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    Effect of magnesium sulfate on renal ischemia-reperfusion injury in streptozotocin-induced diabetic rats
    (Verduci Publisher, 2016) Akan, M.; Ozbilgin, S.; Boztas, N.; Celik, A.; Ozkardesler, S.; Ergur, B. U.; Guneli, E.; Sisman, A. R.; Akokay, P.; Meseri, R.
    OBJECTIVE: Ischemia/reperfusion (I/R) injury is a major cause of acute organ dysfunction and I/R related acute renal failure is a common clinical problem. Diabetes mellitus is defined as a risk factor for the development of acute renal injury as diabetic nephropathy compromises the renal tolerance to ischemia. The aim of this study was to investigate the protective effect of magnesium sulfate in a diabetic rat renal I/R injury model. MATERIALS AND METHODS: Diabetes mellitus was induced using streptozotocin. Thirty-five rats were divided into five groups: Group I: Nondiabetic sham group; Group II: Diabetic sham group; Group III: Diabetic I/R group; Group IV: Diabetic I/R + prophylactic (preischemic) MgSO4; and Group V: Diabetic I/R + therapeutic (following reperfusion) MgSO4 group. MgSO4 was administered 200 mg/kg intraperitoneally. Renal I/R (45 min ischemia + 4 h reperfusion) was induced in both kidneys. Histomorphological, immunohistochemical (caspase-3 and iNOS) and biochemical (BUN, Creatinine) methods were performed to assess the blood and tissue samples. RESULTS: Histomorphological injury scores and immunostaining intensities (for both caspase-3 and iNOS) were significantly lower in the MgSO4 administered groups (prophylactic and therapeutic) than in the Diabetic IR group. There were no significant differences in biochemical parameters (BUN, Cr) between the MgSO4 administered groups and the Diabetic IR group. CONCLUSIONS: In the present study, it was demonstrated by histomorphological and immunohistochemical methods that magnesium sulfate administration before ischemia or following reperfusion significantly reduced renal I/R injury in a diabetic rat model.
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    IS OVERACTIVE BLADDER MICROVASCULATURE DISEASE A COMPONENT OF SYSTEMIC ATHEROSCLEOROSIS?
    (Wiley, 2017) Yeniel, A. O.; Ergenoglu, A. M.; Meseri, R.; Kismali, E.; Kavukcu, G.; Ari, A.; Aydin, H. H.; Ak, H.; Atay, S.; Itil, I. M.
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    Prevalence of food insecurity and malnutrition, factors related to malnutrition in the elderly: A community-based, cross-sectional study from Turkey
    (Springer, 2013) Simsek, H.; Meseri, R.; Sahin, S.; Ucku, R.
    Background and aim: Malnutrition is an important cause of mortality and morbidity in the elderly. The objectives of this study were to determine the malnutrition and food insecurity prevalence in the elderly in the Balcova District of Izmir and to evaluate the risk factors leading to malnutrition. Methods: This cross-sectional study (n = 650) was carried out among elderly participants in a lower socio-economic area of the Balcova District in Izmir. Malnutrition was determined using the Mini Nutritional Assessment (MNA) tool. Food insecurity was defined according to the Nutrition Survey of the Elderly in New York State (NSENY) study. Data was collected at home via face-to-face interview and measuring anthropometric indices. Chi-square and logistic regression were used in analysis. Results: Among participants, 62.9% of them (n = 409) were female. The mean age was found to be 74.1 +/- 6.3 (65-97). Food insecurity prevalence was 21.7%, whereas for malnutrition and malnutrition risk it was 2.7% and 28.0% respectively. The following factors were found to significantly increase the risk of malnutrition: Increased age (OR = 1.06 P = 0.001) and number of chronic diseases (OR = 1.41 P < 0.001), not being married (OR = 2.13 P = 0.002), bad-very bad perceived economic (OR = 2.49 P = 0.002) and health status (OR = 4.33 P < 0.001), being orthopedically disabled (OR = 1.95 P = 0.047) and presence of food insecurity (OR = 2.49 P = 0.001). Conclusion: Based on our research of previous related studies, we expected food insecurity and malnutrition rates to be lower. In order to determine food insecurity and malnutrition risk in the community-dwelling elderly, first it was necessary to establish a monitoring programme. (C) 2013 Elsevier Masson SAS and European Union Geriatric Medicine Society. All rights reserved.