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Öğe Distribution of I-131-labeled recombinant human erythropoietin in maternal and fetal organs following intravenous administration in pregnant rats(Springer, 2007) Yilmaz, O.; Lambrecht, F. Y.; Gokmen, N.; Erbayraktar, S.; Durkan, K.The aim of the present study was to demonstrate the possible transplacental transmission of I-131 labeled recombinant human erythropoietin (I-131-rh-EPO) in pregnant rats and its distribution through maternal and fetal organs. Six Wistar Albino Rats in their pregnancy of 18 days were used I-131 labeled recombinant human erythropoietin (specific activity = 2.4 mu Ci/IU) was injected into the tail vein of rats. After 30 minutes labeled erythropoietin infusion maternal stomach, kidney, lung, liver, brain and heart as well as fetus were removed. Then, the same organs were removed from each fetus. Measuring weight of maternal and fetal organs as well as placenta were followed by radioactivity count via Cd(Te) detector. I-131 labeled recombinant human erythropoietin was found to be able to pass rat placenta and its distribution order in fetal organs was similar to those of maternal organs. Besides, as measurements were performed closer to cornu uteri, uptakes were decreasing in every fetus and its corresponding placenta.Öğe Preparation of 131I-Pentamidine and Evaluation for scintigraphy of experimentally Leishmania tropica infected Hamsters(Springer, 2013) Inceboz, T.; Lambrecht, F. Y.; Eren, M. S.; Girginkardesler, N.; Bekis, R.; Yilmaz, O.; Er, O.; Ozbilgin, A.Öğe Radiolabeling of codeine with I-131 and its biodistribution in rats(Springer, 2009) Enginar, H.; Unak, P.; Lambrecht, F. Y.; Muftuler, F. Z. Biber; Medine, E. I.; Yolcular, S.; Yurt, A.; Seyitoglu, B.; Bulduk, I.Codeine which was extracted from dry capsules of the opium poppy (Papaver somniferum) was purified by HPLC (High Performance Liquid Chromatography) and characterized by NMR (Nuclear Magnetic Resonance) and IR (Infrared) spectroscopy techniques. The purified compound was labeled with I-131 and biodistribution studies were performed in rats. Radioiodinated codeine distributed uniformly in the cerebellum, m.pons, striatum and hypothalamus while the other branch of brain and Stomach, urinary bladder, and small intestine uptakes were significantly higher than other tissues.Öğe Synthesis, radiolabeling and biodistribution of morphine glucuronide (mor-glu)(Springer, 2012) Enginar, H.; Unak, P.; Muftuler, F. Z. Biber; Lambrecht, F. Y.; Medine, E. I.; Yolcular, S.; Kilcar, A. Yurt; Seyitoglu, B.; Bulduk, I.The aim of this study was to synthesize a glucuronide conjugated morphine derivative which could be labeled with I-131, as a radiopharmaceutical, and to investigate its radiopharmaceutical potential using biodistribution studies in male Albino Wistar rats. Morphine was extracted from dry capsules of the opium poppy (Papaver somniferum L.). It was conjugated with UDP-glucuronic acid by using UDP-glucuronyl transferase (UDPGT) enzyme rich microsomes, purified by high performance liquid chromatography (HPLC) and characterized by nuclear magnetic resonance (NMR), infrared (IR) spectroscopy and liquid chromatography mass spectroscopy (LC-MS/MS). Normal and receptor blockage biodistribution studies were performed in male Albino Wistar rats. The results of the tissue distribution studies showed that I-131 labeled morphine glucuronide (I-131-mor-glu) uptake in the small intestine, large intestine and urinary bladder was higher than in the other tissues of the rats in the blocked receptor and unblocked receptor. A greater uptake of the radio labeled substance was observed in the hypothalamus and mid brain than in the other branches of the rats' brains.
