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    Investigations on the anti-ulcerogenic activity of Sideritis caesarea H. Duman, Aytac & Baser
    (Elsevier Ireland Ltd, 2020) Gunbatan, Tugba; Gurbuz, Ilhan; Bedir, Erdal; Ozkan, Ayse Mine Gencler; Ozcinar, Ozge
    Ethnopharmacological relevance: Aerial parts of Sideritis caesarea H. Duman, Aytac & Baser are used for complaints such as stomach-aches, and intestinal spasms as traditional medicine in Kayseri, Turkey. Aim of study: To investigate the anti-ulcerogenic activity by using bioassay guided fractionation technique (BAGF) and to identify the compound(s) that are responsible for anti-ulcerogenic activity through ethanol-induced anti-ulcerogenic activity model in vivo. Materials and methods: Liquid-liquid partition and then different chromatographic techniques were utilized for the BAGF of the ethanol (80%) extract of the aerial parts of Sideritis caesarea. Ethanol-induced gastric ulcer method on rats was employed for the determination of the anti-ulcerogenic activity, and the ulcer index was also calculated for anti-ulcerogenic activity detection. Results: the ethanol (80%) extract of S. caesarea showed statistically potent anti-ulcerogenic activity (95.9% ulcer inhibition, p < 0.001). Among the liquid-liquid fractions, strongest anti-ulcerogenic activity was observed with the ethyl acetate fraction (91.4% inhibition, p< 0.001) and therefore BAGF studies were proceeded with the ethyl acetate fraction. Two anti-ulcerogenic flavonoids {4'-O-methylhypolaetin-7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]- 6 ''-O-acetyl-beta-D-glucopyranoside and isoscutellarein-7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside} were isolated from this fraction together with a sesquiterpene glycoside [(2E,6E)-2,6,10-trimethyl-2,6,11-dodecatriene-1,10-diol-1-O-beta-D-glucopyranoside] and two additional flavonoids {4'-O-methylhypolaetin-7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside and isoscutellarein- 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside}. Conclusions: Traditional use of S. caesarea in the treatment of stomach-aches was supported by this study and four flavonoids were isolated by using BAGF method and two of them were determined to have significant antiulcerogenic activity. Additionally, (2E,6E)-2,6,10-trimethyl-2,6,11-dodecatriene-1,10-diol-1-O-beta-D-glucopyranoside was obtained from a Sideritis genus for the first time.
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    THE SEROPREVALENCE OF HEPATITIS A IN ADULTS IN IZMIR: PRIOR TO INTRODUCING VACCINE INTO ROUTINE VACCINATION PROGRAM
    (Nobel Ilac, 2013) Kose, Sukran; Mandiracioglu, Aliye; Cavdar, Gulsun; Ulu, Yildiz; Nohutcu, Nese; Gurbuz, Ilhan; Sariavci, Senol; Ozkan, Mehmet
    Objective: Hepatitis A virus (HAV) is an important public health problem in Turkey. This study was aimed to determine the population-based seroprevalence of HAV in Izmir. Material and Method: In this cross-sectional study, a representative sample of the population, which was at the age of 5 years, was selected by using random stratification method. A total of 2156 healthy subjects participated in this present study Blood specimens were collected for testing anti-HAV IgG, and were examined by using enzyme-linked immunosorbent assay (ELISA). A questionnaire was also administered to obtain data regarding demographic characteristics and living conditions of the participants. Results: Anti-HAV IgG positivity was 93.9%. It was found that anti-HAV IgG seropositivity was higher in the subjects with lower income levels, lower education status, at older age, whereas it was lower in younger an(d) single subjects. Conclusion: Improved water and food sanitation resulted in reduced seroprevalence of HAV at younger age groups in Izmir.
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    Seroprevalence of varicella-zoster virus in the prevaccine era: A population-based study in Izmir, Turkey
    (Elsevier Science London, 2013) Kose, Sukran; Mandiracioglu, Aliye; Senger, Suheyla Serin; Ulu, Yildiz; Cavdar, Gulsun; Gol, Basak; Gurbuz, Ilhan; Sariavci, Senol; Nohutcu, Nese
    Purpose: To determine the population-based seroprevalence of varicella zoster virus (VZV) and related risk factors in Izmir. Materials and methods: A population-based household survey was conducted. A representative sample of the population older than 15 years of age was selected using multistage random sampling. A total of 2136 healthy persons participated in this cross-sectional study. The participants completed a questionnaire designed to collect data related to socio-demographic characteristics and risk factors. Blood samples were collected, and VZV-specific IgG was measured using an ELISA. Results: In total, 94.3% of individuals were seropositive for VZV. The difference between VZV seroprevalence in urban and rural populations was significant (OR: 2.6 (95% CI, 1.7-3.8)). No statistically significant differences in seropositivity were observed with respect to other sociodemographic characteristics. Conclusion: A large proportion of the participants were found to be immune to VZV. (C) 2012 King Saud Bin Abdulaziz University for Health Sciences. Published by Elsevier Ltd. All rights reserved.