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    Pulmonary complications of chemical pneumonia; a case report
    (Soc Argentina Pediatria, 2016) Erdem, Semiha Bahceci; Nacaroglu, Hikmet T.; Isguder, Rana; Karkiner, Canan S. Unsal; Alper, Hudaver; Can, Demet
    Hydrocarbon aspiration (HA) can cause significant lung disease by inducing an inflammatory response, hemorrhagic exudative alveolitis, and loss of surfactant function. The most serious side effect of HA is aspiration pneumonia. Pneumothorax, pneumatocele, acute respiratory distress syndrome (ARDS), pulmonary abscess, bronchopleural fistula, bilateral hemorrhagic pleural effusion and pyopneumothorax were previously reported. Hereby we report a patient hospitalized due to aspiration pneumonia who developed pleurisy and pneumothorax after drinking paint thinner. It is presented as it was seldom reported in children to cause distinct pulmonary complications. Patients with complaints associated with hydrocarbon poisoning must be fully evaluated. They must not be discharged from the hospital early and must be followed for at least 48 hours even if they don't have respiratory symptoms. It should be kept in mind that severe pulmonary complications can develop in patients with chemical pneumonia.
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    Surface TREM-1 as a Prognostic Biomarker in Pediatric Sepsis
    (Springer India, 2020) Sen, Semra; Kamit, Fulya; Isguder, Rana; Yazici, Pinar; Bal, Zumrut Sahbudak; Devrim, Ilker; Vardar, Fadil
    Objectives To investigate the association between the triggering receptor expressed on myeloid cells-1 (TREM-1) levels and prognosis in septic children. Methods Patients admitted to pediatric intensive care units (PICU) of three tertiary centers were included in this prospective observational study. Serum samples were taken at admission from patients who were hospitalized with sepsis. Results of the 87 patients included, 34 (39.1%) had severe sepsis and 53 (60.9%) had septic shock. the median age was 2 y (2 mo to 16 y). TREM-1 values were found to be significantly higher in septic shock patients 129 pg/ml (min 9.85- max 494.90) compared to severe sepsis 105 pg/ml (min 8.21- max 289.17) (p = 0.048). Despite higher TREM-1 levels been measured in non-survivors compared to survivors, it was not statistically significant [168.98 pg/ml (min 9.85- max 494.90) vs. 110.79 pg/ml (min 8.21- max 408.90), (p = 0.075)]. Conclusions Admission TREM-1 levels were higher in septic shock compared to severe sepsis patients. There was no association between mortality and TREM-1 levels in sepsis. TREM-1 measurements should be used carefully in pediatric sepsis prognosis.
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    Two Siblings with Beta-Ketothiolase Deficiency: One Genetic Defect Two Different Pictures
    (Galenos Yayincilik, 2016) Kose, Melis Demir; Canda, Ebru; Kagnici, Mehtap; Isguder, Rana; Unalp, Aycan; Ucar, Sema Kalkan; Bahr, Luzy; Britschgi, Corinne; Sass, Jorn Oliver; Coker, Mahmut
    Deficiency of mitochondrial acetoacetyl-coenzyme A thiolase T2 (methylacetoacetyl-coenzyme A thiolase, MAT) or beta-ketothiolase is a rare autosomal recessive disorder that is characterized by ketoacidosis episodes. Outcomes vary from normal development to severe cognitive impairment or even death after an acute episode of ketoacidosis. The classical biochemical profile of T2 deficiency is a result of mutations in both alleles of the ACAT1 gene and comprises characteristic abnormalities in urinary organic acids and blood or plasma acylcarnitine profiles. In this study, we present two sibling cases with quite different clinical properties.