Turan, I.; Ersoz, G.; Sezis, M.; Asci, G.; Ozkahya, M.; Zeytinoglu, A.; Erensoy, S.; Ok, E.Background: The aim of this study was to compare the clinical and histopathological course of HCV infection acquired before and during or after renal transplantation. Methods: According to HCV status, 197 RT patients were divided into three groups. At the time of RT, anti-HCV antibody was positive in 47 patients (pre-RT HCV group). In 27 patients, in whom anti-HCV negative at the time of RT, anti-HCV and/or HCV RNA was found to be positive following an ALT elevation episode after RT (post-RT HCV group). Both anti-HCV and HCV RNA were negative at all times in remaining 123 patients (control group). Results: Liver biopsy was performed in 31 of 47 patients in pre-RT and 24 of 27 in post-RT HCV group after RT. Duration of follow-up was similar in all groups with a mean of 7.1 +/- 4.0 yr. Ascites and encephalopathy were seen in only post-RT HCV group (22%). Histological grade (6.5 +/- 2.7 vs. 4.1 +/- 1.4) and stage (2.0 +/- 1.5 vs. 0.8 +/- 0.8) was significantly severe in post-RT HCV group (p < 0.01). Three patients died due to liver failure in post-RT HCV group. Conclusions: HCV infection acquired during or after RT shows a severe and rapidly progressive clinicopathological course, which is significantly different from pre-transplant anti-HCV positive patients.Öğe The acquisition time of infection: a determinant of the severity of hepatitis C virus-related liver disease in renal transplant patients(Wiley-Blackwell Publishing, Inc, 2009) Toz, H.; Nart, D.; Turan, I.; Ersoz, G.; Sezis, M.; Asci, G.; Ozkahya, M.; Zeytinoglu, A.; Erensoy, S.; Ok, E.Background: The aim of this study was to compare the clinical and histopathological course of HCV infection acquired before and during or after renal transplantation. Methods: According to HCV status, 197 RT patients were divided into three groups. At the time of RT, anti-HCV antibody was positive in 47 patients (pre-RT HCV group). In 27 patients, in whom anti-HCV negative at the time of RT, anti-HCV and/or HCV RNA was found to be positive following an ALT elevation episode after RT (post-RT HCV group). Both anti-HCV and HCV RNA were negative at all times in remaining 123 patients (control group). Results: Liver biopsy was performed in 31 of 47 patients in pre-RT and 24 of 27 in post-RT HCV group after RT. Duration of follow-up was similar in all groups with a mean of 7.1 +/- 4.0 yr. Ascites and encephalopathy were seen in only post-RT HCV group (22%). Histological grade (6.5 +/- 2.7 vs. 4.1 +/- 1.4) and stage (2.0 +/- 1.5 vs. 0.8 +/- 0.8) was significantly severe in post-RT HCV group (p < 0.01). Three patients died due to liver failure in post-RT HCV group. Conclusions: HCV infection acquired during or after RT shows a severe and rapidly progressive clinicopathological course, which is significantly different from pre-transplant anti-HCV positive patients.Öğe Characteristics of steatohepatitic hepatocellular carcinoma in a series of predominantly virus-related cirrhosis(Springer, 2013) Aykutlu, U.; Uguz, A.; Unalp, O.; Nart, D.; Karasu, Z.; Sozbilen, M.; Yilmaz, F.Öğe Ciliated hepatic foregut cyst: Report of four cases and review of the literature(Springer, 2017) Erbil, S.; Ergun, O.; Yilmaz, F.; Nart, D.Öğe Correlation of immunohistochemistry on liver biopsy and serum HBVDNA levels(Elsevier Science Bv, 2008) Yilmaz, F.; Nart, D.; Vardar, R.; Gunsar, F.; Ersoz, G.; Karasu, Z.; Sertoz, R.; Erensoy, S.; Ilter, T.; Batur, Y.; Akarca, U. S.Öğe Diagnostic effectiveness of cell block preparation in routine thyroid cytology(Springer, 2017) Aykutlu, U.; Yildirim, Z. E.; Veral, A.; Nart, D.Öğe The diagnostic value of cell blocks in Liquid-Based Cytology of bronchial aspiration and bronchial brushing materials(Wiley, 2018) Sadullahoglu, C.; Yaman, B.; Veral, A.; Nart, D.IntroductionFibreoptic bronchoscopy is used for the diagnosis and treatment of several pulmonary diseases. Conventional smear and Liquid-based cytology (LBC) methods are applied to cytology samples of various bronchoscopic techniques. If the cytology sample is sufficient for evaluation, a cell block (CB) can be prepared from the remaining material. The aim of this study is to identify the diagnostic value of conventional smear, LBC and CB methods in bronchial cytological specimens. MethodsA retrospective review of 329 samples from 240 patients was made and, of these, 144 patients were found to have neoplasia. A blind review of the specimens was performed and all were reclassified individually. The endoscopic findings of the 144 patients with neoplasia were analysed retrospectively. The cytological diagnoses were then compared with the final diagnosis or the endoscopic findings of patients with neoplasia. The sensitivity was calculated for each method, both separately and together. ResultsIt was determined that CB led to a 10.1% increase in the diagnostic sensitivity for bronchial aspiration (BA) specimens, while no significant increase was seen in bronchial brush specimens. In BA specimens of neoplasia patients with normal bronchoscopic findings, while three methods were applied together with an increase in the number of cases diagnosed as malignant cytology, there was no significant increase in bronchial brush specimens. ConclusionThis study demonstrated that adding cell block to CB and LBC seemed to contribute the cytological diagnosis in BA materials significantly. Another advantage of CB is the opportunity of applying advanced methods such as immunocytochemical and molecular techniques. Additional methods applied to bronchoscopic cytology and histology samples enable performing further studies in the diagnosis of lung cancer, as well as molecular analysis. This study aimed to investigate the diagnostic value of conventional smears, liquid-based cytology and cell blocks prepared from bronchial aspiration and brush materials by comparison with the final diagnosis based on histologic, radiologic and clinical data.Öğe Diffuse Idiopathic Pulmonary NeuroEndocrine Cell Hyperplasia (DIPNECH) in association with a sclerosing hemangioma: A case report(Springer, 2013) Yaman, B.; Nart, D.; Cagirici, U.; Veral, A.Öğe Expression of Matrix Metal loproteinase Type 9 in Hepatocellular Carcinoma and Correlation with Histopathologic Parameters(Nature Publishing Group, 2009) Nart, D.; Incili, N.; Zeytunlu, M.; Kilic, M.; Karasu, Z.; Yilmaz, F.Öğe Expression of Matrix Metalloproteinase Type 9 in Hepatocellular Carcinoma and Correlation with Histopathologic Parameters(Nature Publishing Group, 2009) Nart, D.; Incili, N.; Zeytunlu, M.; Kilic, M.; Karasu, Z.; Yilmaz, F.Öğe FACTORS CD10, CYTOKERATIN 19 AND STAGING-GRADING SYSTEMS IN PREDICTING THE PROGNOSIS OF PANCREATIC NEUROENDOCRINE TUMORS (PNET)(Editura Acad Romane, 2012) Uguz, A.; Unalp, O. V.; Yeniay, L.; Farajov, R.; Yoldas, T.; Sezer, T. O.; Ipek, N. Y.; Nart, D.; Yilmaz, F.; Sozbilen, M.; Coker, A.Objective. This study was undertaken to examine prognostic factors in patients with pancreatic neuroendocrine tumors (PNET) undergoing surgical treatment to evaluate the prognostic value of recently introduced immunohistochemical staining methods of CD10 and cytokeratin 19. Materials and Methods. Tumors were classified on the basis of 2004 WHO Classification Guidelines and European Neuroendocrine Tumor Society (ENETS) grading system. Immunohistochemical staining with Ki-67, CD10 and cytokeratin 19 was performed. Results. A total of 36 patients with a mean age of 53.7 +/- 12.0 years were included. Overall, 33 patients had a long-term follow-up with 10 patients (30.3%) experiencing recurrence. Seven patients (21.1%) died. Clinical parameters that were associated with recurrence included liver metastasis at the time of surgery and extra-pancreatic invasion (p < 0.005). Positive surgical margins, extra-pancreatic invasion, and multi-focal disease were associated with reduced survival (p < 0.05). In addition, there was an association between survival and WHO 2004 classification (p < 0.05). Conclusions. Although vascular and peripancreatic invasion showed increased risk of recurrence, they were unrelated to survival. Of the histopathological examinations, Ki-67 and mitotic activity showed a correlation with both recurrence and survival, while immunohistochemical staining with cytokeratin 19 and CD 10 did not provide adequate prognostic information.Öğe FIBROSIS SHOULD BE INCLUDED INTO THE NONALCOHOLIC STEATOHEPATITIS SCORING SYSTEM FOR BEING MORE PROGNOSTICATIVE(Elsevier Science Bv, 2009) Gunsar, F.; Yilmaz, F.; Unal, N. G.; Bayrakci, B.; Karasu, Z.; Nart, D.; Ersoz, G.; Akarca, U. S.Öğe Fine needle aspiration biopsy of atypia of undetermined significance (AUS) with predominant Hurthle cells of the thyroid(Springer, 2020) Buyuktalanci, D. Ozyigit; Nart, D.; Ertan, Y.; Veral, A.; Ozdemir, M.; Soyaltin, U. E.; Ozbek, S.[No Abstract Available]Öğe GLUTAMINE SYNTHETASE,GLYPICAN-3 AND ARGINSASE-1 EXPRESSION IN THE DIFFERENTIAL DIAGNOSIS OF HEPATOCELLULAR CARCINOMA VS.METASTATIC CARCINOMAS OF THE LIVER(Verduci Publisher, 2019) Argon, A.; Erbil, S.; Nart, D.; Yilmaz, F.Objective: Diagnosis of metastatic liver carcinomas (MLCs) vs. hepatocellular carcinomas (HCCs) may be problematic especially in the non-cirrhotic liver. Glutamine Synthetase (GS), Glypican3 (GPC3, and Arginase-1 (Arg-1) immunohistochemistry can demonstrate the hepatocellular origin of a given tumor. This study aims to investigate the characteristics of GS, GPC3, and Arg -1 expression and the value of their combination in MLCs and in HCCs. Patients and Methods: Tissue samples were obtained from 86 patients with liver tumors, (16 HCCs, 70 MLCs) who underwent liver transplantation or resection. Immunohistochemical staining for GS, GPC3, and Arg-1 was performed on formalin fixed paraffin embedded sections. Demographic, laboratory, and clinical data obtained from patient files were analyzed for the confirmation of the primary origin of the tumors. Statistical analyses were made using the SPSS version 19.0 (IBM, Armonk, NY, USA). Results: Staining pattern of GS and GPC3 was cytoplasmic. Arg-1 staining was cytoplasmic in MLCs vs. cytoplasmic and nuclear in HCCs. Among HCCs, 100%, 38%, and 94% showed positive staining with GS, GPC3, and Arg-1, respectively. Overall, MLCs showed positive staining with GS, GPC3, and Arg-1 in 73%, 4%, and 4% of the cases, respectively. The combination of GS+/GPC3+/Arg-1+ was detectable in 38% of HCCs, but in 0% of MCTs. The specificity of GS, GPC3, and Arg-1 for HCC was 27%, 96%, 96%, and sensitivity was 100%, 38%, and 94%, respectively. Conclusions: Expression of GS in MLCs is high, therefore GS/GPC3/Arg-1 should be used as a panel in addition to other markers when the differential diagnosis of MLC vs HCC is challenging. Cytoplasmic and nuclear Arg-1positivity should be a prerequisite for the diagnosis of HCC.Öğe The incidence and management of acute and chronic rejection after living donor liver transplantation(Elsevier Science Inc, 2006) Yilmaz, F.; Aydin, U.; Nart, D.; Zeytunlu, M.; Karasu, Z.; Kaya, T.; Ozer, I.; Yuce, G.; Aydogdu, S.; Kilic, M.Living donor liver transplantation (LDLT) is a good alternative to cadaveric liver transplantation for end-stage liver disease. Herein we report the outcome of 132 LDLTs performed between 1999 and 2005, with special emphasis on the incidence and management of acute and chronic rejection. Among the LDLT population a first acute rejection episode (ARE) was clinically suspected in 24% and proven by liver biopsy in 11%. According to the Banff classification, 50% of AREs were grade 1, and 50%, grade 2. There was no grade 3 AREs. The first ARE occurred between 7 days and 23 months posttransplantation (mean 97 days, median 70 days). Ninety-seven percent (31/32) of the AREs occurred within the first year after transplantation and 3% (1/32) in the second year. Among the patients with ARE, 23% developed a second ARE between 4 and 11 months. A third ARE was detected in 8% of patients after month 18. All AREs responded to adjustment of immunosuppressive doses or steroid boluses. Chronic rejection (CR) was detected in 2%. In conclusion, the incidences of ARE and CR are consistent with the previously reported data. Acute and chronic rejections seem to be mild and easily manageable clinical conditions. Our results also showed a significant difference between clinically suspected and biopsy-proven ARE emphasizing the importance of indicated liver biopsies in the management of the LDLT population.Öğe Intracelular Localization of Beta-Catenin Expression Plays a Key Role on the Outcome of Hepatoblastoma Patients(Wiley, 2020) Celtik, U.; Dokumcu, Z.; Divarci, E.; Guler, E.; Nart, D.; Barbet, F. Yilmaz; Ergun, O.[No Abstract Available]Öğe Intraductal papillary neoplasm of the bile duct: clinicopathological characteristics and insulin-like growth factor II mRNA binding protein 3 (IMP3) expression in 24 cases(Springer, 2019) Buyuktalanci, E.; Damirli, A.; Tekin, F.; Uguz, A.; Unalp, V.; Zeytunlu, M.; Nart, D.; Ersoz, G.; Ozutemiz, O.; Yilmaz, F.Öğe Intrahepatic Cholangiocarcinoma Arising in Chronic Viral Hepatitis-Associated Cirrhosis: Two Transplant Cases(Elsevier Science Inc, 2008) Nart, D.; Ertan, Y.; Pala, E. E.; Zeytunlu, M.; Kilic, M.; Yilmaz, F.Hepatitis C vir-us (HCV) or hepatitis B virus (HBV)-related cirrhosis is known to be a risk factor for hepatocellular carcinoma (HCC). Recently, these viruses have been reported to have an etiologic role in the development of intrahepatic cholangiocarcinoma (ICC). Herein we have reported two cases of HCV- and HBV-related cirrhosis with ICC in whom the pretransplant diagnosis was HCC. The patient with HCV cirrhosis, was a 47-year-old woman with a large nodule in the right lobe. The patient with HBV cirrhosis was a 45-year-old man with two nodules. Serum tumor marker levels, carcinoembryonic antigen (CEA), alphafetoprotein (AFP), and carbohydrate antigen 19-9 (CA 19-9) were determined before live donor liver transplantation (LDLT). The patient with HCV cirrhosis showed mildly elevated serum levels of AFP. The patient with HBV cirrhosis showed an elevated CA 19-9 level. On microscopic examination, all nodules exhibited typical morphological findings of adenocarcinoma. The patient with HCV cirrhosis developed brain metastases 4 years after LDLT. The patient with HBV cirrhosis is disease-free at 18 months after transplantation. In cirrhotic patients with active malignancy who are candidates for LDLT, ICC should be considered in the differential diagnosis. Although the literature is limited, selected patients with ICC may benefit from LDLT.Öğe Involvement of Intracellular Domain of EpCAM in Hepatocellular Carcinoma(Nature Publishing Group, 2014) Sahin, E.; Nart, D.; Kunter, I.; Kandemis, E.; Barbet, F. Yilmaz; Atabey, N.; Erdal, E.Öğe Involvement of Intracellular Domain of EpCAM in Hepatocellular Carcinoma(Nature Publishing Group, 2014) Sahin, E.; Nart, D.; Kunter, I.; Kandemis, E.; Barbet, F. Yilmaz; Atabey, N.; Erdal, E.
