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Öğe Assessment of disease activity in large-vessel vasculitis: Results of an international delphi exercise(Journal of Rheumatology, 2017) Aydin S.Z.; Direskeneli H.; Merkel P.A.; Toloza S.; Blockmans D.; Sato E.I.; De Souza A.W.S.; Cabral D.; Carette S.; Famorca L.; Khalidi N.; Milman N.; Yacyshyn E.; Tesar V.; Baslund B.; Faurschou M.; Guillevin L.; Puéchal X.; Aries P.; Hellmich B.; Herlyn K.; Holle J.; Lamprecht P.; Moosig F.; Neumann T.; Zwerina J.; Tómasson G.; Bambery P.; Jois R.; Rajasekhar L.; Sharma A.; Sivakumar R.; Molloy E.; Hashkes P.; Catapano F.; Cimino L.; De Fanti A.; Pipitone N.; Salvarani C.; Vaglio A.; Kobayashi S.; Suzuki K.; Flores-Suárez L.F.; Hinojosa-Azaola A.; Brouwer E.; Rutgers A.; Stegeman C.; Suppiah R.; Hollan I.; Arguis P.; Cid M.C.; Daikeler T.; Alibaz-Oner F.; Hamuryudan V.; Hatemi G.; Hazirolan T.; Inanc M.; Kalayci M.B.; Kamali S.; Kansu T.; Karaaslan Y.; Karadag O.; Keser G.; Onat A.M.; Ozbalkan Z.; Ozen S.; Ozer H.T.E.; Pamuk Ö.N.; Yilmaz S.G.; Basu N.; Casian A.; Chakravarty K.; D'Cruz D.; Edelsten C.; Harper L.; Jayne D.; Levy J.; Mason J.; Robson J.; Scott D.; Stanford M.; Watts R.; Albert D.; Amudala N.; Beckman J.; Chacko B.; Chung S.; Fessler B.; Giardino A.; Grayson P.; Hunder G.; Langford C.; Lerman M.; Liang K.; Litt H.; Mason T.; Matteson E.; Mikdashi J.; Mohler E.; Monach P.; Rice B.; Sharma A.; Sreih A.; Stone J.; Tsapatsaris N.; Villa-Forte A.; Warrington K.; Yazici Y.; Ytterberg S.Objective. To arrive at consensus for candidate outcomes for disease activity assessment in largevessel vasculitis (LVV) in clinical trials. Methods.A Delphi survey including 99 items was circulated among international experts for 3 rounds. Results. Fifty-seven items were accepted for both giant cell arteritis and Takayasu arteritis. Sixty-seven percent of experts voted to have a common approach for both diseases with additional disease-specific items such as weight loss, scalp tenderness/necrosis, morning stiffness, dizziness, visual symptoms, and imaging. Conclusion. This study highlights similarities and differences in experts' perspectives for assessing clinical activity in LVV and may guide a consensus-driven core set of validated outcomes. Copyright © 2017. All rights reserved.Öğe Assessment of patients with Takayasu arteritis in routine practice with Indian Takayasu clinical activity score(Journal of Rheumatology, 2015) Alibaz-Oner F.; Aydin S.Z.; Akar S.; Aksu K.; Kamali S.; Yucel E.; Karadag O.; Ozer H.; Kiraz S.; Onen F.; Inanc M.; Keser G.; Akkoc N.; Direskeneli H.Objective. To assess the Indian Takayasu Clinical Activity Score (ITAS2010) in followup of Takayasu arteritis (TA). Methods. ITAS2010 forms were filled in prospectively (n = 144). Clinical activity was assessed with physician's global assessment (PGA) and criteria defined by Kerr, et al. Results. ITAS2010 was significantly higher in patients with active disease. Total agreement between ITAS2010 and PGA was 66.4%, and between ITAS2010 and Kerr, et al was 82.8%. During followup, 14 of 15 patients showing vascular progression with imaging were categorized as having inactive disease according to ITAS2010. Conclusion. ITAS2010 was discriminatory for activity during the followup, but the agreement between PGA and ITAS2010 was moderate. Future work should include the incorporation of advanced vascular imaging and demonstration of ITAS2010 as a scalable measure and not simply a dichotomous measure of activity/flare versus remission. © 2015 The Journal of Rheumatology. All rights reserved.Öğe Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: Results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database(2010) Avouac J.; Walker U.; Tyndall A.; Kahan A.; Matucci-Cerinic M.; Allanore Y.; Miniati I.; Müller A.; Iannone F.; Giacomelli R.; Distler O.; Becvar R.; Sierakowsky S.; Kowal-Bielecka O.; Coelho P.; Cabane J.; Cutolo M.; Shoenfeld Y.; Valentini G.; Rovensky J.; Riemekasten G.; Nicoara I.; Vlachoyiannopoulos P.; Caporali R.; Jiri S.; Inanc M.; Gorska I.Z.; Carreira P.; Novak S.; Czirjak L.; Ramos F.O.; Jendro M.; Chizzolini C.; Kucharz E.J.; Richter J.; Cozzi F.; Rozman B.; Mallia C.M.; Gabrielli A.; Farge D.; Kiener H.P.; Schöffel D.; Sticherling M.; Airo P.; Wollheim F.; Martinovic D.; Trotta F.; Hunzelmann N.; Jablonska S.; Reich K.; Bombardieri S.; Siakka P.; Pellerito R.; Bambara L.M.; Morovic-Vergles J.; Denton C.; Hinrichs R.; Van Den Hoogen F.; Damjanov N.; Kötter I.; Ortiz V.; Heitmann S.; Krasowska D.; Seidel M.; Hasler P.; Van Laar J.M.; Kaltwasser J.P.; Foeldvari I.; Juan Mas A.; Bajocchi G.; Wislowska M.; Pereira Da Silva J.A.; Jacobsen S.; Worm M.; Graniger W.; Kuhn A.; Stankovic A.; Cossutta R.; Majdan M.; Rajcevska L.D.; Tikly M.; Nasonov E.L.; Steinbrink K.; Herrick A.; Müller-Ladner U.; Dinc A.; Scorza R.; Sondergaard K.; Indiveri F.; Nielsen H.; Szekanecz Z.; Silver R.M.; Antivalle M.; Espinosa I.B.; García De La Pena Lefebvre P.; Midtvedt O.; Launay D.; Valesini F.; Tuvik P.; Ionescu R.M.; Del Papa N.; Pinto S.; Wigley F.; Mihai C.; Capranu M.S.; Sunderkötter C.; Jun J.B.; Derk C.; Alhasani S.; Distler J.H.; Ton E.; Soukup T.; Seibold J.; Zeni S.; Nash P.; Mouthon L.; De Keyser F.; Duruöz M.T.; Cantatore F.P.; Strauss G.; Von Mülhen C.A.; Pozzi M.R.; Eyerich K.; Szechinski J.; Keiserman M.; Houssiau F.A.; Rom-Ivorra J.A.; Krummel-Lorenz B.; Aringer M.; Westhovens R.; Bellisai F.; Mayer M.; Stoeckl F.; Üprus M.; Volpe A.; Buslau M.; Yavuz S.; Granel B.; Feijó A.V.; Del Galdo F.; Popa S.; Zenone T.; Machado X.R.; Pileckyte M.; Stebbings S.; Mathieu A.; Tulli A.; Tourinho T.; Souza R.; Acayaba De Toledo R.; Stamp L.; Solanki K.; Veale D.; Neto J.F.M.; Bagnato G.F.; Loyo E.; Toloza S.; Li M.; Mohamed W.A.A.A.; Cobankara V.; Olas J.; Salsano F.; Oksel F.; Tanaseanu C.M.; Foti R.; Ancuta C.; Vonk M.; Caramashi P.; Beretta L.; Balbir A.; Shine B.; Chiàla A.; Simic K.P.; Ghio M.; Stamenkovic B.; Rednic S.; Host N.; Pellerito R.; Hachulla E.; Furst D.E.Objective. To determine the prevalence of and independent factors associated with joint involvement in a large population of patients with systemic sclerosis (SSc). Methods. This study was cross-sectional, based on data collected on patients included in the European League Against Rheumatism (EULAR) Scleroderma Trials and Research (EUSTAR) registry. We queried this database to extract data regarding global evaluation of patients with SSc and the presence of any clinical articular involvement: synovitis (tender and swollen joints), tendon friction rubs (rubbing sensation detected as the tendon was moved), and joint contracture (stiffness of the joints that decreased their range of motion). Overall joint involvement was defined by the occurrence of synovitis and/or joint contracture and/or tendon friction rubs. Results. We recruited 7286 patients with SSc; their mean age was 56 ± 14 years, disease duration 10 ± 9 years, and 4210 (58%) had a limited cutaneous disease subset. Frequencies of synovitis, tendon friction rubs, and joint contractures were 16%, 11%, and 31%, respectively. Synovitis, tendon friction rubs, and joint contracture were more prevalent in patients with the diffuse cutaneous subset and were associated together and with severe vascular, muscular, renal, and interstitial lung involvement. Moreover, synovitis had the highest strength of association with elevated acute-phase reactants taken as the dependent variable. Conclusion. Our results highlight the striking level of articular involvement in SSc, as evaluated by systematic examination in a large cohort of patients with SSc. Our data also show that synovitis, joint contracture, and tendon friction rubs are associated with amore severe disease and with systemic inflammation. The Journal of Rheumatology Copyright © 2010. All rights reserved.Öğe Co-creation of tourism experiences: A conceptual framework(Taylor and Francis Inc., 2020) Inanc M.; Kozak M.[No abstract available]Öğe Identification of susceptibility loci in IL6, RPS9/LILRB3, and an intergenic locus on chromosome 21q22 in takayasu arteritis in a genome-wide association study(John Wiley and Sons Inc., 2015) Renauer P.A.; Saruhan-Direskeneli G.; Coit P.; Adler A.; Aksu K.; Keser G.; Alibaz-Oner F.; Aydin S.Z.; Kamali S.; Inanc M.; Carette S.; Cuthbertson D.; Hoffman G.S.; Akar S.; Onen F.; Akkoc N.; Khalidi N.A.; Koening C.; Karadag O.; Kiraz S.; Langford C.A.; Maksimowicz-Mckinnon K.; McAlear C.A.; Ozbalkan Z.; Ates A.; Karaaslan Y.; Duzgun N.; Monach P.A.; Ozer H.T.E.; Erken E.; Ozturk M.A.; Yazici A.; Cefle A.; Onat A.M.; Kisacik B.; Pagnoux C.; Kasifoglu T.; Seyahi E.; Fresko I.; Seo P.; Sreih A.G.; Warrington K.J.; Ytterberg S.R.; Cobankara V.; Cunninghame-Graham D.S.; Vyse T.J.; Pamuk O.N.; Ercan Tunc S.; Dalkilic E.; Bicakcigil M.; Yentur S.P.; Wren J.D.; Merkel P.A.; Direskeneli H.; Sawalha A.H.Objective Takayasu arteritis is a rare large vessel vasculitis with incompletely understood etiology. This study was undertaken to perform the first unbiased genome-wide association analysis of Takayasu arteritis. Methods Two independent cohorts of patients with Takayasu arteritis from Turkey and North America were included in our study. The Turkish cohort consisted of 559 patients and 489 controls, and the North American cohort consisted of 134 patients and 1,047 controls of European ancestry. Genotyping was performed using the Omni1-Quad and Omni2.5 genotyping arrays. Genotyping data were subjected to rigorous quality control measures and subsequently analyzed to discover genetic susceptibility loci for Takayasu arteritis. Results We identified genetic susceptibility loci for Takayasu arteritis with a genome-wide level of significance in IL6 (rs2069837) (odds ratio [OR] 2.07, P = 6.70 × 10-9), RPS9/LILRB3 (rs11666543) (OR 1.65, P = 2.34 × 10-8), and an intergenic locus on chromosome 21q22 (rs2836878) (OR 1.79, P = 3.62 × 10-10). The genetic susceptibility locus in RPS9/LILRB3 lies within the leukocyte receptor complex gene cluster on chromosome 19q13.4, and the disease risk variant in this locus correlates with reduced expression of multiple genes including the inhibitory leukocyte immunoglobulin-like receptor gene LILRB3 (P = 2.29 × 10-8). In addition, we identified candidate susceptibility genes with suggestive levels of association (P < 1 × 10-5) with Takayasu arteritis, including PCSK5, LILRA3, PPM1G/NRBP1, and PTK2B. Conclusion Our findings indicate novel genetic susceptibility loci for Takayasu arteritis and uncover potentially important aspects of the pathophysiology of this form of vasculitis. © 2015, American College of Rheumatology.Öğe PTPN22 gene polymorphism in Takayasu's arteritis(2008) Sahin N.; Aksu K.; Kamali S.; Bicakcigil M.; Özbalkan Z.; Fresko I.; Özer H.; Akar S.; Onat A.M.; Çobankara V.; Kiraz S.; Öztürk M.A.; Tunç E.; Yücel E.; Ateş A.; Keser G.; Inanc M.; Direskeneli H.; Saruhan-Direskeneli G.Objective. Takayasu's arteritis (TA) is a chronic, rare granulomatous panarteritis of unknown aetiology involving mainly the aorta and its major branches. In this study, genetic susceptibility to TA has been investigated by screening the functional single nucleotide polymorphism (SNP) of PTPN22 gene encoding the lymphoid-specific protein tyrosine phosphatase. Methods. Totally, 181 patients with TA and 177 healthy controls are genotyped by PCR-RFLP method for the SNP rs2476601 (A/G) of PTPN22 gene. Polymorphic region was amplified by PCR and digested with Xcm I enzyme. Results. Detected frequencies of heterozygous genotype (AG) were 5.1% (9/177) in control group and 3.8% (7/181) in TA group (P = 0.61, odds ratio: 0.75, 95% CI: 0.3, 2.0). No association with angiographic type, vascular involvement or prognosis of TA was observed either. Conclusion. The distribution of PTPN22 polymorphism did not reveal any association with TA in Turkey. © The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.
