Yazar "Gurlek, Ceren" seçeneğine göre listele

Listeleniyor 1 - 6 / 6
  • Küçük Resim Yok
    Öğe
    Caries-Preventive Effect and Retention of Glass-Ionomer and Resin-Based Sealants: A Randomized Clinical Comparative Evaluation
    (Hindawi Ltd, 2022) Uzel, Ilhan; Gurlek, Ceren; Kuter, Berna; Ertugrul, Fahinur; Eden, Ece
    Background. Deep fissures are highly unprotected from the development of caries. Resin-based materials and glass-ionomer cements for sealing fissures are useful in caries control through physical barrier formation, which prohibits metabolic exchange between fissure microorganisms. Retention is one of the most critical properties of fissure sealants. This in vivo study is aimed at comparing and evaluating the clinical efficacy of resin and glass ionomer-based fissure sealants on first permanent molars with follow-ups at 6-, 12-, and 18-month intervals. Methods. A randomized split-mouth design clinical study was conducted after obtaining the ethical committee approval. A total of 50 patients, aged between 7 and 12 years, were randomized and enrolled in the study to perform a total of 200 sealant placements on all four caries-free and hypoplasia-free first permanent molars having deep fissures, which are susceptible to caries, were included in this study. The four permanent molars were divided into the following four groups: group A (control), B (Grandioseal, Voco, Germany), C (Smartseal & Loc, Detax Gmbh & Co, Germany), and D (Fuji triage capsule, GC, Belgium). The sealed molars were clinically evaluated at intervals of 6, 12, and 18 months to assess sealant retention, surface roughness, marginal coloration, and caries status through visual evaluation of the sealant by two evaluators. Results. Concerning retention, there were statistically significant differences between the sealants in terms of the survival of partial and fully retained sealants as well as in the survival of caries-free teeth. Two resin-based (Smartseal & Loc) and glass-ionomer cement (Fuji triage) sealants showed significantly similar performances in permanent molars for up to 18 months. In terms of retention, one of the resin-based (Grandioseal) sealants performed better as compared to the others and showed better caries prevention in deep fissures. Conclusion. It is concluded that both the sealants had comparable retention and caries-preventive effects in 7 to 12-year-old children and can be considered as suitable sealants for a period of at least 18 months in moderate caries risk patients.
  • Küçük Resim Yok
    Öğe
    Evaluation of Several Microalgal Extracts as Bioactive Metabolites as Potential Pharmaceutical Compounds
    (Springer, 2020) Gurlek, Ceren; Yarkent, Cagla; Kose, Ayse; Oral, Izel; Oncel, Suphi S.; Elibol, Murat
    The nature derived therapeutics is getting intense attention rather than chemical synthesis and synthetic ones. Today the expansion of natural bioactive molecule market is started to be dominated and generic drug and therapeutic understanding looks like to leave its place to a new horizon. Thus, natural originated therapeutics under controlled production conditions are of importance. Besides the public attention on natural molecules are also gain advance and the demand on this bioactive molecules is also increasing dramatically. the bioactive molecules from microalgae show antioxidant, antibacterial, antiviral, anticancer, skin regenerative, sunscreen, antihypertensive, neuroprotective and immunostimulatory effects which are favorable for pharmaceutical, nutraceutical and cosmetics industry. Also a new concept known as functional nutrition also broaden the acceptability and utilization of microalgae derived bioactive metabolites in new dietary formulations. the expansion of microalgal biotechnology and the number of research gained from the role of biologically active microalgal metabolites display the emergence of the microalgae farming for new pharmaceutical formulations. in this study, we prepared solvent and water extracts of G. sulphuraria, N. texensis, S. bacillaris, E. carotinosa, C. minutissima, S. limacinum, C. cohnii, and C. vulgaris. Antioxidant activity using DPPH radical scavenging activity and total phenolic compounds were measured from the methanolic extracts and water extracts. With the bioactive extracts cytotoxicity test were performed on Hep-G2 and B16-F10 cell lines. the results display potential onset of novel therapeutic compounds derived from microalgae.
  • Küçük Resim Yok
    Öğe
    Nutraceutical Aspects of Microalgae Will Our Future Space Foods Be Microalgae Based?
    (Crc Press-Taylor & Francis Group, 2020) Gurlek, Ceren; Yarkent, Cagla; Oral, Izel; Kose, Ayse; Oncel, Suphi S.
    [No abstract available]
  • Küçük Resim Yok
    Öğe
    Plaque Accumulation and Inflammation Adjacent to Restorations of Amorphous Calcium Phosphate-containin Composite in Early Childhood Caries
    (Quintessence Publishing Co Inc, 2018) Gurlek, Ceren; Ertugrul, Fahinur; Nile, Christopher; Lappin, David F.; Buduneli, Nurcan
    Purpose: To evaluate the clinical, biochemical, and microbiological reactions to nanocomposite containing amorphous calcium phosphate (ACP) in comparison to a traditional composite restorative material in early childhood caries. Materials and Methods: Eighteen teeth were restored with the test material (ACP-containing resin) and 18 teeth were restored with the control material (traditional composite, TC) in fourteen paediatric patients using a splitmouth design. One caries- and restoration-free intact tooth in each patient was selected as the healthy control. Gingival crevicular fluid (GCF) and supragingival plaque samples were collected at baseline before the treatment and also on days 1, 7, 14 and 30 after treatment. Unstimulated whole saliva samples were obtained from each patient at baseline, and 1 and 6 months after restoration. GCF and saliva samples were assayed for IL-17A, IL-17F IL-17A/F, IL-17E, OPG and RANKL levels by ELISA, and plaque composition was assessed using RT-PCR. Results: Clinical evaluation indicated no statistically significant differences between the two restorative materials according to the FDI criteria surface lustre, material retention and marginal adaptation properties. Pro-inflammatory IL-17 levels decreased statistically significantly at 6 months compared to baseline and 1-month values (p < 0.05). The baseline pro-inflammatory IL-17 cytokine levels in GCF samples around the carious teeth were higher than those obtained around the healthy teeth (p < 0.05), but similar in GCF from the ACP-test and TC teeth. Microbiological findings were similar in the ACP and T groups. Conclusion: It may be suggested that both ACP-containing and traditional resin composites show similar antimicrobial and biochemical effects in early childhood caries.
  • Küçük Resim Yok
    Öğe
    Potential of microalgal compounds in trending natural cosmetics: A review
    (Elsevier, 2020) Yarkent, Cagla; Gurlek, Ceren; Oncel, Suphi S.
    Microalgae are photosynthetic organisms that produce valuable metabolites as a result of being constantly exposed to stress conditions such as high or low temperature, high salinity, osmotic pressure, photo-oxidation, and ultraviolet radiation. These valuable metabolites drew attention from cosmetic and cosmeceutical industries to be used in anti-aging, sunscreen, and skin whitening products. Microalgal secondary metabolites can have anti-blemish or anti-microbial effect; can also repair and heal skin, protect skin from UV damage, and prevent inflammation. Existing cosmetic products can be replaced by microalgae derived cosmetic products which are environment-friendly and safe which make them publicly important since people want to have products as natural as possible. Currently some microalgal derived products are commercially available and biotechnology of microalgae is getting more and more developed every day which will be resulted in more commercial products in short period of time. This review highlights the potential of microalgae species and, bioactive molecules derived by them in trending natural cosmetics with a special emphasis on application areas and production steps.
  • Küçük Resim Yok
    Öğe
    Screening of antioxidant and cytotoxic activities of several microalgal extracts with pharmaceutical potential
    (Springer Heidelberg, 2020) Gurlek, Ceren; Yarkent, Cagla; Kose, Ayse; Tugcu, Basak; Gebeloglu, Ilgin Kimiz; Oncel, Suphi S.; Elibol, Murat
    The bioactive molecules from microalgae have important properties such as antioxidant, anticancer, antiviral, antibacterial, antihypertensive, skin regenerative, neuroprotective, sunscreen, and, immunostimulatory effects. Bioactive molecules derived from microalgae is getting intense attention from pharmaceuticals, cosmetics and nutraceuticals industries because of these properties and numerous researches have been done to investigate the role of these bioactive molecules that can enlighten microalgal biotechnology to result in new nature derived pharmaceutical formulations. in this study we investigate antioxidant activities of crude extracts of G. Galdieria sulphuraria, Ettlia carotinosa, Neochloris texensis, Chlorella minutissima, Stichococcus bacillaris, Schizochytrium limacinum, Crypthecodinium cohnii, and Chlorella vulgaris with determining radical scavenging activity (RSA) by DPPH (2,2-diphenyl-1-picrylhydrazyl hydrate radical) method and total phenolic content by Folin-Ciocalteu method. Selected extracts according to their antioxidant activities cytotoxicity was evaluated after exposure to human hepatocellular liver carcinoma cells (HepG2) for 48 h. Antioxidant activities of these species ranged from 89 to 95% RSA (radical scavenging activity) while their phenolic contents were also very high, varied from 41 to 312 mg GAE (gallic acid equivalents)/mg extract. MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay also showed microalgae has a potential to be used as a novel therapeutic compound.