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Öğe Demonstration of Epstein-Barr Virus by In Situ Hybridization in Papillary Thyroid Carcinomas Developing on Background of Hashimoto's Thyroiditis(Georg Thieme Verlag Kg, 2024) Karaarslan, Serap; Kasap, Esin; Ipek, Fatma Nur; Akyildiz, MahirAim This study aimed to demonstrate the role of Epstein-Barr Virus (EBV) in papillary thyroid carcinomas (PTC) developing on the background of Hashimoto's thyroiditis (HT). Methods The presence of EBV in tumoral tissue, lymphocytes, and peritumoral normal thyroid tissue was investigated using the in situ hybridization method in paraffin blocks. The subtypes of PTC, tumor diameter, TNM stage, multifocality, invasion of thyroid capsule, perineural invasion, and muscular tissue invasion were identified and compared according to EBV involvement. Results Eighty-one patients with HT diagnosis, with 93.8% (n=76) female and 6.2% (n=5) male, were included in the study. Papillary microcarcinoma was the pathological diagnosis in 24.2% (n=15) of the cases. EBV was identified in 58.06% (n=36) of the tumor cells nuclei, 58.06% (n=36) in the tumor cell cytoplasm, 16.12% (n=10) in tumor infiltrative lymphocytes, and 53.2% (n=33) in normal parenchymal follicle epithelial cells (NPFEC). In the T2 stage, the rate of EBV nuclear positivity in patients was significantly higher (p=0.034). The classic variant of papillary carcinoma was accompanied by a significantly higher rate of EBV-negative NPFEC (67.6%, p=0.049). In multifocal tumors, EBV positivity was found to be significantly higher in lymphocytes in the surrounding tissues (58.3%, p=0.034). Conclusion A significant increase in EBV positivity in the surrounding tissue lymphocytes was observed in multifocal PTC developing on a background of HT. This suggests a possible association between HT and EBV.Öğe Doğum şeklinin seksüel fonksiyon üzerine etkisi var mıdır?(2016) Kasap, Esin; Aksu, Emine Ebru; Şahin, Nur; Güçlü, Serkan; Gür, Esra BaharAmaç: Kadınlarda cinsel işlev bozukluğu, orgazma ulaşamama ya da orgazmdan zevk alamama olarak tanımlanmaktadır. Bazı çalışmalarda, cinsel sağlığın doğum yöntemiyle değişebildiği gösterilmiştir. Bu çalışmada, Türkiye'de, kadın popülasyonunda doğum yönteminin postpartum dönemde cinsel fonksiyonu etkileyip etkilemediğini araştırmayı amaçlamaktadır. Yöntemler: Bu prospektif çalışmada, 2012-2014 yılları arasında Şifa Hastanesinde (40) Normal vaginal doğum (NVD) ve (40) sezaryen (CS) ameliyatı olan primipar hastaların doğum sonrası 6.-24. aylarda sexüel fonksiyonlarını karşılaştırmayı amaçladık. Cinsel işlev bozukluğunu değerlendirme yöntemi olarak Kadın Cinsel İşlev İndeksi (FSFI) formunu kullandık. Gruplar demografik özellikler, tıbbi özgeçmiş ve obstetrik detaylar ve vücut kitle indeksi değerleri açısından eşleştirildi.Bulgular: Çalışma grupları arasında vücut kitle indeksi (VKİ) dışında yaş, eğitim düzeyi, sexüel aktivite sıklığı, evlilik yılı, iş durumu ve sosyoekonomik düzey açısından istatistiksel olarak farklılık göstermediler. Her iki grup arasında yapılan karşılaştırmada, istek, uyarılma, lubrikasyon, ağrı, orgazm, cinsel başarı yönünden anlamlı bir fark saptanmamıştır.Sonuç: Çalışmamızda, vajinal doğumun postnatal cinsel işlevleri olumsuz şekilde etkilemediği gösterilmektedir.Öğe The efficacy of complete blood count parameters in the diagnosis of tubal ectopic pregnancy(Studio K, 2014) Eskicioglu, Fatma; Ozdemir, Alper Tunga; Turan, Guluzar Arzu; Gur, Esra Bahar; Kasap, Esin; Genc, MineObjective: Ectopic pregnancy (EP) is the major cause of maternal morbidity and is responsible for maternal mortality in the first trimester In order to reduce undesirable results, it is necessary to find rapid and accurate, non-surgical diagnostic tests for EP The goal of the study was to investigate the differences in complete blood count parameters between tubal EPs and healthy pregnancies in be used in the diagnosis of ectopic pregnancy Study design: White blood cell (WBC), neutrophil, monocyte, lymphocyte, platelet (PLT) counts, mean PLT volume (MPV) and PLT distribution width (POW) levels in the complete blood count samples have been obtained from subjects with diagnosed tubal EP (n=78; study group) and women with healthy intrauterine gestations (n=79; control group). Statistical comparisons between groups were performed using the t test Results: POW levels were found to be significantly higher in the control group than EP (p<0.001). However no differences between the study and control groups with regard to PLT and MPV levels were observed. WBC levels were found to be significantly higher in the EP group as compared to controls (p<0.001). When leukocyte differentials were compared, monocyte counts in the EP group were significantly higher than in controls (p=0.005). No statistically significant differences in neutrophil and lymphocyte values were observed in either group. Conclusion: POW as an indicator of PLT activation is lower in tubal EP than intrauterine pregnancy so, possibly endometrial invasion in the intrauterine pregnancy needs more PLT activation. Monocyte counts are higher in tubal indicating that monocyte activation in the pathophysiology of EP could be effective in the formation of tubal motility and microenvironment regulation.Öğe Polycystic ovary syndrome is associated with increased osteopontin levels(Bioscientifica Ltd, 2016) Saklamaz, Ali; Calan, Mehmet; Yilmaz, Ozgur; Kume, Tuncay; Temur, Muzaffer; Yildiz, Nurdan; Kasap, Esin; Genc, Mine; Yurekli, Banu Sarer; Kocabas, Gokcen UnalObjective: Osteopontin (OPN) is a multi-functional secreted glycoprotein that plays a crucial role in glucose metabolism and inflammatory process. Growing evidence suggests that there is a link between OPN and ovarian function. However, no such link has yet been found for OPN in polycystic ovary syndrome (PCOS). Our aim was to ascertain whether circulating OPN levels are altered in women with PCOS and to determine whether OPN levels differ between the follicular phase and mid-cycle of the menstrual cycle in eumenorrheic women. Design and methods: In total, 150 women with PCOS and 150 age-and BMI-matched controls without PCOS were recruited for this prospective observational study. OPN levels were measured using ELISA. Metabolic parameters were also determined. Results: Circulating OPN levels were significantly elevated in PCOS women compared with controls (69.12 +/- 31.59 ng/ml vs 42.66 +/- 21.28 ng/ml; P<0.001). OPN levels were significantly higher at mid-cycle than in the follicular phase in eumenorrheic women. OPN was positively correlated with BMI, homeostasis model assessment of insulin resistance (HOMA-IR), free testosterone, and high sensitivity C-reactive protein (hs-CRP). Multivariate logistic regression analyses revealed that the odds ratio (OR) for PCOS was 3.64 for patients in the highest quartile of OPN compared with those in the lowest quartile (OR=3.64; 95% CI=2.42-5.57; P=0.011). Our findings indicate that BMI, HOMA-IR, hs-CRP, and free testosterone are independent factors influencing serum OPN levels and that OPN is an independent predictor for HOMA-IR. Conclusion: PCOS is associated with increased OPN levels.Öğe Typical and Atypical Imaging Findings of Abdominal Teratomas(Bentham Science Publ Ltd, 2015) Sahin, Neslin; Genc, Mine; Solak, Aynur; Kasap, Esin; Yalaz, Seyhan; Solak, Ilhami; Genc, Berhan; Karaarslan, SerapTeratomas are most commonly observed as lesions of ovarian origin. They can also be detected in extragonadal regions such as brain, face, neck, mediastinum, retroperitoneum, and sacrococcygeal region. Ovarian teratomas are usually in mature cystic form as benign, well-differentiated, and cystic lesions. Immature teratomas and monodermal teratomas (struma ovarii, carcinoid tumors and neural tumors) are rare forms. Mature cystic teratomas are usually diagnosed by ultrasound (US) and magnetic resonance (MR) imaging. On US, a variety of appearances including echogenic sebaceous material and calcification are observed. MR imaging can specifically demonstrate fat component by fat-saturation sequences. On the other hand, teratomas are usually incidentally detected on computed tomography (CT) and fat attenuation within a cyst is diagnostic. It may be difficult to characterize immature teratomas due to nonspesicific findings on US. However, CT and MR can provide diagnosis by identifying small foci of fat within a mass with irregular solid component containing coarse calcifications. A small proportion of mature cystic teratomas can undergo malignant transformation (carcinomas or sarcomas). The purpose of this paper is to review the imaging features of various types of abdominally located teratomas for differentiation and diagnosis.
