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Öğe Association of decreased C1q/tumor necrosis factor- related protein-5 levels with metabolic and hormonal disturbance in polycystic ovary syndrome(Galenos Yayincilik, 2019) Calan, Mehmet; Alan, Murat; Alarslan, Pinar; Kocabas, Gokcen Unal; Bozkaya, Giray; Acara, Ahmet Cagdas; Aslanipour, Behnaz; Fenercioglu, Ozge; Isil, Ahmet Murat; Guler, AsliObjective: C1q/tumor necrosis factor-related protein-5 (CTRP5) is a novel peptide hormone involved in the metabolism of energy regulation. Polycystic ovary syndrome (PCOS), which is a reproductive and metabolic disorder, is associated with insulin resistance. The aim of the current study was to compare circulating levels of CTRP5 in women with and without PCOS and to investigate possible associations between CTRP5 and metabolic-hormonal parameters. Material and Methods: The present cross-sectional study contained 80 women with PCOS and 80 age and body mass index-matched women without PCOS. Circulating levels of CTRP5 were calculated using an enzyme-linked immunosorbent assay. We also measured hormonal and metabolic parameters. Results: Patients with PCOS had lower levels of circulating CTRP5 compared with women without PCOS (6.90 +/- 2.64 vs 11.73 +/- 3.66 ng/mL, p<0.001). CTRP5 was negatively correlated with insulin resistance, free-androgen index, and body mass index in both the PCOS and control groups. Moreover, patients with PCOS who had insulin resistance showed lower circulating CTRP5 levels compared with those without insulin resistance. In both the control and PCOS groups, overweight subjects had lower circulating levels of CTRP5 compared with participants of normal weight. Logistic regression analyses indicated that subjects in the lowest tertile for CTRP5 level had higher risk for PCOS compared with those in the highest tertile of CTRP5. Conclusion: Decreased circulating levels of CTRP5 were associated with higher risk of PCOS, as well as having metabolic disturbance among women with PCOS.Öğe A case of an ectopic prolactinoma(Informa Healthcare, 2012) Simsir, Ilgin Yildirim; Kocabas, Gokcen Unal; Sahin, Serap Baydur; Erdogan, Mehmet; Cetinkalp, Sevki; Saygili, Fusun; Yilmaz, Candeger; Ozgen, Ahmet GokhanA 34-year-old female presented to our clinic with a 1.5 year history of secondary amenorrhea and galactorrhea. Prolactin (PRL) level was found to be 151.89 ng/ml. Pituitary imaging was reported to be normal. An examination of the patient revealed that PRL level was still high so the dose of cabergoline was further increased and subsequently, bromocriptine was added to the treatment. There was no reduction in PRL levels in controls. A scanning was performed to look for an ectopic focus. Abdominal computerized tomography revealed a heterogenous mass lesion originating from the uterus. Octreotide scintigraphy was performed and we observed an involvement consistent with the mass in the uterus. The patient underwent abdominal total hysterectomy. PRL dropped to 0.4 ng/ml the next day after the operation. The pathology result was a low-grade malignant mesenchymal tumor. Prolactin was found to be immunohistochemically negative. However, galactorrhea disappeared postoperative and PRL levels are still low. Elevated levels of PRL, resistant to bromocriptine and cabergoline, rapidly returned to normal after hysterectomy, which obviously indicates that hyperprolactinemia was associated with the myoma of the uterus.Öğe Elevated circulating levels of betatrophin are associated with polycystic ovary syndrome(Springer, 2016) Calan, Mehmet; Yilmaz, Ozgur; Kume, Tuncay; Kocabas, Gokcen Unal; Senses, Pinar Yesil; Senses, Yasar Mehmet; Temur, Muzaffer; Calan, Ozlem GursoyBetatrophin is a newly identified hormone determined to be a potent inducer of pancreatic beta cell proliferation in response to insulin resistance in mice. Polycystic ovary syndrome (PCOS) is an inflammatory-based metabolic disease associated with insulin resistance. However, no evidence is available indicating whether betatrophin is involved in women with PCOS. The objective of this study was to ascertain whether betatrophin levels are altered in women with PCOS. This study was conducted in secondary referral center. This cross-sectional study included 164 women with PCOS and 164 age- and BMI-matched female controls. Circulating betatrophin levels were measured using ELISA. Metabolic and hormonal parameters were also determined. Circulating betatrophin levels were significantly elevated in women with PCOS compared with controls (367.09 +/- 55.78 vs. 295.65 +/- 48.97 pg/ml, P < 0.001). Betatrophin levels were positively correlated with insulin resistance marker homeostasis model assessment of insulin resistance (HOMA-IR), free-testosterone, high-sensitivity C-reactive protein (hs-CRP), atherogenic lipid profiles, and BMI in PCOS. Multivariate logistic regression analyses revealed that the odds ratio for PCOS was 2.51 for patients in the highest quartile of betatrophin compared with those in the lowest quartile (95 % CI 1.31-4.81, P = 0.006). Multivariate regression analyses showed that HOMA-IR, hs-CRP, and free-testosterone were independent factors influencing serum betatrophin levels. Betatrophin levels were increased in women with PCOS and were associated with insulin resistance, hs-CRP, and free-testosterone in these patients. Elevated betatrophin levels were found to increase the odds of having PCOS. Further research is needed to elucidate the physiologic and pathologic significance of our findings.Öğe Evaluation of youtube videos about hashimoto’s thyroiditis in terms of quality and reliability(2022) Alarslan, Pınar; Kocabas, Gokcen UnalThis study aimed to evaluate the quality and reliability of Turkish YouTube videos about Hashimoto’s thyroiditis. This cross-sectional study was carried out using the first 66 videos, sorted according to the relevance, obtained following a video search performed on June 18, 2020, by typing ‘Hashimoto thyroiditis’ on YouTube. The quality and reliability of included YouTube videos were evaluated by two independent researchers using DISCERN, Global Quality Score [GQS] and JAMA criteria. The GQS2 scores of the patient (p=0.035), other healthcare personnel (p=0.019) and non-endocrinologist videos (p=0.028) were lower than those of endocrinologist videos (p=0.03). DISCERN2 scores of non-endocrinologist doctor (p=0.014), other healthcare personnel (p=0.022) and patient (p=0.008) videos were lower than those of endocrinologist videos (p<0.05). The number of views (p=0.002) and subscribers (p=0.007) of channels belonging to the institution or doctors were less than those of other groups. A positive correlation was found between video duration and number of likes (r=0.47), number of dislikes (r=0.28), JAMA1 (r=0.28), JAMA2 (r=0.29), DISCERN1 (r=0.27) and DISCERN2 (r=0.26). A positive correlation was found between the number of views and number of likes (r=0.82), dislikes (r=0.90) and subscribers (r=0.49). A positive correlation was found between JAMA1, JAMA2, GQS1, GQS2, DISCERN1 and DISCERN2 scores. The quality and reliability of endocrinologist videos for Hashimoto’s thyroiditis were greater. The quality and reliability of Hashimoto’s thyroiditis videos were not related to their popularity. YouTube videos published by doctors can serve as a quality and reliable learning interface about Hashimoto’s thyroiditis.Öğe Increased adipsin is associated with carotid intima media thickness and metabolic disturbances in polycystic ovary syndrome(Wiley, 2016) Calan, Ozlem Gursoy; Calan, Mehmet; Senses, Pinar Yesil; Kocabas, Gokcen Unal; Ozden, Ebru; Sari, Kerime R.; Kocar, Merve; Imamoglu, Cetin; Senses, Yasar M.; Bozkaya, Giray; Bilgir, OktayContextAdipsin, a protein secreted mainly from the adipose tissue, is a structural homologous of complement factor D, a rate-limiting enzyme of the alternative complement system. Growing evidence suggests that the alternative complement system plays a role both in the regulation of energy homoeostasis and in the atherosclerosis. Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disease. ObjectiveTo ascertain whether circulating adipsin levels are altered in women with PCOS, and whether there is an association between adipsin and metabolic parameters or carotid intima media thickness (CIMT). ParticipantsA total of 144 women with PCOS and 144 age- and BMI-matched controls without PCOS were recruited for this cross-sectional study. Main Outcome MeasuresCirculating adipsin levels were measured using ELISA. Metabolic, hormonal parameters and CIMT were also determined. ResultsAdipsin levels were significantly elevated in women with PCOS compared with controls (9152 1411 vs 6031 +/- 971 ng/ml, P < 0001). Adipsin positively correlated with BMI, homoeostasis model assessment of insulin resistance (HOMA-IR), free testosterone, high-sensitivity C-reactive protein (hs-CRP) and CIMT in both groups. Multivariate logistic regression analyses revealed that the odds ratio for PCOS was 325 for patients in the highest quartile of adipsin compared with those in the lowest quartile (OR=325, 95% CI=264-400, P = 0016). Our findings further indicate that BMI, HOMA-IR, hs-CRP and free testosterone are independent factors influencing serum adipsin levels and that adipsin is an independent predictor for CIMT. ConclusionCirculating adipsin levels are significantly higher in women with PCOS, and the peptide is closely related to increased cardiovascular risk and metabolic disturbances.Öğe Increased urocortin 3 levels are associated with the risk of having type 2 diabetes mellitus(Wiley, 2020) Alarslan, Pinar; Kocabas, Gokcen Unal; Demir, Ismail; Guler, Asli; Bozkaya, Giray; Aslanipour, Behnaz; Calan, MehmetBackground Urocortin 3 (UCN3) is a peptide hormone playing a pivotal role in glucose and lipid metabolisms. However, its clinical implications remain unclear. Our aims were to investigate the altered levels of UCN3 in newly diagnosed type 2 diabetes mellitus (nT2DM) patients in comparison to subjects with normal glucose tolerance (NGT) and to determine the presence of any possible link between UCN3 levels and metabolic parameters. Methods Eighty nT2DM and 80 age-, body mass index (BMI)-, and gender-matched NGT subjects were enrolled into this case-control study. the circulating UCN3 levels were measured using the enzyme-linked immunoabsorbent assay (ELISA). Metabolic parameters of enrolled subjects were also determined. A standard 75-g 2-hour oral glucose tolerance test was used for diagnosis of type 2 diabetes mellitus (T2DM). Results UCN3 levels were higher in subjects with nT2DM than in controls (115.64 +/- 39.26 vs 86.16 +/- 22.81 pg/mL, P < .001). UCN3 levels were increased in subjects with metabolic syndrome compared to subjects without metabolic syndrome in both nT2DM and NGT groups. UCN3 levels showed a positive correlation with BMI in both groups. Moreover, UCN3 levels were positively and independently associated with insulin, fasting blood glucose, insulin resistance, 2-hour plasma glucose, glycosylated hemoglobin, and triglycerides, whereas UCN3 levels were negatively and independently associated with high-density lipoprotein cholesterol. According to logistic regression analysis, increased risk of T2DM and metabolic syndrome were parallel with the highest elevated levels of UCN3. Conclusions Increased levels of UCN3 are associated with unfavorable metabolic profiles in T2DM, indicating a potential role of UCN3 in glucose and lipid metabolisms in T2DM. Highlights Urocortin 3 (UCN3) may play a crucial role in glucose and lipid metabolisms. Circulating levels of UCN3 were investigated in subjects with newly diagnosed type 2 diabetes mellitus (nT2DM). Circulating UCN3 levels were significantly elevated in nT2DM subjects. Increased UCN3 levels are associated with having the risk of type 2 diabetes mellitus and metabolic syndrome.Öğe The low levels of bone morphogenic protein-4 and its antagonist noggin in type 2 diabetes(Springer International Publishing Ag, 2018) Yurekli, Banu Sarer; Kocabas, Gokcen Unal; Aksit, Murat; Kutbay, Nilufer Ozdemir; Suner, Asli; Yurekli, Ismail; Cakir, Habib; Bozkaya, Giray; Cetinkalp, SevkiObjective Bone morphogenic protein-4 (BMP-4) is a proinflammatory cytokine which is controlled by BMP-4 antagonists. Our aim was to investigate the levels of BMP-4 and its antagonists, noggin and matrix Gla protein (MGP), in prediabetes and diabetes. Design One hundred and forty-two type 2 diabetic, 32 prediabetic, and 58 control subjects participated in this cross-sectional study. BMP-4, noggin, and MGP were measured with the ELISA method. Results There was a significant difference between the three groups in relation to sex, hypertension, fasting plasma glucose, HbA1c, lipid profiles, and diastolic blood pressure (p < 0.05). BMP-4 levels were significantly lower in the diabetic group compared to the control group (108.5 and 127.5 ng/mL, respectively, p < 0.001 diabetes vs. control). Noggin levels were significantly lower in the diabetic group compared to the prediabetic and control groups (10.5, 11.5, and 12.0 ng/mL, as median, respectively, p < 0.001; diabetes vs. control, p = 0.002; diabetes vs. prediabetes). BMP-4 was associated significantly with noggin in the entire study population (beta coefficient = 0.796, p < 0.001). Receiver operating characteristic (ROC) curve analysis showed that the area under the ROC curve was 0.708 (95% CI 0.551-0.864, p = 0.011) for BMP-4 levels. The optimal cutoff value of BMP-4 for detecting albuminuria was 118.5 ng/mL for which sensitivity was 71.4% and specificity was 66.4%. Conclusions BMP-4 and noggin levels were lower in the diabetic group. High BMP-4 levels were significantly associated with albuminuria. Further studies are warranted to determine the role of BMP-4 in the pathogenic processes underlying albuminuria and hyperglycemia in patients with type 2 diabetes.Öğe A novel CYP11B1 mutation in a Turkish patient with 11 beta-hydroxylase deficiency: An association with the severe hypokalemia leading to rhabdomyolysis(Hellenic Endocrine Soc, 2016) Yurekli, Banu Sarer; Kutbay, Nilufer Ozdemir; Onay, Huseyin; Simsir, Ilgin Yildirim; Kocabas, Gokcen Unal; Erdogan, Mehmet; Cetinkalp, Sevki; Ozgen, Gokhan; Saygili, FusunÖğe Polycystic ovary syndrome is associated with increased osteopontin levels(Bioscientifica Ltd, 2016) Saklamaz, Ali; Calan, Mehmet; Yilmaz, Ozgur; Kume, Tuncay; Temur, Muzaffer; Yildiz, Nurdan; Kasap, Esin; Genc, Mine; Yurekli, Banu Sarer; Kocabas, Gokcen UnalObjective: Osteopontin (OPN) is a multi-functional secreted glycoprotein that plays a crucial role in glucose metabolism and inflammatory process. Growing evidence suggests that there is a link between OPN and ovarian function. However, no such link has yet been found for OPN in polycystic ovary syndrome (PCOS). Our aim was to ascertain whether circulating OPN levels are altered in women with PCOS and to determine whether OPN levels differ between the follicular phase and mid-cycle of the menstrual cycle in eumenorrheic women. Design and methods: In total, 150 women with PCOS and 150 age-and BMI-matched controls without PCOS were recruited for this prospective observational study. OPN levels were measured using ELISA. Metabolic parameters were also determined. Results: Circulating OPN levels were significantly elevated in PCOS women compared with controls (69.12 +/- 31.59 ng/ml vs 42.66 +/- 21.28 ng/ml; P<0.001). OPN levels were significantly higher at mid-cycle than in the follicular phase in eumenorrheic women. OPN was positively correlated with BMI, homeostasis model assessment of insulin resistance (HOMA-IR), free testosterone, and high sensitivity C-reactive protein (hs-CRP). Multivariate logistic regression analyses revealed that the odds ratio (OR) for PCOS was 3.64 for patients in the highest quartile of OPN compared with those in the lowest quartile (OR=3.64; 95% CI=2.42-5.57; P=0.011). Our findings indicate that BMI, HOMA-IR, hs-CRP, and free testosterone are independent factors influencing serum OPN levels and that OPN is an independent predictor for HOMA-IR. Conclusion: PCOS is associated with increased OPN levels.Öğe Serum Dehydroepiandrosterone Sulfate Levels in Premenopausal Women with Chronic Lymphocytic Thyroidtis(Endocrine Soc, 2014) Yurekli, Banu Pinar Sarer; Kocabas, Gokcen Unal; Akkaya, Aysegul; Mirili, Cern; Unal, Serkan; Guvercin, Guray; Erdogan, MehmetÖğe Thyrotoxic hypokalemic periodic paralysis in a Turkish patient presenting with a U wave on ECG(Springer International Publishing Ag, 2016) Gezer, Emre; Yurekli, Banu Sarer; Kocabas, Gokcen Unal
