Yazar "Karaca, Iclal" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Baclofen Intoxication
    (Galenos Yayincilik, 2015) Bor, Canan; Karaca, Iclal; Karakoc, Ozge; Cankayali, Ilkin; Demirag, Kubilay; Uyar, Mehmet
    Baclofen is a beta-(rho-chlorophenyl) derivative of the neurotransmitter gammaaminobutyric acid (GABA) and is usually prescribed for spasticity of spinal cord origin, intractable hiccup, trigeminal neuralgia, hemifacial spasm, and tardive dyskinesia. The usual recommended daily dose ranges from 40-80 mg, and the total dose should not exceed 80 mg per day. A 41 year old woman using baclofen for migraine therapy intended suicide after a bitter headache attack by taking 37 tablets, 10 mg in each. On arrival to emergency room, she was conscious and co-operable, but somnolent, her pupils were normoisocoric and light reflex was intact bilaterally. On her follow up, respiratory insufficiency and unconsciousness was observed so she was entubated orotracheally and transferred to intensive care unit (ICU) for advanced tests and therapy. No pathology was determined on cranial CT. On ICU follow up, she was unconscious and mechanically ventilated, her Glasgow Coma Scale was 3/ 15 (E1M1VE) and pupils were mid-dilated with no light reflex. Since she was again conscious, oriented and co-operable on 19th hour of arrival to ICU and 20th hour of arrival to emergency room, spontaneous breathing trials was started. Extubation was carried out on her 31th hour of arrival to ICU and 32th hour of arrival to emergency room. In conclusion; since baclofen overdose may cause deep coma, it should also be included in differential diagnosis. According to our opinion, performing diagnostic toxicological tests is not always possible that's why history and physical examination is fundamental in case of baclofen intoxication and we can get good results by giving frequent neurological examination, supportive and extracorporeal therapy in such a case.
  • Küçük Resim Yok
    Öğe
    Protective Effect of Hypothermia During Experimental Sepsis
    (Galenos Yayincilik, 2019) Karaca, Iclal; Cankayali, Ilkin; Demirag, Kubilay; Uyar, Mehmet
    Objective: In our study, we aimed to investigate the effect of hypothermia on survival, C-reactive protein (CRP), procalcitonin and leukocyte levels in rat models, induced with cecal ligation-perforation procedure. Materials and Methods: After formation of the sepsis, the rats were randomized as hypothermic sham, septic (32 degrees C-34 degrees C) and normothermic sham, septic (36 degrees C-38 degrees C). At the beginning of study (0 h) and at 6th hour blood was taken from all rats in all groups; CRP, procalcitonin, leukocyte levels were measured and the survival time of rats in all groups was recorded. Results: A statistically significant difference was found between the hypothermic and normothermic septic group in terms of survival time (hypothermic septic 24.3 +/- 20.2, normothermic septic group 15.9 +/- 13.5 h, p=0.039). There was no statistically significant difference for time dependent changes of CRP and procalcitonin all groups. Conclusion: It can be suggested that hypothermia in experimental sepsis might have positive effects on survival but the effect on the markers of infection is unclear and further studies are needed.