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Öğe BUDD-CHIARI SYNDROME IN BEHCET'S DISEASE: A RETROSPECTIVE MULTICENTER STUDY(Bmj Publishing Group, 2017) Akyol, L.; Toz, B.; Bayindir, O.; Zengin, O.; Cansu, D. Uskudar; Yigit, M.; Cetin, G. Yildirim; Omma, A.; Erden, A.; Kucuksahin, O.; Altuner, M. S.; Corba, B. S.; Unal, A. U.; Kucuk, H.; Kucuk, A.; Balkarli, A.; Gonullu, E.; Tufan, A. N.; Ureyen, S. Bakirci; Oner, S. Yilmaz; Kobak, S.; Yazici, A.; Ozgen, M.; Sahin, A.; Koca, S. S.; Erer, B.; Gul, A.; Aksu, K.; Keser, G.; Onat, A. M.; Kisacik, B.; Kasifoglu, T.; Cefle, A.; Kalyoncu, U.; Sayarlioglu, M.Öğe CARD15/NOD2 MUTATIONS IN TURKISH PATIENTS WITH ANKYLOSING SPONDYLITIS(Bmj Publishing Group, 2013) Kobak, S.; Orman, M.; Berdeli, A.Öğe CLINICAL CHARACTERISTICS OF SARCOID ARTHROPATHY(Bmj Publishing Group, 2016) Kobak, S.; Sever, F.; Usluer, O.; Goksel, T.; Orman, M.Öğe Coexistence of sarcoidosis and Hashimoto thyroiditis(Pagepress Publ, 2018) Semiz, H.; Yalcin, M.; Kobak, S.Sarcoidosis is a chronic, inflammatory disease with unknown cause characterized by non-caseating granuloma formations. It can present with bilateral hilar lymphadenopathy, skin lesions, eye involvement and locomotor system findings. Hashimoto thyroiditis is an organ-specific autoimmune disease characterized by increased autoantibody synthesis. Sarcoidosis can involve different endocrine glands. Thyroid gland involvement may lead to increased thyroid function disorders and autoantibodies. Herein, we report an 80-year-old female patient with sarcoidosis and Hashimoto coexistence.Öğe CONCOMITANT AUTOIMMUNE DISEASES IN PATIENTS WITH SARCOIDOSIS(Bmj Publishing Group, 2017) Kobak, S.; Sever, F.; Semiz, H.; Orman, M.Öğe DEMOGRAPHIC, CLINICAL, AND LABORATORY CHARACTERISTICS OF ELDERLY ONSET PSORIATIC ARTHRITIS(Bmj Publishing Group, 2017) Kobak, S.; Orman, M.Öğe Demonstrating disease activity in patients with rheumatoid arthritis(Georg Thieme Verlag Kg, 2013) Karapolat, I.; Sertpoyraz, F.; Oncel, G.; Kobak, S.; Yalcin, M.; Kumanlioglu, K.Aim: We aimed to investigate the relationship of fluor-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT) with clinical, laboratory pa rameters and conventional radiographs in patients with rheumatoid arthritis (RA). Patients, material, methods: 25 patients with RA diagnosis were evaluated by sociodemo, graphic, clinical [duration of disease (year), the joints in which the complaints started, most recent joint involvement]; other parameters used in RA-specific clinical assessment [Steinbocker functional staging, disease activity score 28 (DAS 28 score), health assess, ment questionnaire score (HAQ score), general RA assessment (patients' and physicians' global assessment), patients' assessments of "pain and general health condition (visual analog scale)], laboratory, radiological [conventional radiology of hand and foot joints], positron emission tomography [F-18 FDG PET visual total score and maximum standardized uptake value (SUVmax) total score] parameters. Results: No significant correlation was detected between the F-18 FDG PET total score and SUVmax total score of the patients and clinical, laboratory, and radiological parameters (p > 0.05). There was no relationship between the cut-off values determined according to the disease activity and F-18 FDG PET/SUVmax total values (p > 0.05). Conclusions: In our study, no relationship was found between disease activity demonstrated by F-18 FDG PET/CT in RA patients and clinical, laboratory, and radiological parameters. F-18 FDG PET/CT appears to be a more sensitive method in demonstrating disease activity compared to other evaluated methods.Öğe Demonstrating disease activity in patients with rheumatoid arthritis(Georg Thieme Verlag Kg, 2013) Karapolat, I.; Sertpoyraz, F.; Oncel, G.; Kobak, S.; Yalcin, M.; Kumanlioglu, K.Aim: We aimed to investigate the relationship of fluor-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT) with clinical, laboratory pa rameters and conventional radiographs in patients with rheumatoid arthritis (RA). Patients, material, methods: 25 patients with RA diagnosis were evaluated by sociodemo, graphic, clinical [duration of disease (year), the joints in which the complaints started, most recent joint involvement]; other parameters used in RA-specific clinical assessment [Steinbocker functional staging, disease activity score 28 (DAS 28 score), health assess, ment questionnaire score (HAQ score), general RA assessment (patients' and physicians' global assessment), patients' assessments of "pain and general health condition (visual analog scale)], laboratory, radiological [conventional radiology of hand and foot joints], positron emission tomography [F-18 FDG PET visual total score and maximum standardized uptake value (SUVmax) total score] parameters. Results: No significant correlation was detected between the F-18 FDG PET total score and SUVmax total score of the patients and clinical, laboratory, and radiological parameters (p > 0.05). There was no relationship between the cut-off values determined according to the disease activity and F-18 FDG PET/SUVmax total values (p > 0.05). Conclusions: In our study, no relationship was found between disease activity demonstrated by F-18 FDG PET/CT in RA patients and clinical, laboratory, and radiological parameters. F-18 FDG PET/CT appears to be a more sensitive method in demonstrating disease activity compared to other evaluated methods.Öğe ELDERLY - ONSET SARCOIDOSIS: A SINGLE CENTER COMPARATIVE STUDY(Bmj Publishing Group, 2017) Kobak, S.; Sever, F.; Semiz, H.; Orman, M.Öğe THE FREQUENCY OF SACROILIITIS AND SPONDYLARTHRITIS IN PATIENTS WITH SARCOIDOSIS(Bmj Publishing Group, 2014) Kobak, S.; Sever, F.; Ince, O.; Orman, M.Öğe Increased circulating interleukin-23 level in patients with sarcoidosis(Ediciones Doyma, S.L., 2023) Kobak, S.; Semiz, H.; Akyildiz, M.; Gokduman, A.; Atabay, T.; Vural, H.Background: Sarcoidosis is a Th1-mediated chronic inflammatory disease characterized by non-caseating granulomas. Its pathogenesis is not yet clear, but the possible role of various proinflammatory cytokines is being discussed. Aim: This study aims to determine serum cytokine (IL-6, IL-12, IL-17, and IL-23) levels in patients with sarcoidosis, and to determine a possible correlation with clinical and laboratory findings of the disease. Material and method: Forty-four biopsy-proven sarcoidosis patients followed up at a single centre and 41 healthy volunteers were included in the study. Demographic, clinical, laboratory, and radiological data of all patients were recorded. Serum samples from the patients and the control group were taken and IL-6, IL-12, IL-17, IL-23 were measured by ELISA method. Results: Of the 44 sarcoidosis patients, 13(29.5%) were male and 31(70.5%) were female. Average patient age was 47.4 years, mean disease duration was 3.2 years. Twenty-one (47.7%) patients had erythema nodosum, three (6.8%) had uveitis, 40(90.9%) had arthralgia, 23(52.3%) had ankle arthritis, 15(34.1%) had enthesitis. Laboratory evaluation showed increased serum ACE levels in 24(54.5%) patients, increased serum calcium levels in 11 (25%) patients, increased serum D3 levels in 5(11.4%) patients, increased ESR and CRP levels in 22(50%) and 23(52.3%) patients, respectively. Compared with the control group higher serum IL-23 levels were found in the patients with sarcoidosis (p = .01). Serum IL-23 was associated with ankle arthritis (p = .02). Serum IL-6, IL-12, and IL-17 levels were similar in the sarcoidosis patients and the control group (p = .128, p = .212, p = .521 respectively). Conclusion: In our study, we found increased serum IL-23 in patients with sarcoidosis, while serum IL-6, IL-12, and IL-17 were detected as normal. Although our results are somewhat contradictory to other studies in the literature, the question should still be whether sarcoidosis is a Th1/Th17 disease. Multicentre studies are needed in this regard. © 2022 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de ReumatologíaÖğe Magnetic resonance imaging of the sacroiliac joints in ankylosing spondylitis before and after therapy with anti-tumor necrosis factor alpha(B M J Publishing Group, 2007) Kobak, S.; Oksel, F.; Kabasakal, Y.; Doganavsargil, E.Öğe MALIGNANCY IN PATIENTS WITH SARCOIDOSIS: A RETROSPECTIVE COHORT STUDY FROM TURKEY(Bmj Publishing Group, 2018) Kobak, S.; Yildiz, F.; Semiz, H.; Orman, M.Öğe NOD2/CARD15 GENE MUTATIONS IN PATIENTS WITH GOUTY ARTHRITIS(Bmj Publishing Group, 2016) Karaarslan, A.; Kobak, S.; Berdeli, A.Öğe NOD2/CARD15 mutations in Turkish patients with ankylosing spondylitis(Informa Healthcare, 2013) Kobak, S.; Orman, M.; Berdeli, A.Öğe NOD2/CARD15 mutations in Turkish patients with ankylosing spondylitis(Informa Healthcare, 2013) Kobak, S.; Orman, M.; Berdeli, A.Öğe PREVALENCE AND SIGNIFICANCE OF MEFV GENE MUTATIONS IN PATIENTS WITH GOUTY ARTHRITIS(Bmj Publishing Group, 2016) Kobak, S.; Karaarslan, A.; Kaya, I.; Intepe, N.; Orman, M.; Berdeli, A.Öğe Prevalence and significance of MEFV gene mutations in patients with sarcoidosis(Taylor & Francis Ltd, 2016) Sever, F.; Kobak, S.; Goksel, O.; Goksel, T.; Orman, M.; Berdeli, A.Objectives: Sarcoidosis is a chronic granulomatous disease. Pyrin has anti-inflammatory activity in the regulation of inflammasomes and is encoded by the Mediterranean fever (MEFV) gene. MEFV gene mutations trigger the inflammatory cascade and cause familial Mediterranean fever (FMF). A relationship between various rheumatic diseases and MEFV gene mutations has been demonstrated. The aim of this study was to determine the prevalence of the MEFV gene mutation in Turkish patients with sarcoidosis and to detect any possible correlation with disease phenotype.Method: The study included 78 sarcoidosis patients and 85 healthy subjects matched for age, gender, and ethnicity. MEFV gene mutations were investigated with the FMF strip assay, which is based on reverse hybridization of biotinylated polymerase chain reaction (PCR) products.Results: Of the 78 patients with sarcoidosis, nine (11.5%) were found to be carriers of MEFV gene mutations. The distribution of these nine mutations were: three (3.8%) V726A, two (2.5%) E148Q, two (2.5%) M680I, one (1.3%) A744S, and one (1.3%) K695R. Carriers of M694V, M694I, R761H, and P369S were not detected in any of the sarcoidosis patients. None of the sarcoidosis patients were found to be compound heterozygous carriers. The prevalence of the MEFV gene mutation carrier detected in the healthy control group was 22.4%. The distribution of the 19 MEFV gene mutations found in the healthy controls was: nine (10.6%) E148Q, two (2.3%) M694V, one (1.2%) M694I, one (1.2%) M680I, two (2.3%) V726A, one (1.2%) A744S, two (2.3%) K695R, and one (1.2%) P369S. When compared with the control group, a lower prevalence of the MEFV gene mutation carrier was found in sarcoidosis patients but this was not statistically significant (p=0.067). In nine patients found to be MEFV gene mutation carriers, higher serum erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels and higher numbers patients with arthritis, enthesitis, and ankle arthritis were found (p=0.01, p=0.04, p=0.028, p=0.05, p=0.05, respectively).Conclusions: When we compared Turkish sarcoidosis patients with the healthy control group, we found a lower prevalence of MEFV gene mutations. In sarcoidosis patients, the MEFV gene mutation carrier was found to be related to high acute-phase responses, arthritis, and enthesitis. The existence of MEFV gene mutations may have a preventive role with regard to the development of sarcoidosis. Prospective studies that include larger patient populations are needed.Öğe PREVALENCE AND SIGNIFICANCE OF MEFV GENE MUTATIONS IN PATIENTS WITH SARCOIDOSIS(Bmj Publishing Group, 2015) Kobak, S.; Sever, F.; Goksel, O.; Goksel, T.; Orman, M.; Berdeli, A.Öğe PREVALENCE AND SIGNIFICANCE OF MEFV GENE MUTATIONS IN PATIENTS WITH SARCOIDOSIS(Bmj Publishing Group, 2015) Kobak, S.; Sever, F.; Goksel, O.; Goksel, T.; Orman, M.; Berdeli, A.
