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Öğe Amicrobial pustulosis of the folds associated with autoimmune disorders: report a new case of Sjogren's syndrome(Medcom Ltd, 2020) Dirican, F.; Acar, A.; Yaman, B.; Keser, G.; Karaarslan, IAmicrobial pustulosis of the folds is a relatively new entity, characterised by recurring aseptic pustular lesions, predominantly involving the cutaneous folds and occurring in patients with autoimmune disorders. Few cases have been reported in the literature. We present a case of amicrobial pustulosis of the folds in a woman with Sjogren's syndrome.Öğe ANTI-TUMOR NECROSIS FACTOR-ALPHA THERAPY IN REFRACTORY BEHCET UVEITIS: A SINGLE CENTER EXPERIENCE(Bmj Publishing Group, 2013) Yilmaz, S. G.; Aksu, K.; Keser, G.; Yilmaz, Z.; Sozeri, B.; Ates, H.Öğe Are swimming or aerobic exercise better than conventional exercise in ankylosing spondylitis patients? A randomized controlled study(Edizioni Minerva Medica, 2009) Karapolat, H.; Eyigor, S.; Zoghi, N.; Akkoc, Y.; Kirazli, Y.; Keser, G.Aim. The aim of the study was to compare the effects of conventional exercise (CE), swimming and walking on the pulmonary functions, aerobic capacity, quality of life, Bath indexes and psychological symptoms in patients with ankylosing spondylitis (AS). Methods. Forty-five patients were randomised into either swimming (group 1), walking (group 2), CE group (group 3). Patients in Group I performed CE and swimming, patients in Group 2 performed CE and walking and patients in Group 3 performed CE only. Exercise sessions were performed three times a week for a period of six weeks. Patients were assessed before and after the rehabilitation program, with respect to, pulmonary function test (forced vital capacity [FVC, mL], forced expiration volume in one second [FEV1, mL], FEV1/FVC (%) and vital capacity [VC, mL]), maximal oxygen uptake (p(V) over dotO(2)), 6-minute walking test (6MWT), Bath Ankylosing Spondylitis Functional index, Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Metrology Index, Nottingham Health Profile and Beck Depression Inventory. Results. There were significant increases in p(V) over dotO(2) and 6MWT after treatment in Groups 1 and 2 (P<0.05). FeV1, FVC and VC improved significantly with treatment in all three groups (P<0.05). A statistically significant improvement was observed in energy, emotional reaction and physical mobility sub-scores of NHP in three exercise groups after completion of the exercise program (P<0.05). Conclusion. Swimming, walking and CE had beneficial effects on the quality of life and pulmonary functions. Aerobic exercises such as swimming and walking in addition to CE increased functional capacities of patients.Öğe Are swimming or aerobic exercise better than conventional exercise in ankylosing spondylitis patients? A randomized controlled study(Edizioni Minerva Medica, 2009) Karapolat, H.; Eyigor, S.; Zoghi, N.; Akkoc, Y.; Kirazli, Y.; Keser, G.Aim. The aim of the study was to compare the effects of conventional exercise (CE), swimming and walking on the pulmonary functions, aerobic capacity, quality of life, Bath indexes and psychological symptoms in patients with ankylosing spondylitis (AS). Methods. Forty-five patients were randomised into either swimming (group 1), walking (group 2), CE group (group 3). Patients in Group I performed CE and swimming, patients in Group 2 performed CE and walking and patients in Group 3 performed CE only. Exercise sessions were performed three times a week for a period of six weeks. Patients were assessed before and after the rehabilitation program, with respect to, pulmonary function test (forced vital capacity [FVC, mL], forced expiration volume in one second [FEV1, mL], FEV1/FVC (%) and vital capacity [VC, mL]), maximal oxygen uptake (p(V) over dotO(2)), 6-minute walking test (6MWT), Bath Ankylosing Spondylitis Functional index, Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Metrology Index, Nottingham Health Profile and Beck Depression Inventory. Results. There were significant increases in p(V) over dotO(2) and 6MWT after treatment in Groups 1 and 2 (P<0.05). FeV1, FVC and VC improved significantly with treatment in all three groups (P<0.05). A statistically significant improvement was observed in energy, emotional reaction and physical mobility sub-scores of NHP in three exercise groups after completion of the exercise program (P<0.05). Conclusion. Swimming, walking and CE had beneficial effects on the quality of life and pulmonary functions. Aerobic exercises such as swimming and walking in addition to CE increased functional capacities of patients.Öğe BUDD-CHIARI SYNDROME IN BEHCET'S DISEASE: A RETROSPECTIVE MULTICENTER STUDY(Bmj Publishing Group, 2017) Akyol, L.; Toz, B.; Bayindir, O.; Zengin, O.; Cansu, D. Uskudar; Yigit, M.; Cetin, G. Yildirim; Omma, A.; Erden, A.; Kucuksahin, O.; Altuner, M. S.; Corba, B. S.; Unal, A. U.; Kucuk, H.; Kucuk, A.; Balkarli, A.; Gonullu, E.; Tufan, A. N.; Ureyen, S. Bakirci; Oner, S. Yilmaz; Kobak, S.; Yazici, A.; Ozgen, M.; Sahin, A.; Koca, S. S.; Erer, B.; Gul, A.; Aksu, K.; Keser, G.; Onat, A. M.; Kisacik, B.; Kasifoglu, T.; Cefle, A.; Kalyoncu, U.; Sayarlioglu, M.Öğe Case management model in care of patients with rheumatoid arthritis(B M J Publishing Group, 2006) Tokem, Y.; Argon, G.; Keser, G.Öğe Comments on the development of aortic structural damage (aneurysm or dilatation) in patients with giant cell arteritis(Clinical & Exper Rheumatology, 2016) Keser, G.; Tekeoglu, S.; Zihni, F. Yargucu; Aksu, K.Öğe Comparison of 18F-FDG PET/CT findings with current clinical disease status in patients with Takayasu's arteritis(Clinical & Exper Rheumatology, 2013) Karapolat, I.; Kalfa, M.; Keser, G.; Yalcin, M.; Inal, V.; Kumanlioglu, K.; Pirildar, T.; Aksu, K.Objective. 18F-fluorodeoxyglucosepositron emission tomography/computed tomography (18F-FDG PET/CT) scanning has been proposed as a new tool to assess disease activity in Takayasu arteritis (TA). We investigated whether 18F-FDG PET/CT findings were consistent with current clinical disease status in patients with TA. Methods. In this cross sectional study, 22 patients with TA were enrolled. Clinical disease activity was assessed by the combination of National Institutes of Health (NIH) criteria, Disease Extent Index-Takayasu (DEI-Tak) score, physician global assessment and 18F-FDG PET/CT scans. Results. At the time 18F-FDG PET/CT scans were taken, the majority of the patients (17122) were using immunosuppressive (IS) drugs, and only four patients had clinically active disease. 18F-FDG PET/CT scans confirmed the presence of active vasculitic lesions in those four patients. In 16 out of 18 patients who were accepted to be in clinical remission, 18F-FDG PET/CT scans were also normal. There were only two patients with discordant results, i.e. active 18F-FDG PET/CT findings despite the lack of clinical activity. Interestingly, clinical exacerbation occurred four weeks later in one of them. Overall sensitivity and specificity of 18F-FDG PET/CT findings for clinical activity were 100% and 88.9%, respectively. Conclusion. We found that 18F-FDG PET/CT findings were generally consistent with clinical disease status in TA. Although use of IS drugs certainly impairs diagnostic accuracy of 18F-FDG PET/CT in TA, this imaging method may still have a potential for confirming remission or detecting disease activity in patients with TA receiving treatment.Öğe Comparison of 18F-FDG PET/CT findings with current clinical disease status in patients with Takayasu's arteritis(Clinical & Exper Rheumatology, 2013) Karapolat, I.; Kalfa, M.; Keser, G.; Yalcin, M.; Inal, V.; Kumanlioglu, K.; Pirildar, T.; Aksu, K.Objective. 18F-fluorodeoxyglucosepositron emission tomography/computed tomography (18F-FDG PET/CT) scanning has been proposed as a new tool to assess disease activity in Takayasu arteritis (TA). We investigated whether 18F-FDG PET/CT findings were consistent with current clinical disease status in patients with TA. Methods. In this cross sectional study, 22 patients with TA were enrolled. Clinical disease activity was assessed by the combination of National Institutes of Health (NIH) criteria, Disease Extent Index-Takayasu (DEI-Tak) score, physician global assessment and 18F-FDG PET/CT scans. Results. At the time 18F-FDG PET/CT scans were taken, the majority of the patients (17122) were using immunosuppressive (IS) drugs, and only four patients had clinically active disease. 18F-FDG PET/CT scans confirmed the presence of active vasculitic lesions in those four patients. In 16 out of 18 patients who were accepted to be in clinical remission, 18F-FDG PET/CT scans were also normal. There were only two patients with discordant results, i.e. active 18F-FDG PET/CT findings despite the lack of clinical activity. Interestingly, clinical exacerbation occurred four weeks later in one of them. Overall sensitivity and specificity of 18F-FDG PET/CT findings for clinical activity were 100% and 88.9%, respectively. Conclusion. We found that 18F-FDG PET/CT findings were generally consistent with clinical disease status in TA. Although use of IS drugs certainly impairs diagnostic accuracy of 18F-FDG PET/CT in TA, this imaging method may still have a potential for confirming remission or detecting disease activity in patients with TA receiving treatment.Öğe DNA damage and its relationship with other oxidative stress parameters in Behcet's disease(Springer Heidelberg, 2012) Sezer, E. D.; Aksu, K.; Caglayan, O.; Keser, G.; Karabulut, G.; Ercan, G.Beh double dagger et's disease (BD) is a multisystemic, chronic inflammatory, relapsing disorder that is characterized by oral/genital ulcerations, ocular, arthritic, vascular, and neurologic involvements. Recent findings suggest the role of increased oxidative stress and insufficient antioxidant defence system in BD pathogenesis. It has been proposed that the increase in phagocytic cell activity by triggering oxidative reactions in various targets such as lipids, proteins, and DNA leads to severe inflammatory and degenerative pathologies seen in BD In this study, oxidant/antioxidant status of patients with BD was evaluated in comparison with controls and in respect to disease activity by measuring serum nitrite/nitrate, vitamin A, malondialdehyde (MDA), 8-hydroxy deoxyguanosine (8-OHdG), and total sulfhydryl levels (T-SH). The increase in serum MDA and 8-OHdG levels (respectively 30.04 vs. 17.93 nmol/ml, P = 0.0004 and 1.60 vs. 1.03 ng/ml, P = 0.0019) and the decrease in T-SH levels of patients with BD in comparison with controls (0.69 vs. 0.76 mmol/l, P = 0.0085) all indicate the impaired oxidant/antioxidant status in BD. The positive correlation found between MDA/8-OHdG levels (P = 0.02), and the negative correlations both between T-SH/8-OHdG levels (P = 0.031) and T-SH/MDA levels (P = 0.009) show the concordance between the parameters evaluating oxidant-antioxidant status. Among the parameters used for evaluating oxidant/antioxidant status, serum 8-OHdG was the only one showing significantly higher levels in patients with clinically active disease in comparison (P = 0.004) to patients in inactive period. Therefore, 8-OHdG that is assessed for the fist time in BD with this study can be proposed as a more reliable indicator of oxidant stress in evaluating disease activity.Öğe DO POSTURAL DEFORMITIES IN PATIENTS WITH ANKYLOSING SPONDYLITIS CAUSE BALANCE PROBLEMS?(Bmj Publishing Group, 2014) Cinar, E.; Akkoc, Y.; Karapolat, H.; Keser, G.Öğe Endothelial nitric oxide synthase gene Glu298Asp polymorphism is associated with Behcet's disease(Clinical & Exper Rheumatology, 2006) Oksel, F.; Keser, G.; Ozmen, M.; Aksu, K.; Kitapcioglu, G.; Berdeli, A.; Doganavsargil, E.Objective. The 894 G -> T (Glu298Asp) polymorphism in exon 7 of the endothelial nitric oxide synthase (eNOS) gene was previously reported to be associated with Behcet's Disease (BD) susceptibility in Italian origin and Korean patients, but not in a group of unrelated Turkish patients. We analyzed whether this polymorphism is associated with BD, in another group of Turkish patients. Methods. We studied 132 consecutive Turkish BD patients being followed up by Ege University Rheumatology Department and 91 healthy controls. All individuals were genotyped by PCR-RFLP for 894 G -> T in exon 7 (Glu298Asp). Results. The frequency of the T allele in BD group (1011264) was significantly higher than in healthy controls (OR 1.88, %95 CI 1.27-2.49, p < 0.001). The frequency of the homozygote (TT) Glu298Asp polymorphism in BD (27/132) was also significantly higher than in healthy controls (5/91) (OR 3.72, %95 CI 3.44-4.0, p < 0.001). However, no association was found between the Glu298Asp polymorphism and clinical parameters in BD. Conclusions. In this study, we found that Glu298Asp polymorphism of the eNOS gene was associated with BD in Turkish patients.Öğe Epidemiology of Takayasu's arteritis in Turkey(Clinical & Exper Rheumatology, 2016) Birlik, M.; Kucukyavas, Y.; Aksu, K.; Solmaz, D.; Can, G.; Taylan, A.; Akar, S.; Sari, I.; Keser, G.; Onen, F.; Akkoc, N.Objective. To estimate the prevalence and incidence of Takayasu arteritis (TA) among the residents of the city of Izmir, the third largest metropolis in Turkey. Methods. Five tertiary care teaching hospitals, which were the only ones that provided rheumatology specialty care during the study period in the city of Izmir from 2006 through 2010, were invited to take part in the present study. A case search was performed electronically in the information systems of these hospitals using The International Classification of Diseases Tenth Revision (ICD-10) code for Takayasu arteritis (M31.4). The diagnosis was confirmed through chart review by a rheumatologist according to the 1990 American College of Rheumatology (ACR) criteria. Annual prevalence was calculated based on the number of patients that were alive at the end of 2010. Age-and sex-adjusted prevalence rates were standardised according to the 2010 Turkish population, based on 2010 Turkish Census. Results. A total of 41 patients were confirmed to have TA and also to live within the targeted area. The annual prevalence was estimated as 12.8 (95% CI 12.0-13.6) per million; 23.5/million (95% CI 21.9-25.0) in females and 1.9/million (95% CI 1.5-2.4) in males. The prevalence was higher 8.8/million (95% CI 7.7-10.0) in the population >40 years of age. During the study period, the mean annual incidence of TA was estimated as 1.11/million (95% CI 0.54-1.67). Conclusion. The first epidemiologic study of TA in a Turkish population suggests that TA is a relatively common vasculitis in Turkey.Öğe EVALUATION OF PLASMA PENTRAXIN-3 LEVEL IN PATIENTS WITH TAKAYASU'S ARTERITIS(Bmj Publishing Group, 2015) Alibaz-Oner, F.; Aksu, K.; Yentur, S. P.; Keser, G.; Saruhan-Direskeneli, G.; Direskeneli, H.Öğe EVALUATION OF PLASMA PENTRAXIN-3 LEVEL IN PATIENTS WITH TAKAYASU'S ARTERITIS(Bmj Publishing Group, 2015) Alibaz-Oner, F.; Aksu, K.; Yentur, S. P.; Keser, G.; Saruhan-Direskeneli, G.; Direskeneli, H.Öğe EVALUATION OF PLASMA PENTRAXIN-3 LEVEL IN PATIENTS WITH TAKAYASU'S ARTERITIS(Bmj Publishing Group, 2015) Alibaz-Oner, F.; Aksu, K.; Yentur, S. P.; Keser, G.; Saruhan-Direskeneli, G.; Direskeneli, H.Öğe Evaluation of telomerase activity in 53 cases with connective tissue disorders(B M J Publishing Group, 2006) Tarhan, F.; Kosova, B.; Vural, F.; Aksu, K.; Cogulu, O.; Keser, G.; Gunduz, C.; Tombuloglu, M.; Oder, G.; Karaca, E.; Doganavsargil, E.Öğe Impact of rheumatoid arthritis in Turkey: a questionnaire study(Clinical & Exper Rheumatology, 2014) Direskeneli, H.; Akkoc, N.; Bes, C.; Cakir, N.; Cefle, A.; Cobankara, V.; Dalkilic, E.; Dinc, A.; Ertenli, T.; Gul, A.; Hamuryudan, V.; Inanc, M.; Kalyoncu, U.; Karaaslan, Y.; Kasifoglu, T.; Keser, G.; Keskin, G.; Kisacik, B.; Kiraz, S.; Masatlioglu, S.; Onat, A. M.; Ozbek, S.; Ozturk, M. A.; Pamuk, O. N.; Pay, S.; Pirildar, T.; Sayarlioglu, M.; Senel, S.; Senturk, T.; Tasan, D.; Terzioglu, E.; Yazici, A.; Yucel, E.Objective Unmet needs of rheumatoid arthritis (RA) patients regarding physician/patient communication, treatment preferences and quality of life issues were investigated in a Turkish survey study. Methods The study was conducted with the contribution of 33 rheumatologists, and included 519 RA patients. The study population included patients who had been on biologic therapy for >6 months and were still receiving biologic therapy (BT group), and those who were biologic naive, but found eligible for biologic treatment (NBT group). Of the RA patients, 35.5% initially had a visit to an internal disease specialist, 25.5% to a physical therapy and rehabilitation specialist, and 12.2% to a rheumatology specialist for their RA complaints. The diagnosis of RA was made by a rheumatologist in 48.2% of patients. Results The majority of RA patients (86.3%) visit their doctor within 15-week intervals. Most of the physician-patient communication focused on disease symptoms (99.0%) and impact of the disease on quality of life (61.8%). The proportion of RA patients who perceived their health status as good/very good/excellent was higher in the BT group than in the NBT group (74.3% vs. 51.5%, p<0.001). However, of those RA patients in the NBT group, only 24.8% have been recommended to start a biologic treatment by their doctors. With respect to dose frequency options, once-monthly injections were preferred (80%) to a bi-weekly injection schedule (8%). Conclusion In conclusion, RA patients receiving biologic therapy reported higher rates of improved symptoms and better quality of life and seemed to be more satisfied with their treatment in our study.Öğe Incomplete thymus involution in systemic sclerosis(B M J Publishing Group, 2007) Tarhan, E.; Biteroglu, S.; Terzioglu, E.; Savas, R.; Keser, G.; Oksel, F.Öğe Influence of methylenetetrahydrofolate reductase gene polymorphisms on methotrexate toxicity in patients with rheumatoid arthritis(B M J Publishing Group, 2007) Tetik, A.; Keser, G.; Inal, V.; Aksu, K.; Eroglu, Z.
