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Öğe Are antibacterial component additions in etchants and adhesives effective against Streptococcus Mutans?(Taylor & Francis Ltd, 2018) Atalayin, Cigdem; Turkun, L. Sebnem; Ates, Mustafa; Kemaloglu, Hande; Turkun, MuratThe aim was to investigate the antibacterial activity of various acids and adhesives with and without antibacterial components against Streptococcus mutans. The antibacterial activities of 35% phosphoric acid (Ultra-Etch), 37% phosphoric acid with benzalkonium chloride (Etch-37), adhesive with chlorhexidine (Peak Universal Bond) and without any agent (PQ1) were investigated by agar-diffusion test. The inhibition-zones were measured after 48 h of incubation. For the tooth-cavity model test; cylindrical cavities were prepared on occlusal dentin surfaces of human molars and divided into four groups (n = 10 cavity/group). Group 1: Ultra-Etch + Peak Universal Bond, Group 2: Ultra-Etch + PQ1, Group 3: Etch-37 + PQ1 were applied. The fourth group without any agent application served as control. The teeth were immersed in 5.8 x 10(6) cfu/ml of S. mutans solution to infect the cavities for 72 h before the application of the groups. After 72 h, dentin chips were collected from the cavity walls with burs for bacterial counting. Statistical analysis was performed by ANOVA, Bonferroni and Dunnett C tests (p < 0.05). Ultra-Etch and Etch-37 performed similar antibacterial activities in agar-diffusion test. Both acids showed better antibacterial activity compared to adhesives (p < 0.05). The antibacterial activity of PQ1 and Peak Universal Bond was observed to be inactivated by light-polymerization. According to the tooth-cavity model; Group I, II, and III demonstrated reduction in bacterial number and there was no significant difference between them. Antibacterial component additions in etchant and adhesive did not show superior antibacterial activity against S. mutans in both in vitro tests.Öğe Can Reduced-Step Polishers Be as E'ective as Multiple-STep Polishers in Enhancing Sur-ace Smoothness?(Wiley, 2017) Kemaloglu, Hande; Karacolak, Gamze; Turkun, L. SebnemObjectives: The aim of this study was to evaluate the effects of various finishing and polishing systems on the final surface roughness of a resin composite. Hypotheses tested were: (I) reduced-step polishing systems are as effective as multiple-step systems on reducing the surface roughness of a resin composite and (2) the number of application steps in an F/P system has no effect on reducing surface roughness. Materials and Methods: Ninety discs of a nano-hybrid resin composite were fabricated and divided into nine groups (n = 10). Except the control, all ofthe specimens were roughened prior to be polished by: Enamel Plus Shiny Venus Supra,One-gloss, Sof-Lex Wheels, Super-Snap, Enhance/PoGo,Clearfil TNist Dia, and rubber cups.The surface roughness was measured and the surfaces were examined under scanning electron microscope. Results were analyzed with analysis of variance and Holm-Sidak's multiple comparisons test (p < Results: Significant differences were found among the surface roughness of all groups (p < 0.05).The smoothest surfaces were obtained under Mylar strips and the results were not differentthan Super-Snap, Enhance/PoGo, and Sof-Lex Spiral Wheels. I he group that showed the roughest surface was the rubber cup group and these results were similar to those ofthe One-gloss, Enamel Plus Shiny, and Venus Supra groups. Conclusions: (I) The number of application steps has no effect on the performance of F/P systems. (2) Reduced-step polishers used after a finisher can be preferable to multiple-step systems when used on nanohybrid resin composites. (3) The effect of F/P systems on surface roughness seems to be material-dependent rather than instrument- or system-dependent.Öğe Does post-bleaching fluoridation affect the further demineralization of bleached enamel? An in vitro study(Biomed Central Ltd, 2014) Kemaloglu, Hande; Tezel, Huseyin; Ergucu, ZeynepBackground: Topical fluoride agents have been shown to be the most effective method in treating demineralized enamel after in-office bleaching treatments. Thus, this study aimed to examine the effects of two different post-bleaching fluoridation agents: 1.5% titanium tetrafluoride (TiF4) (9200 ppm) and 2.1% sodium fluoride (NaF) (9500 ppm), on the calcium loss of enamel after an acidic challenge. Methods: Ten maxillary premolars were sectioned into four pieces and then divided into the following four groups: Group 1: Control, kept in artificial saliva, no treatment; Group 2: 38% hydrogen peroxide (HP); Group 3: 38% HP followed by 1.5% TiF4; Group 4: 38% HP followed by 2.1% NaF solution. The specimens were subjected to demineralization for 16 days, refreshing the solution every 4 days; that is, on the 4th, 8th, 12th, and 16th days. Calcium ion (Ca2+) concentration was determined by an atomic absorption spectrophotometer. Data were analyzed using Friedman and Wilcoxon tests (p = 0.05). Results: The loss of Ca2+ in each of the test groups was compared with that of the control group, depicting that there was a statistically significant difference among the groups after 4, 8, 12, and 16 days and in total (p < 0.05). The calcium released from the fluoride-applied groups was lower when compared with the 38% HP and control group. At the end of the 16th day, the total amount of calcium released from the TiF4-treated samples (9.12 mg/mL) was less than from the NaF-treated samples (13.67 mg/mL) (p < 0.05). Conclusions: Regarding the results of our in vitro study, the risk of further demineralization was significantly reduced with the use of TiF4 and NaF after bleaching with 38% HP. TiF(4)was found to be more effective in preventing Ca2+ release owing to acid attack when compared with NaF. In the case of an intra-oral acidic exposure, the use of topical 1.5% TiF4 and 2.1% NaF agents might be beneficial after bleaching with 38% HP.Öğe The effect of composite placement technique on the internal adaptation, gap formation and microshear bond strength(Istanbul Univ Press, Istanbul Univ Rectorate, 2022) Peskersoy, Cem; Recen, Duygu; Kemaloglu, HandePurpose This study aimed to compare the efficiency of placement technique on internal adaptation, gap formation and microshear bond strength (#SBS) of bulk-fill composite resin materials. Materials and Methods Standardized class V cavities were prepared for microcomputed tomography (mCT) test and divided into four groups (n=12) as follows: Group SDR: Smart Dentin Replacement system/bulk fill; Group SF2: Sonic-Fill system/bulk fill sonic-activated composite placement system; Group CHU: Herculite-XRV-Ultra composite resin inserted with Compothixo/sonic-vibrated composite resin placement system; Group HIT: Herculite-XRV-Ultra composite resin applied with incremental technique. Self-etch adhesive (Optibond-XTR) was used for bonding in all groups. After 10000 thermocycling, mCT scans were taken to reveal gap formation at the tooth restoration interface and universal testing machine was used to test microshear bond strength (#SBS) values (n=10). ANOVA, post-hoc Bonferroni and Tukey HSD tests were used for evaluating the gap formation and #SBS values (p=0.05). Results SF2 and CHU showed the best adaptability compared with both SDR and HIT. The difference between groups SDR and HIT was statistically significant (p<0.05). #SBS values were found to be the highest for SF2, and the lowest for HIT groups (p>0.05). Conclusion Bulk-fill composite resins placed either with sonic-activated or sonic-vibrated instrument demonstrated better adaptability, less gap formation and higher bond strength than both the bulk-fill flowable composite and conventional incremental techniques.Öğe Follow-up of flowable resin composites performed with a universal adhesive system in non-carious cervical lesions: A randomized, controlled 24-month clinical trial(Mosher & Linder, Inc, 2020) Kemaloglu, Hande; Atalayin, Cigdem; Ergucu, Zeynep; Onal, BanuPurpose: This randomized, controlled study evaluated the 2-year clinical performance of two flowable resin composites performed with a universal adhesive in two etching modes for restoring non-carious cervical lesions (NCCLs). Methods: One hundred NCCLs were restored with two flowable composites (Charisma Opal Flow and G-aenial Universal Flo) and a universal adhesive (Single Bond Universal) with two etching modes (self-etch and etch&rinse) in a random order. the restorations were evaluated for retention, marginal adaptation, anatomic form, marginal discoloration, surface texture and secondary caries (modified USPHS criteria) at baseline, and after 6, 12 and 24 months. Results: the clinical success for retention, surface texture and secondary caries parameters was scored as 100% for each group after 6, 12 and 24 months. the first acceptable changes (Bravo score) in marginal adaptation, anatomical form and marginal discoloration started to show up after 12 months for all test groups, except for etch&rinse+Charisma Opal Flow. Self-etch+Charisma Opal Flow and self-etch+G-aenial Universal Flo showed progressive marginal discoloration that remained in the clinical acceptability level after 2 years. After 24 months, each resin composite restored with either the etch&rinse mode or the self-etch mode of the universal adhesive showed similar clinical performance. Marginal discoloration was higher in the restorations performed with the self-etch system. Selective-etching can be favorable.Öğe Implementation of machine learning models as a quantitative evaluation tool for preclinical studies in dental education(Wiley, 2024) Oguzhan, Aybeniz; Peskersoy, Cem; Devrimci, Elif Ercan; Kemaloglu, Hande; Onder, Tolga KaganPurpose and objective: Objective, valid, and reliable evaluations are needed in order to develop haptic skills in dental education. The aim of this study is to investigate the validity and reliability of the machine learning method in evaluating the haptic skills of dentistry students. Materials and methods: One-hundred fifty 6th semester dental students have performed Class II amalgam (C2A) and composite resin restorations (C2CR), in which all stages were evaluated with Direct Observation Practical Skills forms. The final phase was graded by three trainers and supervisors separately. Standard photographs of the restorations in the final stage were taken from different angles in a special setup and transferred to the Python program which utilized the Structural Similarity algorithm to calculate both the quantitative (numerical) and qualitative (visual) differences of each restoration. The validity and reliability analyses of inter-examiner evaluation were tested by Cronbach's Alpha and Kappa statistics (p = 0.05). Results: The intra-examiner reliability between Structural Similarity Index (SSIM) and examiners was found highly reliable in both C2A (alpha = 0.961) and C2CR (alpha = 0.856). The compatibility of final grades given by SSIM (53.07) and examiners (56.85) was statistically insignificant (p > 0.05). A significant difference was found between the examiners and SSIM when grading the occlusal surfaces in C2A and on the palatal surfaces of C2CR (p < 0.05). The concordance of observer assessments was found almost perfect in C2A (kappa = 0.806), and acceptable in C2CR (kappa = 0.769). Conclusion: Although deep machine learning is a promising tool in the evaluation of haptic skills, further improvement and alignments are required for fully objective and reliable validation in all cases of dental training in restorative dentistry.Öğe The protective effect of resveratrol against dentin bonding agents-induced cytotoxicity(Japanese Soc Dental Materials Devices, 2015) Atalayin, Cigdem; Armagan, Guliz; Konyalioglu, Sibel; Kemaloglu, Hande; Tezel, Huseyin; Ergucu, Zeynep; Keser, Aysegul; Dagci, Taner; Onal, BanuThis study was designed to evaluate the cytotoxicity of four dentin bonding agents and the effects of an antioxidant addition. Group A: G-aerial Bond, Group B: Optibond All in One, Group C: Gluma Self Etch and Group D: Clearfil S-3 Bond were added to the medium using extract method. The cells were cultured with or without resveratrol (RES) addition. MTT, reactive oxygen species (ROS), DCF, Comet and 8-OHdG measurements were performed. The agents had a dose-dependent (1:1>1:10>1:20) cytotoxic effect. Considering 1:10 concentration; Group D at 1 h (p<0.01) and Group B and D at 24 h had the weakest cytotoxic effect (p<0.05). After RES addition, the highest cell viability was determined in Groups B+RES and D+RES at 1 h and in Groups A+RES and B+RES at 24 h (p<0.01). The dentin bonding agents induced ROS production and DNA damage regarding to their composition. However, RES addition decreased the indicated parameters.Öğe SALIVARY PRO-INFLAMMATORY CYTOKINES AND SALIVARY BACTERIAL CHALLENGE EFFECT ON DENTAL CARIES: A CLINICO-MOLECULAR CROSS-SECTIONAL STUDY (vol 1, pg 77, 2020)(Dokuz Eylul Univ Inst Health Sciences, 2022) Pakdemirli, Ahu; Kocal, Gizem Calibasi; Kilinc, Gulser; Daskin, Ezgi; Kemaloglu, Hande; Basbinar, Yasemin; Ellidokuz, Hulya[No Abstract Available]
