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Öğe Assessment of left ventricular function by strain echocardiography in healthy first degree relatives of non-familial idiopathic dilated cardiomyopathy patients(Oxford Univ Press, 2014) Gurgun, C.; Okten, M. S.; Simsek, E.Öğe Changes in plasma neprilysin levels after left ventricular assist device implantation and association of outcomes during 1-year follow-up(Wiley, 2019) Yuce, E. I. Elif Ilkay; Demir, E.; Simsek, E.; Ozturk, P.; Parildar, Z.; Engin, C.; Yagdi, T.; Ozbaran, M.; Nalbantgil, S.; Gurgun, C.Öğe Changes in plasma neprilysin levels after left ventricular assist device implantation and association with short-term outcomes(Oxford Univ Press, 2018) Yuce, E. I.; Demir, E.; Simsek, E.; Ozturk, P.; Parildar, Z.; Engin, C.; Yagdi, T.; Ozbaran, M.; Nalbantgil, S.; Gurgun, C.Öğe Effect of increasing doses of rosuvastatin on lipoprotein particles and inflammatory parameters in patients with metabolic syndrome and low HDL level(Oxford Univ Press, 2011) Ural, D.; Sansoy, V.; Yigit, Z.; Esen, A. M.; Oguzhan, A.; Gurgun, C.; Kutlu, M.; Boyaci, B.; Yuksel, H.Öğe Etiology and risk evaluation in prosthetic valve dysfunctions and re-operation(Oxford Univ Press, 2006) Duygu, H.; Cinar, C. S.; Gurgun, C.Öğe Increased TIMI frame counts in patients without significant coronary atherosclerosis but with left ventricular dysfunction during dobutamine stress echocardiography(Oxford Univ Press, 2005) Yavuzgil, O.; Gurgun, C.; Ildizli, M.; Cinar, C. S.; Ozerkan, F.; Kultursay, H.Öğe OUR RESULTS OF ALCOHOL SEPTAL ABLATION IN SYMPTOMATIC PATIENTS WITH HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY(Elsevier Ireland Ltd, 2011) Yavuzgil, O.; Tuluce, K.; Gurgun, C.; Kultursay, H.; Payzin, S.; Hasdemir, C.; Can, L. H.; Turkoglu, C.Öğe Prevalence and characteristics of inappropriate sinus tachycardia in the outpatient clinic of a tertiary hospital(Oxford Univ Press, 2017) Simsek, E.; Ozbay, B.; Mutlu, I.; Baskovski, E.; Gurses, E.; Kemal, H.; Gurgun, C.Öğe Relation between NT-proBNP levels, iron overload and early stage of myocardial dysfunction in beta-thalassemia major patients(Oxford Univ Press, 2011) Tuluce, K.; Tuluce, S. Yakar; Balkan, C.; Basol, G.; Ay, Y.; Yilmaz, D.; Gurgun, C.; Bayindir, O.; Kavakli, K.Öğe Screening first-degree relatives of patients with idiopathic dilated cardiomyopathy(Urban & Vogel, 2017) Okten, M. Sefa; Tuluce, K.; Tuluce, S. Yakar; Kilic, S.; Kemal, H. Soner; Sayin, A.; Vuran, O.; Yagmur, B.; Mutlu, I.; Simsek, E.; Cinar, C. Soydas; Gurgun, C.Background. This study evaluated whether subclinical myocardial dysfunction occurs in first-degree relatives of patients with idiopathic dilated cardiomyopathy (IDCM), using strain echocardiographic imaging, before apparent left ventricular (LV) failure is observed. Patients and method. The study comprised 77 subjects aged 16-63 years who had first-degree relatives with a previous or new diagnosis of IDCM. LV myocardial deformation parameters of the first-degree relatives with normal LVEF (55%) values, as assessed using 2D echocardiography, were evaluated. The findings of the first-degree relatives were compared with an age- and sex-matched control group (n = 86). Results. No difference in terms of age, gender, and body surface area was detected between first-degree relatives and controls. First-degree relatives of IDCM patients had significantly lower LVEF (62.04 +/- 5.8% vs. 65.65 +/- 6.3%, p < 0.001) and FS values (39.4 +/- 6.6 vs. 41.45 +/- 5.5, p = 0.03) compared with the controls. Assessment of LV deformation parameters revealed that LV global longitudinal strain (-17.34 +/- 2.19% vs. -19.21 +/- 2.16%, p < 0.001) and strain rate (0.94 +/- 0.14 s(-1) vs. 1.03 +/- 0.14 s(-1), p < 0.001), radial strain (34.47 +/- 9.14% vs 42.79 +/- 11.91%, p < 0.001) and strain rate (1.6 +/- 0.38 s(-1) vs. 1.75 +/- 0.29 s(-1), p = 0.006), circumferential strain (-6.07 +/- 2.83% vs. -18.29 +/- 3.39%, p < 0.001) and strain rate (1.09 +/- 0.24 s(-1) vs. 1.2 +/- 0.25 s(-1), p = 0.004), and torsion (10.07 +/- 5.18(o)/cm vs. 12.42 +/- 5.78(o)/cm, p = 0.009) were significantly reduced in first-degree relatives compared with controls. Conclusions. LV deformation parameters are impaired in first-degree relatives of patients with IDCM. Screening of this population using standard 2D echocardiography and strain imaging may provide early detection of those with subclinical myocardial dysfunction.Öğe Short-term statin treatment has beneficial effects on cardiac functions and inflammation in chronic heart failure(Oxford Univ Press, 2006) Gurgun, C.; Ildizli, M.; Yavuzgil, O.; Sin, A.; Apaydin, A.; Cinar, C.; Kultursay, H.
