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Öğe Comparison of the effects of droperidol, chlorpromazine and lidocaine on the incidence of postoperative nausea-vomiting in children undergoing strabismus surgery [SASILIK OPERASYONU UYGULANAN COCUKLARDA POSTOPERATIF BULANTI-KUSMA UZERINE DROPERIDOL, LIDOKAIN VE KLORPROMAZININ ETKILERININ KARSILASTIRILMASI](1995) Turkoglu M.; Ozyar B.; Kayaalti B.; Ugur G.The effects of droperidol, chlorpromazine and lidocaine given intravenously for prophylactic treatment on, the incidence of nausea-vomiting and recovery time were compared. 60 children undergoing strabismus surgery under general anesthesia were divided randomly into 4 groups. Before the induction of anesthesia, the patients received 0.075 mg/kg droperidol in the first group, 1 mg/kg lidocaine in the second, 0.3 mg/kg chlorpromazine in the third, 0.075 mg/kg droperidol plus 1 mg/kg lidocaine in the fourth group. Then anesthesia was maintained in a standard technique in all groups. The incidence of post-anesthesic nausea and vomiting was the highest in the third group, but it was not statistically significant. In the recovery period, the time for recovery of full alertness in the third group was significantly different from either the second and the fourth group (p<0.01 and p<0.01 respectively). This time was the longest in the third group (65.6 ± 18.5 min) and the shortest in the fourth group (40.7 ± 14.4 min). There was no significant difference among the four groups with respect to heart rate and mean arterial pressure. According to the results of this study, we recommend to use a combination of lidocaine which is known to diminish physiological reflex activity, and droperidol, a strong antiemetic, in order to reduce the incidence of post-operative nausea and vomiting.Öğe Comparison of the effects of mannitol and furosemide after transurethral resection of the prostate (TURP)(1994) Turkoglu M.; Ozyar B.; Kayaalti B.; Ugur G.; Nazli O.In our study, we compared the effects of mannitol and furosemide on electrolyte balance and hemodynamic parameters in 20 patients undergoing TURP under spinal anaesthesia. We gave 80 g mannitol to ten patients and 40 mg furosemide to the others intravenously after the resection. Sodium concentration in both serum and urine and serum osmolarity are analysed in the samples taken before the operation, immediately after the prostatic resection, 1 hour, 4 hours and 24 hours after the operation. Heart rate, central venous pressure (CVP), systolic and diastolic arterial blood pressure were monitored and the patient's level of consciousness was observed during the operation. In the mannitol group, serum osmolarity decreased significantly in the samples, taken immediately after the resection, 4 and 24 hours after the operation. In the furosemide group urine sodium concentration increased significantly in the samples taken immediately after the resection and 1 hour after the operation. Systolic and diastolic arterial blood pressure, heart rate, CVP measurements ranged between normal limits in all patients. No patient showed any pathological sign of central nervous system disturbance. We conclude that both mannitol and furosemide can be used in order to prevent TUR syndrome and coagulum retention.Öğe Effect of nitrous oxide on cardiac dysrhythmias during anaesthesia(1994) Hamamcioglu G.; Askar F.Z.; Certug A.; Kultursay H.; Kayaalti B.In this study the authors aimed to investigate the effect of nitrous oxide (N2O) on cardiac rhythm during general anaesthesia. Thirty-two cases were included in this study and were randomized into 3 groups. In all groups thiopenthone sodium and vecuronium bromide were used as induction agents. First group (n=11) received 50% O2 + 50% N2O, second group (n=11) 30% O2 + 70% N2O and control group (n-10) 100% O2 during induction. Isoflurane was added in order to achieve adequate levels of anaesthesia in all groups. Systolic, diastolic and mean arterial pressures, pulse rate, twelve leads EGG and cardiac rhythm in lead II were recorded at five different periods. In control group only sinus rhythm was observed. In the first group, one patient showed sinus + atrioventricular junctional rhythm (AVJR) and in the second group one patient showed sinus + bigeminal ventricular premature beat + aberrant conduction of QRS while one patient showed AVJR. No statistically significant difference was found between groups as far as frequency of rhythm disturbance formation was concerned. The authors concluded that, although there was no statistically significant difference between above mentioned groups, it was considered that N2O could increase tendency for AVJR.Öğe Effects of droperidol, chlorpromazine and sodium nitroprusside on vascular resistance during cardiopulmonary bypass(1991) Yetginer A.; Kayaalti B.; Certug A.; Buket S.; Ayanoglu O.; Okur F.[No abstract available]Öğe Effects of intrathecal nalbuphine with spinal anaesthesia on postoperative analgesia and respiratory function(1993) Ugur G.; Kayaalti B.; Turkoglu M.; Ozyar B.; Gulerce Z.; Kabasakal T.[No abstract available]Öğe The effects of propofol on upper cortical brain functions(1992) Ulusoy B.; Kayaalti B.; Yegul I.; Akarsu D.[No abstract available]Öğe Myocardial metabolism during administration of a metabolic myocardial protection in coronary artery surgery [KORONER CERRAHI OLGULARINDA MIYOKARDIN METABOLIK KORUNMASI SIRASINDA METABOLIZMASI](1994) Askar F.Z.; Discigil B.; Buket S.; Sevinc A.; Yuksel M.; Erel L.; Kayaalti B.Preischemic glucose-insulin-potassium administration in open heart surgery has been implicated in better myocardial protection during cross clamping of the aorta. To assess the metabolic effects of myocardial substrate alteration in patients undergoing coronary artery bypass grafting (CABG), glucose (0.5 g/kg/h) - insulin (1 U/kg/h) - potassium (25 mmol/h) was administered intravenously for 30 minutes to 12 patients (Acute Parenteral Alimentation, APA) before cardiopulmonary bypass was commenced. Another 12 patients to whom 0.9 % NaCl and 25 mmol/h potassium was given with the same infusion rate served as control group. Simultaneous arterial (a) and coronary sinus (cs) samples were obtained before and after a 30 minute infusion period; samples were assayed for sodium, potassium, glucose, lactate and blood gas analysis. The cs potassium level in the APA group decreased from 4.377±0.196 to 3.787±0.146 mmol/L, whereas there was an increase from 4.033±0.062 to 4.650±0.070 mmol/L in the control group. The difference between two groups was significant, p<0.01. Upon infusion of glucose-insulin-potassium, myocardial glucose extraction (a-cs difference) increased from 54.42±6.28 mg/dl to 92.5±12 mg/dl; whereas it was reduced from 50.25±4.58 mg/dl to 37.67±4.43 mg/dl in the control group (p<0.01). While myocardial lactate extraction increased from 0.461±0.103 mmol/L to 0.987±0.114 mmol/L in APA group with the glucose-insulin administration (p<0.01), it remained unchanged in the control group. The enhancement of myocardial carbohydrate utilisation, evidenced with the increase in myocardial glucose and lactate uptake with the action of glucose-potassium-insulin before the initiation of cardiopulmonary bypass, would be particularly important for the patients undergoing myocardial revascularization that, this may further improve ischemic tolerance of the myocardium during cross clamping of the aorta.Öğe Plasma calcium, magnesium and phosphate levels during and after hypothermic cardiopulmonary bypass(1993) Kayaalti B.; Askar F.Z.; Turkoglu M.; Mutaf I.; Turhan A.; Certug A.[No abstract available]Öğe Sodium nitroprusside metabolism during hypothermic cardiopulmonary bypass(1993) Askar F.Z.; Kayaalti B.; Guner I.; Turkoglu M.; Yetginer A.; Certug A.To prevent the systemic vascular resistance increase during cardiopulmonary bypass (CPB), sodium nitroprusside (SNP) was used at infusion rates as suggested in normothermia (0.5-8 µg/kg/min) in randomly selected 16 patients undergoing coronary artery bypass grafting (CABG). SNP infusion was started when mean arterial blood pressure (MAP) increased over 80 mmHg and continued until it decreased to 60 mmHg. The mean SNP doses and infusion rates and related blood cyanide (CN-) levels were measured in 10 patients and plasma thiocyanate (SCN-) levels in 16 patients before, during and after hypothermia. At the beginning of CPB, but before SNP infusion, blood CN- and plasma SCN levels are 0.437 ± 0.05 µmol/L and 0.250 ± 0.02 mg/dl respectively. At 28°C, blood CN- level was 0.712 ± 0.15 µmol/L and plasma SCN- level was 0.313 ± 0.03 mg/dl. At the end of hypothermia, they were 1.468 ± 0.29 µmol/L and 0.405 ± 0.04 mg/dl respectively. The highest blood CN- level observed was in the third blood sample (1.468 ± 0.29) taken at the end of hypothermia. The peak plasma SCN level was reached (0.623 ± 0.12) four hours after rewarming. No patient showed toxicity symptoms and blood levels never reached to toxic levels. In conclusion, SNP can be used safely at infusion rates as suggested in normothermia in CPB. But especially in prolonged hypothermia CPB, the risk of CN-toxicity must be considered and metabolic status of the patient must be examined carefully.
