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Öğe The association of RANK gene C421T and C575T polymorphisms with bone mineral density in postmenopausal Turkish women(Springer Heidelberg, 2013) Isleten, Banu; Durmaz, Burak; Durmaz, Berrin; Onay, Huseyin; Özkınay, Ferda; Durmaz, Asude; Turan, Volkan; Oztekin, KemalTo investigate the association between C421T polymorphism within exon 4, C575T polymorphism within exon 6 of the RANK gene and bone mineral density (BMD) variations in postmenopausal Turkish women. One hundred seventy-eight postmenopausal women (patients = 100 and controls = 78) who applied to Ege University Faculty of Medicine, Department of Physical Medicine and Rehabilitation, for osteoporosis examination were analyzed. BMDs of the lumbar spine and femoral sites were measured. Patient and control groups were established based on their T-score values being above and/or below -1. After venous blood sampling, C421T and C575T polymorphisms of the RANK gene were assessed through PCR process following DNA extraction. Genotype frequencies for the C421T and C575T polymorphisms were compared between the control group and the patient group. No significant difference was detected between the two groups for both polymorphisms. There was also no significant difference between the control and patient groups in terms of the combined genotype (p = 0.752) and the combined haplotype analysis of the C421T and C575T polymorphisms (p = 0.723). In the control and patient groups separately, no significant differences in BMD values either at the femoral sites or at the lumbar spine were detected between the combined genotypes of the two polymorphisms. The genotypes, combined genotypes and allele frequencies of C421T and C575T polymorphisms of the RANK gene have not been found to be associated with BMD in Turkish women. Further studies including both sexes and more cases are required.Öğe Bisphosphonate-Related Osteonecrosis of the Jaw Bones in a Patient with Ankylosing Spondylitis Receiving Anti-Tumor Necrosis Factor Treatment(Turkish League Against Rheumatism, 2011) Isleten, Banu; Hepguler, Simin; Bayraktaroglu, Selen; Keser, GokhanBisphosphonate-related osteonecrosis of the jaw bones is a rare, but well-recognized pathology, occurring mainly in patients receiving parenteral and high doses of bisphosphonates for the treatment of skeletal metastasis and/or hypercalcemia associated with cancer. However, to a lesser extent, this complication may also occur in patients receiving oral bisphosphonates for the treatment of osteoporosis. In this article, we present a 58-year-old female patient with ankylosing spondylitis (AS) who developed mandible osteonecrosis following long-term oral alendronate treatment for osteoporosis. Dental tooth extraction possibly triggered the occurrence of mandible osteonecrosis in this patient. This patient is notable for receiving concomitant anti-tumor necrosis factor (anti-TNF) treatment. To our knowledge, occurrence of bisphosphonate-related jaw osteonecrosis in a patient with AS receiving concomitant anti-TNF treatment has not been reported previously in the literature.Öğe Does the Use of Electrotherapies Increase the Effectiveness of Neck Stabilization Exercises for Improving Pain, Disability, Mood, and Quality of Life in Chronic Neck Pain?(Lippincott Williams & Wilkins, 2018) Yesil, Hilal; Hepguler, Simin; Dundar, Umit; Taravati, Sahel; Isleten, BanuStudy Design. This study was a prospective, randomized, controlled study. Objective. The aim of this study was to determine whether transcutaneous electrical nerve stimulation (TENS) or interferential current (IFC) increase the effectiveness of neck stabilization exercises (NSEs) on pain, disability, mood and quality of life for chronic neck pain (CNP). Summary of Background Data. Neck pain is one of the three most frequently reported complaints of the musculoskeletal system. Electrotherapies, such as IFC and TENS, have been applied solo or combined with exercise for management of neck pain; however, the efficacy of these combinations is unclear. Methods. A total of 81 patients with CNP were included in this study. Patients were randomly assigned into three groups regarding age and gender. First group had NSE, second group had TENS and NSE, and third group had IFC and NSE. Pain levels [visual analogue scale (VAS)], limits of cervical range of motion (ROM), quality of life (short form-36), mood (Beck depression inventory), levels of disability (Neck Pain and Disability Index), and the need for analgesics of all patients were evaluated before treatment, at 6th and 12th week follow-up. Physical therapy modalities were applied for 15 sessions in all groups. All participants had group exercise accompanied by a physiotherapist for 3 weeks and an additional 3 weeks of home exercise program. Results. According to the intragroup assessment, the study achieved its purpose of pain reduction, ROM increase, improvement of disability, quality of life, mood and reduction in drug use in all three treatment groups (P < 0.05). However, clinical outcomes at 6th and 12 th week had no significant difference among the three groups (P > 0.05). Conclusion. TENS and IFC therapies are effective in the treatment of CNP patients. However, they have no additional benefit or superiority over NSE.Öğe Efficacy of Therapeutic Ultrasound for the Management of Knee Osteoarthritis(Lippincott Williams & Wilkins, 2014) Cakir, Serap; Hepguler, Simin; Ozturk, Cihat; Korkmaz, Murat; Isleten, Banu; Atamaz, Funda CalisObjective The aim of this study was to compare whether the effectiveness of continuous ultrasound (US) was superior against pulsed US and against sham US in knee osteoarthritis. Design A randomized controlled study was carried out on 60 patients diagnosed with knee osteoarthritis according to American College of Rheumatology. The patients were randomized into the following three treatments: (1) continuous US (at a frequency of 1 MHz with intensity of 1 W/cm(2)), (2) pulse US (same frequency and intensity on 1:4 pulse ratio), and (3) sham US. All treatments were applied with 5-cm(2) head US device five times a week for 2 weeks in addition to home exercise program including quadriceps isometric exercise, muscle strength exercises, and stretching exercises of the lower extremity muscles for at least three times per week. Assessments were performed at baseline, at the end of the treatment, and at the end of the treatments and at the sixth month using the following measurements: Western Ontario and McMaster University Osteoarthritis Index-pain, stiffness, function, visual analog scale-pain at rest, visual analog scale-pain on movement, visual analog scale-disease severity, and 20-m walking time. Among these parameters, the Western Ontario and McMaster University Osteoarthritis Index-pain was the primary outcome. Results All groups showed a significant improvement in all parameters in both following visits (P < 0.05). However, there was no significant difference between the groups. Although the mean reduction percent in Western Ontario and McMaster University Osteoarthritis Index-pain was significantly higher in group I (continuous US) when compared to sham group (46.5% vs 28.9%, P < 0.05) at the end of the treatment, this result was not found in other pain parameters. Conclusions The present study demonstrated that all assessment parameters significantly improved in all groups without a significant difference. This result suggested that therapeutic US provided no additional benefit in improving pain and functions in addition to exercise training.Öğe Traumatic Central Cord Syndrome: A Case Report(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2009) Isleten, Banu; Ozturk, Cihat; Hepgueler, SiminThe central cord syndrome is the most common type of the incomplete traumatic cervical cord syndromes. First described by Schneider in 1954, it is characterized by disproportionately greater motor impairment in the upper than in the lower extremities, bladder dysfunction, and varying degrees of sensory loss below the level of lesion. It has generally good prognosis for neurological and functional recovery. In this article, a 64-year-old male patient, diagnosed as central cord syndrome because of spinal cord injury is presented and discussed in the light of the relevant literature. Turk J Phys Med Rehab 2009;55:128-31.Öğe Traumatic Central Cord Syndrome: A Case Report(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2009) Isleten, Banu; Ozturk, Cihat; Hepgueler, SiminThe central cord syndrome is the most common type of the incomplete traumatic cervical cord syndromes. First described by Schneider in 1954, it is characterized by disproportionately greater motor impairment in the upper than in the lower extremities, bladder dysfunction, and varying degrees of sensory loss below the level of lesion. It has generally good prognosis for neurological and functional recovery. In this article, a 64-year-old male patient, diagnosed as central cord syndrome because of spinal cord injury is presented and discussed in the light of the relevant literature. Turk J Phys Med Rehab 2009;55:128-31.
