Yazar "Karakus, Volkan" seçeneğine göre listele
Listeleniyor 1 - 12 / 12
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Acquired Hemophilia A In Adults: A Multicenter Study from Turkey(Springer India, 2022) Davulcu, Eren Arslan; Demirci, Zuhal; Yilmaz, Umut; Ar, Muhlis Cem; Teke, Hava Uskudar; Karakus, Volkan; Ciftciler, RafiyeAcquired hemophilia A (AHA) is a rare disease caused by autoantibodies inhibiting factor VIII (FVIII) activity. Although the conditionis usually idiopathic, there may be other underlying diseases. Treatment consists of two steps: treatment of acute bleeding and immunosuppression. In this multicenter study, we aimed to demonstrate the clinical characteristics, management details, and survival of AHA patients in Turkey. Data was collected from eleven centers in Turkey. aPTT, FVIII, FVIII inhibitor, and hemoglobin (HB) levels, mixing test results, and demographics at diagnosis, treatment information, adverse events, bleeding episodes during follow-up, relapses, and outcome were analyzed. Twenty-nine patients were analyzed (58.6% female). No underlying disorder could be detected in 14 patients. The most prevalent etiologies were pregnancy, malignancy and infections. The median FVIII activity and FVIII inhibitor titer at diagnosis were 0.7% (0.0-29.4%) and 32.6 BU (0.6-135.6 BU) respectively. Bleeding was severe in 44.8% of patients. The HB value was significantly lower in patients with severe bleeding. Most of the patients (n = 25, 86.2%) had only one bleeding episode without relapse, three patients (10.3%) had two bleeding episodes, and one patient had more than three bleedings. 21 (75%) patients received hemostatic therapy. The use of recombinant FVIIa was slightly higher than activated prothrombin complex concentrate (15 versus 10 patients). Immunosuppressive treatment was initiated in 26 (93%) patients. Regimens containing steroid, cyclophosphamide, and rituximab in different combinations were the most preferred. The median follow-up period was 13 months (2-156 months). Median overall survival was 154.97 months. Four and six-year survival were 90.9 +/- 0.8% and 77.9 +/- 14.1% respectively. This is a unique study that investigated the demographic characteristics, treatment approaches, and patient survival of AHA in Turkey.Öğe Acute Lymphoblastic Leukemia in Routine Practice: A Turkish Multicenter Study(Galenos Yayincilik, 2019) Ciftciler, Rafiye; Sevindik, Omur Gokmen; Tekgunduz, Ali Irfan Emre; Erkurt, Mehmet Ali; Vural, Filiz; Turgut, Burhan; Kaynar, Leylagul; Payzn, Bahriye; Dogu, Mehmet Hilmi; Karakus, Volkan; Altuntas, Fevzi; Buyukasik, Yahya; Demirkan, FatihObjective: Significant developments occurred in the clinical management of acute lymphoblastic leukemia (ALL) in adults in recent decades. However, treatment results are still not satisfactory, especially in routine practice. The objective of this study was to evaluate the general clinical features, treatment details, and outcomes of a large group of patients followed in multiple centers in Turkey with a diagnosis of ALL. Materials and Methods: A retrospective analysis of the data of patients with ALL was made, the patients having been diagnosed and treated between January 2003 and June 2017 by different protocols in the hematology clinics of ten different centers. A total of 288 patients, aged between 17 and 76 years old, were included in the study. In this retrospective multicenter analysis of patients with ALL, classification of patients was performed based on treatment period, Philadelphia chromosome positivity, treatment regimen, and administration of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Results: The majority of cases were B-cell in origin, while 224 patients had B-ALL and 64 of the patients had T-ALL. Median follow-up duration for all patients was 18.2 months (range: 0.03-161 months). Philadelphia chromosome positivity was determined in 49 patients (21.9%), and 54 patients (18.8%) were receiving allo-HSCT. After induction chemotherapy, 219 patients (76.0%) achieved complete remission, 32 patients (11.2%) were evaluated as treatment refractory, and 37 patients (12.8%) were deceased. Median overall survival was 47.7 months (95% confidence interval: 36.1-59.2) and median disease-free survival was 23.4 months (95% confidence interval: 6.7-40.0) for all patients. Conclusion: Multicenter studies are extremely important for defining the specific clinical features of a particular disease. The results of this study will make a significant contribution to the literature as they reflect real-life data providing valuable information about the Turkish ALL patient profile.Öğe Acute Monoblastic Leukemia Presenting with Multiple Granulocytic Sarcoma Nodules(Galenos Yayincilik, 2017) Kara, Asude; Belli, Asli Akin; Dere, Yelda; Karakus, Volkan; Kasap, Sukru; Kurtoglu, Erdal; Hekimgil, MineÖğe A Case Series of CML Patients Who Were Presented with Isolated Thrombocytosis(Amer Soc Hematology, 2022) Karakus, Volkan; Aslan, Vedat; Parca, Guleycan; Sevindik, Omur Gokmen; Karadag, Fatma Keklik; Kurtoglu, Erdal; Saydam, Guray[No abstract available]Öğe Different clinical courses with the same findings: two cases of paroxysmal nocturnal hemoglobinuria presenting with thrombocytopenia(Pagepress Publ, 2021) Karakus, Volkan; Kaya, Egemen; Dere, Yelda; Sahin, FahriParoxysmal nocturnal hemoglobinuria (PNH) is a clonal stem cell disease that manifests with chronic intravascular hemolysis, thrombosis, and bone marrow failure. Various degrees of cytopenias accompany the disease. Although laboratory and clinical findings are similar, the disease may show different courses and require different treatments. Herein, we report two different courses of PNH with similar clinical and laboratory findings.Öğe Gaucher disease in an adult: A rare cause of hepatosplenomegaly in adults(Kare Publ, 2018) Karakus, Volkan; Dere, Yelda; Dere, Ozcan; Sahin, Fahri; Ozsan, NazanÖğe Management of Adult Primary Immune Thrombocytopenia: DelphiBased Consensus Recommendations(Galenos Publ House, 2024) Demir, Ahmet Muzaffer; Umit, Elif Gulsum; Ar, Muhlis Cem; Ayer, Mesut; Ayli, Meltem; Karakus, Volkan; Kaya, EminObjective: Primary immune thrombocytopenia (pITP) is an acquired autoimmune disorder related to the increased destruction and/or impaired production of platelets. Its diagnosis and management are challenging and require expertise and the interpretation of international consensus reports and guidelines with national variations in availability. We aimed to assess the agreement of hematologists in T & uuml;rkiye on certain aspects of both first -line and second -line management of patients with pITP. Materials and Methods: Applying a modified Delphi method, the Turkish National ITP Working Group (14 steering committee members), founded under the auspices of the Turkish Society of Hematology, developed a 21 -item questionnaire consisting of statements regarding the first -line and second -line treatment of pITP. A total of 107 adult hematologists working in either university or state hospitals voted for their agreement or disagreement with the statements in two consecutive rounds. Results: The participants reached consensus on the use of corticosteroids as first -line treatment and with limited duration. Methylprednisolone was the corticosteroid of choice rather than dexamethasone. Use of intravenous immunoglobulin was not preferred for patients without bleeding. It was also agreed that thrombopoietin receptor antagonists (TPO-RAs) or rituximab should be recommended as second -line treatment and that splenectomy could be considered 12-24 months after diagnosis in patients with chronic pITP. Conclusion: The optimization of the dose and duration of TPO-RAs in addition to corticosteroids is necessary to improve the management of patients with pITP.Öğe PAROXYSMAL NOCTURNAL HEMOGLOBINURIA PRESENTING WITH THROMBOCYTOPENIA: TWO PESG CASES(Pergamon-Elsevier Science Ltd, 2017) Karakus, Volkan; Kara, Ahmet; Dere, Yelda; Azik, Fatih; Sahin, FahriÖğe Pesg PNH diagnosis, follow-up and treatment guidelines(E-Century Publishing Corp, 2016) Sahin, Fahri; Akay, Olga Meltem; Ayer, Mesut; Dal, Mehmet Sinan; Ertop, Sehmus; Ilhan, Osman; Karakus, Volkan; Ozcan, Mehmet Ali; Ozkocaman, Vildan; Ozsan, Hayri; Salim, Ozan; Tobu, Mahmut; Tombak, Anil; Tuglular, Tulin Firatli; Yilmaz, Mehmet; Unal, Ali; Yenerel, Mustafa Nuri; Saydam, GürayPNH Education and Study Group ( PESG) have been established in December 2013 as a non-profit, independent, medical organization www.pesg.org. Paroxysmal Nocturnal Hemoglobinuria ( PNH) is a multi-systemic disease that should be treated with a multidisciplinary approach. Patients may apply to the clinics other than the hematology due to variability and diversity of clinical findings which lower the rate of diagnosis due to low awareness about PNH. PNH might be overlooked and diagnosis might be delayed. Regarding these, PESG was established with the collaboration of Immunology, Cardiology, Thorax Diseases ( Pulmonology), Neurology, Gastroenterology, General Surgery and Urology specialists in addition to hematologists dealing with PNH. The PESG study group aims to increase the awareness about PNH, including training activities about PNH, strengthening the relations between clinics and planning of clinical studies as a goal. It is the first professional organization focusing on PNH, in Turkey. In this guideline, we want to facilitate the diagnosis attributes of physicians from all specializations that deal with PNH and its systemic complications. One can perceive this as a tailor made guideline of international guidelines but not a compilation.Öğe Prospective registry of adult patients receiving therapeutic plasma exchange with a presumptive diagnosis of thrombotic microangiopathy (TMA): The Turkish hematology research and education group (ThREG)-TMA02 study(Pergamon-Elsevier Science Ltd, 2022) Akpinar, Seval; Tekgunduz, Emre; Esen, Ramazan; Yilmaz, Mehmet; Karakus, Volkan; Vural, Filiz; Gediz, FusunTo understand who uses social media and how often they do so, we examined the personality traits that predict frequency of using a set of 10 different types of social media (e.g., social networks, blogs, virtual worlds). Using survey data collected from two large-scale samples of young adults (Exploratory Study 1 N = 1586, Confirmatory Study 2 N =1432), we conducted direct replications of our findings to test whether the observed relationships between social media use and personality traits were reliable. Our replicated findings reveal that sex, age and extraversion are reliable predictors of several types of social media use (e.g., Facebook, Messaging Platforms, Online Forums), while other traits (e.g., agreeableness, Machiavellianism) showed unreliable associations. Our findings also reveal dimensions of multiplatform social media use that categorize the media ecologies of young adults and show significant associations with individual difference measures. (C) 2020 Published by Elsevier Inc.Öğe Turkish Acute Lymphoblastic Leukemia Registry, Retrospective Phase Data(Amer Soc Hematology, 2019) Demirkan, Fatih; Ciftciler, Rafiye; Sevindik, Omur Gokmen; Tekgunduz, Emre; Erkurt, Mehmet Ali; Vural, Filiz; Karakus, Volkan[No Abstract Available]Öğe The Turkish experience with therapeutic plasma exchange: A national survey(Pergamon-Elsevier Science Ltd, 2019) Korkmaz, Serdal; Medeni, Serife Solmaz; Demirkan, Fatih; Besisik, Sevgi Kalayoglu; Dadin, Senem Altay; Cagliyan, Gulsum Akgun; Hacioglu, Sibel Kabukcu; Sari, Ismail; Sahin, Deniz Goren; Arat, Mutlu; Dagdas, Simten; Ozet, Gulsum; Kutlu, Nermin; Akyol, Tulay Karaagac; Ozcebe, Osman Ilhami; Teke, Hava Uskudar; Unal, Demet Kiper; Guner, Naile; Tombak, Anil; Celik, Halil; Bay, Ilker; Kiki, Ilhami; Ozgur, Gokhan; Erkurt, Mehmet Ali; Ozatli, Duzgun; Meletli, Ozgur; Demircioglu, Sinan; Demir, Cengiz; Kurtoglu, Erdal; Vural, Filiz; Tobu, Mahmut; Karakus, Abdullah; Ayyildiz, Orhan; Dal, Mehmet Sinan; Ozturk, Berna Afacan; Albayrak, Murat; Ocakci, Serkan; Bolaman, Zahit; Sonmez, Mehmet; Karakus, Volkan; Sevindik, Omur Gokmen; Berber, Ilhami; Dogu, Mehmet Hilmi; Gulturk, Emine; Ulas, Turgay; Payzin, Bahriye; Kuku, Irfan; Cagirgan, Seckin; Altuntas, FevziTherapeutic plasma exchange (TPE) is used to treat more than 60 diseases worldwide and has drawn growing interest. Little is known about the current situation of TPE activity in Turkey, so we developed a survey to obtain information about this timely topic. We collected data on TPE from 28 apheresis units throughout Turkey. We performed a total of 24,912 TPE procedures with 3203 patients over the past decade. Twenty years ago, the majority of procedures were performed for neurological and hematological disorders, and today, most TPE procedures are done for the same reasons. The only historical change has been an increase in TPE procedures in renal conditions. Currently, renal conditions were more frequently an indication for TPE than rheumatic conditions. Fresh frozen plasma was the most frequently used replacement fluid, followed by 5% albumin, used in 57.9% and 34.6% of procedures, respectively. The most frequently used anticoagulants in TPE were ACD-A and heparin/ACD-A, used with 1671 (52.2%) and 1164 (36.4%) patients, respectively. The frequency of adverse events (AEs) was 12.6%. The most common AEs were hypocalcemia-related symptoms, hypotension, and urticaria. We encountered no severe AEs that led to severe morbidity and mortality. Overall, more than two thirds of the patients showed improvement in the underlying disease. Here, we report on a nationwide survey on TPE activity in Turkey. We conclude that there has been a great increase in apheresis science, and the number of TPE procedures conducted in Turkey has increased steadily over time. Finally, we would like to point out that our past experiences and published international guidelines were the most important tools in gaining expertise regarding TPE.
