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Öğe The development of a specific health-related quality of life (QOL) scale for patients with allergic rhinoconjunctivitis [Allerjik rinokonjonktivit hastalari i·çin özel yaşam kalitesi ölçegi geliştirilmesi](Turkiye Klinikleri, 2009) Köse Ş.; Mandiracioglu A.Objective: Allergic rhinitis drastically impairs patients' health-related quality of life (QOL). The aim of this study was to assess the psychometric properties of QOL scale for patients with allergic rhinoconjunctivitis (ARC). Material and Methods: An initial draft questionnaire was designed and a cross-sectional validation study was conducted. Three hundred and seventy five adults with ARC in regional hospitals in İzmir were requested to complete the questionnaire. Test-retest was measured using Pearson's correlation coefficient, internal consistency was estimated using Cronbach's alpha. The questionnaire was readministered to 70 patients 7 days after the first visit for evaluating test-retest reliability. Responsiveness was assessed in a group of 30 patients at baseline and after treatment. Paired t-test was used to examine statistically significant changes of mean scores between pre-treatment and post-treatment periods. Known-group validity was established by comparing ARC symptoms severity scores. A principal component analysis was conducted to examine the construct validity. Results: Test-retest reliability of this new scale ranged from 77% to 84% and internal consistency for these items was excellent (Cronbach's alpha= 0.90). Factor analytical techniques revealed three interpretable scales explaining 52.4% of the total variance: the physical and functional, emotional and daily life problems. Five items were cancelled from the list. The QOL score negatively moderate correlated with ARC symptoms severity scores. The improvements in health were statistically significant for the QOL. Conclusion: Our results suggest that the psychometric properties of the quality of life scale for patients with ARC were good. Copyright © 2009 by Türkiye Klinikleri.Öğe Identification of Brucella species isolated from proven brucellosis patients in Izmir, Turkey(2005) Köse Ş.; Kiliç S.; Özbel Y.In many parts of the world, brucellosis has significantly decreased, but it is still a problem in some regions of Turkey. Totally, 11 Brucella strains isolated from the blood cultures of patients with presumptive diagnosis of brucellosis were identified to species and biovar level. For species identification, (i) CO2 requirements of isolates; (ii) detection of urease activation; (iii) detection of H2S production; (iv) dye sensitivities (thionine and basic fuchsin); (v) susceptibility to Brucella phage and (vi) agglutination with monospecific antisera (A and M) were performed. Ten out of 11 isolates were identified as B. melitensis biovar 3 and one out of 11 were identified as B. melitensis biovar 1. The sensitivity of isolates to antibiotics was determined by the E-test. All isolates were found to be sensitive to doxycycline, rifampin, ciprofloxacin and cephtriaxone. Only one out of 11 isolates was found to be semi-sensitive to trimethoprim/sulfamethoxazole (cotrimoxazole). © 2005 WILEY-VCH Verlag GmbH & Co. KGaA.Öğe Management of chronic hepatitis in special hosts and special situations: A consensus report of the study group for viral hepatitis of the Turkish society of clinical microbiology and infectious diseases [Özel Konaklarda ve Özel Durumlarda Kronik Hepatit Yönetimi: Türk Klinik Mikrobiyoloji ve İnfeksiyon Hastalıkları Derneği Viral Hepatit Çalışma Grubu Uzlaşı Raporu](AVES Ibrahim Kara, 2014) Mıstık R.; Aydın M.; Aksoy S.; Altın N.; Altunal N.; Avşar K.; Bezirgan S.; Büke Ç.; Çelik A.K.; Çelik E.; Dikici N.; Hızel K.; İskender S.; Kaya A.; Korkmaz F.; Köse Ş.; Saçlıgil C.; Sırmatel F.; Tarakçı H.; Turgut H.; Tütüncü E.; Yuluğkural Z.Study Group for Viral Hepatitis of the Turkish Society of Clinical Microbiology and Infectious Diseases convened a meeting to develop a consensus report on management of chronic hepatitis in special hosts and special situations. Relevant literature and international guidelines were reviewed, and recommendations agreed are presented at the end of each section such as therapy of chronic hepatitis B (CHB) in patients with compensated and decompensated cirrhosis, prevention and therapy of recurrent hepatitis B after liver transplantation, management of fulminant hepatitis B, therapy of CHB in hemodialysis patients, management of CHB in nonliver solid organ transplant recipients, management of CHB in immunosuppressed nontransplant patients, therapy of hepatitis B virus (HBV) and human immunodeficiency virus (HIV) coinfection, management of HBV and hepatitis C virus (HCV) coinfection, management of CHB in alcoholic patients and injecting drug users, therapy of CHB in pregnancy and lactation period, extrahepatic manifestations in HBV infection, HBV, HCV and hepatitis D virus coinfection, therapy of chronic hepatitis C (CHC) in patients with compensated and decompensated cirrhosis, treatment of patients with recurrent HCV infection following liver transplantation, therapy of CHC in hemodialysis patients, management of CHC in nonliver solid organ transplant recipients, therapy of HCV, HBV and HIV coinfection, management of CHC in immunosuppressed nontransplant patients, HCV infection and biological agents, HCV infection and chemotherapy, management of CHC in alcoholic patients and injecting drug users, fatty liver and CHC, hemoglobinopathy and CHC, CHC in pregnancy and lactation period, extrahepatic manifestations in HCV infection. Klimik Dergisi © 2014, AVES Ibrahim Kara. All rights reserved.Öğe MEASURING THE KNOWLEDGE LEVEL OF COVID-19 AND ITS TREATMENT IN PHARMACISTS(University of Ankara, 2022) Nalli B.; Köse Ş.; Demir Ö.; Gökmen E.; Özdağ E.; Mandiracioğlu A.Objective: The aim of this study is to measure the knowledge level of pharmacists working in Turkey about COVID-19 Material and Method: The online questionnaire consisting of 16 questions in the form of true-false, developed by the authors after a comprehensive review of the literature, was delivered to pharmacists via social media and professional platforms (such as WhatsApp, Gmail, Instagram, LinkedIn) using the Google form. 364 pharmacists from all over Turkey who filled out the questionnaire were included in the study. Result and Discussion: In this study carried out in Turkey, it was determined that 99.5% of the pharmacists had good knowledge. When the factors affecting the level of knowledge of COVID-19 were examined, in our study, no relationship was found with the independent variables since the level of knowledge was homogeneously high. In the literature, it is reported that age, years of professional experience, having a master's and doctorate education are associated with better knowledge, while the length of experience is associated with the level of knowledge, while in some studies it is stated that no feature is related. However, the fact that it is a cross-sectional study creates a limitation in explaining the cause-effect relationship. Although the number of participants met the sample, it would have been desirable to have more. © 2022 University of Ankara. All rights reserved.Öğe Prevalence of atopy in young healthy population, in Izmir, Turkey(1997) Sin A.; Köse Ş.; Terzioglu E.; Kokuludag A.; Sebik F.; Kabakçi T.The aim of this study was to determine the prevalence of atopy especially in young aged group in which allergic diseases are frequently seen. We carried out this study in İzmir which is located on the west coast of Turkey and has all the characteristics of mediterranean climate. However, we evaluated whether geographical characteristics such as climate, dampness, kinds of plant might be affected on prevalence of atopy. Participants were randomly selected and detailed standard questionnaire about if they or their relatives had any allergic symptoms were applied. The skin prick tests (SPT) with standardized allergen extracts were performed and serum total IgE levels were assayed. The study group consisted of 277 individuals, aged 15-25 years. Based on the questionnaire, 123 (44.4%) participants described positive history of atopy. In 127 of 277 subjects (46%) was found at least one positive skin-test response and the most frequent allergen was house-dust mites. SPT was positive in 68 (55.2%) of 123 subjects who had atopic history and in 59 (38%) of 154 subjects who had negative history of atopy. The subjects who had atopic history showed more frequently positive SPT prevalence than the others (p < 0.01). Geometric mean of total IgE level was 105.5 kU/L in SPT positive 127 subjects and 57.7 kU/L in SPT negative 150 subjects. There was a positive relationship between total IgE level and positive SPT (p < 0.01). History of atopy was correlated with total IgE levels in males (p < 0.01) but not in females. Women more often than men reported atopic history in the absence of true atopy.Öğe Prevalence of latex allergy among healthcare workers in Izmir (Turkey)(Czech National Institute of Public Health, 2014) Köse Ş.; Mandıracıoğlu A.; Tatar B.; Gül S.; Erdem M.The purpose of this study was to determine prevalence of natural rubber latex (NRL) allergy among healthcare employees and identify sensitive individuals. A total of 1,115 healthcare workers (HCWs) employed in Izmir Tepecik Education and Research Hospital participated in the study. Information on age, gender, occupation, history of allergy, and complaints were collected through a questionnaire. Serum latex-specific IgE level was determined. Among HCWs enrolled in the study, prevalence of latex sensitization was determined as 4.2%. More frequent occurrence of latex allergy was detected among nurses. Family history of allergy and history of personal food allergy were significantly more often noted among individuals with latex allergy. Latex is considered to be the leading source of occupational health problems. © 2014, Czech National Institute of Public Health. All rights reserved.Öğe The seroprevalence of hepatitisa in adults in Izmir: Prior to introducing vaccine into routine vaccination program [İzmi·r i·li·nde eri·şki·nlerde hepati·t a vi·rüs seroprevalansi: Ruti·n aşilama programina gi·ri·ş öncesi· durum](2013) Köse Ş.; Mandiracioglu A.; Çavdar G.; Ulu Y.; Nohutcu N.; Gürbüz I.; Sariavci Ş.; Özkan M.Objective: Hepatitis A virus (HAV) is an important public health problem in Turkey. This study was aimed to determine the population-based seroprevalence of HAV in i·zmir. Material and Method: In this cross-sectional study, a representative sample of the population, which was at the age of ?15 years, was selected by using random stratification method. A total of 2156 healthy subjects participated in this present study. Blood specimens were collected for testing anti-HAV IgG, and were examined by using enzymelinked immunosorbent assay (ELISA). A questionnaire was also administered to obtain data regarding demographic characteristics and living conditions of the participants. Results: Anti-HAV IgG positivity was 93.9%. It was found that anti-HAV IgG seropositivity was higher in the subjects with lower income levels, lower education status, at older age, whereas it was lower in younger and single subjects. Conclusion: Improved water and food sanitation resulted in reduced seroprevalence of HAV at younger age groups in i·zmir.
