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Öğe Antimicrobial Activity of TiO2-coated Orthodontic Ceramic Brackets against Streptococcus mutans and Candida albicans(Korean Soc Biotechnology & Bioengineering, 2010) Ozyildiz, E.; Guden, M.; Uzel, A.; Karaboz, I.; Akil, O.; Bulut, H.Polycrystalline alumina ceramic orthodontic brackets were coated with anatase TiO2 film via a sol-gel dip-coating method. The surface structure morphology and composition of the films were evaluated via scanning electron microscopy, atomic force microscopy, and X-ray diffraction. The antimicrobial activity of the ceramic brackets was assessed against two oral pathogens, S. mutans and C. albicans. The results demonstrated that TiO2-coated brackets exposed to low energy UV-A illumination efficiently reduced the populations of test microorganisms relative to the uncoated brackets. The reduction efficiencies were 98% for S. mutans ATCC 10449 and 93% for C. albicans ATCC 60193.Öğe Arsenic pollution and arsenic-resistant bacteria of drying Urmia Salt Lake(Frontiers Media SA, 2023) Haghi, M.; Diznabi, S.H.; Karaboz, I.; Ersoy, Omeroglu, E.Extensive arsenic contamination of groundwater, rivers, and agricultural farms has led to widespread arsenic poisoning and consequent problems associated with health and economy. In recent years, many studies have been performed to understand bacterial arsenic detoxification and metabolism which has paved the way for bioremediation applications. This study attempted to isolate and characterize arsenic-resistant bacteria from the drying Urmia lake. As a result of the 16S rDNA analysis, six arsenic-resistant strains were identified as the members of Shouchella, Salipaludibacillus, and Evansella genera. For some of the strains, the maximum tolerance concentration for either arsenate or arsenite was considerably high, 320 and 16 mM, respectively. All the strains harbored the arsenate reductase gene (arsC). The arsenate permease (arsB) gene was identified in all strains except in strains S1, S12, and E15. The metabolic genes of respiratory arsenate reductase (arrB) and arsenite oxidase (arxA) were identified in none of these strains. This feature of the strains with the arsC gene region can be exploited to bioremediate arsenic from contaminated areas by using a two-step process. The second step can be carried out by the adsorption of arsenite to iron oxide or by precipitation with sulfide. Today, more and more ecosystems are being destroyed due to anthropogenic pollution, and it is important to reveal the negative effects and solutions of this situation on the ecosystems. So, the current study provides a potential source of bacteria for such studies that implement bioremediation practices to prevent arsenic catastrophe in vicinal territories, and reveals arsenic pollution in Urmia lake. Copyright © 2023 Haghi, Diznabi, Karaboz and Ersoy Omeroglu.Öğe A new combination immunotherapy approach with anti-PD-L1 and HER2/neu loaded dendritic cell vaccine along with saponin adjuvant(Elsevier Sci Ltd, 2018) Ozverel, C. S.; Karaboz, I.; Nalbantsoy, A.