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    The Clinical Impact of Low Doses of Dasatinib in Patients with Chronic Myeloid Leukemia
    (Akad Doktorlar Yayinevi, 2012) Aksu, Salih; Sahin, Fahri; Uz, Burak; Yavuz, Selim A.; Atay, Hilmi; Kelkitli, Engin; Turgut, Mehmet; Pehlivan, Mustafa; Akay, Meltem O.; Guray, Emel; Demir, Muzaffer; Kahraman, Selda; Demirkan, Fatih; Paydas, Semra; Saydam, Güray; Haznedaroglu, Ibrahim C.
    We report our experience in 41 patients with chronic phase (CF)-chronic myeloid leukemia (CML) who had discontinued imatinib switched to dasatinib, retrospectively. The CF-CML patients received dasatinib at starting dose of 100 once daily. Dose adjustment were observed in 11 patients, respectively. In case of other circumstances, treatment has been continued with a lower dose if needed. The median dose of dasatinib was 100 mg daily (range: 50 to 140 mg). We conclude that even low-dose dasatinib therapy is an effective and safe in second line treatment of CML patients patients.