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    Effects of acetate or bicarbonate dialysis solutions on serum HDL and HDL subfractions of patients undergoing haemodialysis
    (Librapharm, 1999) Yalçin A.; Kocaoglu S.; Akçiçek F.; Özyer A.
    The aim of this study was to compare the effect of acetate- and bicarbonate-containing dialysis solutions (buffers) on serum lipid (triglyceride and total cholesterol) and lipoprotein (LDH, HDL and its subfractions as HDL2 and HDL3. Apolipoprotein A1 and Apolipoprotein B) values in patients undergoing haemodialysis. Lipid concentrations in 16 patients on bicarbonate and in 18 patients on acetate haemodialysis were investigated initially and after four weeks of dialysis treatments had no negative effects on either HDL or HDL subfractions, and these buffering systems were indistinguishable from each other. We confirm that HDL is the major factor that is changed in the lipid profile in haemodialysis patients undergoing acetate or bicarbonate dialysis and suggest that the relation between LDL and HDL subfractions may be useful for monitoring the lipid changes in haemodialysis patients at risk of atherogenesis.
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    Study on the role of urine gamma-glutamyl transpeptidase activity during investigation of nephrotoxicity
    (1994) Kocaoglu S.; Berkan T.; Karan A.; Basdemir G.
    In this study, gamma-glutamyl transpeptidase activities of the 24 h urine samples taken at the end of the fourth day from the rats to which 160 mg/kg/day gentamicin was applied i.p. for 4 days, were measured. Glucose determination in urine by the use of the glucose hexokinase method was also applied in order to control the reabsorption potentials of the tubules. The formation of necrosis in the kidneys was investigated by histological examinations of the damage occurred by the nephrotic effect. All the results were compared with the values obtained from the control group. The average gamma-glutamyl transpeptidase activity for the control group (n = 22) was determined as 5.68 ± 0.26 IU/24 h whereas this level was detected as 15.6 ± 1.0 IU/24 h in the drug applied group (n = 15). The measurement of gamma-glutamyl transpeptidase activity in urine can be applied as a useful parameter on determination of nephrotoxicity, especially for indicating the dimensions of this toxic effect.