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The Association of Minor Congenital Anomalies and Childhood Cancer
(Wiley, 2011) Durmaz, Asude; Durmaz, Burak; Kadioglu, Bengu; Aksoylar, Serap; Karapinar, Deniz; Koturoglu, Guldane; Orman, Mehmet N.; Özkınay, Ferda; Cogulu, Ozgur
Background. Although the association of some congenital malformations and specific genetic syndromes is well understood, the association between minor anomalies and cancer is not well known. In recent years some researchers have reported studies establishing this association in different types of cancer. In this study, we aimed to investigate the prevalence and patterns of age-independent minor anomalies in childhood cancer patients. Procedure. Two hundred patients with various types of cancer and 200 healthy controls were examined by two different medical geneticists for minor anomalies who evaluated all the cases and controls simultaneously. Besides minor anomalies, information on the consanguinity between the parents and occurrence of cancer in relatives were also recorded. The types of minor anomalies in different types of cancer, the number of minor anomalies in patients and controls, the association between cancer and the occurrence of different types of minor anomalies were also evaluated. Results. The consanguinity and the history of cancer in relatives were significantly more prevalent in patients (P = 0.04 and P < 0.001, respectively). The number of minor anomalies in patients were significantly higher compared to the controls (P < 0.01). Particularly, the presence of hypertelorism, high-arched palate (approximately 40-fold higher, 95% CI: 12.895-125.037) and hand-foot anomalies were found to be more prevalent in patients having cancer compared to the controls. Conclusion. The common pathways during the embryogenesis may play a role in the development of cancer. The presence and the combination of minor anomalies seem to be associated with a higher prevalence of cancer. Pediatr Blood Cancer 2011;56:1098-1102. (C) 2011 Wiley-Liss, Inc.
Bordetella Pertussis Infection in Hospitalized Infants with Acute Bronchiolitis
(Springer India, 2018) Gokce, Sule; Kurugol, Zafer; Aydemir, S. Sohret; Cicek, Candan; Aslan, Asli; Koturoglu, Guldane
Objective To assess the frequency of B. pertussis infection among young infants hospitalized with acute bronchiolitis and to determine whether B. pertussis infection affects the clinical course of acute bronchiolitis. Methods A total of 172 infants <6 months of age hospitalized with acute bronchiolitis were tested for B. pertussis and respiratory viruses with real-time PCR. Cases were divided into 2 groups according to B. pertussis positive or negative. Clinical parameters, clinical severity scores and laboratory characteristics of the pertussis-positive and pertussis-negative cases were compared. Results Bordetella pertussis infection was detected in 44 (25.6%) of the 172 infants hospitalized for acute bronchiolitis, and as co-infection with respiratory viral agents in 27 (61.4%) infants. Of the 44 pertussis-positive infants, only 17 (38.6%) experienced a paroxysmal cough, 13 (29.5%) had whooping and 15 (34.1%) had post-tussive vomiting. There was no significant difference between pertussis-positive and pertussis-negative infants according to Wang clinical score at admission (4.9 +/- 1.5 vs. 5.2 +/- 2.5; p = 0.689). The overall disease severity score was also similar between the two groups (6.5 +/- 1.4 vs. 6.9 +/- 1.6; p = 0.095). Conclusions Bordetella pertussis infection is common in young infants hospitalized for acute bronchiolitis, mostly as co-infection with respiratory viruses. The clinical features of pertussis in the infants are not characteristic. Viral bronchiolitis and pertussis cases could not be differentiated by clinical findings. Co-infection with pertussis did not affect the clinical outcome in infants hospitalized with acute bronchiolitis.
Changing epidemiology of hepatitis A infection in Izmir, Turkey
(Elsevier Sci Ltd, 2011) Kurugol, Zafer; Aslan, Asli; Turkoglu, Ebru; Koturoglu, Guldane
The seroprevalence study was conducted in order to determine the current seroepidemiology hepatitis A in Izmir, Turkey and to evaluate the epidemiological shift in HAV serostatus. Blood samples collected from 595 subjects aged 1-60 years were analyzed for anti-HAV IgG antibodies. The current study results were compared with those of a previous study conducted in 1998 involving the same location. There was a marked decrease in the prevalence of anti-HAV between 1998 and 2008. While anti-HAV seroprevalence rates in the current study were 4.6% in children aged 1-4 years, 23% in children aged 10-14 years, and 85% in young adults aged 20-29 years, the prevalence rates were 36% in the 1-4 years age group, 65% in the 10-14 years age group, and 95% in young adults in the previous study, indicating a shift in HAV seroprevalence from the younger to the higher age groups. As HAV infection in childhood is decreasing, the pool of susceptible adolescents and young adults is increasing in Izmir, Turkey. The majority of adolescent population is susceptible to HAV infection. The potential risk of HAV epidemics still exists. The situation of Turkey, suggested to need for mass immunization. Also, introduction of hepatitis A vaccination into the national immunization schedule of Turkey should be considered. (C) 2011 Elsevier Ltd. All rights reserved.
A clinical and laboratory approach to the evaluation of innate immunity in pediatric CVID patients
(Frontiers Media Sa, 2015) Kutukculer, Necil; Azarsiz, Elif; Karaca, Neslihan Edeer; Ulusoy, Ezgi; Koturoglu, Guldane; Aksu, Guzide
Defective adaptive immune responses are well studied in common variable immunodeficiency (CVID) patients; however, more focus is needed on innate immune system defects to explain CVID's clinical and laboratory heterogeneity. This is the first study comparing migratory function of granulocytes, oxidative burst activity of phagocytic cells, surface integrin expressions on neutrophils and lymphocytes, natural killer (NK) cell numbers and cytotoxic activity, natural killer T cells, lymphocyte subsets such as CD8(+)CD28(+), CD4(+)CTLA-4(+) cells in CVID patients (n: 20) and healthy controls (n: 26). The relationship between laboratory findings and some clinical was also investigated. CD3(+)CD8(+) T cytotoxic cells were found to be elevated in CVID patients, but CD3(+)CD8(+)CD28(+) or CD3(+)CD8(+)CD28(-) cells did not show any significant difference. CD4(+)CTLA-4(+) cell percentages were significantly lower in CVID patients compared to healthy controls. Severe CVID patients had decreased percentages of NK cells with increased NK cell cytotoxicity suggesting possibly increased activation. Furthermore, CD3(-)CD16(+)CD56(+)CD28(+) cells of CVID patients were elevated while percentage of CD28(-) NK cells was decreased. Neutrophil migration percentages were lower but and oxidative burst activity was not affected. CD11a expressions on these cells were depressed in contrast to increased expression of CD18. Innate immunity defects may affect the extent of recurrence and severity of infections in CVID. Our observations highlight some of these associations and indicate the need for further similar studies for improving better innate system evaluation batteries for these patients. Further phenotypic correlations of these analyses will help clinicians reach a more definitive target for the molecular genetic diagnostic of pediatric CVID patients.
A clinical and laboratory approach to the evaluation of innate immunity in pediatric CVID patients
(Frontiers Media Sa, 2015) Kutukculer, Necil; Azarsiz, Elif; Karaca, Neslihan Edeer; Ulusoy, Ezgi; Koturoglu, Guldane; Aksu, Guzide
Defective adaptive immune responses are well studied in common variable immunodeficiency (CVID) patients; however, more focus is needed on innate immune system defects to explain CVID's clinical and laboratory heterogeneity. This is the first study comparing migratory function of granulocytes, oxidative burst activity of phagocytic cells, surface integrin expressions on neutrophils and lymphocytes, natural killer (NK) cell numbers and cytotoxic activity, natural killer T cells, lymphocyte subsets such as CD8(+)CD28(+), CD4(+)CTLA-4(+) cells in CVID patients (n: 20) and healthy controls (n: 26). The relationship between laboratory findings and some clinical was also investigated. CD3(+)CD8(+) T cytotoxic cells were found to be elevated in CVID patients, but CD3(+)CD8(+)CD28(+) or CD3(+)CD8(+)CD28(-) cells did not show any significant difference. CD4(+)CTLA-4(+) cell percentages were significantly lower in CVID patients compared to healthy controls. Severe CVID patients had decreased percentages of NK cells with increased NK cell cytotoxicity suggesting possibly increased activation. Furthermore, CD3(-)CD16(+)CD56(+)CD28(+) cells of CVID patients were elevated while percentage of CD28(-) NK cells was decreased. Neutrophil migration percentages were lower but and oxidative burst activity was not affected. CD11a expressions on these cells were depressed in contrast to increased expression of CD18. Innate immunity defects may affect the extent of recurrence and severity of infections in CVID. Our observations highlight some of these associations and indicate the need for further similar studies for improving better innate system evaluation batteries for these patients. Further phenotypic correlations of these analyses will help clinicians reach a more definitive target for the molecular genetic diagnostic of pediatric CVID patients.
A clinical and laboratory approach to the evaluation of innate immunity in pediatric CVID patients
(Frontiers Media Sa, 2015) Kutukculer, Necil; Azarsiz, Elif; Karaca, Neslihan Edeer; Ulusoy, Ezgi; Koturoglu, Guldane; Aksu, Guzide
Defective adaptive immune responses are well studied in common variable immunodeficiency (CVID) patients; however, more focus is needed on innate immune system defects to explain CVID's clinical and laboratory heterogeneity. This is the first study comparing migratory function of granulocytes, oxidative burst activity of phagocytic cells, surface integrin expressions on neutrophils and lymphocytes, natural killer (NK) cell numbers and cytotoxic activity, natural killer T cells, lymphocyte subsets such as CD8(+)CD28(+), CD4(+)CTLA-4(+) cells in CVID patients (n: 20) and healthy controls (n: 26). The relationship between laboratory findings and some clinical was also investigated. CD3(+)CD8(+) T cytotoxic cells were found to be elevated in CVID patients, but CD3(+)CD8(+)CD28(+) or CD3(+)CD8(+)CD28(-) cells did not show any significant difference. CD4(+)CTLA-4(+) cell percentages were significantly lower in CVID patients compared to healthy controls. Severe CVID patients had decreased percentages of NK cells with increased NK cell cytotoxicity suggesting possibly increased activation. Furthermore, CD3(-)CD16(+)CD56(+)CD28(+) cells of CVID patients were elevated while percentage of CD28(-) NK cells was decreased. Neutrophil migration percentages were lower but and oxidative burst activity was not affected. CD11a expressions on these cells were depressed in contrast to increased expression of CD18. Innate immunity defects may affect the extent of recurrence and severity of infections in CVID. Our observations highlight some of these associations and indicate the need for further similar studies for improving better innate system evaluation batteries for these patients. Further phenotypic correlations of these analyses will help clinicians reach a more definitive target for the molecular genetic diagnostic of pediatric CVID patients.
Comparison of ELISA with shell vial cell culture method for the detection of human rotavirus in fecal specimens
(Edizioni Internazionali Srl, 2007) Cicek, Candan; Karatas, Tuba; Altuglu, Imre; Koturoglu, Guldane; Kurugol, Zafer; Bilgic, Altinay
The aim of the study was to compare an enzyme immunoassay method with shell vial cell culture method for detection of rotavirus in fecal specimens. In addition, the correlation between laboratory results and clinical scores of patients with gastroenteritis was evaluated. A total of 219 fecal specimens from children (ages 3 weeks to 5 years) with acute gastroenteritis submitted to pediatric emergency room were evaluated by both ELISA and shell vial cell culture. A Vesikari score was used for assessing the severity of the illness. Among 219 stool samples tested, 107 (48.9%) were determined to be positive. Two specimens were positive by shell vial cell culture method while they were ELISA negative. According to these results the calculated sensitivity, specificity, PPV, and NPV of ELISA were 98.1%, 100%, 100%, and 98.2%, respectively The mean severity score for the 107 episodes of rotavirus diarrhoea was 11.0 +/- 3.6 compared to 4.5 +/- 1.9 for the 112 episodes of non-rotavirus diarrhea in the same population. Our study indicates that ELISA, which is easier to perform, faster and cheaper than cell culture methods may be suitable for routine diagnosis of rotavirus infections. The severity of rotavirus positive gastroenteritis was significantly higher than that of rotavirus negative patients.
Comparison of Vesikari and Clark scales regarding the definition of severe rotavirus gastroenteritis in children
(Taylor & Francis Ltd, 2015) Aslan, Asli; Kurugol, Zafer; Cetin, Hulya; Karakaslilar, Sabahat; Koturoglu, Guldane
Background: Two clinical severity scales, the Vesikari scale and the Clark scale, are commonly used to assess the efficacy of rotavirus vaccines. The results obtained using the two severity scales differ significantly and hamper comparisons. The aim of this study was to compare the Clark and Vesikari scales and to determine whether modified classifications would provide a better correlation between the two scales. Methods: The severity of rotavirus gastroenteritis was assessed for each child using both the Vesikari and Clark scales. To make a statistical comparison between the two scales, the classifications were modified. Results: In total, 200 children with rotavirus gastroenteritis were evaluated. Of these, 57% were classified as severe by the Vesikari scale, and only 1.5% by the Clark scale (p < 0.001). When the Clark three-category scale was transformed into a two-category scale by merging mild and moderate categories as non-severe, a good correlation with the Vesikari scale still could not be found. Using the median of the severity scores as the severity threshold did not provide a better correlation between the two scales. Transforming the Vesikari two-category scale into a three-category scale by further subdividing the severe category into two parts, as moderate and severe (>= 16), provided a better correlation between the two severity scales, but still did not achieve a good level of agreement. Conclusions: The Clark and Vesikari scales differ significantly in the definition of severe gastroenteritis. Even the attempts at reclassifying the scales did not achieve a good correlation.
Comparison of Vesikari and Clark scales regarding the definition of severe rotavirus gastroenteritis in children
(Taylor & Francis Ltd, 2015) Aslan, Asli; Kurugol, Zafer; Cetin, Hulya; Karakaslilar, Sabahat; Koturoglu, Guldane
Background: Two clinical severity scales, the Vesikari scale and the Clark scale, are commonly used to assess the efficacy of rotavirus vaccines. The results obtained using the two severity scales differ significantly and hamper comparisons. The aim of this study was to compare the Clark and Vesikari scales and to determine whether modified classifications would provide a better correlation between the two scales. Methods: The severity of rotavirus gastroenteritis was assessed for each child using both the Vesikari and Clark scales. To make a statistical comparison between the two scales, the classifications were modified. Results: In total, 200 children with rotavirus gastroenteritis were evaluated. Of these, 57% were classified as severe by the Vesikari scale, and only 1.5% by the Clark scale (p < 0.001). When the Clark three-category scale was transformed into a two-category scale by merging mild and moderate categories as non-severe, a good correlation with the Vesikari scale still could not be found. Using the median of the severity scores as the severity threshold did not provide a better correlation between the two scales. Transforming the Vesikari two-category scale into a three-category scale by further subdividing the severe category into two parts, as moderate and severe (>= 16), provided a better correlation between the two severity scales, but still did not achieve a good level of agreement. Conclusions: The Clark and Vesikari scales differ significantly in the definition of severe gastroenteritis. Even the attempts at reclassifying the scales did not achieve a good correlation.
Comparison of Vesikari and Clark scales regarding the definition of severe rotavirus gastroenteritis in children
(Taylor & Francis Ltd, 2015) Aslan, Asli; Kurugol, Zafer; Cetin, Hulya; Karakaslilar, Sabahat; Koturoglu, Guldane
Background: Two clinical severity scales, the Vesikari scale and the Clark scale, are commonly used to assess the efficacy of rotavirus vaccines. The results obtained using the two severity scales differ significantly and hamper comparisons. The aim of this study was to compare the Clark and Vesikari scales and to determine whether modified classifications would provide a better correlation between the two scales. Methods: The severity of rotavirus gastroenteritis was assessed for each child using both the Vesikari and Clark scales. To make a statistical comparison between the two scales, the classifications were modified. Results: In total, 200 children with rotavirus gastroenteritis were evaluated. Of these, 57% were classified as severe by the Vesikari scale, and only 1.5% by the Clark scale (p < 0.001). When the Clark three-category scale was transformed into a two-category scale by merging mild and moderate categories as non-severe, a good correlation with the Vesikari scale still could not be found. Using the median of the severity scores as the severity threshold did not provide a better correlation between the two scales. Transforming the Vesikari two-category scale into a three-category scale by further subdividing the severe category into two parts, as moderate and severe (>= 16), provided a better correlation between the two severity scales, but still did not achieve a good level of agreement. Conclusions: The Clark and Vesikari scales differ significantly in the definition of severe gastroenteritis. Even the attempts at reclassifying the scales did not achieve a good correlation.
Complications of Varicella in Healthy Children
(Aves Yayincilik, Ibrahim Kara, 2015) Koturoglu, Guldane; Kurugol, Zafer
Complications of Varicella in Healthy Children
(Aves Yayincilik, Ibrahim Kara, 2015) Koturoglu, Guldane; Kurugol, Zafer
Complications of Varicella in Healthy Children
(Aves Yayincilik, Ibrahim Kara, 2015) Koturoglu, Guldane; Kurugol, Zafer
Complications of Varicella in Healthy Children: Is It Increasing?
(Galenos Yayincilik, 2015) Koturoglu, Guldane; Kurugol, Zafer; Halicioglu, Oya; Devrim, Ilker; Vardar, Fadil
Aim: Varicella is a common and self-limiting disease caused by the varicella zoster. However it may cause severe morbidity and mortality, due to complications in healthy children. These complications can be prevented by vaccination. The aim of this study was to determine the type of complications of varicella in hospitalized children. Also these data were compared with the study carried out in 2005 and changes in the varicella hospitalizations were analyzed to obtain the necessary data for the study of the vaccine. Materials and Methods: A retrospective study involving 262 children hospitalized for complications due to varicella between January 2005 and December 2009 was carried out. Incidence and clinical spectrum of complications and their age and seasonal variations related distribution was analyzed. Results: We identified 262 children hospitalized for complications of varicella. Fourteen children with immune deficiency or on immunosuppressive treatment were excluded. The majority of varicella complications occurred in children under 5 years of age. The most common complications were infectious complications (41.9%). Thereafter, neurologic complications (35.6%) and hematological complications were seen (3.6%). The seasonal distribution of complications associated with varicella had a higher incidence in January (21.4%). Three patients died due to these complications. Conclusion: Complications of varicella were more frequent than previously reported. Also mortality rates were higher than those in the previous study. Varicella can be accompanied by severe complications and death in immunologically healthy children. In this study, the importance of varicella vaccination was emphasized again.
Complications of Varicella in Healthy Children: Is It Increasing?
(Galenos Yayincilik, 2015) Koturoglu, Guldane; Kurugol, Zafer; Halicioglu, Oya; Devrim, Ilker; Vardar, Fadil
Aim: Varicella is a common and self-limiting disease caused by the varicella zoster. However it may cause severe morbidity and mortality, due to complications in healthy children. These complications can be prevented by vaccination. The aim of this study was to determine the type of complications of varicella in hospitalized children. Also these data were compared with the study carried out in 2005 and changes in the varicella hospitalizations were analyzed to obtain the necessary data for the study of the vaccine. Materials and Methods: A retrospective study involving 262 children hospitalized for complications due to varicella between January 2005 and December 2009 was carried out. Incidence and clinical spectrum of complications and their age and seasonal variations related distribution was analyzed. Results: We identified 262 children hospitalized for complications of varicella. Fourteen children with immune deficiency or on immunosuppressive treatment were excluded. The majority of varicella complications occurred in children under 5 years of age. The most common complications were infectious complications (41.9%). Thereafter, neurologic complications (35.6%) and hematological complications were seen (3.6%). The seasonal distribution of complications associated with varicella had a higher incidence in January (21.4%). Three patients died due to these complications. Conclusion: Complications of varicella were more frequent than previously reported. Also mortality rates were higher than those in the previous study. Varicella can be accompanied by severe complications and death in immunologically healthy children. In this study, the importance of varicella vaccination was emphasized again.
Complications of Varicella in Healthy Children: Is It Increasing?
(Galenos Yayincilik, 2015) Koturoglu, Guldane; Kurugol, Zafer; Halicioglu, Oya; Devrim, Ilker; Vardar, Fadil
Aim: Varicella is a common and self-limiting disease caused by the varicella zoster. However it may cause severe morbidity and mortality, due to complications in healthy children. These complications can be prevented by vaccination. The aim of this study was to determine the type of complications of varicella in hospitalized children. Also these data were compared with the study carried out in 2005 and changes in the varicella hospitalizations were analyzed to obtain the necessary data for the study of the vaccine. Materials and Methods: A retrospective study involving 262 children hospitalized for complications due to varicella between January 2005 and December 2009 was carried out. Incidence and clinical spectrum of complications and their age and seasonal variations related distribution was analyzed. Results: We identified 262 children hospitalized for complications of varicella. Fourteen children with immune deficiency or on immunosuppressive treatment were excluded. The majority of varicella complications occurred in children under 5 years of age. The most common complications were infectious complications (41.9%). Thereafter, neurologic complications (35.6%) and hematological complications were seen (3.6%). The seasonal distribution of complications associated with varicella had a higher incidence in January (21.4%). Three patients died due to these complications. Conclusion: Complications of varicella were more frequent than previously reported. Also mortality rates were higher than those in the previous study. Varicella can be accompanied by severe complications and death in immunologically healthy children. In this study, the importance of varicella vaccination was emphasized again.
Determination of Lymphocyte Cytokinesis-Block Micronucleus Values in Apparently Healthy Children by means of Age and Sex
(Hindawi Ltd, 2019) Durmaz, Burak; Taslidere, Hasan; Koturoglu, Guldane; Gunduz, Cumhur; Orman, Mehmet; Cogulu, Ozgur
The cytokinesis-block micronucleus (MN) assay on blood lymphocytes is one of the most important tests implemented in cytogenetics for the measurement of genotoxicity. For the purpose of biological dosing, it is crucial to know the spontaneous frequency of MN and its normal values in general population, especially in children, which are used for the population databases. in this study, MN levels were investigated in cytokinesis-blocked lymphocytes of 150 apparently healthy children aged 1 to 15. Our aim was to assess the variability of MN values according to age and sex. the mean MN frequency among boys was 3.69 +/- 1.747 parts per thousand and 4.12 +/- 1.867 parts per thousand in girls where there was no significant difference in relation to age and sex. However, when we separated age groups as 0-2 years, 3-5 years, 6-10 years, and 11-15 years, one-way ANOVA test showed significant association. Significance was obvious in the 0-2 years age group with the 3-5 years age group and 6-10 years age group. When we grouped our study population as 0-2 years and 3-15 years, the mean MN frequency among the 0-2 years age group was 2.85 +/- 1.599 parts per thousand and 4.07 +/- 1.867 parts per thousand in the 3-15 years age group which was also statistically significant. This difference may be attributed to age-related increase of close contact with environmental hazardous agents. in conclusion, normal values of MN obtained in this study will add valuable information in regard to update the current childhood population data and will act as a reference for further genotoxicity studies.
Development of Paralytic Ileus with Acute Gastroenteritis
(Galenos Yayincilik, 2015) Gokce, Sule; Turan, Gulizar; Kiymet, Elif; Ozdemir, Ozgur; Koturoglu, Guldane
Paralytic ileus (intestinal pseudo-obstruction) is a clinical condition caused by autonomic dysregulation. Acute paralytic ileus which can develop following surgery, takes the name chronic pseudo-obstruction if the clinical findings recur or become continuous. Atoni-intestinal motor activity disorder is the basic pathology of the disease. Among the diseases that cause this autonomic imbalance, the most frequently seen are trauma, electrolyte imbalance, bacterial or viral gastroenteritis, surgical procedures and mesentery ischemia. The most common symptoms are abdominal pain, abdominal distension, vomiting, gas, and reduced fecal output. In diagnostic evaluation the first step is abdominal radiography taken while the patient is standing. In this paper, two cases that were hospitalized due to acute gastroenteritis and who developed paralytic ileus during follow-up are presented.
Diagnostic Value of the Mean Platelet Volume in the Prediction of Respiratory Syncytial Virus in Acute Bronchiolitis
(Galenos Yayincilik, 2019) Gokce, Sule; Kurugol, Zafer; Koturoglu, Guldane; Asian, Asli; Polater, Sibel; Cicek, Candan
Aim: Respiratory syncytial virus (RSV) is a viral pathogen that causes lower respiratory system infections in childhood. The purpose of this study was to examine whether mean platelet volume (MPV) changes are significant in the prediction of RSV bronchiolitis. Materials and Methods: One hundred and eighty-four infants who were diagnosed with acute bronchiolitis were divided into groups based on being RSV positive and other respiratory viruses positive. Using the receiver operating characteristic (ROC), diagnostic accuracy was evaluated according to the areas under the curves (AUC) for the diagnosis of bronchiolitis. A p value of < 0.05 was considered statistically significant. Results: MPV was significantly lower in patients with single RSV (6.6 +/- 1.1 vs 7 +/- 1.2, p < 0.05). The MPVs were similar in patients diagnosed with positive and negative RSV bronchiolitis (6.8 +/- 1.5 vs 7 +/- 1.3, p > 0.05) and other viruses. ROC curve analysis indicates that the MPV level cut-off point for making the diagnosis of single RSV bronchiolitis was 6.63 fL with a sensitivity and specificity of 55% and 63% respectively. The median AUC was 0.384 for the MPV (95% CI 0.270-0.499, p = 0.04). Conclusion: Volume of MP may be a useful marker to provide a prediction on single RSV bronchiolitis. However, the measurement of MPV might not be correct and sufficient to provide a prediction on the types of respiratory viruses in bronchiolitis.
Evidence of an association between mannose binding lectin codon 54 polymorphism and adenoidectomy and/or tonsillectomy in children
(Elsevier Ireland Ltd, 2007) Koturoglu, Guldane; Onay, Huseyin; Midilli, Rasit; Pehlivan, Sacide; Eren, Erdem; Itirli, Gulcin; Kurugol, Zafer; Apaydin, Fazil; Özkınay, Cihangir; Özkınay, Ferda
Mannose binding lectin (MBL) is a calcium-dependent lectin that plays an important role innate immunity by activating the complement pathway. There have been a number of studies describing an association between the MBL genotype and disease susceptibility. MBL deficiency has been described as one of the factors leading to a number of infections in children with recurrent upper respiratory tractus infections (URTI). We hypothesized that MBL deficiency may be associated with recurrent URTI, which requires adenoidectomy and/or adenotonsillectomy. In this study to clarify this hypothesis we investigated whether there may be an association between two tow producing MBL variants and adenoidectomy and/or tonsillectomy due to recurrent URTI in children. Blood samples were collected, adenoidectomy and/or tonsillectomy due to recurrent URTI and 50 controls (mean age 80.53 +/- 32.62 months). In all patients and controls codon 54 and codon 57 polymorphisms of the MBL gene were analyzed. None of the subjects from the patient group and control group carried codon 57 polymorphism of the MBL gene. The frequency of low-level MBL genotypes (AB and BB) for codon 54 polymorphism in the patient group was found to be significantly higher compared to the control subjects (55.7% versus 14%) (p < 0.001). This study shows that the presence of low-level MBL alleles is associated with adenoidectomy and/or tonsillectomy caused by recurrent URTI in children. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

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