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Öğe Diagnosis of ethylmalonic encephalopathy in a patient with a preliminary diagnosis of fanconi anemia: a case report(Springernature, 2024) Gungor, Ozge; Kok Kilic, Gizem; Gunes, Burcak Tatli; Karaca, Emin; Akin, Haluk[Abstarct Not Available]Öğe Higher Expression of the Novel Gene Upregulated Gene 4 in Two Acute Lymphoblastic Leukemia Patients with Poor Prednisolone Response(Karger, 2012) Oymak, Yesim; Dodurga, Yavuz; Turedi, Aysen; Yaman, Yontem; Ozek, Gulcihan; Carti, Ozgur; Gunes, Burcak Tatli; Erbudak, Esin; Berber, Ergul; Avci, Cigir Biray; Vergin, CananElucidation of the molecular mechanisms of leukemogenesis is important for a better understanding of the prognosis of acute lymphoblastic leukemia (ALL). Studies have shown that the expression of upregulated gene 4 (URG4), which promotes cell growth and survival, is increased in different types of carcinomas including hepatocellular carcinoma, gastric cancer and osteosarcoma. Similarly, higher expression of URG4 and cyclin D1 gene might promote proliferation of the blast cells by causing escape from the G1 checkpoint and entry into the S phase. This study reports the high expression level of URG4 in 2 high-risk ALL patients for the first time in the literature. In conclusion, the higher expression of URG4 in our 2 patients suggests that URG4 might be involved in leukemogenesis. Future studies with a large number of high-risk ALL patients and cell culture studies are needed to demonstrate the exact role of URG4 in leukemogenesis. Copyright (C) 2012 S. Karger AG, BaselÖğe Intracranial Bleeding in a Female Hemophilia Patient: Molecular Analysis of the Factor 8 Gene and Determination of a Novel Mutation(Galenos Yayincilik, 2018) Gunes, Burcak Tatli; Sivis, Zuhal Onder; Ataseven, Eda; Malbora, Baris; Turker, Meral; Belen, Fatma Burcu; Atabay, Berna; Atik, Tahir; Isik, Esra; Özkınay, FerdaÖğe Procoagulant Phospholipid Activity, Whole Blood Thromboelastography and Thrombin Generation Assay to Detect Hypercoagulability in Thalassemic Children(Amer Soc Hematology, 2014) Gunes, Burcak Tatli; Turker, Meral; Gozmen, Salih; Oymak, Yesim; Ay, Yilmaz; Ince, Dilek; Ozek, Gulcihan; Karapinar, Tuba Hilkay; Atabay, Berna; Vergin, Canan
