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Öğe Accommodative esotropia following surgical treatment of infantile esotropia: Frequency and risk factors(2008) Uretmen O.; Civan B.B.; Kose S.; Yuce B.; Egrilmez S.Purpose: We aimed to examine the frequency of and risk factors for the development of accommodative esotropia following surgical treatment for infantile esotropia. Methods: A total of 29 children were recruited. Potential risk factors for the development of accommodative esotropia included: sex; angle of deviation at initial and final visits; cycloplegic refractive error at initial and final visits; increase in hyperopia; amblyopia; amblyopia treatment; age at surgical treatment; pre- and postoperative latent nystagmus; dissociated vertical deviation or inferior oblique muscle overaction; additional surgical procedures; unstable alignment, and binocular sensory status. Result: Overall, 14 (48.2%) of 29 children developed accommodative esotropia during the 36- to 132-month postoperative follow-up period. Twelve (85.7%) of the 14 patients developed refractive accommodative esotropia and two developed non-refractive accommodative esotropia. The onset of accommodative esotropia occurred at a mean of 8.8 months (range 6-24 months) after the initial surgical alignment. This corresponded to a mean age of onset for accommodative esotropia of 43.2 months. We determined that, among children with infantile esotropia, those who had hyperopia of ?3.0D and increasing hyperopia after surgery and those who did not develop dissociated vertical deviation during the follow-up period were more likely to develop accommodative esotropia. Conclusions: Children who have the established risk factors should be followed closely for the development of accommodative esotropia. The treatment of these children with appropriate glasses may prevent the development of adverse effects of accommodative esotropia on sensory and motor functions. © 2008 The Authors Journal compilation © 2008 Acta Ophthalmol.Öğe Central nervous system infections in the absence of cerebrospinal fluid pleocytosis(Elsevier B.V., 2017) Erdem H.; Ozturk-Engin D.; Cag Y.; Senbayrak S.; Inan A.; Kazak E.; Savasci U.; Elaldi N.; Vahaboglu H.; Hasbun R.; Nechifor M.; Tireli H.; Kilicoglu G.; Defres S.; Gulsun S.; Ceran N.; Crisan A.; Johansen I.S.; Namiduru M.; Dayan S.; Kayabas U.; Parlak E.; Khalifa A.; Kursun E.; Sipahi O.R.; Yemisen M.; Akbulut A.; Bitirgen M.; Popovic N.; Kandemir B.; Luca C.; Parlak M.; Stahl J.P.; Pehlivanoglu F.; Simeon S.; Ulu-Kilic A.; Yasar K.; Yilmaz G.; Yilmaz E.; Beovic B.; Catroux M.; Lakatos B.; Sunbul M.; Oncul O.; Alabay S.; Sahin-Horasan E.; Kose S.; Shehata G.; Andre K.; Dragovac G.; Gul H.C.; Karakas A.; Chadapaud S.; Hansmann Y.; Harxhi A.; Kirova V.; Masse-Chabredier I.; Oncu S.; Sener A.; Tekin R.; Deveci O.; Ozkaya H.D.; Karabay O.; Agalar C.; Gencer S.; Karahocagil M.K.; Karsen H.; Kaya S.; Pekok A.U.; Celen M.K.; Deniz S.; Ulug M.; Demirdal T.; Guven T.; Bolukcu S.; Avci M.; Nayman-Alpat S.; Yaşar K.; Pehlivano?lu F.; Ates-Guler S.; Mutlu-Yilmaz E.; Tosun S.; Sirmatel F.; Batirel A.; Öztoprak N.; Kadanali A.; Turgut H.; Baran A.I.; Karaahmetoglu G.; Sunnetcioglu M.; Haykir-Solay A.; Denk A.; Ayaz C.; Gorenek L.; Larsen L.; Poljak M.; Barsic B.; Argemi X.; Sørensen S.M.; Bohr A.L.; Tattevin P.; Gunst J.D.; Baštáková L.; Jereb M.; Johansen I.S.; Chehri M.; Beraud G.; Del Vecchio R.F.; Maresca M.; Yilmaz H.; Sharif-Yakan A.; Kanj S.S.; Korkmaz F.; Komur S.; Coskuner S.A.; Ince N.; Akkoyunlu Y.; Halac G.; Nemli S.A.; Ak O.; Kaya S.; Gunduz A.; Gozel M.G.; Hatipoglu M.; Cicek-Senturk G.; Akcam F.Z.; Inkaya A.C.; Sagmak-Tartar A.; Ersoy Y.; Tuncer-Ertem G.; Balkan I.I.; Cetin B.; Ersoz G.; Ozgunes N.; Yesilkaya A.; Erturk A.; Gundes S.; Turhan V.; Yalci A.; Aydin E.; Diktas H.; Ulcay A.; Seyman D.; Leblebicioglu H.Previous multicenter/multinational studies were evaluated to determine the frequency of the absence of cerebrospinal fluid pleocytosis in patients with central nervous system infections, as well as the clinical impact of this condition. It was found that 18% of neurosyphilis, 7.9% of herpetic meningoencephalitis, 3% of tuberculous meningitis, 1.7% of Brucella meningitis, and 0.2% of pneumococcal meningitis cases did not display cerebrospinal fluid pleocytosis. Most patients were not immunosuppressed. Patients without pleocytosis had a high rate of unfavorable outcomes and thus this condition should not be underestimated. © 2017 The Author(s)Öğe Comparison of achromatic and blue-on-yellow perimetry in patients with resolved central serous chorioretinopathy(2005) Afrashi F.; Erakgun T.; Uzunel D.; Mentes J.; Kose S.; Akkin C.Central serous chorioretinopathy (CSCR) is a disorder characterized by the serous detachment of the sensory retina in the posterior pole. Although CSCR usually resolves spontaneously, the patients may notice residual visual deficits, despite recovering normal visual acuity. The aim of this study is to compare the blue-on-yellow perimetric parameters with conventional automated perimetric parameters in the detection of visual deficits in patients with resolved CSCR. Eighteen patients who had spontaneous recovered from CSCR were enrolled this study. All subjects were examined twice with each type of perimetry. Wilcoxon test was used for statistical analysis. The achromatic perimetric mean deviation values were significantly higher in patients with CSCR than in the control group, while statistically a significant difference was determined for all of blue-on-yellow perimetric values. In conclusion the loss of central retinal sensitivity remains after resolution of the CSCR even if the visual acuity has recovered to normal. Blue-on-yellow perimetry is more sensitive than achromatic perimetry to reveal this central sensitivity loss. Copyright © 2005 S. Karger AG.Öğe Condolence houses in Sanliurfa: Fading away of a tradition and a creative attempt to preserve it(2005) Yanik M.; Vahip I.; Kose S.This article reports the results of qualitative research conducted to investigate the change in the traditional manner of giving and accepting condolences in Sanliurfa, a city with a unique sociocultural structure in the southeastern part of Turkey. Our methodology was based on direct observation of behavior and detailed, open-ended interviews with participants. This article aims to investigate the reasons for moving the condolence tradition from family homes to specially built condolence houses a decade ago and discusses the functional significance of the ceremonial events in giving and accepting condolences.Öğe Effectiveness and tolerability of aripiprazole in a real-world outpatient population of youth [Günlük uygulamada ayaktan tedavi gören bir ergen hasta popülasyonunda aripiprazolün etkinlik ve tolerabilitesi](2012) Bildik T.; Ozbaran N.B.; Kose S.; Cetin S.K.Objectives: To identify the pattern of initiation for offlabel use of aripiprazole among adolescent outpatients; determine whether or not aripiprazole is effective and tolerable for the treatment of adolescents with a wide range of psychiatric symptoms and disorders or not. Methods: Medical charts were retrospectively reviewed for the effectiveness and tolerability of aripiprazole. The Clinical Global Impression Scale (CGI), the Brief Symptom Inventory (BSI), and the Extrapyramidal Symptom Rating Scale were used. Results: The data were available on 31 patients. The sample consisted of mostly females (87.1%). The mean age was 16.38±1.14 years, and the ages range was 15-19 years. Twenty-one patients (67.8%) had at least one comorbid disorder. The most common comorbid disorder was major depressive disorder. The mean initial dosage of aripiprazole was 4.83±3.59 mg (2.50 mg - 20.00 mg), and the mean endpoint dosage was 8.62±3.46 mg (2.50 mg - 15.00 mg). The mean duration of aripiprazole medication was 19.56±1.23 months (range: 4-48 months). Endpoint CGI-S scores were significantly lower compared with baseline CGI-S score (p<0.001). Similarly, the difference between depression severity (z=-3.232; p=0.001), anxiety severity (z=-3.004; p=0.003), hostility severity (z=-3.207; p=0.001), psychoticism severity (z=-1.973; p=0.049), and paranoid ideation severity (z=2.733; p=0.006) scores were statistically significant. The difference between the baseline and endpoint BSI Global Indices of distress scores were found to be statistically significant (The Global Severity Index: z=-2.987; p=0.003, the Positive Symptom Distress Index: z=-3.435; p=0.001, and the Positive Symptom Total: z=-3.023; p=0.003). Six cases (20.0%) discontinued the treatment. The most frequent adverse effects were asthenia (50.0%), somnolence (42.9%), and dizziness (39.30%). The most severe extrapyramidal symptoms were: impression of slowness or weakness, difficulty in carrying out routine tasks (11.5%), and tonic muscular contractions localized to one or several muscle groups, particularly in the throat, neck or back (11.5%). None of the cases had abnormal involuntary movements (dyskinesia) of the extremities or trunk. Conclusion: Aripiprazole was well tolerated and effective in our clinical practice and appears to be a safe and efficacious alternative in adolescents. However, a prospective clinical trial with a randomized controlled design is warranted.Öğe The efficacy of systemic fluconazole treatment in fungal keratitis(1993) Kose S.; Pamukcu K.; Akkin C.; Yagci A.; Tumbay E.Nine patients with fungal keratitis were treated with systemic fluconazole, which is a second generation triazole compound and has been proven to be an effective antifungal agent in experimental studies. The lesions healed with peroral 200 mg fluconazole per day, in a period of minimum 3, maximum 6 weeks. Neither a complication or any side-effect resulted from this therapy. One eye was eviscerated because of deteriorating infection and panophthalmitis. This is a pilot study investigating the efficacy of systemic fluconazole treatment in fungal keratitis, and we concluded that it is an effective alternative of antifungal treatment.Öğe The evaluation of binocular visual function in patients with congenital Brown's syndrome(2005) Afrashi F.; Uretmen O.; Kose S.; Pamukcu K.We evaluated the binocular visual function of 14 patients with Brown's syndrome and compared this data with that collected from 14 visually normal subjects of similar age and sex. Patients with Brown's syndrome underwent a full ophthalmologic examination including a detailed strabismological evaluation. Stereoacuity was measured with the Titmus and TNO stereotests. Visual evoked potentials (VEPs) were recorded. Patients with congenital Brown's syndrome had reduced stereoacuity levels compared to the control group. They also had longer binocular VEP latencies and smaller VEP amplitudes. Binocular enhancement of VEP amplitude was present in both groups but more evident in the control group. In conclusion, partial binocular visual functional abnormalities could be found in patients with congenital Brown's syndrome in addition to the characteristic ocular motility restrictions.Öğe Hypohidrotic ectodermal dysplasia: a multidisciplinary approach.(2012) Bildik T.; Ozbaran B.; Kose S.; Koturoglu G.; Gokce B.; Gunaydin A.; Altintas I.Hypohidrotic ectodermal dysplasia (HED; Christ-Siemens-Touraine syndrome) is a genetic disorder characterized by sparse hair, oligodontia with peg-shaped teeth, reduced sweating, and defects in a number of other ectodermal organs. A partial or complete absence of eccrine glands can lead to recurrent severe overheating that may cause seizures and neurological deficits. This clinical report presents a 14-year-old male patient with hypohidrotic ectodermal dysplasia, including the clinical and radiographic findings, and multidisciplinary treatment. The Schedule for Affective Disorders and Schizophrenia for School Aged Children-Present and Lifetime Version (K-SADS-PL) was administered to patient along with mother to assess for any psychiatric disorders. The screening and rating scales completed by mother and two teachers to evaluate the severity of attention deficit hyperactivity disorder (ADHD) symptoms, and other behavioral problems. Patient's academic performance, adaptive functioning, and problem behavior was evaluated using. The Teacher Report Form. Mental capacity was assessed with the Wechsler Intelligence Scale for Children (WISC-R). Illness Perception Questionnaire Revised was used to systematically assess illness representation attributes and emotional representations of illness. On the psychiatric diagnosis assessment using K-SADS-PL sub-threshold attention deficits and anxiety symptoms were determined. In this case we established a multidisciplinary approach in his treatment with pediatric, dermatological, and dental examinations, beside his psychiatric evaluation. The prosthetic rehabilitation included restoring upper teeth with copings and fabrication of upper and lower complete dentures. Metal framework was not incorporated in the partial denture design allowing modifications as the oral and maxillofacial development continued. Removable complete or partial dentures without metal framework is a treatment of choice until the completion of facial growth at which definitive treatment is considered.Öğe Mutation analysis of the NRXN1 gene in autism spectrum disorders(Walter de Gruyter GmbH, 2016) Onay H.; Kacamak D.; Kavasoglu A.N.; Akgun B.; Yalcinli M.; Kose S.; Ozbaran B.The aim of this study was to identify the sequence mutations in the Neurexin 1 (NRXN1) gene that has been considered as one of the strong candidate genes. A total of 30 children and adolescents (aged 3-18) with non syndromic autism were enrolled this study. Sequencing of the coding exons and the exon-intron boundaries of the NRXN1 gene was performed. Two known mutations were described in two different cases. Heterozygous S14L was determined in one patient and heterozygous L748I was determined in another patient. The S14L and L748I mutations have been described in the patients with autism before. Both of these mutations were inherited from their father. In this study, two of 30 (6.7%) autism spectrum disorder (ASD) patients carrying NRXN1 gene mutations were detected. It indicates that variants in the NRXN1 gene might confer a risk of developing nonsyndromic ASD. However, due to the reduced penetrance in the gene, the causal role of the NRXN1 gene mutations must be evaluated carefully in all cases. © 2016 Walter de Gruyter GmbH, Berlin/Boston 2016.Öğe Occupational health risks of barbers and coiffeurs in Izmir(2009) Mandiracioglu A.; Kose S.; Gozaydin A.; Turken M.; Kuzucu L.The objective of this study was to examine self-reported occupational health risks and health complaints of barbers and hairdressers. A total of 1284 individuals from 300 workplaces in Izmir participated in this study. The workers completed the questionnaires during their training in occupational health. Self-reported symptoms were allergy: 35% and musculoskeletal symptoms: 32%. The frequency of allergy complaints was found to be significantly higher in older individuals and in women. Allergic complaints were more frequent in i) those having history of allergy, ii) in the group where the use of protective clothing and gloves was lower, iii) in smokers and in those who found ventilation in the workplace to be inadequate. Only 41.2% reported that they used gloves and 15.2% reported the use of protective clothing within the last month. It appears that poor occupational factors in barbers' salons and exposure to hairdressing chemicals bring about health problems of the hairdressers.Öğe Psychiatric evaluation of children and adolescents with left ventricular assist devices(Lippincott Williams and Wilkins, 2012) Ozbaran B.; Kose S.; Yagdi T.; Engin C.; Erermis S.; Uysal T.; Ayik F.; Karakula S.; Ulger Z.; Atay Y.; Ozbaran M.Objectives: To evaluate the psychiatric symptoms of children equipped with a ventricular assist device (VAD) and follow them up for 6 months. With the shortage of donor hearts available for the treatment of end-stage heart failure, VADs have been used to provide temporary treatment until a heart becomes available. VADs provide external sources of power for mechanical circulatory support and are capable of sustaining life over weeks and months. This study provides preliminary details about the psychiatric symptoms and disorders of the first eight children equipped with a VAD in Turkey. Methods: Eight pediatric patients who recently underwent VAD implantation, aged 1 to 16 years, were evaluated using the Kiddie Schedule for Affective Disorders and Schizophrenia, Child Behavior Checklist, Children's Depression Inventory, Beck Depression Inventory, and State-Trait Anxiety Inventory for Children and followed up for 6 months. Results: In the first evaluation, five participants had a psychiatric disorder diagnosis. Two patients had adjustment disorder with depressive and anxiety symptoms; one had anxiety disorder, not otherwise specified; and two had major depressive disorder. The anxiety and depressive symptom levels in questionnaires were consistent with psychiatric diagnoses. Two patients had heart transplantation during the follow-up period. Conclusions: To determine and treat psychiatric symptoms and disorders at an earlier stage, it is important for children and adolescents with a VAD and those who have undergone heart transplantation to be evaluated by a multidisciplinary consultation liaison team including psychiatrists, psychologists, consultant nurses, and counselors. Abbreviations: VAD = ventricular assist deviceK-SADS = Kiddie Schedule for Affective Disorders and SchizophreniaCBCL = Child Behavior ChecklistBDI = Beck Depression InventoryCDI = Children's Depression InventorySTAI-C = State-Trait Anxiety Inventory for ChildrenMDD = major depressive disorderAD = adjustment disorderPE.I = initial psychiatric evaluationPE.II = second psychiatric evaluation © 2012 by the American Psychosomatic Society.Öğe The results of surgery in a series of partially accommodative esotropic patients(Informa Healthcare, 1996) Pamukcu K.; Kose S.; Cengiz H.; Akkin C.Three different surgical procedures were pet-formed in 32 partially accommodative esotropic patients with a high accommodative convergence/accommodation (AC/A) ratio. The patients were followed-up for an average period of 2.5 years (range: four months to seven years). Recession of the medial rectus and resection of the lateral rectus (group I), bimedial recession (group 2) or bimedial recession with bimedial Faden operation (group 3) were performed, guided by the preoperative AC/A ratio, the difference between the distance and near deviations, and the alternation pattern. At the end of the follow-up period, the average distance and near deviations were found to be less than 10 ? in all three groups. The AC/A ratio of all patients was normal or close to normal in the postoperative period.Öğe Seroprevalence of hepatitis b and c viruses:awareness and safe practices of hairdressers in izmir-a survey(Nofer Institute of Occupational Medicine, 2011) Kose S.; Mandiracioglu A.; Oral A.M.; Emek M.; Gozaydin A.; Kuzucu L.; Turken M.Objectives: The aim of the study is to determine the seroprevalence of hepatitis B (HBV) and hepatitis C virus (HCV) infection in barbers and to assess the awareness of these employees related to occupational risks of HBV and HCV. Materials and Methods: In this study, 2145 barbers in Izmir were given an occupational safety seminar. Blood samples were collected from 2066 voluntary participants and 1284 individuals completed the questionnaires. Sera were tested for the presence of HBV and HCV markers by ELISA. Results: Our results document low levels of knowledge about HBV and HCV infection, risk perception and adequate protection among participants before the seminar session. Of the participants, 63.5% reported that they had suffered from equipment-related injuries during the last month. The prevalence of HBsAg positive and anti-HCV individuals of the 2066 person was found to be 2.2% and 0.4%, respectively. Conclusions: Hairdressers' knowledge of HBV, HCV and health hazards associated with their profession was inadequate. The prevalence of HBsAg positive and anti-HCV was similar to that among the general population. © Nofer Institute of Occupational Medicine.Öğe Strabismus in infants following congenital cataract surgery(Springer Verlag, 2015) Demirkilinc Biler E.; Bozbiyik D.I.; Uretmen O.; Kose S.Purpose: This study aimed to determine the incidence and characteristics of strabismus following congenital cataract surgery in infants. Materials and methods: Patients aged <12 months who underwent surgery for congenital cataract and were followed-up for ?1 years were included. Patients that had strabismus prior to surgery were excluded. Data regarding gender, cataract laterality, morphology, and density, age at the time of cataract surgery, ocular motility post surgery, and the presence of nystagmus were retrospectively obtained from the patients’ records. Results: The study included 79 patients (48 male and 31 female). Unilateral surgery was performed in 14 of the patients, versus bilateral surgery in 65. Strabismus did not occur post surgery in 32 (40.5 %) of the patients (group 1), whereas 47 (59.5 %) (group 2) developed strabismus following surgery. The patients in group 1 were followed-up for a mean 50.7 ± 38.5 months, versus 50.3 ± 39 months in group 2. Mean age at the time of cataract surgery in groups 1 and 2 was 3.6 ± 1.9 years and 4.6 ± 3.2 months respectively. Mean duration of time between cataract surgery and the development of strabismus was 13.3 ± 13 months (range: 1–60 months). Unilateral cases were more prone to develop strabismus, which was statistically significant (p = 0.028). Age at the time of cataract surgery, gender, cataract density, the occurrence of aphakic glaucoma, the presence of nystagmus, and additional ocular surgery were not significantly associated with the development of strabismus. Conclusion: Strabismus develops more frequently in children undergoing cataract surgery. In the present study strabismus occurred in more of the patients that underwent unilateral surgery. Based on the present findings, we think that long-term careful follow-up to monitor the development of strabismus is required in all infants undergoing cataract surgery, especially unilateral cases. © 2015, Springer-Verlag Berlin Heidelberg.Öğe Therapeutic effect of intracameral streptokinase injection in eyes with pseudophakic fibrinoid reaction [INTRAKAMERAL STREPTOKINAZ ENJEKSIYONUNUN PSODAFAKIK FIBRINOID MEMBRANLI GOZDEKI TERAPOTIK ETKISI](1994) Akkin C.; Mentes J.; Kaskaloglu M.; Erbakan G.; Kose S.Intracameral 1000 IU purified streptokinase was injected into the eyes with pseudophakic fibrinoid pupillary membrane, occurred in 8 eyes of 8 patients after cataract operation. Three of them had been operated for traumatic cataract, one for congenital cataract, one for complicated cataract, and the others for senile cataract with concurrent pathologic conditions like diabetes mellitus and glaucoma. In 7 eyes (%87.5), pupillary fibrinoid membrane disappeared in a period ranging from one hour to 5 days. The visual acuity improved in all patients, and increased from mean 0.06 to mean 0.3 after the injection. None of the eyes developed hyphema or corneal edema during follow-up time of mean 4.3 months. We concluded that intracameral streptokinase injection is an effective treatment modality of pseudophakic fibrinoid pupillary membrane.Öğe Treatment duration is associated with functioning and prognosis in children with attention deficit hyperactivity disorder [Dikkat eksikligi ve hiperaktivite bozuklugu olan cocuklari{dotless}n tedavi süresi işlevsellik ve prognoz ile ilişkilidir](2012) Ercan E.S.; Kose S.; Kutlu A.; Akyol O.; Durak S.; Aydin C.Objective: Attention Deficit Hyperactivity Disorder (ADHD) persists through adolescence and adulthood, and 15-80% of the children diagnosed with ADHD continue to have the disorder into adulthood, depending on the diagnostic criteria used; however, these findings have mostly been derived from follow-up studies in North America. The longitudinal outcomes of ADHD children from non-Western countries, such as Turkey, and the prognostic differences between ADHD+Oppositional Defiant Disorder (ODD) and ADHD+Conduct Disorder (CD) cases require further exploration. Six years after an initial study of 18 months conducted between 2000 and 2002, we sought to evaluate 120 cases of ADHD with comorbid ODD or CD. Methods: The original sample included 120 ADHD + ODD/CD children, followed for 18 months during 2000-2002. We evaluated the last-known psychiatric status, academic achievement, substance use, and social functionality of 60 children who were interviewed six years earlier. The treatment duration was divided into three groups: less than 15 months, 15-45 months, and greater than 45 months. Results: In the initial study, we found that both combined treatment (parent training and stimulant treatment) and only stimulant treatment were effective in reducing ADHD, ODD, and CD symptoms. Six years after the initial study, the ADHD treatment was found to be effective in many areas, including academic success (p<0.001), grade retention (p=0.026), expulsion or suspension from school (p=0.009), rate of accidents and broken bones requiring reduction (p=0.001), and cigarette smoking (p=0.018). Conclusions: ADHD symptoms are associated with impairments in multiple functional domains, and ADHD treatment is effective for Turkish children in many of these domains. There is a statistically significant difference in treatment success between groups created according to the treatment duration.
