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    Antimicrobial activity of volatile components and various extracts of the red alga Jania rubens
    (John Wiley & Sons Ltd, 2007) Karabay-Yavasoglu, N. Ulku; Sukatar, Atakan; Ozdemir, Guven; Horzum, Zerrin
    The methanol, dichloromethane, hexane, chloroform and volatile oil extracts of the red alga Jania rubens were tested in vitro for their antimicrobial activity (five Gram-positive, four Gram-negative bacteria and Candida albicans ATCC 10239). GC-MS analysis of the volatile components of J. rubens identified 40 compounds which constituted 77.53% of the total. The volatile components of J. rubens consisted of n-docosane (6.35%), n-eicosane (5.77%) and n-tetratriacontane (5.58%) as major components. The methanol and chloroform extracts (4 mg/disc) showed more potent antimicrobial activity than the hexane and dichloromethane extracts and the volatile oil of J. rubens. Copyright (c) 2006 John Wiley & Sons, Ltd.
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    Evaluation of the antinociceptive and anti-inflammatory activities of Satureja thymbra L. essential oil
    (Taylor & Francis Ltd, 2006) Karabay-Yavasoglu, N. Ulku; Baykan, Sura; Ozturk, Bintug; Apaydin, Sebnem; Tuglular, Isik
    The aim of this study was to investigate the antinociceptive and anti-inflammatory activities of the essential oil of Satureja thymbra L. (Lamiaceae). Antinociceptive activity of the essential oil was measured by the formalin test in mice and by the light tail-flick and hot-plate methods in rats. The paw-edema test was performed in rats to evaluate the anti-inflammatory effect of the essential oil. Motor coordination was assessed with a rotarod apparatus. Although the essential oil produced an antinociceptive effect during both the early (50 and 100 mg kg(-1)) and late phases (25, 50, and 100 mg kg(-1)) of the formalin test, it did not exert any significant antinociceptive and anti-inflammatory effects in tail-flick and paw-edema tests, respectively. In addition, a significant antinociceptive effect was detected in the hot-plate test (100 and 200 mg kg(-1)). No significant change was detected in sensory motor performance. In conclusion, S. thymbra L. essential oil does not exert any anti-inflammatory effect while it may have central analgesic activity in mice and rats.