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    Medicolegal aspects of blood-urine toluene and urinary ortho-cresol concentrations in toluene exposure
    (2001) Akgür S.A.; Öztürk P.; Kurtulmuş Y.; Karali H.; Ertürk S.
    Toluene is a widely used solvent in different industrial areas and has a depressant effect on the central nervous system. In medicolegal cases, for the possible influence of toluene on actions or conditions prior to death, a reliable indicator of exposure must be precisely investigated. We developed an appropriate method for toluene analysis and investigate the blood-urine toluene levels and urinary ortho-cresol levels in toluene-exposed workers. Blood and urine toluene levels from 50 male subjects were detected by Gas Chromatography-FID (GC-FID) using the head-space method, and urinary o-cresol levels, a metabolite of toluene, were analyzed by GC. The significance of difference of ocresol/creatinine levels was evaluated by the nonparametric statistics Kruskal-Wallis One Way Anova, and correlation and regression statistics were determined by Pearson Correlation of bivariant analysis. The toluene concentrations in blood ranged from 0.07 to 2.12 mg/g. Urinary o-cresol levels were not correlated significantly with blood or urine toluene levels. There was no significant difference for ortho-cresol/creatinine levels between the control and worker groups. It is concluded that for medicolegal purposes, urine toluene and urinary o-cresol levels are not reliable markers, and direct toluene analysis in blood must be preferrred in toluene exposure.