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    Autonomic nerve involvement and venous leakage in diabetic men with impotence
    (Wiley, 1999) Colakoglu, Z; Kutluay, E; Ertekin, C; Altay, B; Killi, R; Alkis, A
    Objective To determine the neurophysiological and vascular factors in diabetic impotence, particularly the role of autonomic neuropathy on venous leakage and erectile impotence. Patients and methods Thirty-four diabetic men with impotence were investigated using Various neurophysiological and radiological methods, The results were compared with those from patients with idiopathic penile Venous leakage for autonomic neuropathy, especially for spontaneous cavernosal activity (SCA). Results Of the neurophysiological tests, the SCA was most frequently abnormal, with the loss of normal periodic oscillations, Penile venous leakage, either alone or with arterial insufficiency, was the most frequent vascular problem (67%) in patients with diabetic impotence, in whom the SCA was absent in most (83%). Conversely, the SCA was normal in all impotent patients with idiopathic venous leakage. Conclusion Venous leakage in diabetic patients is probably produced by autonomic dysfunction of the penile vascular innervation or degeneration of penile smooth muscles, because the SCA was absent more often in these patients.
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    Brain SPECT in anterior opercular syndrome due to a unilateral lesion
    (Springer Verlag, 1996) Kutluay, E; Colakoglu, Z; Dirlik, A; Kumral, K
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    The nature of spontaneous cavernosal activity
    (Blackwell Science Ltd, 1999) Colakoglu, Z; Kutluay, E; Ertekin, C
    Objective To determine the characteristics of spontaneous cavernosal activity (SCA) and to relate this to previous descriptions of spontaneous potentials from the cavernosum (single potential analysis of cavernosal activity, SPACE), Subjects and methods The SCA was recorded in 31 normal men with no sexual problems; various manipulations were applied using concentric-needle (CN), bipolar needle (BN) and surface electrodes. The electrical activity was compared with the observed slow retractile movements of the flaccid penis and with other assessments of electrical activity from skin, Results SCA appeared synchronously from both sides of the cavernosal bodies in all normal subjects when detected by CN electrodes. The synchronous recordings both by CN and BN electrodes, or both by CN and surface electrodes registered similar oscillatory potentials. Slow retractile movements of the penis occurred synchronously with these potentials in all subjects and both were absent during erection. Conclusion SCA is apparently related to biomechanical slow movement artefacts of the flaccid penis; it may be a consequence of the summed contractions of smooth muscle groups in the cavernosum Observing the small retractile slow movements of the flaccid penis and recording the SCA may be a useful indirect method to characterize cavernosal neural innervation and smooth muscle activity.
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    Subclinical cerebral involvement in Behcet's disease: a SPECT study
    (Lippincott Williams & Wilkins, 1998) Avci, O; Kutluay, E; Argon, M; Erdem, S; Gunes, AT
    Neurologic involvement has been reported in Behcets disease (BD) with prevalence rates of 4-49%. Involvement of the central nervous system (CNS) usually follows systemic manifestations of BD by months to years, but as the initial future in only 5% of cases. The variance of the prevalence rates of neurologic involvement in BD raises the possibility of subclinical neurologic involvement. For the purpose of explaining the variance in the prevalence rates, 20 patients with BD, but without neurological symptoms and signs, were investigated by using cerebral single photon emission computed tomography (SPECT) which seems to be more convenient for BD than other scanners. A control group of patients with various diseases that were not expected to influence the cerebral blood flow was included. Brain magnetic resonance imaging (MRI) scans were performed in cases in which abnormal SPECT findings were obtained. Decreased and asymmetrical tracer uptakes were detected in 35% of patients with BD. MRI scans were normal in these patients. We concluded that functional imaging using SPECT may detect abnormalities at an initial stage prior to their progression to morphological damage detectable by MRI, and this imaging modality can be used even in cases which show no neurologic symptom to indicate the subclinical neurologic involvement.